3,886 research outputs found
Interacting bosons in an optical lattice: Bose-Einstein condensates and Mott insulator
A dense Bose gas with hard-core interaction is considered in an optical
lattice. We study the phase diagram in terms of a special mean-field theory
that describes a Bose-Einstein condensate and a Mott insulator with a single
particle per lattice site for zero as well as for non-zero temperatures. We
calculate the densities, the excitation spectrum and the static structure
factor for each of these phases.Comment: 17 pages, 5 figures; 1 figure added, typos remove
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Amblyopia and real-world visuomotor tasks
A question of increasing interest to the basic science and clinical management communities during the past decade is whether children and adults with amblyopia and associated binocular visual abnormalities experience difficulties in executing real-world actions, to which vision normally makes an important functional contribution. Here we provide objective evidence that they do, by reviewing quantitative data from a number of studies comparing their performance with that of matched normally sighted subjects on a range of everyday visuomotor tasks. Because in real life, these tasks (grasping objects, walking, driving, reading) are habitually performed with both eyes open, our focus is on their binocular skill deficits, rather than those with their amblyopic eye alone. General findings are that individuals with abnormal binocularity show impairments in critical aspects of motor control--movement speed, accuracy or both--on every one of these activities, the extent of which correlates with their loss of stereoacuity, but not the severity of their amblyopia. Impairments were especially marked when the task was time-limited or novel. Implications are that children and adults with severely reduced or absent binocularity may be accident-prone when required to respond rapidly to unexpected situations and that amblyopia management should focus more attention on evaluating and restoring stereoacuity and stereomotion processing
Latent protein trees
Unbiased, label-free proteomics is becoming a powerful technique for
measuring protein expression in almost any biological sample. The output of
these measurements after preprocessing is a collection of features and their
associated intensities for each sample. Subsets of features within the data are
from the same peptide, subsets of peptides are from the same protein, and
subsets of proteins are in the same biological pathways, therefore, there is
the potential for very complex and informative correlational structure inherent
in these data. Recent attempts to utilize this data often focus on the
identification of single features that are associated with a particular
phenotype that is relevant to the experiment. However, to date, there have been
no published approaches that directly model what we know to be multiple
different levels of correlation structure. Here we present a hierarchical
Bayesian model which is specifically designed to model such correlation
structure in unbiased, label-free proteomics. This model utilizes partial
identification information from peptide sequencing and database lookup as well
as the observed correlation in the data to appropriately compress features into
latent proteins and to estimate their correlation structure. We demonstrate the
effectiveness of the model using artificial/benchmark data and in the context
of a series of proteomics measurements of blood plasma from a collection of
volunteers who were infected with two different strains of viral influenza.Comment: Published in at http://dx.doi.org/10.1214/13-AOAS639 the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
New measurements of the cosmic infrared background fluctuations in deep Spitzer/IRAC survey data and their cosmological implications
We extend previous measurements of cosmic infrared background (CIB)
fluctuations to ~ 1 deg using new data from the Spitzer Extended Deep Survey.
Two fields, with depths of ~12 hr/pixel over 3 epochs, are analyzed at 3.6 and
4.5 mic. Maps of the fields were assembled using a self-calibration method
uniquely suitable for probing faint diffuse backgrounds. Resolved sources were
removed from the maps to a magnitude limit of AB mag ~ 25, as indicated by the
level of the remaining shot noise. The maps were then Fourier-transformed and
their power spectra were evaluated. Instrumental noise was estimated from the
time-differenced data, and subtracting this isolates the spatial fluctuations
of the actual sky. The power spectra of the source-subtracted fields remain
identical (within the observational uncertainties) for the three epochs
indicating that zodiacal light contributes negligibly to the fluctuations.
Comparing to 8 mic power spectra shows that Galactic cirrus cannot account for
the fluctuations. The signal appears isotropically distributed on the sky as
required for an extragalactic origin. The CIB fluctuations continue to diverge
to > 10 times those of known galaxy populations on angular scales out to < 1
deg. The low shot noise levels remaining in the diffuse maps indicate that the
large scale fluctuations arise from the spatial clustering of faint sources
well below the confusion noise. The spatial spectrum of these fluctuations is
in reasonable agreement with an origin in populations clustered according to
the standard cosmological model (LCDM) at epochs coinciding with the first
stars era.Comment: ApJ, to be publishe
Automated Absorber Attachment for X-ray Microcalorimeter Arrays
Our goal is to develop a method for the automated attachment of large numbers of absorber tiles to large format detector arrays. This development includes the fabrication of high quality, closely spaced HgTe absorber tiles that are properly positioned for pick-and-place by our FC150 flip chip bonder. The FC150 also transfers the appropriate minute amount of epoxy to the detectors for permanent attachment of the absorbers. The success of this development will replace an arduous, risky and highly manual task with a reliable, high-precision automated process
The 1/N Expansion in Noncommutative Quantum Mechanics
We study the 1/N expansion in noncommutative quantum mechanics for the
anharmonic and Coulombian potentials. The expansion for the anharmonic
oscillator presented good convergence properties, but for the Coulombian
potential, we found a divergent large N expansion when using the usual
noncommutative generalization of the potential. We proposed a modified version
of the noncommutative Coulombian potential which provides a well-behaved 1/N
expansion.Comment: v2: resided version, to appear in PRD, 18 pages, 4 figure
Submillimeter Imaging of NGC 891 with SHARC
The advent of submillimeter wavelength array cameras operating on large
ground-based telescopes is revolutionizing imaging at these wavelengths,
enabling high-resolution submillimeter surveys of dust emission in star-forming
regions and galaxies. Here we present a recent 350 micron image of the edge-on
galaxy NGC 891, which was obtained with the Submillimeter High Angular
Resolution Camera (SHARC) at the Caltech Submillimeter Observatory (CSO). We
find that high resolution submillimeter data is a vital complement to shorter
wavelength satellite data, which enables a reliable separation of the cold dust
component seen at millimeter wavelengths from the warmer component which
dominates the far-infrared (FIR) luminosity.Comment: 4 pages LaTeX, 2 EPS figures, with PASPconf.sty; to appear in
"Astrophysics with Infrared Surveys: A Prelude to SIRTF
A Computational Framework for High-Throughput Isotopic Natural Abundance Correction of Omics-Level Ultra-High Resolution FT-MS Datasets
New metabolomics applications of ultra-high resolution and accuracy mass spectrometry can provide thousands of detectable isotopologues, with the number of potentially detectable isotopologues increasing exponentially with the number of stable isotopes used in newer isotope tracing methods like stable isotope-resolved metabolomics (SIRM) experiments. This huge increase in usable data requires software capable of correcting the large number of isotopologue peaks resulting from SIRM experiments in a timely manner. We describe the design of a new algorithm and software system capable of handling these high volumes of data, while including quality control methods for maintaining data quality. We validate this new algorithm against a previous single isotope correction algorithm in a two-step cross-validation. Next, we demonstrate the algorithm and correct for the effects of natural abundance for both 13C and 15N isotopes on a set of raw isotopologue intensities of UDP-N-acetyl-D-glucosamine derived from a 13C/15N-tracing experiment. Finally, we demonstrate the algorithm on a full omics-level dataset
Immunocytochemical demonstration of PTHrP protein in neoplastic tissue of HTLV-1 positive human adult T cell leukaemia/lymphoma: implications for the mechanism of hypercalcaemia.
The infiltrated tissues from seven West Indian patients with HTLV-1 positive adult T cell lymphoma/leukaemia (ATLL) have been analysed by immunocytochemical techniques for the presence of immunoreactive parathyroid hormone-related protein (PTHrP), a hormonal mediator of humoral hypercalcaemia of malignancy. Six of the seven were hypercalcaemic at some stage of the course of their disease. Four of the six evaluable patients showed evidence of specific cellular and extracellular expression of PTHrP protein in neoplastic tissues. This finding suggests that PTHrP may be involved in the production of hypercalcaemia in at least some cases of T cell lymphoma - proof of a causal relationship however must await the demonstration of tissue release of PTHrP resulting in raised circulating hormone levels
Implications of a High Angular Resolution Image of the Sunyaev-Zel'dovich Effect in RXJ1347-1145
The most X-ray luminous cluster known, RXJ1347-1145 (z=0.45), has been the
object of extensive study across the electromagnetic spectrum. We have imaged
the Sunyaev-Zel'dovich Effect (SZE) at 90 GHz (3.3 mm) in RXJ1347-1145 at 10"
resolution with the 64-pixel MUSTANG bolometer array on the Green Bank
Telescope (GBT), confirming a previously reported strong, localized enhancement
of the SZE 20" to the South-East of the center of X-ray emission. This
enhancement of the SZE has been interpreted as shock-heated (> 20 keV) gas
caused by an ongoing major (low mass-ratio) merger event. Our data support this
interpretation. We also detect a pronounced asymmetry in the projected cluster
pressure profile, with the pressure just east of the cluster core ~1.6 times
higher than just to the west. This is the highest resolution image of the SZE
made to date.Comment: 9 pages, 7 figures; accepted for publication in The Astrophysical
Journa
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