Electrical cabling withstands severe environmental conditions

Multiconductor electrical cables retain their circuit integrity and remain flexible and abrasion resistant in severe environmental conditions of heat, vibration, and water

Frangible tube energy dissipation Patent

Energy dissipating shock absorbing system for land payload recovery or vehicle brakin

Break-up of metal tube makes one-time shock absorber, bars rebound

A frangible metal tube has the capability to dissipate the energy generated when a vehicle lands with excessive velocity. The tube is so placed that, at impact, it is forced against a die and, as it fragments, energy is absorbed

Physicians' Experiences as Patients with Statin Side Effects: A Case Series.

Physicians are among those prescribed statins and therefore, subject to potential statin adverse effects (AEs). There is little information on the impact of statin AEs on physicians affected by them. We sought to assess the character and impact of statin AEs occurring in physicians and retired physicians, and to ascertain whether/how personal experience of AEs moderated physicians' attitude toward statin use. Seven active or retired physicians from the United States communicated with the Statin Effects Study group regarding their personal experience of statin AEs. AE characteristics, experience with (their own) physicians, and impact of AE was ascertained. We inquired whether or how their experience altered their own attitude toward statins or statin AEs. Patient A: Atorvastatin 40 then 80 mg was followed by cognitive problems, neuropathy, and glucose intolerance in a Radiologist in his 50s (Naranjo criteria: probable causality). Patient B: Atorvastatin 10 mg was followed in 2 months by muscle weakness and myalgia in an Internist in his 40s (probable causality). Patient C: Atorvastatin, ezetimibe/simvastatin, rosuvastatin at varying doses was followed shortly after by irritability, myalgia, and fatigue in a Cardiac Surgeon in his 40s (probable causality). Patient D: Simvastatin 20 then 40 mg was followed in 4 years by mitochondriopathy, myopathy, neuropathy, and exercise intolerance in an Emergency Medicine physician in his 50s (definite causality). Patient E: Simvastatin 20 mg and niacin 1000 mg was followed in one month by muscle weakness and myalgia in a Physical Medicine and Rehabilitation physician in his 50s (probable causality). Patient F: Lovastatin 20 mg then simvastatin 20 mg, atorvastatin 20 mg, rosuvastatin 5 mg, niacin 20 mg and ezetimbe 10 mg was followed by muscle weakness and myalgia in an Obstetrician/Gynecologist in his 70s (definite causality). Patient G: Ezetimibe/simvastatin and atorvastatin (dose unavailable) was followed shortly after by cognitive problems in a Radiologist in her 80s (probable causality). Thus AEs affected multiple quality-of-life relevant domains, often in combination, encompassing muscle (N = 5), fatigue (N = 2), peripheral neuropathy (N = 2), cognitive (N = 2), dysglycemia (N = 1) and behavioral manifestations (N = 1). In five, the AEs affected the physician professionally. Five physicians experienced dismissive attitudes in some of their own healthcare encounters. One noted that his experience helped not only his own attention to statin AEs, but that of other physicians in his community. Several stated that their experience altered their understanding of and/or attitude toward statin AEs, and/or their view of settings in which statin use is warranted. Statin AEs can have profound impact in high functioning professionals with implications to the individual, their professional life, and those whom they serve professionally

Criminal Law - Mail Fraud - Statutory Interpretation - Scope

The United States Supreme Court has held that the coverage of the mail fraud statute, 18 U.S.C. § 1341, is limited to the prosecution of fraudulent schemes utilizing the mails that lead to the deprivation of monetary and property interests, while the deprivation of intangible rights, such as the right to honest and impartial government, is not included within the scope of the mail fraud statute. McNally v. United States, 107 S. Ct. 2875 (1987)

Generalized Domination.

This thesis develops the theory of the everywhere domination relation between functions from one infinite cardinal to another. When the domain of the functions is the cardinal of the continuum and the range is the set of natural numbers, we may restrict our attention to nicely definable functions from R to N. When we consider a class of such functions which contains all Baire class one functions, it becomes possible to encode information into these functions which can be decoded from any dominator. Specifically, we show that there is a generalized Galois-Tukey connection from the appropriate domination relation to a classical ordering studied in recursion theory. The proof techniques are developed to prove new implications regarding the distributivity of complete Boolean algebras. Next, we investigate a more technical relation relevant to the study of Borel equivalence relations on R with countable equivalence classes. We show than an analogous generalized Galois-Tukey connection exists between this relation and another ordering studied in recursion theory.PhDMathematicsUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/113539/1/danhath_1.pd

A suite of computational tools to interrogate sequence data with local haplotype analysis within complex ​Plasmodium​ infections and other microbial mixtures

The rapid development of DNA sequencing technologies has opened up new avenues of research, including the investigation of population structure within infectious diseases (both within patient and between populations). In order to take advantage of these advances in technologies and the generation of new types of data, novel bioinformatics tools are needed that won’t succumb to artifacts introduced by the data generation, and thus provide accurate and precise results. To achieve this goal I have create several tools. First, SeekDeep, a pipeline for analyzing targeted amplicon sequencing datasets from various technologies, is able to achieve 1-base resolution even at low frequencies and read depths allowing for accurate comparison between samples and the detection of important SNPs. Next, PathWeaver, a local haplotype assembler designed for complex infections and highly variable genomic regions with poor reference mapping. PathWeaver is able to create highly accurate haplotypes without generating chimeric assemblies. PathWeaver was used on the key protein in pregnancy-associated malaria Plasmodium falciparum VAR2CSA which revealed population sub-structuring within the key binding domain of the protein observed to be present globally along with confirming copy number variation. Finally, the program Carmen is able to utilize PathWeaver to augment the results from targeted amplicon approaches by reporting where and when local haplotypes have been found previously. These rigorously tested tools allow the analysis of local haplotype data from various technologies and approaches to provide accurate, precise and easily accessible results

Laser anemometer measurements in a transonic axial-flow fan rotor

Laser anemometer surveys were made of the 3-D flow field in NASA rotor 67, a low aspect ratio transonic axial-flow fan rotor. The test rotor has a tip relative Mach number of 1.38. The flowfield was surveyed at design speed at near peak efficiency and near stall operating conditions. Data is presented in the form of relative Mach number and relative flow angle distributions on surfaces of revolution at nine spanwise locations evenly spaced from hub to tip. At each spanwise location, data was acquired upstream, within, and downstream of the rotor. Aerodynamic performance measurements and detailed rotor blade and annulus geometry are also presented so that the experimental results can be used as a test case for 3-D turbomachinery flow analysis codes

1,2-Diiodo-4,5-dimethyl­benzene

The structure of the title compound, C8H8I2, conforms closely to the mm2 symmetry expected for the free mol­ecule and is the first reported structure of a diiodo­dimethyl­benzene. Repulsion by neighboring I atoms and the neighboring methyl groups opposite to them results in a slight elongation of the mol­ecule along the approximate twofold rotation axis that bis­ects the ring between the two I atoms. In the extended structure, the mol­ecules form inversion-related pairs which are organized in approximately hexa­gonal close-packed layers and the layers then stacked so that mol­ecules in neighboring layers abut head-to-tail in a manner that optimizes dipole–dipole inter­actions