A Direct Distance to the LMC Cepheid HV 12198 from the Infrared Surface Brightness Technique

We report on a first application of the infrared surface brightness technique on a Cepheid in the Large Magellanic Cloud, the variable HV 12198 in the young globular cluster NGC 1866. From this one star, we determine a distance modulus of 18.42 +- 0.10 (random and systematic uncertainty) to the cluster. When the results on further member Cepheids in NGC 1866 become available, we expect to derive the distance to the LMC with a +- 3-4 percent accuracy, including systematic errors, from this technique.Comment: 4 pages, 4 figures, accepted in ApJ Letter

2XMM J083026+524133: The most X-ray luminous cluster at redshift 1

In the distant universe X-ray luminous clusters of galaxies are rare objects. Large area surveys are therefore needed to probe the high luminosity end of the cluster population at redshifts z >= 1. We correlated extended X-ray sources from the second XMM-Newton source catalogue (2XMM) with the SDSS in order to identify new clusters of galaxies. Distant cluster candidates in empty SDSS fields were imaged in the R and z bands with the Large Binocular Telescope. We extracted the X-ray spectra of the cluster candidates and fitted thermal plasma models to the data. We determined the redshift 0.99 +-0.03 for 2XMM J083026+524133 from its X-ray spectrum. With a bolometric luminosity of 1.8 x 10^45 erg/sec this is the most X-ray luminous cluster at redshifts z >= 1. We measured a gas temperature of 8.2 +- 0.9 keV and and estimate a cluster mass M(500) = 5.6 x 10^14 M(solar). The optical imaging revealed a rich cluster of galaxies.Comment: New version, as accepted for publication in Astronomy & Astrophysic

Theoretical insights into the RR Lyrae K-band Period-Luminosity relation

Based on updated nonlinear, convective pulsation models computed for several values of stellar mass, luminosity and metallicity, theoretical constraints on the K-band Period-Luminosity (PLK) relation of RR Lyrae stars are presented. We show that for each given metal content the predicted PLK is marginally dependent on uncertainties of the stellar mass and/or luminosity. Then, by considering the RR Lyrae masses suggested by evolutionary computations for the various metallicities, we obtain that the predicted infrared magnitude M_K over the range 0.0001< Z <0.02 is given by the relation MK=0.568-2.071logP+0.087logZ-0.778logL/Lo, with a rms scatter of 0.032 mag. Therefore, by allowing the luminosities of RR Lyrae stars to vary within the range covered by current evolutionary predictions for metal-deficient (0.0001< Z <0.006) horizontal branch models, we eventually find that the infrared Period-Luminosity- Metallicity (PLZK) relation is MK=0.139-2.071(logP+0.30)+0.167logZ, with a total intrinsic dispersion of 0.037 mag. As a consequence, the use of such a PLZK relation should constrain within +-0.04 mag the infrared distance modulus of field and cluster RR Lyrae variables, provided that accurate observations and reliable estimates of the metal content are available. Moreover, we show that the combination of K and V measurements can supply independent information on the average luminosity of RR Lyrae stars, thus yielding tight constraints on the input physics of stellar evolution computations. Finally, for globular clusters with a sizable sample of first overtone variables, the reddening can be estimated by using the PLZK relation together with the predicted MV-logP relation at the blue edge of the instability strip (Caputo et al. 2000).Comment: 8 pages, including 5 postscript figures, accepted for publication on MNRA

Distances to six Cepheids in the LMC cluster NGC1866 from the near-IR surface-brightness method

We derive individual distances to six Cepheids in the young populous star cluster NGC1866 in the Large Magellanic Cloud employing the near-IR surface brightness technique. With six stars available at the exact same distance we can directly measure the intrinsic uncertainty of the method. We find a standard deviation of 0.11 mag, two to three times larger than the error estimates and more in line with the estimates from Bayesian statistical analysis by Barnes et al. (2005). Using all six distance estimates we determine an unweighted mean cluster distance of 18.30+-0.05. The observations indicate that NGC1866 is close to be at the same distance as the main body of the LMC. If we use the stronger dependence of the p-factor on the period as suggested by Gieren et al. (2005) we find a distance of 18.50+-0.05 (internal error) and the PL relations for Galactic and MC Cepheids are in very good agreement.Comment: Presented at the conference "Stellar Pulsation and Evolution" in Monte Porzio Catone, June 2005. To appear in Mem. Soc. Ast. It. 76/

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development

&lt;p&gt;Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized. It was suggested that it is important for the supply of reducing equivalents during intra-erythrocytic development of Plasmodium and, therefore, a suitable drug target.&lt;/p&gt; &lt;p&gt;Methods: The gene encoding the NADP(H)-dependent GDHa has been disrupted by reverse genetics in P. falciparum and the effect on the antioxidant and metabolic capacities of the resulting mutant parasites was investigated.&lt;/p&gt; &lt;p&gt;Results: No growth defect under low and elevated oxygen tension, no up-or down-regulation of a number of antioxidant and NADP(H)-generating proteins or mRNAs and no increased levels of GSH were detected in the D10(Delta gdha) parasite lines. Further, the fate of the carbon skeleton of [(13)C] labelled glutamine was assessed by metabolomic studies, revealing no differences in the labelling of a-ketoglutarate and other TCA pathway intermediates between wild type and mutant parasites.&lt;/p&gt; &lt;p&gt;Conclusions: First, the data support the conclusion that D10(Delta gdha) parasites are not experiencing enhanced oxidative stress and that GDHa function may not be the provision of NADP(H) for reductive reactions. Second, the results imply that the cytosolic, NADP(H)-dependent GDHa protein is not involved in the oxidative deamination of glutamate but that the protein may play a role in ammonia assimilation as has been described for other NADP(H)dependent GDH from plants and fungi. The lack of an obvious phenotype in the absence of GDHa may point to a regulatory role of the protein providing glutamate (as nitrogen storage molecule) in situations where the parasites experience a limiting supply of carbon sources and, therefore, under in vitro conditions the enzyme is unlikely to be of significant importance. The data imply that the protein is not a suitable target for future drug development against intra-erythrocytic parasite development.&lt;/p&gt

Critical behaviour in the nonlinear elastic response of hydrogels

In this paper we study the elastic response of synthetic hydrogels to an applied shear stress. The hydrogels studied here have previously been shown to mimic the behaviour of biopolymer networks when they are sufficiently far above the gel point. We show that near the gel point they exhibit an elastic response that is consistent with the predicted critical behaviour of networks near or below the isostatic point of marginal stability. This point separates rigid and floppy states, distinguished by the presence or absence of finite linear elastic moduli. Recent theoretical work has also focused on the response of such networks to finite or large deformations, both near and below the isostatic point. Despite this interest, experimental evidence for the existence of criticality in such networks has been lacking. Using computer simulations, we identify critical signatures in the mechanical response of sub-isostatic networks as a function of applied shear stress. We also present experimental evidence consistent with these predictions. Furthermore, our results show the existence of two distinct critical regimes, one of which arises from the nonlinear stretch response of semi-flexible polymers.

BVRIJK light curves and radial velocity curves for selected Magellanic Cloud Cepheids

We present high precision and well sampled BVRIJK light curves and radial velocity curves for a sample of five Cepheids in the SMC. In addition we present radial velocity curves for three Cepheids in the LMC. The low metallicity (Fe/H ~ -0.7) SMC stars have been selected for use in a Baade-Wesselink type analysis to constrain the metallicity effect on the Cepheid Period-Luminosity relation. The stars have periods of around 15 days so they are similar to the Cepheids observed by the Extragalactic Distance Scale Key Project on the Hubble Space Telescope. We show that the stars are representative of the SMC Cepheid population at that period and thus will provide a good sample for the proposed analysis. The actual Baade-Wesselink analysis are presented in a companion paper.Comment: Accepted for publication in A&A, 23 pages, 10 figures, data tables will be made available electronically from the CD

Search for the second forbidden beta decay of 8B to the ground state of 8Be

A significant decay branch of 8B to the ground state of 8Be would extend the solar neutrino spectrum to higher energies than anticipated in the standard solar models. These high-energy neutrinos would affect current neutrino oscillation results and also would be a background to measurements of the hep process. We have measured the delayed alpha particles from the decay of 8B, with the goal of observing the two 46-keV alpha particles arising from the ground-state decay. The 8B was produced using an in-flight radioactive beam technique. It was implanted in a silicon PIN-diode detector that was capable of identifying the alpha-particles from the 8Be ground state. From this measurement we find an upper limit (at 90% confidence level) of 7.3 x 10^{-5} for the branching ratio to the ground state. In addition to describing this measurement, we present a theoretical calculation for this branching ratio.Comment: One reference corrected. Minor edits in tex