Geodesic Flow on the Normal Congruence of a Minimal Surface

We study the geodesic flow on the normal line congruence of a minimal surface in ${\Bbb{R}}^3$ induced by the neutral K\"ahler metric on the space of oriented lines. The metric is lorentz with isolated degenerate points and the flow is shown to be completely integrable. In addition, we give a new holomorphic description of minimal surfaces in ${\Bbb{R}}^3$ and relate it to the classical Weierstrass representation.Comment: AMS-LATEX 8 pages 2, figure

Weyl-type Fields with Geodesic Lines of Force

The static electrogravitational equations are studied and it is shown that an aligned type D metric which has a Weyl-type relationship between the gravitational and electric potential has shearfree geodesic lines of force. All such fields are then found and turn out to be the fields of a charged sphere, charged infinite rod and charged infinite plate. A further solution is also found with shearing geodesic lines of force. This new solution can have $m>|e|$ or $m<|e|$, but cannot be in the Majumdar-Papapetrou class (in which $m = |e|$). It is algebraically general and has flat equipotential surfaces.Comment: 13 pages, RevTe

Auxin-Regulated Gene Expression

A number of cDNA clones to independent mRNAs that increase in amount after brief exposure to auxins have been isolated. From soybean, sequenced, and characterized. Increases in mRNA abundance can be detected as early as 2.5 minutes after auxin application to excised elongating regions of soybean hypocotyls. Increased transcription rates on the genes which encode the auxin-responsive mRNAs account, at least partly, for the accumulation of mRNAs. A variety of auxins induce the accumulation of the mRNAs, but other plant hormones have no effect on the mRNA abundance. Some of the genes which encode the mRNAs are clustered in the soybean genome. The soybean gene cluster is expressed under auxin control when transferred into petunia via Agrobacterium T-DNA. In soybean and pea, expression of some of the auxin regulated genes is greatest in the elongating regions of hypocotyl and epicotyl. Some of the genes are primarily expressed in epidermal and outer cortical cells of elongating hypocotyl region. During gravitropism, some of the auxin responsive mRNAs turn over very rapidly and accumulate on the more rapidly elongating side of the hypocotyl

Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications.

The ability to deliver drug molecules effectively across the blood-brain barrier into the brain is important in the development of central nervous system (CNS) therapies. Cerebral microdialysis is the only existing technique for sampling molecules from the brain extracellular fluid (ECF; also termed interstitial fluid), the compartment to which the astrocytes and neurones are directly exposed. Plasma levels of drugs are often poor predictors of CNS activity. While cerebrospinal fluid (CSF) levels of drugs are often used as evidence of delivery of drug to brain, the CSF is a different compartment to the ECF. The continuous nature of microdialysis sampling of the ECF is ideal for pharmacokinetic (PK) studies, and can give valuable PK information of variations with time in drug concentrations of brain ECF versus plasma. The microdialysis technique needs careful calibration for relative recovery (extraction efficiency) of the drug if absolute quantification is required. Besides the drug, other molecules can be analysed in the microdialysates for information on downstream targets and/or energy metabolism in the brain. Cerebral microdialysis is an invasive technique, so is only useable in patients requiring neurocritical care, neurosurgery or brain biopsy. Application of results to wider patient populations, and to those with different pathologies or degrees of pathology, obviously demands caution. Nevertheless, microdialysis data can provide valuable guidelines for designing CNS therapies, and play an important role in small phase II clinical trials. In this review, we focus on the role of cerebral microdialysis in recent clinical studies of antimicrobial agents, drugs for tumour therapy, neuroprotective agents and anticonvulsants

Co-Administration in the Zunils Regional Municipal Protected Area, Guatemala

Co-administration, as a joint protected area governance approach, has increased substantially around the world. In Guatemala, one of the most rapidly growing forms of co-administration is that of protected areas managed by municipal governments in conjunction with central government agencies. There are high expectations for these protected areas coadministered by municipalities to ensure local participation and strengthen the government’s ongoing decentralization and conservation processes. However, little research has been conducted on the outcomes of these types of arrangements. This study presents an in-depth understanding about the co-administration of the Regional Municipal Protected Area of Zunil, from the perspective of different stakeholders. The Participatory Action Research Methodology was used to promote participation, learning, and action. The key area of strength of the current co-administration efforts in Zunil identified by co-participants was increased institutional coordination as reflected in such operational programs as environmental education, wildlife monitoring, and patrolling. The key area of weakness identified by co-participants was administrative structures and processes such as inadequate financing mechanisms, lack of processes to increase capacities of personnel, high and frequent rotation of personnel, and lack of active involvement of local stakeholders. In this case, successful co-administration required building human and social capital; ensuring mutual benefits for stakeholders involved; promoting involvement and active participation of local communities; negotiating and signing a shared co-management agreement; engaging in inclusive decision-making; improving organizational structures at the local level; and promoting sustainable development initiatives (e.g. tourism)

Principal component analysis of the cytokine and chemokine response to human traumatic brain injury.

There is a growing realisation that neuro-inflammation plays a fundamental role in the pathology of Traumatic Brain Injury (TBI). This has led to the search for biomarkers that reflect these underlying inflammatory processes using techniques such as cerebral microdialysis. The interpretation of such biomarker data has been limited by the statistical methods used. When analysing data of this sort the multiple putative interactions between mediators need to be considered as well as the timing of production and high degree of statistical co-variance in levels of these mediators. Here we present a cytokine and chemokine dataset from human brain following human traumatic brain injury and use principal component analysis and partial least squares discriminant analysis to demonstrate the pattern of production following TBI, distinct phases of the humoral inflammatory response and the differing patterns of response in brain and in peripheral blood. This technique has the added advantage of making no assumptions about the Relative Recovery (RR) of microdialysis derived parameters. Taken together these techniques can be used in complex microdialysis datasets to summarise the data succinctly and generate hypotheses for future study

Neutral perfect fluids of Majumdar-type in general relativity

We consider the extension of the Majumdar-type class of static solutions for the Einstein-Maxwell equations, proposed by Ida to include charged perfect fluid sources. We impose the equation of state $\rho+3p=0$ and discuss spherically symmetric solutions for the linear potential equation satisfied by the metric. In this particular case the fluid charge density vanishes and we locate the arising neutral perfect fluid in the intermediate region defined by two thin shells with respective charges $Q$ and $-Q$. With its innermost flat and external (Schwarzschild) asymptotically flat spacetime regions, the resultant condenser-like geometries resemble solutions discussed by Cohen and Cohen in a different context. We explore this relationship and point out an exotic gravitational property of our neutral perfect fluid. We mention possible continuations of this study to embrace non-spherically symmetric situations and higher dimensional spacetimes.Comment: 9 page

Preliminary results from a survey of oyster production areas in Ireland for norovirus

A survey of 18 oyster production areas in Ireland for norovirus (NoV) contamination was initiated in August 2006. The findings presented are the preliminary results from the first seven months of the survey. Prior to the survey commencing, a simple desk bask sanitary survey of each area was undertaken. This provided an assessment enabling each site to be ranked into 3 categories (low, medium and high) on the basis of the risk of NoV contamination. Samples were collected on a monthly basis and tested for the presence of NoV using semi-quantitative real-time PCR allowing relative quantitation of NoV levels. A correlation was observed between occurrence and levels of NoV detected and the risk categories ascribed to each production area. To date NoV was detected in 60.7, 30.0 and 2.5 percent of samples from the high, medium and low risk categorised areas, respectively. A strong seasonal bias towards increased winter contamination was observed with NoV detected in 15.5 and 50 % of samples in August and February, respectively. The preliminary results from this survey indicate that it may be possible to predict the relative risk of NoV contamination in a shellfish harvesting area. This in conjunction with targeted NoV monitoring using real-time PCR could aid the further development of risk management procedures in shellfisheries

REDRISK: reduction of the virus risk in shellfish harvesting areas

Filter feeding bivalve shellfish can accumulate human pathogenic bacteria and viruses if grown in sewage-contaminated waters. Current consumer protection legislation relies on classification of harvesting areas based on their sanitary quality, using E coli as an indicator of sewage contamination. Advances in viral monitoring have shown that E coli can underestimate the extent of the contamination. The most common cause of gastroenteritis associated with shellfish is norovirus, commonly known as winter vomiting virus. The REDRISK project was undertaken to investigate the main environmental factors that cause viral contamination in shellfish. The REDRISK project is part of a EU research pillar with parallel research being undertaken in the UK, France and Spain. A recently developed technique to quantify norovirus in shellfish, real-time PCR, has been used in the REDRISK project. Clew Bay, in Co. Mayo was chosen as the study area in Ireland. The bay is generally considered to have good water quality but with certain areas subject to intermittent sewage contamination. The cooperation of local producers and organisations such as the Clew Bay Marine Forum and the Native Oyster Co-op greatly helped the project. The project was divided into a two-phased approach. Phase one involved the identification of contamination sources impacting the bay through a sanitary survey and selection of appropriate sites for further study. Results of the first phase of this study were presented previously at this forum (Keaveney, et al 2006) and the characteristics of the sites selected for study and locations within the bay are shown in table 1 and figure 1 respectively. The second phase of the project focused on monitoring environmental conditions and microbiological levels in shellfish to identify environmental conditions leading to viral contamination. This paper reports the finding of this monitoring