PCORnet's Collaborative Research Groups.

The Patient-Centered Outcomes Research Institute (PCORI) launched a multi-institutional "network of networks" in 2013 - Patient-Centered Clinical Research Network (PCORnet) - that is designed to conduct clinical research that is faster, less expensive, and more responsive to the information needs of patients and clinicians. To enhance cross-network and cross-institutional collaboration and catalyze the use of PCORnet, PCORI has supported formation of 11 Collaborative Research Groups focusing on specific disease types (e.g., cardiovascular health and cancer) or particular patient populations (e.g., pediatrics and health disparities). PCORnet's Collaborative Research Groups are establishing research priorities within these focus areas, establishing relationships with potential funders, and supporting development of specific research projects that will use PCORnet resources. PCORnet remains a complex, multilevel, and heterogeneous network that is still maturing and building a diverse portfolio of observational and interventional people-centered research; engaging with PCORnet can be daunting, particularly for outside investigators. We believe the Collaborative Research Groups are stimulating interest and helping investigators navigate the complexity, but only time will tell if these efforts will bear fruit in terms of funded multicenter PCORnet projects

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

Wnt-11 promotes cancer cell migration and invasion independently of β-catenin but the receptors involved remain unknown. Here, we provide evidence that FZD8 is a major Wnt-11 receptor in prostate cancer that integrates Wnt-11 and TGF-β signals to promote EMT. FZD8 mRNA is upregulated in multiple prostate cancer datasets and in metastatic cancer cell lines in vitro and in vivo. Analysis of patient samples reveals increased levels of FZD8 in cancer, correlating with Wnt-11. FZD8 co-localizes and co-immunoprecipitates with Wnt-11 and potentiates Wnt-11 activation of ATF2-dependent transcription. FZD8 silencing reduces prostate cancer cell migration, invasion, three-dimensional (3D) organotypic cell growth, expression of EMT-related genes, and TGF-β/Smad-dependent signaling. Mechanistically, FZD8 forms a TGF-β-regulated complex with TGF-β receptors that is mediated by the extracellular domains of FZD8 and TGFBR1. Targeting FZD8 may therefore inhibit aberrant activation of both Wnt and TGF-β signals in prostate cancer

National Soils Database

End of project reportThe objectives of the National Soils Database project were fourfold. The first was to generate a national database of soil geochemistry to complete the work that commenced with a survey of the South East of Ireland carried out in 1995 and 1996 by Teagasc (McGrath and McCormack, 1999). Secondly, to produce point and interpolated spatial distribution maps of major, minor and trace elements and to interpret these with respect to underlying parent material, glacial geology, land use and possible anthropogenic effects. A third objective was to investigate the microbial community structure in a range of soil types to determine the relationship between soil microbiology and chemistry. The final objective was to establish a National Soils Archive

Application of open pore cellular foam for air breathing PEM fuel cell

This is an accepted manuscript of an article published by Elsevier in International Journal of Hydrogen Energy on 07/06/2017, available online: https://doi.org/10.1016/j.ijhydene.2017.05.114 The accepted version of the publication may differ from the final published version.Open Pore Cellular Foam (OPCF) has received increased attention for use in Proton Exchange Membrane (PEM) fuel cells as a flow plate due to some advantages offered by the material, including better gas flow, lower pressure drop and low electrical resistance. In the present study, a novel design for an air-breathing PEM (ABPEM) fuel cell, which allows air convection from the surrounding atmosphere, using OPCF as a flow distributor has been developed. The developed fuel cell has been compared with one that uses a normal serpentine flow plate, demonstrating better performance. A comparative analysis of the performance of an ABPEM and pressurised air PEM (PAPEM) fuel cell is conducted and poor water management behaviour was observed for the ABPEM design. Thereafter, a PTFE coating has been applied to the OPCF with contact angle and electrochemical polarisation tests conducted to assess the capability of the coating to enhance the hydrophobicity and corrosion protection of metallic OPCF in the PEM fuel cell environment. The results showed that the ABPEM fuel cell with PTFE coated OPCF had a better performance than that with uncoated OPCF. Finally, OPCF was employed to build an ABPEM fuel cell stack where the performance, advantages and limitations of this stack are discussed in this paper

Nutrient management planning on Irish dairy farms

End of Project ReportThe objective of the work undertaken was to investigate nutrient use on intensive dairy farms. A survey of 12 dairy farms was undertaken in 1997 to determine nutrient management practices. These were compared with current nutrient advice and recommended practices. Data recording was completed by the farmer and supplemented by regular farm visits to assist with and validate the process. The mean farm size was 64.8 ha with an average of 128 cows and an annual milk yield per cow of 5594 kg. The mean stocking rate was 2.58 Livestock Units/ha. Dairy cows accounted for highest proportion of the total livestock with most of the younger stock consisting of dairy replacements. Approximately 80% of soil P levels were greater than 6 mg/l while 67% of soils had soil K levels in excess of 100 mg/l. The mean soil P and K levels on the grazing and silage areas were 11 and 128 mg/l, 12 and 117 mg/l, respectively. The mean farm nutrient balance (inputs - outputs) established an annual surplus of N, P and K of 304, 18 and 53 kg/ha, respectively. The adoption of nutrient management plans instead of current practice would reduce N, P and K inputs on average by 44, 13 and 24 kg/ha, respectively. The use of the Teagasc revised P nutrient advice would further reduce the P input requirements by 2 kg/ha. On average the farms had 90% of the 16 week slurry storage capacity. Approximately 14, 42, 14 and 31% of the slurry was applied in spring, summer, autumn and winter, respectively. In all cases there was significant between farm variability. The soil P fertility on the survey farms is skewed towards index 3 and 4 when compared with the average for all samples received at Johnstown Castle. There is no agronomic advantage in terms of crop or animal production for soils to have P levels in excess 10 mg/l. This result indicates that P inputs to farms of this type can be reduced in many cases without prejudicing production potential. The nutrient balance conducted highlighted the extent of the nutrient surpluses and the between farm variability. The data suggest that there is not a serious nutrient surplus on the survey farms, which would require the use of additional off-farm land for slurry recycling, as obtains on pig and poultry farms. The study also indicates that although farm unit cost savings may be small in adopting nutrient management planning, overall farm savings may be significant. For example on the survey farms, savings of up to £2,000 can be achieved apart from the obvious positive environmental impact

Effect of an agri-environmental measure on nitrate leaching from a beef farming system in Ireland

peer-reviewedAgricultural nitrogen (N) management remains a key environmental challenge. Improving N management is a matter of urgency to reduce the serious ecological consequences of the reactive N. Nitrate (NO3−–N) leaching was measured under suckler beef production systems stocked at two intensities: (1) intensive, 210 kg organic N ha−1 with two cut silage harvests; and (2) rural environmental protection scheme (REPS), 170 kg organic N ha−1 with one cut silage harvest. Three replicate plots of each treatment were instrumented with ceramic cups (8 per plot), randomly placed within each plot at a depth of 1 m to collect soil solution for NO3−–N at 50 kPa suction to collecting vessels one week prior to sampling. Samples were taken on a total of 53 sampling dates over 3 winter drainage periods (2002/03, 2003/04 and 2004/05). Over the course of the experiment the mean annual soil solution NO3−–N concentration exceeded the MAC twice out of 15 means (5 treatments over 3 years). The REPS grazing and silage sub treatments had significantly lower mean annual soil solution total oxidized N (TON) concentrations than the respective intensive treatments in years 2 and 3. Annual total NO3−–N losses over the three years in intensive and REPS systems ranged from 55 to 71 and 15 to 20 kg N ha−1, respectively. Mean N surpluses in intensive and REPS systems were 210 and 95 kg ha−1, respectively with the corresponding mean N inputs of 272 and 124 kg N ha−1. The reduction in N inputs under the REPS system results in lower N leaching losses and contributed to a significant reduction in pressures on water quality

Composite mirror facets for ground based gamma ray astronomy

Composite mirrors for gamma-ray astronomy have been developed to fulfill the specifications required for the next generation of Cherenkov telescopes represented by CTA (Cherenkov Telescope Array). In addition to the basic requirements on focus and reflection efficiency, the mirrors have to be stiff, lightweight, durable and cost efficient. In this paper, the technology developed to produce such mirrors is described, as well as some tests that have been performed to validate them. It is shown that these mirrors comply with the needs of CTA, making them good candidates for use on a significant part of the array.Comment: 16 pages, 13 figures, accepted to be published on NIM

Multiple causes of interannual sea surface temperature variability in the equatorial Atlantic Ocean

The eastern equatorial Atlantic Ocean is subject to interannual fluctuations of sea surface temperatures, with climatic impacts on the surrounding continents. The dynamic mechanism underlying Atlantic temperature variability is thought to be similar to that of the El Nino/Southern Oscillation (ENSO) in the equatorial Pacific, where air-sea coupling leads to a positive feedback between surface winds in the western basin, sea surface temperature in the eastern basin, and equatorial oceanic heat content. Here we use a suite of observational data, climate reanalysis products, and general circulation model simulations to reassess the factors driving the interannual variability. We show that some of the warm events can not be explained by previously identified equatorial wind stress forcing and ENSO-like dynamics. Instead, these events are driven by a mechanism in which surface wind forcing just north of the equator induces warm ocean temperature anomalies that are subsequently advected toward the equator. We find the surface wind patterns are associated with long-lived subtropical sea surface temperature anomalies and suggest they therefore reflect a link between equatorial and subtropical Atlantic variability