Variable cavity volume tooling for high-performance resin infusion moulding

This article describes the research carried out by Warwick under the BAE Systems/EPSRC programme ‘Flapless Aerial Vehicles Integrated Interdisciplinary Research – FLAVIIR’. Warwick's aim in FLAVIIR was to develop low-cost innovative tooling technologies to enable the affordable manufacture of complex composite aerospace structures and to help realize the aim of the Grand Challenge of maintenance-free, low-cost unmanned aerial vehicle manufacture. This article focuses on the evaluation of a novel tooling process (variable cavity tooling) to enable the complete infusion of resin throughout non-crimp fabric within a mould cavity under low (0.1 MPa) injection pressure. The contribution of the primary processing parameters to the mechanical properties of a carbon composite component (bulk-head lug section), and the interactions between parameters, was determined. The initial mould gap (di) was identified as having the most significant effect on all measured mechanical properties, but complex interactions between di, n (number of fabric layers), and vc (mould closure rate) were observed. The process capability was low due to the manual processing, but was improved through process optimization, and delivered properties comparable to high-pressure resin transfer moulding

Lessons from the operation of the "Penning-Fluorescent" TPC and prospects

We have recently reported the development of a new type of high-pressure Xenon time projection chamber operated with an ultra-low diffusion mixture and that simultaneously displays Penning effect and fluorescence in the near-visible region (300 nm). The concept, dubbed `Penning-Fluorescent' TPC, allows the simultaneous reconstruction of primary charge and scintillation with high topological and calorimetric fidelity

The T-REX project: Micromegas for rare event searches

The T-REX project aims at developing novel readout techniques for Time Projection Chambers for experiments searching for Rare Events. The Micromegas detectors are a good option, because of their good performance regarding low background levels, energy and time resolution, gain and stability of operation. In the present we will shortly refer to two particular cases, on one hand their performance in the CAST experiment and on the other the studies carried out within NEXT, a neutrinoless double-beta decay experiment

Rare event searches based on micromegas detectors: The T-REX project

Micromegas readouts are an attractive option for many of the rare event searches, due to their performance regarding energy resolution, gain stability, homogeneity and material budget. The T-REX project aims at developing further these novel readout techniques for Time Projection Chambers and their potential use in experiments searching for rare events. Here we will refer to the latest results regarding the use and prospects of Micromegas read-outs in axion physics (CAST and the future helioscope), as well as the R&D carried out within NEXT, to search for the neutrinoless double-beta decay

Status of R&D on Micromegas for Rare Event Searches : The T-REX project

The T-REX project aims at developing novel readout techniques for Time Projection Chambers in experiments searching for rare events. The enhanced performance of the latest Micromegas readouts in issues like energy resolution, gain stability, homogeneity, material budget, combined with low background techniques, is opening new windows of opportunity for their application in this field. Here we review the latest results regarding the use and prospects of Micromegas readouts in axion physics (CAST and the future helioscope), as well as the R&D carried out within NEXT, to search for the neutrinoless double-beta decay

Low background x-ray detection with Micromegas for axion research

Axion helioscopes aim at the detection of solar axions through their conversion into x-rays in laboratory magnetic fields. The use of low background x-ray detectors is an essential component contributing to the sensitivity of these searches. Here we review the recent advances on Micromegas detectors used in the CERN Axion Solar Telescope (CAST) and proposed for the future International Axion Observatory (IAXO). The most recent Micromegas setups in CAST have achieved background levels of 1.5$\times10^{-6}$\ckcs, a factor of more than 100 lower than the ones obtained by the first generation of CAST detectors. This improvement is due to the development of active and passive shielding techniques, offline discrimination techniques allowed by highly granular readout patterns, as well as the use of radiopure detector components. The status of the intensive R&D to reduce the background levels will be described, including the operation of replica detectors in test benches and the detailed Geant4 simulation of the detector setup and the detector response, which has allowed the progressive understanding of background origins. The best levels currently achieved in a test setup operating in the Canfranc Underground Laboratory (LSC) are as low as $\sim10^{-7}$\ckcs, showing the good prospects of this technology for application in the future IAXO.Axion helioscopes aim at the detection of solar axions through their conversion into x-rays in laboratory magnetic fields. The use of low background x-ray detectors is an essential component contributing to the sensitivity of these searches. Here we review the recent advances on Micromegas detectors used in the CERN Axion Solar Telescope (CAST) and proposed for the future International Axion Observatory (IAXO). The most recent Micromegas setups in CAST have achieved background levels of 1.5 × 10(−)(6) keV(−)(1) cm(−)(2) s(−)(1), a factor of more than 100 lower than the ones obtained by the first generation of CAST detectors. This improvement is due to the development of active and passive shielding techniques, offline discrimination techniques allowed by highly granular readout patterns, as well as the use of radiopure detector components. The status of the intensive R&D to reduce the background levels will be described, including the operation of replica detectors in test benches and the detailed Geant4 simulation of the detector setup and the detector response, which has allowed the progressive understanding of background origins. The best levels currently achieved in a test setup operating in the Canfranc Underground Laboratory (LSC) are as low as ~ 10(−)(7) keV(−)(1) cm(−)(2) s(−)(1), showing the good prospects of this technology for application in the future IAXO.Axion helioscopes aim at the detection of solar axions through their conversion into x-rays in laboratory magnetic fields. The use of low background x-ray detectors is an essential component contributing to the sensitivity of these searches. Here we review the recent advances on Micromegas detectors used in the CERN Axion Solar Telescope (CAST) and proposed for the future International Axion Observatory (IAXO). The most recent Micromegas setups in CAST have achieved background levels of 1.5$\times10^{-6}$\ckcs, a factor of more than 100 lower than the ones obtained by the first generation of CAST detectors. This improvement is due to the development of active and passive shielding techniques, offline discrimination techniques allowed by highly granular readout patterns, as well as the use of radiopure detector components. The status of the intensive R&D to reduce the background levels will be described, including the operation of replica detectors in test benches and the detailed Geant4 simulation of the detector setup and the detector response, which has allowed the progressive understanding of background origins. The best levels currently achieved in a test setup operating in the Canfranc Underground Laboratory (LSC) are as low as $\sim10^{-7}$\ckcs, showing the good prospects of this technology for application in the future IAXO

Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design

Cardiovascular disease (CVD) and type 2 diabetes (T2D) are increasing worldwide. This is mainly due to an unhealthy nutrition, implying that variation in CVD risk may be due to variation in the capacity to manage a nutritional load. We examined the genomic basis of postprandial metabolism. Our main purpose was to introduce the GEMM Family Study (Genetics of Metabolic Diseases in Mexico) as a multi-center study carrying out an ongoing recruitment of healthy urban adults. Each participant received a mixed meal challenge and provided a 5-hours’ time course series of blood, buffy coat specimens for DNA isolation, and adipose tissue (ADT)/skeletal muscle (SKM) biopsies at fasting and 3 h after the meal. A comprehensive profiling, including metabolomic signatures in blood and transcriptomic and proteomic profiling in SKM and ADT, was performed to describe tendencies for variation in postprandial response. Our data generation methods showed preliminary trends indicating that by characterizing the dynamic properties of biomarkers with metabolic activity and analyzing multi-OMICS data it could be possible, with this methodology and research design, to identify early trends for molecular biology systems and genes involved in the fasted and fed states

Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults

We previously reported preliminary characterization of adipose tissue (AT) dysfunction through the adiponectin/leptin ratio (ALR) and fasting/postprandial (F/P) gene expression in subcutaneous (SQ) adipose tissue (AT) biopsies obtained from participants in the GEMM study, a precision medicine research project. Here we present integrative data replication of previous findings from an increased number of GEMM symptom-free (SF) adults (N = 124) to improve characterization of early biomarkers for cardiovascular (CV)/immunometabolic risk in SF adults with AT dysfunction. We achieved this goal by taking advantage of the rich set of GEMM F/P 5 h time course data and three tissue samples collected at the same time and frequency on each adult participant (F/P blood, biopsies of SQAT and skeletal muscle (SKM)). We classified them with the presence/absence of AT dysfunction: low (1) ALR. We also examined the presence of metabolically healthy (MH)/unhealthy (MUH) individuals through low-grade chronic subclinical inflammation (high sensitivity C-reactive protein (hsCRP)), whole body insulin sensitivity (Matsuda Index) and Metabolic Syndrome criteria in people with/without AT dysfunction. Molecular data directly measured from three tissues in a subset of participants allowed fine-scale multi-OMIC profiling of individual postprandial responses (RNA-seq in SKM and SQAT, miRNA from plasma exosomes and shotgun lipidomics in blood). Dynamic postprandial immunometabolic molecular endophenotypes were obtained to move towards a personalized, patient-defined medicine. This study offers an example of integrative translational research, which applies bench-to-bedside research to clinical medicine. Our F/P study design has the potential to characterize CV/immunometabolic early risk detection in support of precision medicine and discovery in SF individuals