1,096 research outputs found
Monte Carlo simulation of a two-field effective Hamiltonian of complete wetting
Recent work on the complete wetting transition for three dimensional systems
with short-ranged forces has emphasized the role played by the coupling of
order-parameter fluctuations near the wall and depinning interface. It has been
proposed that an effective two-field Hamiltonian, which predicts a
renormalisation of the wetting parameter, could explain the controversy between
RG analysis of the capillary-wave model and Monte Carlo simulations on the
Ising model. In this letter results of extensive Monte Carlo simulations of the
two-field model are presented. The results are in agreement with prediction of
a renormalized wetting parameter .Comment: To appear in Europhysics Letters. Latex file, 6 pages, 2 figure
Rapid localization of proteins in chromatographic eluates
Rapid localization of proteins in chromatographic eluate
Acute renal failure in four Comrades Marathon runners ingesting the same electrolyte supplement: Coincidence or causation?
Objectives. To evaluate common factors associated with the development of acute renal failure (ARF) in Comrades Marathon runners.Methods. This was a retrospective case series of 4 runners hospitalised post-race with ARF in the 89 km 2010 Comrades Marathon. The outcome measures were incidence of analgesic use, levels of creatine phosphokinase (CPK) and degree of electrolyte supplementation (sodium, potassium, calcium and magnesium).Results. The prevalence of ARF was 1/4 125 runners. They presented with rhabdomyolysis (mean admission CPK of 36 294 IU) and hyponatraemia (mean admission blood sodium level of 133 mEq/l). All had ingested an analgesic during the run (3 ingested a non-steroidal anti-inflammatory drug) and the same readily available anti-cramp electrolyte supplement. The average amount of supplemental sodium (452 mg), potassium (393 mg), calcium (330 mg) and magnesium (154 mg) ingested via this particular electrolyte supplement before and during the run did not exceedthe recommended upper limits of daily intake. Three of the runners were Comrades Marathon novices.Conclusions. There is a continuing need to clarify the specific cluster variants that cause ARF in Comrades Marathon runners, as the risk factors appear to have evolved since the first case was described over 40 years ago.S Afr Med J 2011;101:876-878
Coupled Fluctuations near Critical Wetting
Recent work on the complete wetting transition has emphasized the role played
by the coupling of fluctuations of the order parameter at the wall and at the
depinning fluid interface. Extending this approach to the wetting transition
itself we predict a novel crossover effect associated with the decoupling of
fluctuations as the temperature is lowered towards the transition temperature
T_W. Using this we are able to reanalyse recent Monte-Carlo simulation studies
and extract a value \omega(T_W)=0.8 at T_W=0.9T_C in very good agreement with
long standing theoretical predictions.Comment: 4 pages, LaTex, 1 postscript figur
Avoid adding insult to injury – correct management of sick female endurance athletes
Objectives. To evaluate the efficacy of Ringer’s lactate, isotonic saline and hypertonic saline on the clinical and biochemical recovery of athletes with exercise-associated hyponatraemic encephalopathy caused by fluid overload.Methods. We retrospectively reviewed serial blood sodium concentrations (Na+) and qualitative signs of recovery and time to recovery in two healthy menstruant females hospitalised with dilutional exercise-associated hyponatraemic encephalopathy after withdrawal from the 2011 Comrades Marathon (89 km) and Argus Cycle Tour (109 km).Results. Improvements in blood Na+ did not occur with intravenous administration of Ringer’s lactate solution, but did occur with administration of isotonic and hypertonic saline. Qualitative improvements in mental status were not quantitatively related to the biochemical value of blood Na+ or subsequent return to normonatraemia.Conclusions. Hyponatraemia should be suspected in all female athletes presenting to the medical area of endurance races with vomiting, altered mental status and a history of high fluid intake. If a diagnosis of exercise-associated hyponatraemia with cerebral encephalopathy is confirmed, the treatment of choice is administration of an intravenous bolus of hypertonic saline. Administration of Ringer’s lactate should be discouraged, as this does not correct Na+ and appears to delay recovery
Differentiation of progenitors in the liver:a matter of local choice
The liver is a complex organ that requires multiple rounds of cell fate decision for development and homeostasis throughout the lifetime. During the earliest phases of organogenesis, the liver acquires a separate lineage from the pancreas and the intestine, and subsequently, the liver bud must appropriately differentiate to form metabolic hepatocytes and cholangiocytes for proper hepatic physiology. In addition, throughout life, the liver is bombarded with chemical and pathological insults, which require the activation and correct differentiation of adult progenitor cells. This Review seeks to provide an overview of the complex signaling relationships that allow these tightly regulated processes to occur
Performance of rectangular duct attenuators under non-ideal configurations with an unlined 90° bend
The acoustic performance of duct attenuators under nonideal conditions is experimentally investigated. The experimental method, a modified variation of the standard ISO 7235:2003 - Laboratory measurement procedures for ducted silencers and air-terminal units, was used to design and test non-ideal configurations that reflect the realities of conditions present in modern building duct systems, comparing static insertion loss between each variant. Since the goal was not to obtain absolute figures, the test was not in strict accordance with the standard. From the measurements, comparisons were made between test data obtained through testing that was done in accordance to the ISO 7235:2003 and data obtained using the modified variation of an ISO test rig. The key differences to a standard test rig were the omission of a cross modal filter and the use of MDF as the duct material. With the limitations of the timber rig understood, complete satisfaction of ISO 7235:2003 requirements was not critical in achieving the project outcome. Hence, the timber test rig was proven to be an appropriate substitute for this research. From the investigation, the inclusion of a 90 degree bend in a duct configuration increases attenuator performance (Static insertion loss). However, it is inconclusive from the result as to whether situating the attenuator before or after the bend may result in the best performance due to the variability measured across the 5 measuring positions along the diagonal of the duct in the measuring station (MS), required by the ISO standard. Factors influencing the variability or Maximum Level Differences (MLD) may be mainly attributed to the anechoic termination (AT) performance, the lack of a modal filter, and cross modal excitation as a result of installing a bend
RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration
During trans-endothelial migration (TEM), leukocytes use adhesion receptors such as intercellular adhesion molecule-1 (ICAM1) to adhere to the endothelium. In response to this interaction, the endothelium throws up dynamic membrane protrusions, forming a cup that partially surrounds the adherent leukocyte. Little is known about the signaling pathways that regulate cup formation. In this study, we show that RhoG is activated downstream from ICAM1 engagement. This activation requires the intracellular domain of ICAM1. ICAM1 colocalizes with RhoG and binds to the RhoG-specific SH3-containing guanine-nucleotide exchange factor (SGEF). The SH3 domain of SGEF mediates this interaction. Depletion of endothelial RhoG by small interfering RNA does not affect leukocyte adhesion but decreases cup formation and inhibits leukocyte TEM. Silencing SGEF also results in a substantial reduction in RhoG activity, cup formation, and TEM. Together, these results identify a new signaling pathway involving RhoG and its exchange factor SGEF downstream from ICAM1 that is critical for leukocyte TEM
Effects of confinement and surface enhancement on superconductivity
Within the Ginzburg-Landau approach a theoretical study is performed of the
effects of confinement on the transition to superconductivity for type-I and
type-II materials with surface enhancement. The superconducting order parameter
is characterized by a negative surface extrapolation length . This leads to
an increase of the critical field and to a surface critical
temperature in zero field, , which exceeds the bulk . When the
sample is {\em mesoscopic} of linear size the surface induces
superconductivity in the interior for .
In analogy with adsorbed fluids, superconductivity in thin films of type-I
materials is akin to {\em capillary condensation} and competes with the
interface delocalization or "wetting" transition. The finite-size scaling
properties of capillary condensation in superconductors are scrutinized in the
limit that the ratio of magnetic penetration depth to superconducting coherence
length, , goes to zero, using analytic
calculations. While standard finite-size scaling holds for the transition in
non-zero magnetic field , an anomalous critical-point shift is found for
H=0. The increase of for H=0 is calculated for mesoscopic films,
cylindrical wires, and spherical grains of type-I and type-II materials.
Surface curvature is shown to induce a significant increase of ,
characterized by a shift inversely proportional to the
radius .Comment: 37 pages, 5 figures, accepted for PR
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