630 research outputs found
The Influence of Ambiguity and Noise on the Measurement of Turbulent Spectra by Doppler Scattering
A fundamental uncertainty in velocity measurement by Doppler scattering is caused by the finite residence time of the scattering particles in the observation volume; the arrival of scattering particles at arbitrary times gives rise to fluctuations in phase (and hence frequency) of the observed Doppler frequency. An estimate is obtained for the spectrum of these frequency fluctuations (called ambiguity noise). The frequency at which the spectral levels of a turbulent signal and the ambiguity noise are equal, provides a limit to the temporal resolution of an instantaneous velocity measurement; this limit is obtained, and shown to be quite restrictive. The influence of electronic noise is also analyzed and found to be negligible.
An experimental installation is described in which instantaneous fluctuating turbulent velocities may be measured by Doppler scattering using coherent radiation from a laser. Measurements are presented of the spectra of ambiguity noise end electronic noise. The agreement with theory is excellent
Heliophysics Event Knowledgebase for the Solar Dynamics Observatory and Beyond
The immense volume of data generated by the suite of instruments on SDO
requires new tools for efficient identifying and accessing data that is most
relevant to research investigations. We have developed the Heliophysics Events
Knowledgebase (HEK) to fill this need. The HEK system combines automated data
mining using feature-detection methods and high-performance visualization
systems for data markup. In addition, web services and clients are provided for
searching the resulting metadata, reviewing results, and efficiently accessing
the data. We review these components and present examples of their use with SDO
data.Comment: 17 pages, 4 figure
Is there something of the MCT in orientationally disordered crystals ?
Molecular Dynamics simulations have been performed on the orientationally
disordered crystal chloroadamantane: a model system where dynamics are almost
completely controlled by rotations. A critical temperature T_c = 225 K as
predicted by the Mode Coupling Theory can be clearly determined both in the
alpha and beta dynamical regimes. This investigation also shows the existence
of a second remarkable dynamical crossover at the temperature T_x > T_c
consistent with a previous NMR and MD study [1]. This allows us to confirm
clearly the existence of a 'landscape-influenced' regime occurring in the
temperature range [T_c-T_x] as recently proposed [2,3].Comment: 4 pages, 5 figures, REVTEX
Serial interferon-gamma release assays during treatment of active tuberculosis in young adults
<p>Abstract</p> <p>Background</p> <p>The role of interferon-γ release assay (IGRA) in monitoring responses to anti-tuberculosis (TB) treatment is not clear. We evaluated the results of the QuantiFERON-TB Gold In-tube (QFT-GIT) assay over time during the anti-TB treatment of adults with no underlying disease.</p> <p>Methods</p> <p>We enrolled soldiers who were newly diagnosed with active TB and admitted to the central referral military hospital in South Korea between May 1, 2008 and September 30, 2009. For each participant, we preformed QFT-GIT assay before treatment (baseline) and at 1, 3, and 6 months after initiating anti-TB medication.</p> <p>Results</p> <p>Of 67 eligible patients, 59 (88.1%) completed the study protocol. All participants were males who were human immunodeficiency virus (HIV)-negative and had no chronic diseases. Their median age was 21 years (range, 20-48). Initially, 57 (96.6%) patients had positive QFT-GIT results, and 53 (89.8%), 42 (71.2%), and 39 (66.1%) had positive QFT-GIT results at 1, 3, and 6 months, respectively. The IFN-γ level at baseline was 5.31 ± 5.34 IU/ml, and the levels at 1, 3, and 6 months were 3.95 ± 4.30, 1.82 ± 2.14, and 1.50 ± 2.12 IU/ml, respectively. All patients had clinical and radiologic improvements after treatment and were cured. A lower IFN-γ level, C-reactive protein ≥ 3 mg/dl, and the presence of fever (≥ 38.3°C) at diagnosis were associated with negative reversion of the QFT-GIT assay.</p> <p>Conclusion</p> <p>Although the IFN-γ level measured by QFT-GIT assay decreased after successful anti-TB treatment in most participants, less than half of them exhibited QFT-GIT reversion. Thus, the reversion to negativity of the QFT-GIT assay may not be a good surrogate for treatment response in otherwise healthy young patients with TB.</p
PCV66 Pharmacoeconomic Analysis of Azilsartan Medoxomil in Patients With Arterial Hypertension: Comparison With Valsartan, Telmisartan, Losartan and Irbesartan in the Mexican Context
Laboratory investigation of lateral dispersion within dense arrays of randomly distributed cylinders at transitional Reynolds number
Published versio
Evidence for energy injection and a fine-tuned central engine at optical wavelengths in GRB 070419A
We present a comprehensive multiwavelength temporal and spectral analysis of
the FRED GRB 070419A. The early-time emission in the -ray and X-ray
bands can be explained by a central engine active for at least 250 s, while at
late times the X-ray light curve displays a simple power-law decay. In
contrast, the observed behaviour in the optical band is complex (from 10 up
to 10 s). We investigate the light curve behaviour in the context of the
standard forward/reverse shock model; associating the peak in the optical light
curve at 450 s with the fireball deceleration time results in a Lorenz
factor at this time. In contrast, the shallow optical
decay between 450 and 1500 s remains problematic, requiring a reverse shock
component whose typical frequency is above the optical band at the optical peak
time for it to be explained within the standard model. This predicts an
increasing flux density for the forward shock component until t 4
10 s, inconsistent with the observed decay of the optical emission
from t 10 s. A highly magnetized fireball is also ruled out due to
unrealistic microphysic parameters and predicted light curve behaviour that is
not observed. We conclude that a long-lived central engine with a finely tuned
energy injection rate and a sudden cessation of the injection is required to
create the observed light curves - consistent with the same conditions that are
invoked to explain the plateau phase of canonical X-ray light curves of GRBs.Comment: 9 pages, 10 figures, accepted for publication in MNRA
Institucionalização da Ciência da Informação no Brasil: estudo da convergência entre a produção científica e os marcos regulatórios da área
Desafios e perspectivas para a integração graduação/pós-graduação em Ciência da Informação: o caso do ICI/UFBA
In Vivo and In Vitro Effects of Antituberculosis Treatment on Mycobacterial Interferon-γ T Cell Response
Background: In recent years, the impact of antituberculous treatment on interferon (IFN)-c response to Mycobacterium tuberculosis antigens has been widely investigated, but the results have been controversial. The objective of the present study was: i) to evaluate longitudinal changes of IFN-c response to M. tuberculosis-specific antigens in TB patients during antituberculous treatment by using the QuantiFERON-TB Gold (QFT-G) assay; ii) to compare the differences in T-cell response after a short or prolonged period of stimulation with mycobacterial antigens; iii) to assess the CD4+ and CD8+ T cells with effector/memory and central/memory phenotype; iv) to investigate the direct in vitro effects of antituberculous drugs on the secretion of IFN-c. Principal Findings: 38 TB patients was evaluated at baseline and at month 2 and 4 of treatment and at month 6 (treatment completion). 27 (71%) patients had a QFT-G reversion (positive to negative) at the end of therapy, while 11 (29%) TB patients remained QFT-G positive at the end of therapy. Among the 11 patients with persistent positive QFT-G results, six had a complete response to the treatment, while the remaining 5 patients did not have a resolution of the disease. All 27 patients who became QFT-G negative had a complete clinical and microbiological recovery of the TB disease. In these patients the release of IFN-c is absent even after a prolonged 6-day incubation with both ESAT-6 and CFP-10 antigens and the percentage of effector/memory T-cells phenotype was markedly lower than subjects with persistent positive QFT-G results. The in vitro study showed that antituberculous drugs did not exert any inhibitory effect on IFN-c production within the range of therapeutically achievable concentrations. Conclusions: The present study suggests that the decrease in the M. tuberculosis-specific T cells responses following successful anti-TB therapy may have a clinical value as a supplemental tool for the monitoring of the efficacy of pharmacologic intervention for active TB. In addition, the antituberculous drugs do not have any direct down-regulatory effect on the specific IFN-c response
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