Decay and interference effects in visuospatial short-term memory

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Bioinformatics: A challenge for statisticians

Bioinformatics is a subject that requires the skills of biologists, computer scientists, mathematicians and staisticians. This paper introduces the reader to one small aspect of the subject: the study of microarrays. It describes some of the complexities of the enormous amounts of data that are available and shows how simple statistical techniques can be used to highlight deficiencies in that data

Low-gravity solidification of cast iron and space technology applications

Two types of analyses relating to cast iron solidification were conducted. A theoretical analysis using a computer to predict the cooling versus time relationship throughout the test specimen was performed. Tests were also conducted in a ground-based laboratory to generate a cooling time curve for cast iron. In addition, cast iron was cooled through the solidification period on a KC-135 and an F-104 aircraft while these aircraft were going through a period of low gravity. Future subjects for low gravity tests are enumerated

A fixed-point approximation for a routing model in equilibrium

We use a method of Luczak (arXiv:1212.3231) to investigate the equilibrium distribution of a dynamic routing model on a network. In this model, there are $n$ nodes, each pair joined by a link of capacity $C$. For each pair of nodes, calls arrive for this pair of endpoints as a Poisson process with rate $\lambda$. A call for endpoints $\{u,v\}$ is routed directly onto the link between the two nodes if there is spare capacity; otherwise $d$ two-link paths between $u$ and $v$ are considered, and the call is routed along a path with lowest maximum load, if possible. The duration of each call is an exponential random variable with unit mean. In the case $d=1$, it was suggested by Gibbens, Hunt and Kelly in 1990 that the equilibrium of this process is related to the fixed points of a certain equation. We show that this is indeed the case, for every $d \ge 1$, provided the arrival rate $\lambda$ is either sufficiently small or sufficiently large. In either regime, we show that the equation has a unique fixed point, and that, in equilibrium, for each $j$, the proportion of links at each node with load $j$ is strongly concentrated around the $j$th coordinate of the fixed point.Comment: 33 page

Serological survey of anti-group A rotavirus IgM in UK adults

Rotaviral associated disease of infants in the UK is seasonal and infection in adults not uncommon but the relationship between these has been little explored. Adult sera collected monthly for one year from routine hospital samples were screened for the presence of anti-group A rotavirus immunoglobulin M class antibodies as a marker of recent infection. Anti-rotavirus IgM was seen in all age groups throughout the year with little obvious seasonal variation in the distribution of antibody levels. IgM concentrations and the proportion seropositive above a threshold both increased with age with high concentrations consistently observed in the elderly. Results suggest either high infection rates of rotavirus in adults, irrespective of seasonal disease incidence in infants, IgM persistence or IgM cross-reactivity. These results support recent evidence of differences between infant and adult rotavirus epidemiology and highlight the need for more extensive surveys to investigate age and time related infection and transmission of rotavirus

Hypersurfaces of bounded Cohen--Macaulay type

Let R = k[[x_0,...,x_d]]/(f), where k is a field and f is a non-zero non-unit of the formal power series ring k[[x_0,...,x_d]]. We investigate the question of which rings of this form have bounded Cohen--Macaulay type, that is, have a bound on the multiplicities of the indecomposable maximal Cohen--Macaulay modules. As with finite Cohen--Macaulay type, if the characteristic is different from two, the question reduces to the one-dimensional case: The ring R has bounded Cohen--Macaulay type if and only if R is isomorphic to k[[x_0,...,x_d]]/(g+x_2^2+...+x_d^2), where g is an element of k[[x_0,x_1]] and k[[x_0,x_1]]/(g) has bounded Cohen--Macaulay type. We determine which rings of the form k[[x_0,x_1]]/(g) have bounded Cohen--Macaulay type.Comment: 16 pages, referee's suggestions and correction

The Population Genetic Signature of Polygenic Local Adaptation

Adaptation in response to selection on polygenic phenotypes may occur via subtle allele frequencies shifts at many loci. Current population genomic techniques are not well posed to identify such signals. In the past decade, detailed knowledge about the specific loci underlying polygenic traits has begun to emerge from genome-wide association studies (GWAS). Here we combine this knowledge from GWAS with robust population genetic modeling to identify traits that may have been influenced by local adaptation. We exploit the fact that GWAS provide an estimate of the additive effect size of many loci to estimate the mean additive genetic value for a given phenotype across many populations as simple weighted sums of allele frequencies. We first describe a general model of neutral genetic value drift for an arbitrary number of populations with an arbitrary relatedness structure. Based on this model we develop methods for detecting unusually strong correlations between genetic values and specific environmental variables, as well as a generalization of $Q_{ST}/F_{ST}$ comparisons to test for over-dispersion of genetic values among populations. Finally we lay out a framework to identify the individual populations or groups of populations that contribute to the signal of overdispersion. These tests have considerably greater power than their single locus equivalents due to the fact that they look for positive covariance between like effect alleles, and also significantly outperform methods that do not account for population structure. We apply our tests to the Human Genome Diversity Panel (HGDP) dataset using GWAS data for height, skin pigmentation, type 2 diabetes, body mass index, and two inflammatory bowel disease datasets. This analysis uncovers a number of putative signals of local adaptation, and we discuss the biological interpretation and caveats of these results.Comment: 42 pages including 8 figures and 3 tables; supplementary figures and tables not included on this upload, but are mostly unchanged from v

Factoring the Adjoint and Maximal Cohen--Macaulay Modules over the Generic Determinant

A question of Bergman asks whether the adjoint of the generic square matrix over a field can be factored nontrivially as a product of square matrices. We show that such factorizations indeed exist over any coefficient ring when the matrix has even size. Establishing a correspondence between such factorizations and extensions of maximal Cohen--Macaulay modules over the generic determinant, we exhibit all factorizations where one of the factors has determinant equal to the generic determinant. The classification shows not only that the Cohen--Macaulay representation theory of the generic determinant is wild in the tame-wild dichotomy, but that it is quite wild: even in rank two, the isomorphism classes cannot be parametrized by a finite-dimensional variety over the coefficients. We further relate the factorization problem to the multiplicative structure of the \Ext--algebra of the two nontrivial rank-one maximal Cohen--Macaulay modules and determine it completely.Comment: 44 pages, final version of the work announced in math.RA/0408425, to appear in the American Journal of Mathematic