Cross-over versus first-order phase transition in holographic gravity-single-dilaton models of QCD thermodynamics

A dilaton potential is adjusted to recently confirmed lattice QCD thermodynamics data in the temperature range $(0.7 \ldots 3.5) T_c$ where $T_c = 155 \text{MeV}$ is the pseudo-critical temperature. The employed holographic model is based on a gravity--single-field dilaton dual. We discuss conditions for enforcing (for the pure gluon plasma) or avoiding (for the QCD quark-gluon plasma) a first-order phase transition, but still keeping a softest point (minimum of sound velocity).Comment: 11 pages, 9 figure

X-ray structure of the quinoprotein ethanol dehydrogenase from \u3ci\u3ePseudomonas aeruginosa\u3c/i\u3e: basis of substrate specificity

The homodimeric enzyme form of quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa ATCC 17933 crystallizes readily with the space group R3. The X-ray structure was solved at 2.6 Å resolution by molecular replacement. Aside from differences in some loops, the folding of the enzyme is very similar to the large subunit of the quinoprotein methanol dehydrogenases from Methylobacterium extorquens or Methylophilus W3A1. Eight W-shaped β-sheet motifs are arranged circularly in a propeller-like fashion forming a disk-shaped superbarrel. No electron density for a small subunit like that in methanol dehydrogenase could be found. The prosthetic group is located in the centre of the superbarrel and is coordinated to a calcium ion. Most amino acid residues found in close contact with the prosthetic group pyrroloquinoline quinone and the Ca2+ are conserved between the quinoprotein ethanol dehydrogenase structure and that of the methanol dehydrogenases. The main differences in the active-site region are a bulky tryptophan residue in the active-site cavity of methanol dehydrogenase, which is replaced by a phenylalanine and a leucine side-chain in the ethanol dehydrogenase structure and a leucine residue right above the pyrrolquinoline quinone group in methanol dehydrogenase which is replaced by a tryptophan side-chain. Both amino acid exchanges appear to have an important influence, causing different substrate specificities of these otherwise very similar enzymes. In addition to the Ca2+ in the active-site cavity found also in methanol dehydrogenase, ethanol dehydrogenase contains a second Ca2+-binding site at the N terminus, which contributes to the stability of the native enzyme

Building ProteomeTools based on a complete synthetic human proteome.

We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research. Here we report the generation and multimodal liquid chromatography-tandem mass spectrometry analysis of \u3e330,000 synthetic tryptic peptides representing essentially all canonical human gene products, and we exemplify the utility of these data in several applications. The resource (available at http://www.proteometools.org) will be extended to \u3e1 million peptides, and all data will be shared with the community via ProteomicsDB and ProteomeXchange

Holographic QCD phase diagram with critical point from Einstein–Maxwell-dilaton dynamics

Supplementing the holographic Einstein–Maxwell-dilaton model of [1,2] by input of lattice QCD data for 2+1 flavors and physical quark masses for the equation of state and quark number susceptibility at zero baryo-chemical potential we explore the resulting phase diagram over the temperature-chemical potential plane. A first-order phase transition sets in at a temperature of about 112 MeV and a baryo-chemical potential of 612 MeV. We estimate the accuracy of the critical point position in the order of approximately 5–8% by considering parameter variations and different low-temperature asymptotics for the second-order quark number susceptibility. The critical pressure as a function of the temperature has a positive slope, i.e. the entropy per baryon jumps up when crossing the phase border line from larger values of temperature/baryo-chemical potential, thus classifying the phase transition as a gas–liquid one. The updated holographic model exhibits in- and outgoing isentropes in the vicinity of the first-order phase transition

Path integral optimization as circuit complexity

Early efforts to understand complexity in field theory have primarily employed a geometric approach based on the concept of circuit complexity in quantum information theory. In a parallel vein, it has been proposed that certain deformations of the Euclidean path integral that prepares a given operator or state may provide an alternative definition, whose connection to the standard notion of complexity is less apparent. In this letter, we bridge the gap between these two proposals in two-dimensional conformal field theories, by explicitly showing how the latter approach from path integral optimization may be given a concrete realization within the standard gate counting framework. In particular, we show that when the background geometry is deformed by a Weyl rescaling, a judicious gate counting allows one to recover the Liouville action as a particular choice within a more general class of cost functions

Technical note: post mortem CT angiography of iliacofemoral arteries after cardiovascular surgery

This technical note details a variation of post mortem computed tomography angiography that usually uses femoral access. In this instance, the focus of the forensic investigation centered around a heavily calcified and surgically altered femoral region. So instead, a subclavian access to the aorta was employed. In order to preserve anatomical areas of interest, alternate access may increase evidential value of resulting imagery and autopsy results