Contact-allergy time

The most commonly used techniques for the in vivo evaluation of the cellular immune response include intracutaneous testing with microbial recall antigens or sensitization with neoantigens. The reliability of these tests for the individual patient usually is low due to the lack of standardization and quantification. Moreover only the efferent branch of the immune response can be judged. The dinitrochlorobenzene-contact allergy time (DNCB-CAT) is a quantitative approach for the assessment of the cellular immune response. 2% DNCBointment is applied on the upper arm in a 1 cm2 area. On the following days patch-testing with 0.05% DNCB-ointment is done on the homolateral forearm in alternating localizations till an allergic contact dermatitis reaction appears. As assessed in patients with malignant melanoma (MM, n=\\5) and with lymphoproliferative disorders (LD, η = 25), the DNCB-CAT correlates with the age of the patients and can be expressed by a formula given by the age (years) χ factor (MM = 0.16; LD = 0.17) + constant figure (MM = 5.5; LD = 4.3). There was no significant difference between the two groups or subgroups investigated. By DNCB-CAT quantitative analysis of the cellular immune response in vivo is possible. It is an appropriate model for further investigations of the cellular immunity under different clinical, histological, prognostic, and therapeutic aspects

The abundance and spatial distribution of ultra-diffuse galaxies in nearby galaxy clusters

Recent observations have highlighted a significant population of faint but large (r_eff>1.5 kpc) galaxies in the Coma cluster. The origin of these Ultra Diffuse Galaxies (UDGs) remains puzzling, as the interpretation of the observational results has been hindered by the subjective selection of UDGs, and the limited study of only the Coma (and some examples in the Virgo-) cluster. We extend the study of UDGs using 8 clusters in the redshift range 0.044<z<0.063 with deep g- and r-band imaging data taken with MegaCam at the CFHT. We describe an automatic selection pipeline for quantitative identification, tested for completeness using image simulations of these galaxies. We find that the abundance of the UDGs we can detect increases with cluster mass, reaching ~200 in typical haloes of M200~10^15 Msun. The cluster UDGs have colours consistent with the cluster red sequence, and have a steep size distribution that declines as n~r_eff^-3.4. Their radial distribution is significantly steeper than NFW in the outskirts, and is significantly shallower in the inner parts. They follow the same radial distribution as the more massive quiescent galaxies in the clusters, except within the core region of r<0.15XR200 (or <300 kpc). Within this region the number density of UDGs drops and is consistent with zero. These diffuse galaxies can only resist tidal forces down to this cluster-centric distance if they are highly centrally dark-matter dominated. The observation that the radial distribution of more compact dwarf galaxies (r_eff<1.0 kpc) with similar luminosities follows the same distribution as the UDGs, but exist down to a smaller distance of 100kpc from the cluster centres, indicates that they may have similarly massive sub-haloes as the UDGs. Although several scenarios can give rise to the UDG population, our results point to differences in the formation history as the most plausible explanation.Comment: 12 pages, 11 figures. Accepted for publication in A&A after minor revisio

Constraint-based Programming: A Survey

Report on constraint-based computer programming analyzing finite-domain and continuous-domain constraint satisfaction methods and existing systems which apply constraints to problem-solving, modeling, and simulation

The hot gas content of fossil galaxy clusters

We investigate the properties of the hot gas in four fossil galaxy systems detected at high significance in the Planck Sunyaev-Zeldovich (SZ) survey. XMM-Newton observations reveal overall temperatures of kT ~ 5-6 keV and yield hydrostatic masses M500,HE > 3.5 x 10e14 Msun, confirming their nature as bona fide massive clusters. We measure the thermodynamic properties of the hot gas in X-rays (out to beyond R500 in three cases) and derive their individual pressure profiles out to R ~ 2.5 R500 with the SZ data. We combine the X-ray and SZ data to measure hydrostatic mass profiles and to examine the hot gas content and its radial distribution. The average Navarro-Frenk-White (NFW) concentration parameter, c500 = 3.2 +/- 0.4, is the same as that of relaxed `normal' clusters. The gas mass fraction profiles exhibit striking variation in the inner regions, but converge to approximately the cosmic baryon fraction (corrected for depletion) at R500. Beyond R500 the gas mass fraction profiles again diverge, which we interpret as being due to a difference in gas clumping and/or a breakdown of hydrostatic equilibrium in the external regions. Overall our observations point to considerable radial variation in the hot gas content and in the gas clumping and/or hydrostatic equilibrium properties in these fossil clusters, at odds with the interpretation of their being old, evolved and undisturbed. At least some fossil objects appear to be dynamically young.Comment: 4 pages, 2 figures. Accepted for publication in A&

A skewer survey of the Galactic halo from deep CFHT and INT images

We study the density profile and shape of the Galactic halo using deep multicolour images from the MENeaCS and CCCP projects, over 33 fields selected to avoid overlap with the Galactic plane. Using multicolour selection and PSF homogenization techniques we obtain catalogues of F stars (near-main sequence turnoff stars) out to Galactocentric distances up to 60kpc. Grouping nearby lines of sight, we construct the stellar density profiles through the halo in eight different directions by means of photometric parallaxes. Smooth halo models are then fitted to these profiles. We find clear evidence for a steepening of the density profile power law index around R=20 kpc, from -2.50 +- 0.04 to -4.85 +- 0.04, and for a flattening of the halo towards the poles with best-fit axis ratio 0.63 +- 0.02. Furthermore, we cannot rule out a mild triaxiality (w>=0.8). We recover the signatures of well-known substructure and streams that intersect our lines of sight. These results are consistent with those derived from wider but shallower surveys, and augur well for upcoming, wide-field surveys of comparable depth to our pencil beam surveys.Comment: 14 pages, 8 figures, 6 table

Finding halo streams with a pencil-beam survey: new wraps in the Sagittarius stream

We use data from two CFHT-MegaCam photometric pencil-beam surveys in the g' and the r' bands to measure distances to the Sagittarius, the Palomar 5 and the Orphan stream. We show that, using a cross-correlation algorithm to detect the turnoff point of the main sequence, it is possible to overcome the main limitation of a two-bands pencil-beam survey, namely the lack of adjacent control-fields that can be used to subtract the foreground and background stars to enhance the signal on the colour-magnitude diagrams (CMDs). We describe the cross-correlation algorithm and its implementation. We combine the resulting main sequence turnoff points with theoretical isochrones to derive photometric distances to the streams. Our results (31 detections on the Sagittarius stream and one each for the Palomar 5 and the Orphan streams) confirm the findings by previous studies, expand the distance trend for the Sagittarius faint southern branch and, for the first time, trace the Sagittarius faint branch of the northern-leading arm out to 56 kpc. In addition, they show evidence for new substructure: we argue that these detections trace the continuation of the Sagittarius northern-leading arm into the southern hemisphere, and find a nearby branch of the Sagittarius trailing wrap in the northern hemisphere.Comment: 16 pages, 15 figures, 2 table

The role of spatial and non-spatial information in visual selection.

Even though it is undisputed that prior information regarding the location of a target affects visual selection, the issue of whether information regarding nonspatial features, such as color and shape, has similar effects has been a matter of debate since the early 1980s. In the study described in this article, measures derived from signal detection theory were used to show that perceptual sensitivity is affected by a top-down set for spatial information but not by a top-down set for nonspatial information. This indicates that knowing where the target singleton is affects perceptual selectivity but that knowing what it is does not help selectivity. Furthermore, perceptual sensitivity can be enhanced by nonspatial features, but only through a process related to bottom-up priming. These findings have important implications for models of visual selection. © 2007 American Psychological Association