Loop level constraints on Seesaw neutrino mixing

Journal of High Energy Physics 2015.10 (2015): 130 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)We perform a detailed study of the importance of loop corrections when deriving bounds on heavy-active neutrino mixing in the context of general Seesaw mechanisms with extra heavy right-handed neutrinos. We find that, for low-scale Seesaws with an approximate B − L symmetry characterized by electroweak scale Majorana masses and large Yukawas, loop corrections could indeed become relevant in a small part of the parameter space. Previous results in the literature showed that a partial cancellation between these important loop corrections and the tree level contributions could relax some constraints and lead to qualitatively different results upon their inclusion. However, we find that this cancellation can only take place in presence of large violations of the B −L symmetry, that lead to acceptably large contributions to the light neutrino masses at loop level. Thus, when we restrict our analysis of the key observables to an approximate B − L symmetry so as to recover the correct values for neutrino masses, we always find loop corrections to be negligible in the regions of the parameter space preferred by dataWe are happy to acknowledge very illuminating discussions with Mattias Blennow, Belen Gavela, Stefano Rigolin and Alfredo Urbano. We also acknowledge financial support by the European Union through the ITN INVISIBLES (PITN-GA-2011-289442). EFM and JHG also acknowledge support from the EU through the FP7 Marie Curie Actions CIG NeuProbes (PCIG11-GA-2012-321582) and the Spanish MINECO through the “Ramon y Cajal” programme (RYC2011-07710), the project FPA2009-09017 and through the Centro de excelencia Severo Ochoa Program under grant SEV-2012-0249. This work was finalized during the stay of EFM at the Aspen Center for Physics, which is supported by the National Science Foundation grant PHY-1066293. This stay was also supported by a grant from the Simons Foundation. ML thanks the IFT UAM/CSIC for the kind hospitality during the early stages of this work. JLP also acknowledges support from the INFN program on Theoretical Astroparticle Physics (TASP) and the grant 2012CPPYP7 (Theoretical Astroparticle Physics) under the program PRIN 2012 funded by the Italian Ministry of Education, University and Research (MIUR

ν electroweak baryogenesis

We investigate if the CP violation necessary for successful electroweak baryo- genesis may be sourced by the neutrino Yukawa couplings. In particular, we consider an electroweak scale Seesaw realization with sizable Yukawas where the new neutrino singlets form (pseudo)-Dirac pairs, as in the linear or inverse Seesaw variants. We find that the baryon asymmetry obtained strongly depends on how the neutrino masses vary within the bubble walls. Moreover, we also find that flavour effects critically impact the final asymmetry obtained and that, taking them into account, the observed value may be obtained in some regions of the parameter space. This source of CP violation naturally avoids the strong constraints from electric dipole moments and links the origin of the baryon asymmetry of the Universe with the mechanism underlying neutrino masses. Interestingly, the mixing of the active and heavy neutrinos needs to be sizable and could be probed at the LHC or future collider experimentsEFM, TO and SRA acknowledge the support of the Spanish Agencia Estatal de Investigación and the EU “Fondo Europeo de Desarrollo Regional” (FEDER) through the projects PID2019-108892RB-I00/AEI/10.13039/501100011033 and FPA2016-78645-P as well as the “IFT Centro de Excelencia Severo Ochoa SEV-2016-0597”. JLP acknowledge the support from Generalitat Valenciana through the “plan GenT” program (CIDEGENT/2018/019) and from the Spanish MINECO under Grant FPA2017-85985-

Inhomogeneous Universe Models with Varying Cosmological Term

The evolution of a class of inhomogeneous spherically symmetric universe models possessing a varying cosmological term and a material fluid, with an adiabatic index either constant or not, is studied.Comment: 11 pages Latex. No figures. To be published in the GRG Journa

Determinación de 15 plaguicidas organoclorados y organofosforados en sedimentos del Lago Cocibolca (Mayo 1994-Junio 1997) Nicaragua

El número de estaciones monitoreadas en el Lago Cocibolca fueron 30; de las cuales en el 80% se detectó pp-DDE, lindano en el 60%, dieldrin 56% y metil-paratión en el 23%. Los valores máximos de los plaguicidas organoclorados detectados en el primer muestreo fueron: pp-DDE con 790.27 pg.g-1 en el punto No 3; lindano 181.30 pg.g-1 y dieldrin con 198.46 pg.g-1, ambos en el punto No 8; heptacloro 84.34 pg.g-1 y aldrin 67.67 pg.g-1, ambos en el punto No 6. El pp-DDT se detectó únicamente en el punto No 23 con 199.60 pg.g-1; el endrin con 66.80 pg.g-1 en el punto No 22. De los plaguicidas organofosforados analizados solamente se detectó la presencia de metil – paratión en un rango de concentración de 1500 pg.g-1 hasta 6 130 pg.g-1 en 7 estaciones. Las mayores concentraciones de plaguicidas organoclorados en el segundo muestreo correspondieron a: pp-DDE (1 352.70 pg.g-1),heptacloro (1 117.90 pg.g-1), lindano (812.0 pg.g-1), dieldrin (204.16 pg.g-1), heptacloroepóxido (386.64 pg.g-1) y endrin (124.13 pg.g-1). En ambos períodos de muestreo (Mayo 1994, Junio 1997) fue notoria la presencia de residuos de plaguicidas (clorados y fosforados) en el Lago Cocibolca, los cuales probablemente causaron la mortandad de peces, ya que las concentraciones de agroquímicos dectectados sobrepasan el límite de tolerancia para los peces y organismos acuáticos

Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP

The transcriptional regulator YAP orchestrates many cellular functions, including tissue homeostasis, organ growth control, and tumorigenesis. Mechanical stimuli are a key input to YAP activity, but the mechanisms controlling this regulation remain largely uncharacterized. We show that CAV1 positively modulates the YAP mechanoresponse to substrate stiffness through actin-cytoskeleton-dependent and Hippo-kinase-independent mechanisms. RHO activity is necessary, but not sufficient, for CAV1-dependent mechanoregulation of YAP activity. Systematic quantitative interactomic studies and image-based small interfering RNA (siRNA) screens provide evidence that this actin-dependent regulation is determined by YAP interaction with the 14-3-3 protein YWHAH. Constitutive YAP activation rescued phenotypes associated with CAV1 loss, including defective extracellular matrix (ECM) remodeling. CAV1-mediated control of YAP activity was validated in vivo in a model of pancreatitis-driven acinar-to-ductal metaplasia. We propose that this CAV1-YAP mechanotransduction system controls a significant share of cell programs linked to these two pivotal regulators, with potentially broad physiological and pathological implications. Moreno-Vicente et al. report that CAV1, a key component of PM mechanosensing caveolae, mediates adaptation to ECM rigidity by modulating YAP activity through the control of actin dynamics and phosphorylation-dependent interaction of YAP with the 14-3-3-domain protein YWHAH. Cav1-dependent YAP regulation drives two pathophysiological processes: ECM remodeling and pancreatic ADM. © 2018 The Author

A quality of service assessment technique for large-scale management of multimedia flows

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-540-75869-3_15Proceedings of 10th IFIP/IEEE International Conference on Management of Multimedia and Mobile Networks and Services, MMNS 2007, San José, USA, October 31 - November 2, 2007This paper presents the concept and preliminary experiments of a system for assessing on the Quality of Service of multimedia flows. The goal is to devise a mechanism that allows a service provider to take action whenever poor quality of service is detected in the delivery of multimedia flows. Such procedure is fully automatic since it is based on a goodness-of-fit test between source and destination packet interarrival histograms. If the null hypothesis of the test is accepted the flow is marked as in good standing, otherwise it is marked as anomalous and the network management system should take action in response. The proposed technique is analyzed in terms of hardware complexity and bandwidth consumption. The results show this technique is feasible and easily deployable at a minimum hardware and bandwidth expense.The authors would like to acknowledge the support of the Comunidad Autónoma de Madrid to this work, under project e-Magerit (S-0505/TIC/000251)

Composición y estructura de la ictiofauna del río Hondo, México-Belice, con base en el uso del arpón

ResumenSe determinó la composición y estructura de la ictiofauna del río Hondo y la variación espacial de éstas en función de los parámetros ambientales. Se realizaron 3 muestreos durante marzo, abril y mayo de 2012, en 6 sitios a lo largo del río. Los datos usados para determinar la estructura se obtuvieron con ayuda de un arpón de 58.5cm, utilizado durante 2h de buceo libre en cada punto de muestreo. Para complementar la lista de especies se utilizaron redes agalleras, palangres, nasas y anzuelos. Además, se realizó una revisión bibliográfica y se consultó material de la colección de peces de ECOSUR en Chetumal. La lista sistemática se conformó por 40 especies en 33 géneros, 18 familias y 11 órdenes. La familia mejor representada fue Cichlidae, incluida la especie exótica Oreochromis niloticus. Los parámetros ambientales que mejor describieron la variación de la distribución y abundancia en los peces en el río Hondo fueron: la anchura del río, distancia a la boca, transparencia, profundidad, concentración de oxígeno disuelto y conductividad. La relación entre las especies y las variables ambientales fue alta en ambos ejes (0.89 y 0.79). Ambientalmente, el río se puede zonificar en 3 partes, aunque su ictiofauna puede dividirse en 2 conjuntos principales.AbstractComposition and structure of the Hondo River ichthyofauna and its spatial variation were determined as a function of environmental parameters. Six sites along the river were sampled in March, April and May 2012. Data for estimating structure of fish assemblages was obtained by means of a 58.5cm harpoon during 2 hours of free diving at each sampling site. The species list for the study area was completed with the aid of gillnets, longlines, double-cone traps, and hook-and-line. In addition, a bibliographical research performed as well as the ichthyological collection of ECOSUR at Chetumal was checked. The systematic list includes 40 species in 33 genera, 18 families and 11 orders. The richest family was Cichlidae, including the exotic Oreochromis niloticus. The environmental parameters that best described distribution and abundance of fish in the Hondo River were river width, distance to mouth, transparency, depth, dissolved oxygen concentration, and conductivity. Correlation between species and environmental parameters was high in both axis (0.89 and 0.79). The river was classified into 3 environmental zones, although its fish fauna could be divided in 2 main assemblages

Molecular analysis of lungs from pigs immunized with a mutant transferrin binding protein B-based vaccine and challenged with Haemophilus parasuis

38 p.The molecular analysis of pigs vaccinated with a mutant transferrin-binding protein B (Y167A) from Haemophilus parasuis was compared with that performed for unvaccinated challenged (UNCH) and unvaccinated unchallenged (UNUN) pigs. Microarray analysis revealed that UNCH group showed the most distinct expression profile for immune response genes, mainly for those genes involved in inflammation or immune cell trafficking. This fact was confirmed by real-time PCR, in which the greatest level of differential expression from this group were CD14, CD163, IL-8 and IL-12. In Y167A group, overexpressed genes included MAP3K8, CD14, IL-12 and CD163. Proteomics revealed that collagen -1 and peroxiredoxins 2 and 6 were overexpressed in Y167A pigs. Our study reveals new data on genes and proteins involved in H. parasuis infection and several candidates of resistance to infection that are induced by Y167A vaccine. The expression of proinflammatory molecules from Y176A pigs is similar to their expression in UNUN pigsS

Plaguicidas organoclorados y organofosforados en aguas y sedimentos del Río San Juan y sus principales sub-cuencas 1992,1993 y 1997

El presente trabajo tiene por objetivo realizar un estudio comparativo sobre los niveles de Plaguicidas organoclorados y organofosforados en aguas y sedimentos en el Río San Juan y el aporte potencial de sus principales sub-cuencas. Este estudio fué realizado en los meses de Julio de 1992, Septiembre de 1993 y Mayo de 1997. De los plaguicidas organoclorados analizados en agua, en el muestreo de 1992, los de mayor incidencia fueron: dieldrín, y lindano en concentraciones máximas de 2.67 ng.L–1 y 0.94 ng.L–1 respectivamente. En el caso de los organofosforados fueron: malatión y terbufos ( 129.2 ng.L–1 y 77.3 ng.L–1 ). En los sedimentos, el plaguicida organoclorado con mayor presencia fue: dieldrín ( 4.51 ng.L–1 ) y de los organofosforados fueron: malatión ( 64,498 ng.L–1 ) y terbufos ( 342 ng.L–1 ). Las concentraciones de plaguicidas organofosforados en agua, del muestreo de 1997 mostraron presencia de fentión y el etil-paratión en concentraciones máximas de 257 ng.L–1 y 126 ng.L–1 respectivamente. Entretanto, en las muestras de sedimentos se detectaron los plaguicidas organoclorados: lindano, pp-DDT, pp-DDE y pp-DDD en concentraciones máximas de 63 pg.g-1; 271.77 pg.g-1; 122.15 pg.g-1; y 124.50 pg.g-1 respectivamente. Son alarmantes las concentraciones de plaguicidas detectadas en el río San Juan y sus principales sub-cuencas, de no tomarse acciones correctivas, las situación futura sería de mayor acumulación en el sedimento causando un impacto negativo en el ecosistema