A grounded theory of inspirational coach leadership

The purpose of this study was to develop a grounded theory of the process of inspirational coach leadership in sport. A Straussian grounded theory methodology was used. Semi‐structured interviews and focus groups were conducted with athletes (n = 22) and coaches (n = 15). Data were analyzed through a process of open and axial coding, and theoretical integration. Through the process of analysis, data were broken down into smaller units (concepts), relationships between concepts were identified, and a substantive grounded theory was developed. The grounded theory of inspirational coach leadership was built around the core category of “athlete(s) inspired through changed awareness of their capabilities.” The core category was underpinned by three categories: (a) establishment of mutual trust and respect with athletes, whereby coaches need to establish trust with athletes in order to inspire athletes; (b) conditions under which inspiration has the potential to occur, which highlighted that athletes are inspired in situations where they are vulnerable or ignorant regarding their potential; and (c) coach acts to change athlete's awareness of their capabilities, which denotes the specific behaviors coaches should display to inspire athletes in such conditions. The theory also highlights that a range of contextual factors relating to the coach, athletes, and performance‐environment interact to impact upon the process. The theory predicts that consistency between coach behavior and the conditions in which inspiration can occur will lead to athlete inspiration, but only if the coach has established a foundation of trust and respect with the athlete

How Kondo Holes Create Intense Nanoscale Heavy-Fermion Hybridization Disorder

Replacing a magnetic atom by a spinless atom in a heavy fermion compound generates a quantum state often referred to as a 'Kondo-hole'. No experimental imaging has been achieved of the atomic-scale electronic structure of a Kondo-hole, or of their destructive impact (Lawrence JM, et al. (1996) Kondo hole behavior in Ce0. 97La0. 03Pd3. Phys Rev B 53:12559-12562; Bauer ED, et al. (2011) Electronic inhomogeneity in a Kondo lattice. Proc Natl Acad Sci. 108:6857-6861) on the hybridization process between conduction and localized electrons which generates the heavy fermion state. Here we report visualization of the electronic structure at Kondo-holes created by substituting spinless Thorium atoms for magnetic Uranium atoms in the heavy-fermion system URu2Si2. At each Thorium atom, an electronic bound state is observed. Moreover, surrounding each Thorium atom we find the unusual modulations of hybridization strength recently predicted to occur at Kondo-holes (Figgins J, Morr DK (2011) Defects in heavy-fermion materials: unveiling strong correlations in real space. Phys Rev Lett 107:066401). Then, by introducing the 'hybridization gapmap' technique to heavy fermion studies, we discover intense nanoscale heterogeneity of hybridization due to a combination of the randomness of Kondo-hole sites and the long-range nature of the hybridization oscillations. These observations provide direct insight into both the microscopic processes of heavy-fermion forming hybridization and the macroscopic effects of Kondo-hole doping.Comment: Main Article + Figures, Supporting Information + Figures; PNAS 201

Potent antiviral activity against HSV-1 and SARS-CoV-2 by antimicrobial peptoids

Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2, affect millions of people each year. However, there are few antiviral drugs that can effectively treat these infections. The standard approach in the development of antiviral drugs involves the identification of a unique viral target, followed by the design of an agent that addresses that target. Antimicrobial peptides (AMPs) represent a novel source of potential antiviral drugs. AMPs have been shown to inactivate numerous different enveloped viruses through the disruption of their viral envelopes. However, the clinical development of AMPs as antimicrobial therapeutics has been hampered by a number of factors, especially their enzymatically labile structure as peptides. We have examined the antiviral potential of peptoid mimics of AMPs (sequence-specific N-substituted glycine oligomers). These peptoids have the distinct advantage of being insensitive to proteases, and also exhibit increased bioavailability and stability. Our results demonstrate that several peptoids exhibit potent in vitro antiviral activity against both HSV-1 and SARS-CoV-2 when incubated prior to infection. In other words, they have a direct effect on the viral structure, which appears to render the viral particles non-infective. Visualization by cryo-EM shows viral envelope disruption similar to what has been observed with AMP activity against other viruses. Furthermore, we observed no cytotoxicity against primary cultures of oral epithelial cells. These results suggest a common or biomimetic mechanism, possibly due to the differences between the phospholipid head group makeup of viral envelopes and host cell membranes, thus underscoring the potential of this class of molecules as safe and effective broad-spectrum antiviral agents. We discuss how and why differing molecular features between 10 peptoid candidates may affect both antiviral activity and selectivity

Promote “we” to inspire me: examining the roles of group identification and trust in the association between identity leadership and follower inspiration

Recent research has highlighted leaders as a source of inspiration for followers in sport, providing leaders embed, embody, and represent the group’s values (i.e., the leader demonstrates identity leadership and creates a shared identity). Consequently, two studies (one cross-sectional and one longitudinal) aimed to examine the relationship between identity leadership and follower inspiration via the mediating roles of group identification and trust in the leader. In Study 1, 233 participants completed measures of identity leadership, group identification, trust in their leader, and follower inspiration in a cross-sectional design. In Study 2, 121 participants completed the same measures at two time points (towards the start and end of the season). Cross sectional findings (Study 1) indicated that group identification and trust serially mediated the positive association between identity leadership principles and follower inspiration. Whereas, in Study 2, identity advancement and identity impresarioship at the start of the season predicted follower inspiration at the end of the season through trust in the leader but not through group identification. Taken together, the findings add weight to the importance of identity leadership by not only suggesting that followers of leaders who engage in identity leadership are more inspired but, also, by highlighting important mechanisms (group identification and particularly trust) that may explain these processes

Promote ‘we’ to inspire me: Examining the roles of group identification and trust in the association between identity leadership and follower inspiration.

Recent research has highlighted leaders as a source of inspiration for followers in sport, providing leaders embed, embody, and represent the group’s values (i.e., the leader demonstrates identity leadership and creates a shared identity). Consequently, two studies (one cross-sectional and one longitudinal) aimed to examine the relationship between identity leadership and follower inspiration via the mediating roles of group identification and trust in the leader. In Study 1, 233 participants completed measures of identity leadership, group identification, trust in their leader, and follower inspiration in a cross-sectional design. In Study 2, 121 participants completed the same measures at two time points (towards the start and end of the season). Cross sectional findings (Study 1) indicated that group identification and trust serially mediated the positive association between identity leadership principles and follower inspiration. Whereas, in Study 2, identity advancement and identity impresarioship at the start of the season predicted follower inspiration at the end of the season through trust in the leader but not through group identification. Taken together, the findings add weight to the importance of identity leadership by not only suggesting that followers of leaders who engage in identity leadership are more inspired but, also, by highlighting important mechanisms (group identification and particularly trust) that may explain these processes

Birds collected in Alaska

p. 231-247 ; 24 cm.Includes bibliographical references

Mammals collected in Alaska

p. 215-230 ; 24 cm.Includes bibliographical references

Intermediate Phenotypes Identify Divergent Pathways to Alzheimer's Disease

Background: Recent genetic studies have identified a growing number of loci with suggestive evidence of association with susceptibility to Alzheimer's disease (AD). However, little is known of the role of these candidate genes in influencing intermediate phenotypes associated with a diagnosis of AD, including cognitive decline or AD neuropathologic burden. Methods/Principal Findings: Thirty-two single nucleotide polymorphisms (SNPs) previously implicated in AD susceptibility were genotyped in 414 subjects with both annual clinical evaluation and completed brain autopsies from the Religious Orders Study and the Rush Memory and Aging Project. Regression analyses evaluated the relation of SNP genotypes to continuous measures of AD neuropathology and cognitive function proximate to death. A SNP in the zinc finger protein 224 gene (ZNF224, rs3746319) was associated with both global AD neuropathology (p = 0.009) and global cognition (p = 0.002); whereas, a SNP at the phosphoenolpyruvate carboxykinase locus (PCK1, rs8192708) was selectively associated with global cognition (p = 3.57×10−4). The association of ZNF224 with cognitive impairment was mediated by neurofibrillary tangles, whereas PCK1 largely influenced cognition independent of AD pathology, as well as Lewy bodies and infarcts. Conclusions/Significance: The findings support the association of several loci with AD, and suggest how intermediate phenotypes can enhance analysis of susceptibility loci in this complex genetic disorder

“You really could be something quite special”: a qualitative exploration of athletes' experiences of being inspired in sport

Objectives: The purpose of this research was to provide an explicit examination of inspiration in sport. In Study 1, we explored (a) what inspires athletes in sport, and (b) the consequences of being inspired. The aims of Study 2 were to explore (a) the contexts in which leaders inspired athletes, (b) leader behaviours and actions that inspire athletes, and (c) the consequences of being inspired by leaders. Design: Two qualitative descriptive studies were conducted in order to explore athletes' experiences of being inspired. Method: In Study 1, 95 athletes wrote about an experience of being inspired in sport. Study 2 utilised semi-structured interviews to explore 17 athletes' experiences of being inspired by leadership. Data were analysed via inductive thematic analysis. Results: In Study 1, athletes' responses revealed three sources of inspiration: personal performance, accomplishments, and thoughts; role models; and leadership. Findings from Study 2 indicated that athletes were inspired by a range of leadership behaviours (e.g., demonstrations of belief) in a variety of, mainly negative, situations (e.g., following poor performance). Broadly, findings from both studies revealed inspiration to impact on athletes' awareness of their capabilities, confidence, motivation, and behaviour. Conclusions: Overall, the findings indicate that an experience of inspiration can be evoked by a range of sources (most prominently leadership) and can have a powerful effect on athletes and their performance. Further research is required to understand how and why leaders can exert an inspirational impact on athletes