444 research outputs found

    Verifying RoboCup Teams

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    Pocreeding of: 5th International Workshop on Model Checking and Artificial Intelligence. MOCHART-2008, Patras, Greece, july, 21st, 2008.Verification of multi-agent systems is a challenging task due to their dynamic nature, and the complex interactions between agents. An example of such a system is the RoboCup Soccer Simulator, where two teams of eleven independent agents play a game of football against each other. In the present article we attempt to verify a number of properties of RoboCup football teams, using a methodology involving testing. To accomplish such testing in an efficient manner we use the McErlang model checker, as it affords precise control of the scheduling of the agents, and provides convenient access to the internal states and actions of the agents of the football teams.This work has been partially supported by the FP7-ICT-2007-1 project ProTest (215868), a RamĂłn y Cajal grant from the Spanish Ministerio de EducaciĂłn y Ciencia, and the Spanish national projects TRA2007-67374-C02-02, TIN2006-15660-C02- 02 (DESAFIOS) and S-0505/TIC/0407 (PROMESAS).Publicad

    Iron causes lipid oxidation and inhibits proteasome function in multiple myeloma cells: A proof of concept for novel combination therapies

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    Adaptation to import iron for proliferation makes cancer cells potentially sensitive to iron toxicity. Iron loading impairs multiple myeloma (MM) cell proliferation and increases the efficacy of the proteasome inhibitor bortezomib. Here, we defined the mechanisms of iron toxicity in MM.1S, U266, H929, and OPM-2 MM cell lines, and validated this strategy in preclinical studies using Vk*MYC mice as MM model. High-dose ferric ammonium citrate triggered cell death in all cell lines tested, increasing malondialdehyde levels, the by-product of lipid peroxidation and index of ferroptosis. In addition, iron exposure caused dose-dependent accumulation of polyubiquitinated proteins in highly iron-sensitive MM.1S and H929 cells, suggesting that proteasome workload contributes to iron sensitivity. Accordingly, high iron concentrations inhibited the proteasomal chymotrypsin-like activity of 26S particles and of MM cellular extracts in vitro. In all MM cells, bortezomib-iron combination induced persistent lipid damage, exacerbated bortezomib-induced polyubiquitinated proteins accumulation, and triggered cell death more efficiently than individual treatments. In Vk*MYC mice, addition of iron dextran or ferric carboxymaltose to the bortezomib-melphalan-prednisone (VMP) regimen increased the therapeutic response and prolonged remission without causing evident toxicity. We conclude that iron loading interferes both with redox and protein homeostasis, a property that can be exploited to design novel combination strategies including iron supplementation, to increase the efficacy of current MM therapies

    Barriers to early identification of autism in Brazil

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    Objective: Parents of children with autism spectrum disorders (ASD) seem to perceive that their child's development is not following the normal pattern as early as the first year of life. However, ASD children may not receive a diagnosis until they are of preschool age, especially in low- and middle-income countries. The objective of this study was to evaluate the pathway between initial parental concerns about atypical child development and ASD diagnosis in Brazil. Methods: Nineteen mothers whose children had been diagnosed with ASD participated and were interviewed. The ASD group consisted of two girls and 17 boys, with a mean age of 93.0 months (SD 48.4 monthsrange 39-197 months). Results: Mothers had their first concerns regarding ASD when children were 23.6 +/- 11.6 months old, but formal diagnosis occurred at a mean +/- SD age of 59.6 +/- 40.5 months, corresponding to a 3-year delay. Most mothers felt discouraged to address their concerns due to negative experiences with health professionals. Conclusion: In Brazil, mothers perceived the first signs of ASD in their children at an age similar to that reported in other countries, but the diagnosis of ASD seemed to be delayed. Consistent with the literature, mothers reported negative experiences with health professionals during the pathway to achieving ASD diagnosis.Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, Ambulatorio Cognicao Social Marcos Tomanik Mercad, Sao Paulo, SP, BrazilUniv Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Dept Psiquiatria, Ambulatorio Cognicao Social Marcos Tomanik Mercad, Sao Paulo, SP, BrazilWeb of Scienc

    Reasoning about the executability of goal-plan trees

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    User supplied domain control knowledge in the form of hierarchically structured agent plans is at the heart of a number of approaches to reasoning about action. This knowledge encodes the “standard operating procedures” of an agent for responding to environmental changes, thereby enabling fast and effective action selection. This paper develops mechanisms for reasoning about a set of hierarchical plans and goals, by deriving “summary information” from the conditions on the execution of the basic actions forming the “leaves” of the hierarchy. We provide definitions of necessary and contingent pre-, in-, and postconditions of goals and plans that are consistent with the conditions of the actions forming a plan. Our definitions extend previous work with an account of both deterministic and non-deterministic actions, and with support for specifying that actions and goals within a (single) plan can execute concurrently. Based on our new definitions, we also specify requirements that are useful in scheduling the execution of steps in a set of goal-plan trees. These requirements essentially define conditions that must be protected by any scheduler that interleaves the execution of steps from different goal-plan trees

    Phase Transformations during the Reaction Heat Treatment

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    The evolution of Nb containing phases during the diffusion heat treatment of three different high critical current Nb3_{3}Sn strand types is compared, based on synchrotron X-ray diffraction results that have been obtained at the ID15 beam line of the European Synchrotron Radiation Facility (ESRF). In all strands studied, Nb3_{3}Sn formation is preceded by the formation of a Cu-Nb-Sn ternary phase, NbSn2 and Nb6Sn5. As compared to the PIT and Tube Type strand, the amount of these phases formed in the RRP strand is relatively small. In the RRP strand subelements with a fine filament structure Nb3_{3}Sn grows more quickly, thereby preventing to a large extent the formation of the other higher tin phases

    Incorporating social practices in BDI agent systems

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    When agents interact with humans, either through embodied agents or because they are embedded in a robot, it would be easy if they could use fixed interaction protocols as they do with other agents. However, people do not keep fixed protocols in their day-to-day interactions and the environments are often dynamic, making it impossible to use fixed protocols. Deliberating about interactions from fundamentals is not very scalable either, because in that case all possible reactions of a user have to be considered in the plans. In this paper we argue that social practices can be used as an inspiration for designing flexible and scalable interaction mechanisms that are also robust. However, using social practices requires extending the traditional BDI deliberation cycle to monitor landmark states and perform expected actions by leveraging existing plans. We define and implement this mechanism in Jason using a periodically run meta-deliberation plan, supported by a metainterpreter, and illustrate its use in a realistic scenario.Comment: An extended abstract of this paper has been accepted for the Eighteenth International Conference on Autonomous Agents and Multiagent Systems (AAMAS), 201

    Open Data as Open Educational Resources: Case studies of emerging practice

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    This collection presents the stories of our contributors’ experiences and insights, in order to demonstrate the enormous potential for openly-licensed and accessible datasets (Open Data) to be used as Open Educational Resources (OER). Open Data is an umbrella term describing openly-licensed, interoperable, and reusable datasets which have been created and made available to the public by national or local governments, academic researchers, or other organisations. These datasets can be accessed, used and shared without restrictions other than attribution of the intellectual property of their creators1.While there are various definitions of OER, these are generally understood as openly-licensed digital resources that can be used in teaching and learning. On the basis of these definitions, it is reasonable to assert that while Open Data is not always OER, it certainly becomes OER when used within pedagogical contexts. Yet while the question may appear already settled at the level of definition, the potential and actual pedagogical uses of Open Data appear to have been under-discussed. As open education researchers who take a wider interest in the various open ‘movements’, we have observed that linkages between them are not always strong, in spite of shared and interconnecting values. So, Open Data tends to be discussed primarily in relation to its production, storage, licensing and accessibility, but less often in relation to its practical subsequent uses. And, in spite of widespread understanding that use of the term ‘OER’ is actually context-dependent, and, therefore, could be almost all-encompassing, the focus of OER practice and research has tended to be on educator-produced learning materials. The search for relevant research literature in the early stages of this project turned up sources which discuss the benefits of opening data, and others advocating improving student engagement with data3, but on the topic of Open Data as an educational resource specifically, there appeared to be something of a gap

    A survey on parallel and distributed Multi-Agent Systems

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    International audienceSimulation has become an indispensable tool for researchers to explore systems without having recourse to real experiments. Depending on the characteristics of the modeled system, methods used to represent the system may vary. Multi-agent systems are, thus, often used to model and simulate complex systems. Whatever modeling type used, increasing the size and the precision of the model increases the amount of computation, requiring the use of parallel systems when it becomes too large. In this paper, we focus on parallel platforms that support multi-agent simulations. Our contribution is a survey on existing platforms and their evaluation in the context of high performance computing. We present a qualitative analysis, mainly based on platform properties, then a performance comparison using the same agent model implemented on each platform

    Probabilistic model checking multi-agent behaviors in dispersion games using counter abstraction

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    Accurate analysis of the stochastic dynamics of multi-agent system is important but challenging. Probabilistic model checking, a formal technique for analysing a system which exhibits stochastic behaviors, can be a natural solution to analyse multi-agent systems. In this paper, we investigate this problem in the context of dispersion games focusing on two strategies: basic simple strategy (BSS) and extended simple strategies (ESS). We model the system using discrete-time Markov chain (DTMC) and reduce the state space of the models by applying counter abstraction technique. Two important properties of the system are considered: convergence and convergence rate. We show that these kinds of properties can be automatically analysed and verified using probabilistic model checking techniques. Better understanding of the dynamics of the strategies can be obtained compared with empirical evaluations in previous work. Through the analysis, we are able to demonstrate that probabilistic model checking technique is applicable, and indeed useful for automatic analysis and verification of multi-agent dynamics.No Full Tex
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