780-4 ST Segment Depression Risk, Menopause, Hysterectomy and Exogenous Estrogen in Asymptomatic Women

In a 1993 follow-up survey, the Women Take Heart Project assessed 1992 menopausal status, including hysterectomy, and validated exogenous estrogen use (both estrogen replacement therapy and birth control pills) in 5932 women (W) who were examined and treadmill stress tested during 1992. 5449 W provided complete data for these analyses.Using logistic regression to estimate the relative likelihood of significant ST segment depression (1mm at 80 msec) while taking into account age, body mass index (kg/m2), cholesterol, resting heart rate, supine systolic blood pressure (SBP, mmHg). educational attainment and weekly aerobic exercise frequency as continuous variables, and employment, black race and smoking as categorical factors, the effects of estrogen and menopausal status (pre-menopausal: Pre, menopausallpost: M, and hysterectomy: Hyst) were examined. Hyst-W were younger than M-W at examination (mean age 56.4 vs. 59.3). and their mean age at hysterectomy was younger than either the mean age of menopause onset or completion that M-W reported (41 vs. 47 and 50 years old). The overall fit of the model was highly significant (model chi-square with 14 df=211.67, p<0.0001).VariableBS.E.dfSigOdds RatioAge (each addtl yr)0.0090.004710.04931.01Estrogen Use0.3720.077510.00001.45Reprod Status Overall30.0048(Pre-menopause: reference category)1.00Menopausal/post0.1870.058210.00131.21Late hyst (<35 yrs)0.1140.063610.07251.12Early hyst–0.2540.092410.00590.78Conclusions: 1) Post-menopausal status, independent of aging, appears to increase women's cardiovascular disease risk. 2) Exogenous estrogen appears to increase women's likelihood of responding to exercise stress testing with ST segment depression

The Structure of Koolau Volcano from Seismic Refraction Studies

Volume: 19Start Page: 306End Page: 31

Slow Slip Events and Time-Dependent Variations in Locking Beneath Lower Cook Inlet of the Alaska-Aleutian Subduction Zone

We identify a series of abrupt changes in GPS site velocities in Lower Cook Inlet, Alaska, in late 2004, early 2010, and late 2011. The site motions during each time period are nearly linear. The surface deformations inferred from GPS for pre-2004 and 2010–2011 are similar to each other, as are 2004–2010 and post-2011. We estimate the slip distribution on the Alaska-Aleutian subduction plate interface accounting for upper plate block rotations and interpret this toggling between two deformation patterns as caused by transient slip. We find that by allowing negative slip deficit rates (i.e., creep rates in excess of relative plate motion), the data in Lower Cook Inlet are fit significantly better during pre-2004 and 2010–2011, suggesting the occurrence of slow slip events (SSEs) there during those time periods. The earlier SSE lasted at least 9 years (observations in that area began in 1995) with Mw ~7.8. The latter SSE had almost the same area as the earlier one and a duration of ~2 years with Mw ~7.2. During 2004–2010 and post-2011, the inversions result in only positive slip deficit rates (i.e., locking) in Lower Cook Inlet. Slip rates are nearly constant during the Lower Cook Inlet SSEs, and the events start and stop abruptly. Both of these properties contrast with observations of SSEs in Upper Cook Inlet and elsewhere. The Lower Cook Inlet SSEs are consistent with previously proposed duration-magnitude scaling laws and demonstrate that slow slip events can last as long as a decade

Reprodução de Meloidogyne incognita raça 1 e Meloidogyne javanica em linhagens avançadas de tomateiro industrial.

bitstream/CNPH-2010/36367/1/bpd-55.pd

JAK inhibition differentially affects NK cell and ILC1 homeostasis

Janus kinase (JAK) inhibitors are widely used in the treatment of multiple autoimmune and inflammatory diseases. Immunologic and transcriptomic profiling have revealed major alterations on natural killer (NK) cell homeostasis associated with JAK inhibitions, while information on other innate lymphoid cells (ILCs) is still lacking. Herein, we observed that, in mice, the homeostatic pool of liver ILC1 was less affected by JAK inhibitors compared to the pool of NK cells present in the liver, spleen and bone marrow. JAK inhibition had overlapping effects on the transcriptome of both subsets, mainly affecting genes regulating cell cycle and apoptosis. However, the differential impact of JAK inhibition was linked to the high levels of the antiapoptotic gene Bcl2 expressed by ILC1. Our findings provide mechanistic explanations for the effects of JAK inhibitors on NK cells and ILC1 which could be of major clinically relevance

Negative Regulation of Immunoglobulin E–dependent Allergic Responses by Lyn Kinase

A role for Lyn kinase as a positive regulator of immunoglobulin (Ig)E-dependent allergy has long been accepted. Contrary to this belief, Lyn kinase was found to have an important role as a negative regulator of the allergic response. This became apparent from the hyperresponsive degranulation of lyn−/− bone marrow–derived mast cells, which is driven by hyperactivation of Fyn kinase that occurs, in part, through the loss of negative regulation by COOH-terminal Src kinase (Csk) and the adaptor, Csk-binding protein. This phenotype is recapitulated in vivo as young lyn−/− mice showed an enhanced anaphylactic response. In vivo studies also demonstrated that as lyn−/− mice aged, their serum IgE increased as well as occupancy of the high affinity IgE receptor (FcεRI). This was mirrored by increased circulating histamine, increased mast cell numbers, increased cell surface expression of the high affinity IgE receptor (FcεRI), and eosinophilia. The increased IgE production was not a consequence of increased Fyn kinase activity in lyn−/− mice because both lyn−/− and lyn−/− fyn−/− mice showed high IgE levels. Thus, lyn−/− mice and mast cells thereof show multiple allergy-associated traits, causing reconsideration of the possible efficacy in therapeutic targeting of Lyn in allergic disease

Studying Exotic Hadrons in Heavy Ion Collisions

We investigate the possibilities of using measurements in present and future experiments on heavy ion collisions to answer some longstanding problems in hadronic physics, namely identifying hadronic molecular states and exotic hadrons with multiquark components. The yields of a selected set of exotic hadron candidates in relativistic heavy ion collisions are discussed in the coalescence model in comparison with the statistical model. We find that the yield of a hadron is typically an order of magnitude smaller when it is a compact multiquark state, compared to that of an excited hadronic state with normal quark numbers. We also find that some loosely bound hadronic molecules are formed more abundantly than the statistical model prediction by a factor of two or more. Moreover, due to the significant numbers of charm and bottom quarks produced at RHIC and even larger numbers expected at LHC, some of the proposed heavy exotic hadrons could be produced with sufficient abundance for detection, making it possible to study these new exotic hadrons in heavy ion collisions.Comment: 18 pages, 2 figure