Enhanced magnetic properties of polymer-magnetic nanostructures synthesized by ultrasonication

Polymer based nickel (Ni) and cobalt (Co) co-doped ferrites were prepared by adept ultrasonication route. Different concentrations of polymer [polyvinyl alcohol (PVA)] (0.2 g and 0.5 g) was added as a surfactant to the magnetic particles. The phase purity of Ni-Co ferrites (spinel structure) was confirmed by X-ray diffraction (XRD). Enhanced saturation magnetization of polymer based magnetic nanoparticles due to shape anisotropy and size. 0.2 wt% doped ferrite showed superparamagnetic characteristics with blocking temperature above room temperature. Hence, ultrasonication route is a rapid and effective technique for tailoring size and morphology of magnetic nanostructure that could be useful in magnetic-sensor applications

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases.

Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non-demented controls, we investigated global disruptions in the co-regulation of genes in two neurodegenerative diseases, late-onset Alzheimer's disease (AD) and Huntington's disease (HD). We identified networks of differentially co-expressed (DC) gene pairs that either gained or lost correlation in disease cases relative to the control group, with the former dominant for both AD and HD and both patterns replicating in independent human cohorts of AD and aging. When aligning networks of DC patterns and physical interactions, we identified a 242-gene subnetwork enriched for independent AD/HD signatures. This subnetwork revealed a surprising dichotomy of gained/lost correlations among two inter-connected processes, chromatin organization and neural differentiation, and included DNA methyltransferases, DNMT1 and DNMT3A, of which we predicted the former but not latter as a key regulator. To validate the inter-connection of these two processes and our key regulator prediction, we generated two brain-specific knockout (KO) mice and show that Dnmt1 KO signature significantly overlaps with the subnetwork (P = 3.1 × 10(-12)), while Dnmt3a KO signature does not (P = 0.017)

Enhanced magnetic properties of polymer-magnetic nanostructures synthesized by ultrasonication

Polymer based nickel (Ni) and cobalt (Co) co-doped ferrites were prepared by adept ultrasonication route. Different concentrations of polymer [polyvinyl alcohol (PVA)] (0.2 g and 0.5 g) was added as a surfactant to the magnetic particles. The phase purity of Ni-Co ferrites (spinel structure) was confirmed by X-ray diffraction (XRD). Enhanced saturation magnetization of polymer based magnetic nanoparticles due to shape anisotropy and size. 0.2 wt% doped ferrite showed superparamagnetic characteristics with blocking temperature above room temperature. Hence, ultrasonication route is a rapid and effective technique for tailoring size and morphology of magnetic nanostructure that could be useful in magnetic-sensor applications

Remarkable thermal conductivity enhancement in Ag—decorated graphene nanocomposites based nanofluid by laser liquid solid interaction in ethylene glycol

We report on the synthesis and enhanced thermal conductivity of stable Ag-decorated 2-D graphene nanocomposite in ethylene glycol based nanofluid by laser liquid solid interaction. A surfactant free nanofluid of Ag nanoparticles anchored onto the 2-D graphene sheets were synthesized using a two-step laser liquid solid interaction approach. In order to understand a pulsed Nd:YAG laser at the fundamental frequency (λ = 1,064 nm) to ablate Ag and graphite composite target submerged in ethylene glycol (EG) to form AgNPs decorated 2-D GNs-EG based nanofluid. From a heat transfer point of view, it was observed that the thermal conductivity of this stable Ag-graphene/EG is significantly enhanced by a factor of about 32.3%; this is highest reported value for a graphene based nanofluid

Cloud computing mobile application for remote monitoring of Bell's palsy

Mobile applications provide the healthcare industry with a means of connecting with patients in their own home utilizing their own personal mobile devices such as tablets and phones. This allows therapists to monitor the progress of people under their care from a remote location and all with the added benefit that patients are familiar with their own mobile devices; thereby reducing the time required to train patients with the new technology. There is also the added benefit to the health service that there is no additional cost required to purchase devices for use. The Facial Remote Activity Monitoring Eyewear (FRAME) mobile application and web service framework has been designed to work on the IOS and android platforms, the two most commonly used today. Results: The system utilizes secure cloud based data storage to collect, analyse and store data, this allows for near real time, secure access remotely by therapists to monitor their patients and intervene when required. The underlying framework has been designed to be secure, anonymous and flexible to ensure compliance with the data protection act and the latest General Data Protection Regulation (GDPR); this new standard came into effect in April 2018 and replaces the Data Protection Act in the UK and Europe

Unmet healthcare needs in adults with childhood-onset neurodisabilities: a protocol for a systematic review

Data availability: No data are associated with this article.Copyright . Background: Many adults with childhood-onset neurodisabilities, such as those with intellectual disability or cerebral palsy, report difficulties accessing the healthcare that they require when they are no longer eligible for paediatric services. Compared to the general population, this population is at greater risk of developing many ageing-related diseases and has higher rates of preventable deaths and premature mortality. Addressing unmet healthcare needs is essential to ensuring equitable access in a quality healthcare system. The aim of this systematic review is to synthesise the current available evidence related to unmet healthcare needs in adults with a range of childhood-onset neurodisabilities. Methods: A systematic review of quantitative research studies of adults with a range of diagnoses that fall under the neurodisability umbrella and outcomes related to unmet healthcare needs will be undertaken. The Conducting Systematic Reviews and Meta-Analyses of Observational Studies (COSMOS-E) guidelines will be adhered to. Searches of key databases will be undertaken, and a two-phase screening process carried out by pairs of independent reviewers to select studies that meet the inclusion criteria. Data will be extracted using a purposefully designed form. Risk of bias will be assessed using the Joanna Briggs Institute Critical Appraisal Tools. If it is possible to pool prevalence data, a meta-analysis will be undertaken. Where pooling of data is not possible, a structured synthesis approach will be used, and results will be presented in tables and summarised narratively. Conclusions: In recent years, there has been increased emphasis placed on promoting positive ageing and improving the healthcare experiences throughout the lifespan for people with neurodisabilities. Findings of this systematic review can inform decision-making related to healthcare for this vulnerable population and has the potential to contribute to reducing preventable deaths and premature mortality and promoting positive and healthy ageing for this group.Elaine Meehan was supported by funding from the Health Research Institute, University of Limerick. Elaine Meehan was also part supported by the Health Research Board (Ireland) and the HSC Public Health Agency (Grant number CBES-2018-001) through Evidence Synthesis Ireland/Cochrane Ireland

Prevalence and incidence of chronic conditions among adults with cerebral palsy: A systematic review and meta-analysis

Data availability statement: Data sharing is not applicable to this article as no new data were created or analyzed in this study.Supporting information is available online at https://onlinelibrary.wiley.com/doi/10.1111/dmcn.15526#support-information-section .Copyright © 2023 The Authors. Aim: To assess the prevalence and incidence of chronic conditions among adults with cerebral palsy (CP) and compare them to the prevalence and incidence among adults without CP. Method: We searched MEDLINE and Embase for studies reporting the prevalence or incidence of one or more chronic conditions among adults with CP. Two independent reviewers screened titles, abstracts, and full-text articles. Two independent reviewers extracted data relating to prevalence and incidence and appraised study quality. We performed random-effects meta-analyses to pool prevalence and incidence. Results: We identified 69 studies; 65 reported the prevalence of 53 conditions and 13 reported the incidence of 21 conditions. At least 20% of adults had the following conditions: depression (21%); anxiety (21%); mood affective disorders (23%); asthma (24%); hypertension (26%); epilepsy (28%); urinary incontinence (32%); malnutrition (38%); and scoliosis (46%). Adults with CP were more likely to have type 2 diabetes, anxiety, bipolar disorder, depression, schizophrenia, hypertension, ischaemic heart disease, stroke, cerebrovascular disease, asthma, liver disease, osteoarthritis, osteoporosis, underweight, and chronic kidney disease than adults without CP. Interpretation: These data from 18 countries, which provide an international perspective, may be used to promote awareness, identify targets for intervention, and inform the development of appropriate supports for adults with CP.Open access funding provided by IReL

Enhanced anticorrosion properties of nitrogen ions modified polyvinyl alcohol/Mg-Ag ions co-incorporated calcium phosphate coatings

Nitrogen ions (70 keV) were implanted on composite coatings containing polymer/Mg (magnesium)–Ag (silver) ions co-incorporated hydroxyapatite which is developed by microwave irradiation. Average crystallite size of modified coatings is reduced to 80% compared to pristine. The variation of bond strength of modified coatings is realized. The electrical resistance (77%), microhardness (4.3%), roughness (4.5 times) and pore size are enhanced on the modified coatings. Superhydrophilic surface is tuned to hydrophobic on implantation. At higher fluence (1×1017 ions/cm2) depicted an enhanced corrosion potential compared to the other coatings. Thus, the new insight of modified coatings is realized by correlating phase-structure, surface and anticorrosion

Self Assembly and Properties of C:WO3 Nano-Platelets and C:VO2/V2O5 Triangular Capsules Produced by Laser Solution Photolysis

Laser photolysis of WCl6 in ethanol and a specific mixture of V2O5 and VCl3 in ethanol lead to carbon modified vanadium and tungsten oxides with interesting properties. The presence of graphene’s aromatic rings (from the vibrational frequency of 1,600 cm−1) together with C–C bonding of carbon (from the Raman shift of 1,124 cm−1) present unique optical, vibrational, electronic and structural properties of the intended tungsten trioxide and vanadium dioxide materials. The morphology of these samples shows nano-platelets in WOx samples and, in VOx samples, encapsulated spherical quantum dots in conjunction with fullerenes of VOx. Conductivity studies revealed that the VO2/V2O5 nanostructures are more sensitive to Cl than to the presence of ethanol, whereas the C:WO3 nano-platelets are more sensitive to ethanol than atomic C

Peculiar Size Effects in Nanoscaled Systems

In this minireview, we intend to shed light on relatively recent examples related to the size and shape effects on materials at the nanoscale and their usage to test a set of quantum mechanics governed phenomena