Ecodemocracy in practice: exploration of debates on limits and possibilities of addressing environmental challenges within democratic systems

This article examines the practical implications of ecological democracy or ecodemocracy, inquiring how capable democratic societies are of addressing environmental challenges. It asks: What is needed to secure democratic legitimacy for policy measures to benefit nonhuman species? What would ecodemocracy look like in practice? Different types of existing and possible types of representation are discussed, including the expansion of the precautionary principle, the Council of All Beings or Parliament of Things, and representation through the Parties for Animals. A possible approach in the form of a mandate for proxy eco-representation similar to civil rights through continuous affirmative action is investigated.  Limitations and possibilities of each approach for nature representation are weighed. Key words. anthropocentrism, democracy, ecocentrism, ecological democracy, ecodemocracy, ecological justice, environmental justice, multispecies justice, rights of natur

Natural disturbance impacts on trade-offs and co-benefits of forest biodiversity and carbon

With accelerating environmental change, understanding forest disturbance impacts on trade-offs between biodiversity and carbon dynamics is of high socio-economic importance. Most studies, however, have assessed immediate or short-term effects of disturbance, while long-term impacts remain poorly understood. Using a tree-ring-based approach, we analysed the effect of 250 years of disturbances on present-day biodiversity indicators and carbon dynamics in primary forests. Disturbance legacies spanning centuries shaped contemporary forest co-benefits and trade-offs, with contrasting, local-scale effects. Disturbances enhanced carbon sequestration, reaching maximum rates within a comparatively narrow post-disturbance window (up to 50 years). Concurrently, disturbance diminished aboveground carbon storage, which gradually returned to peak levels over centuries. Temporal patterns in biodiversity potential were bimodal; the first maximum coincided with the short-term post-disturbance carbon sequestration peak, and the second occurred during periods of maximum carbon storage in complex old-growth forest. Despite fluctuating local-scale trade-offs, forest biodiversity and carbon storage remained stable across the broader study region, and our data support a positive relationship between carbon stocks and biodiversity potential. These findings underscore the interdependencies of forest processes, and highlight the necessity of large-scale conservation programmes to effectively promote both biodiversity and long-term carbon storage, particularly given the accelerating global biodiversity and climate crises

Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting enzymes, tryptophan hydroxylase-1 and -2 (TPH1 and TPH2). We used a gene-targeting approach to generate mice with selective and complete elimination of the two known TPH isoforms. This resulted in dramatically reduced central 5-HT levels in Tph2 knockout (TPH2KO) and Tph1/Tph2 double knockout (DKO) mice; and substantially reduced peripheral 5-HT levels in DKO, but not TPH2KO mice. Therefore, differential expression of the two isoforms of TPH was reflected in corresponding depletion of 5-HT content in the brain and periphery. Surprisingly, despite the prominent and evolutionarily ancient role that 5-HT plays in both vertebrate and invertebrate physiology, none of these mutations resulted in an overt phenotype. TPH2KO and DKO mice were viable and normal in appearance. Behavioral alterations in assays with predictive validity for antidepressants were among the very few phenotypes uncovered. These behavioral changes were subtle in the TPH2KO mice; they were enhanced in the DKO mice. Herein, we confirm findings from prior descriptions of TPH1 knockout mice and present the first reported phenotypic evaluations of Tph2 and Tph1/Tph2 knockout mice. The behavioral effects observed in the TPH2 KO and DKO mice strongly confirm the role of 5-HT and its synthetic enzymes in the etiology and treatment of affective disorders

TFOS European Ambassador meeting: Unmet needs and future scientific and clinical solutions for ocular surface diseases

The mission of the Tear Film & Ocular Surface Society (TFOS) is to advance the research, literacy, and educational aspects of the scientific field of the tear film and ocular surface. Fundamental to fulfilling this mission is the TFOS Global Ambassador program. TFOS Ambassadors are dynamic and proactive experts, who help promote TFOS initiatives, such as presenting the conclusions and recommendations of the recent TFOS DEWS II™, throughout the world. They also identify unmet needs, and propose future clinical and scientific solutions, for management of ocular surface diseases in their countries. This meeting report addresses such needs and solutions for 25 European countries, as detailed in the TFOS European Ambassador meeting in Rome, Italy, in September 2019

Adverse Drug Reactions in Children—A Systematic Review

Adverse drug reactions in children are an important public health problem. We have undertaken a systematic review of observational studies in children in three settings: causing admission to hospital, occurring during hospital stay and occurring in the community. We were particularly interested in understanding how ADRs might be better detected, assessed and avoided

Low-cost communication-assisted line protection for multi-inverter based microgrids

Multi-inverter microgrid systems, particularly those with loop topology, offer higher power supply reliability and robustness compared to conventional radial distribution systems. In meshed systems, communication-less protection schemes have proved to be ineffective for multi-inverter microgrids due to bidirectional power flow, and limited and controlled fault currents generated by the voltage source converters interfacing the energy source to the network. This makes communicationassisted line protection schemes preferable for such systems despite the necessity for communication means. While these protection schemes are effective, their reliability depends much on the communication availability. This requires a back-up communication path in case the main one fails bringing up the cost issue that hinders their uptake. This paper proposes a novel and low-cost line protection based on directional blocking strategy that can operate as a main as well as a back-up protection to any protection scheme using communication means between the line terminals. As the main, it requires low-bandwidth communication system. As a back-up, it would share the same communication means with the main one and use those of the healthy lines when the faulted lines fails. Thus saving the cost of back-up communication system

Microgrid protection using low-cost communication systems

Power electronics interface of renewable energy to system is now the trend in both transmission and distribution segments of power network. Unlike synchronous generators, the fault feeding and control characteristic of these renewable generators are different and mostly influenced by the topology, switching, and control deployed in power electronics interface. So, the network protection design and operational requirements are now challenged in the absence of large fault current. Although the differential current principle still works, its implementation is limited by the significant cost associated to its communication system. This paper proposes a differential line protection scheme based on local fault detection and comparing binary state outputs of relays at both ends of the line thus requiring a simple, flexible and low bandwidth communication system. The performance of the proposed scheme is assessed through simulation of an example system with several scenarios