Acute drug effects on habitual and non-habitual responding in crossed high alcohol preferring mice

RATIONALE: Drug reward plays a central role in acquiring drug-seeking behavior. However, subjects may continue using drugs despite negative consequences because self-administration becomes habitual, and divorced from outcome values. Although a history of drug and alcohol use expedite habit acquisition, and in spite of the fact that self-administration leads to intoxication, the acute effects of drugs on habitual responding are not well understood. OBJECTIVES: We sought to observe how acute ethanol and amphetamine affect the balance between habitual and goal-directed behavior, as measured by a fluid-reinforced operant conditioning task. METHODS: Selectively bred crossed high-alcohol-preferring (cHAP) mice were trained on an operant conditioning task reinforced on a variable interval schedule with 1% banana solution, which was subsequently devalued via LiCl pairing in half the animals. Ethanol (1.0 g/kg), amphetamine (2.0 mg/kg), or saline was administered prior to a post-devaluation test. RESULTS: Overall, mice showed habitual behavior, but when divided into high- or low-responding groups based on training response rates, saline-treated, low-responding animals devalued, while saline-treated high-responding animals did not. Furthermore, amphetamine elicited devaluation even in high-responding animals, while ethanol prevented devaluation even in low-responding animals. CONCLUSIONS: These data show that ethanol shifts animals toward behaving habitually. This may illuminate why alcohol-intoxicated individuals display impaired judgment about the relative merits of drinking, and potentially serve as a mechanism by which intoxicated subjects resume previously devalued behaviors, such as comorbid drug use. These findings also show that high variable interval response rates facilitate a shift from goal-directed to habitual behavior

Shaping the dust mass - star-formation rate relation

There is a remarkably tight relation between the observationally inferred dust masses and star-formation rates (SFRs) of SDSS galaxies, Mdust $\propto$ SFR$^{1.11}$ (Da Cunha et al. 2010). Here we extend the Mdust-SFR relation to the high end and show that it bends over at very large SFRs (i.e., dust masses are lower than predicted for a given SFR). We identify several distinct evolutionary processes in the diagram: (1) A star-bursting phase in which dust builds up rapidly at early times. The maximum attainable dust mass in this process is the cause of the bend-over of the relation. A high dust-formation efficiency, a bottom-light initial mass function, and negligible supernova shock dust destruction are required to produce sufficiently high dust masses. (2) A quiescent star-forming phase in which the subsequent parallel decline in dust mass and SFR gives rise to the Mdust-SFR relation, through astration and dust destruction. The dust-to-gas ratio is approximately constant along the relation. We show that the power-law slope of the Mdust-SFR relation is inversely proportional to the global Schmidt-Kennicutt law exponent (i.e., $\sim 0.9$) in simple chemical evolution models. (3) A quenching phase which causes star formation to drop while the dust mass stays roughly constant or drops proportionally. Combined with merging, these processes, as well as the range in total baryonic mass, give rise to a complex population of the diagram which adds significant scatter to the original Mdust-SFR relation. (4) At very high redshifts, a population of galaxies located significantly below the local relation is predicted.Comment: 5 pages, 1 figure, ApJL, in pres

Space-time diagrammatics

We introduce a new class of two-dimensional diagrams, the \emph{projection diagrams}, as a tool to visualize the global structure of space-times. We construct the diagrams for several metrics of interest, including the Kerr-Newman - (anti) de Sitter family, with or without cosmological constant, and the Emparan-Reall black rings.Comment: 41 pages, minor changes and correction

Equitable Defenses in Patent Law

In patent law, “unenforceability” can have immense consequences. At least five equitable doctrines make up the defense of “unenforceability” as it was codified into the Patent Act in 1952: laches; estoppel; unclean hands; patent misuse; and according to some, inequitable conduct. Yet in the seventy years since incorporation of equitable defenses into the patent statute, the Supreme Court has not clarified their reach. Indeed, twice in the last four years, the Supreme Court avoided giving complete guidance on the crucial questions of whether, and when, such equitable defenses are available to bar damages in cases brought at law. Several interpretive methods have been proposed for determining the reach of generally worded statutes like the Patent Act. Under a dynamic statutory interpretation, courts would be permitted to develop such statutes in accordance with what the law ought to be. Under a traditional faithful agent approach, in contrast, courts would try to determine the scope as set forth by the legislature, piecing together context and history to frame limited words. The scope of equitable defenses in patent law is an ideal proving ground between these methods, having both historical background for use in traditional approaches and high-stakes social questions that factor into a dynamic approach—what conduct do we allow patentees to engage in before we cut off remedies for infringement on innovations that support our health and modern lifestyle? Setting the stage of the statutory interpretive battle, this Article examines the historical and statutory bases of equitable limits on patent law, with a particular focus on the substantive equitable defenses of unclean hands and patent misuse. It contrasts the history of equitable defenses such as estoppel, which crossed fully into courts of law well before the merger of law and equity and the Patent Act, with equitable defenses such as laches, unclean hands, and misuse. This Article walks through these defenses’ pre-codification roots and potential statutory interpretations and presents normative and constitutional considerations under the competing interpretive approaches. It also presents a surprising approach to inequitable conduct, arguing that it is not an equitable defense and should no longer result in infectious invalidity. This Article is the first to provide a comprehensive framework for the analysis of equitable defenses in patent law

A Definite Claim on Claim Indefiniteness: An Empirical Study of Definiteness Cases of the Past Decade with a Focus on the Federal Circuit and the Insolubly Ambiguous Standard

This empirical study of patent claim definiteness cases of the past decade makes several novel findings including: (1) slightly more than half of final Federal Circuit definiteness cases hold the asserted claims not indefinite; (2) the percentage of non-Federal Circuit definiteness cases holding claims not indefinite increased approximately 60 percentage points over the ten-year period focused on in this analysis;(3) the Federal Circuit more often held chemical claims not indefinite, but electrical claims indefinite; and (4) the Federal Circuit more often held claims with term clarity issues not indefinite, but claims with means-plus-function issues indefinite. These differences partially result from the Federal Circuit incorporating an evidentiary burden into the insolubly ambiguous standard and inconsistently applying the insolubly ambiguous standard. After describing other effects of this standard, this Article recommends that the Federal Circuit modify, clarify, or abolish the insolubly ambiguous standard

Alpha-amylase, cortisol, and pupillary responses to social and non-social dynamic scenes in young children with autism spectrum disorder

The symptoms of Autism Spectrum Disorder (ASD) may manifest from deficits in attention/arousal; previous studies found altered autonomic and attentional responses in ASD. We found a larger tonic pupil size (Anderson & Colombo, 2009) and altered phasic pupillary responses to human faces (Anderson, Colombo, & Shaddy, 2006) in 2-5 year old children with ASD. Children (20 - 72 months of age) with ASD (n = 12), Down syndrome (DS; n = 9), and typical development (TD; n = 11) were presented with a social and a non-social video clip to examine pupil, salivary, and visual scanning measures. The ASD group had (a) a larger tonic pupil size, (b) lower tonic levels of AA, significantly related to tonic pupil size, and (c) increased phasic pupil responses to the social stimulus than controls. These findings provide replication and extension of our previous investigations; underlying pathology and early identification measures in ASD are discussed

Continuing the Conversation of The Economic Irrationality of the Patent Misuse Doctrine

This Article uses economic tools to find the best way for courts to construe or for Congress to modify the patent misuse doctrine. It attempts to continue the conversation begun by Professor Mark Lemley in his often-cited Comment, The Economic Irrationality of the Patent Misuse Doctrine. It argues that a partial economic equilibrium in patent misuse doctrine can be achieved by attempting to match Congress’s intended patent scope with the actual patent scope. It then holds that the ideal patent misuse doctrine should (1) adequately discourage patentees from seeking to exceed their patent scope while (2) continuing to encourage innovation by permitting patentees to fully benefit up to Congress’s intended scope. It discusses a variety of solutions proposed by prior scholarship, determines which solutions satisfy this balancing point, and recommends several novel modifications to the patent misuse doctrine. Specifically, the misuse doctrine, if it is not abolished, should apply only where antitrust law applies. Then, an antitrust injury requirement should be added to the misuse doctrine, much like the doctrine of unclean hands requires the party asserting it to have been harmed. Further, the remedy for patent misuse should be balanced in a way that is fair to all parties and does not under- or over-deter misuse or infringement, which necessarily requires the abolishment of the unenforceability remedy. The Article ends briefly discussing how recent Federal Circuit decisions like Princo v. ITC might reignite the conversation on the value of the doctrine of patent misuse

Women at the top: an investigation into the lived experience of women executives holding top posts in the UK

In the contemporary workplace persistent gender imbalance at top executive levels is a matter of public and political debate in the context of a growing realisation that this phenomenon is not only a social and cultural problem, it is also a business problem. From the perspective of improving business outcomes this thesis listens to the lived experience of 12 women holding, or who have recently held, top executive posts in the UK. The research includes two face to face interviews with each participant pursuing an abductive methodology and constructive grounded theory analysis of the data. Key findings of the study include: A unique combination of elite characteristics demonstrated by the women in this study which may inform and target recruitment practice challenging the assumption that a larger pipeline per se will lead to more women taking up top posts. Knowledge can be extended by considering public and private sectors together, including participants from the armed services, legal services and the police. An increase in the number of non-executive directors on boards and top management teams may not increase the likelihood of more executive women at the top. Individual relational capital and emotional choices may be key factors in whether women choose to take up a top post, or not. Sponsorship is a prime driver in promoting women of high potential towards top posts. The print press may account for considerable talent loss at the top in the UK. The domestic contract is key; purchasing private childcare creates financial strain and may contribute to lost talent. Generational change, the changed expectations and ambitions of women in the future, may mean less, not more, women arrive in top posts. The views of women in this qualitative and explorative study are not intended to be representative of other women or of their organisations, but their views are powerful, and there are strong emergent themes which may guide further research and influence perspectives on the likelihood of achieving gender balance in the foreseeable future