Reaction time and incident cancer: 25 years of follow-up of study members in the UK Health and Lifestyle Survey

<b>Objectives</b><p></p> To investigate the association of reaction time with cancer incidence.<p></p> <b>Methods</b><p></p> 6900 individuals aged 18 to 94 years who participated in the UK Health and Lifestyle Survey in 1984/1985 and were followed for a cancer registration for 25 years.<p></p> <b>Results</b><p></p> Disease surveillance gave rise to 1015 cancer events from all sites. In general, there was essentially no clear pattern of association for either simple or choice reaction time with cancer of all sites combined, nor specific malignancies. However, selected associations were found for lung cancer, colorectal cancer and skin cancer.<p></p> <b>Conclusions</b><p></p> In the present study, reaction time and its components were not generally related to cancer risk

Cities: Continuity, transformation and emergence

Book synopsis: This book applies ideas and methods from the complexity perspective to key concerns in the social sciences, exploring co-evolutionary processes that have not yet been addressed in the technical or popular literature on complexity. \ud \ud Authorities in a variety of fields – including evolutionary economics, innovation and regeneration studies, urban modelling and history – re-evaluate their disciplines within this framework. The book explores the complex dynamic processes that give rise to socio-economic change over space and time, with reference to empirical cases including the emergence of knowledge-intensive industries and decline of mature regions, the operation of innovative networks and the evolution of localities and cities. Sustainability is a persistent theme and the practicability of intervention is examined in the light of these perspectives. \ud \ud Specialists in disciplines that include economics, evolutionary theory, innovation, industrial manufacturing, technology change, and archaeology will find much to interest them in this book. In addition, the strong interdisciplinary emphasis of the book will attract a non-specialist audience interested in keeping abreast of current theoretical and methodological approaches through evidence-based and practical examples

The discrete dynamics of small-scale spatial events: agent-based models of mobility in carnivals and street parades

Small-scale spatial events are situations in which elements or objects vary in such away that temporal dynamics is intrinsic to their representation and explanation. Someof the clearest examples involve local movement from conventional traffic modelingto disaster evacuation where congestion, crowding, panic, and related safety issue arekey features of such events. We propose that such events can be simulated using newvariants of pedestrian model, which embody ideas about how behavior emerges fromthe accumulated interactions between small-scale objects. We present a model inwhich the event space is first explored by agents using ?swarm intelligence?. Armedwith information about the space, agents then move in an unobstructed fashion to theevent. Congestion and problems over safety are then resolved through introducingcontrols in an iterative fashion and rerunning the model until a ?safe solution? isreached. The model has been developed to simulate the effect of changing the route ofthe Notting Hill Carnival, an annual event held in west central London over 2 days inAugust each year. One of the key issues in using such simulation is how the processof modeling interacts with those who manage and control the event. As such, thischanges the nature of the modeling problem from one where control and optimizationis external to the model to one where this is intrinsic to the simulation

Thermodynamics and kinetics of heterogeneous reactions

Thermodynamics and kinetics of sublimation, catalytic, and oxidation reaction

Representing multifunctional cities: density and diversity in space and time

In this paper, we define measures of urban diversity, density and segregation using newdata and software systems based on GIS. These allow us to visualise the meaning of themultifunctional city. We begin with a discussion of how cities have become moresegregated in their land uses and activities during the last 200 years and how the currentfocus is on reversing this trend through limiting urban sprawl and bringing new lifeback to the inner and central city. We define various indices which show how diversityand density manifest themselves spatially. We argue that multifunctionalism is a relativeconcept, dependent upon the spatial and temporal scale that we use to think about themixing and concentration of urban land uses. We present three examples using spatiallysmoothed indicators of diversity: for a world city ? London, for a highly controlledpolycentric urban region ? Randstad Holland, and for a much more diffusely populatedsemi-urban region ? Venice-Padua-Teviso. We conclude by illustrating that urbandiversity varies as people engage in different activities associated with different landuses throughout the day, as well as through the vertical, third dimension of the city. Thisimpresses the point that we need to understand multifunctional cities in all theirdimensions of space and time

A New Parameter Set for the Relativistic Mean Field Theory

Subtracting the Strutinsky shell corrections from the selfconsistent energies obtained within the Relativistic Mean Field Theory (RMFT) we have got estimates for the macroscopic part of the binding energies of 142 spherical even-even nuclei. By minimizing their root mean square deviations from the values obtained with the Lublin-Srasbourg Drop (LSD) model with respect to the nine RMFT parameters we have found the optimal set (NL4). The new parameters reproduce also the radii of these nuclei with an accuracy comparable with that obtained with the NL1 and NL3 sets.Comment: Semiar given at the 10th Nuclear Physics Workshop in Kazimierz, Poland, Sep. 24-28, 200

The envirome and the connectome: exploring the structural noise in the human brain associated with socioeconomic deprivation

Complex cognitive functions are widely recognized to be the result of a number of brain regions working together as large-scale networks. Recently, complex network analysis has been used to characterize various structural properties of the large scale network organization of the brain. For example, the human brain has been found to have a modular architecture i.e. regions within the network form communities (modules) with more connections between regions within the community compared to regions outside it. The aim of this study was to examine the modular and overlapping modular architecture of the brain networks using complex network analysis. We also examined the association between neighborhood level deprivation and brain network structure – modularity and grey nodes. We compared network structure derived from anatomical MRI scans of 42 middle-aged neurologically healthy men from the least (LD) and the most deprived (MD) neighborhoods of Glasgow with their corresponding random networks. Cortical morphological covariance networks were constructed from the cortical thickness derived from the MRI scans of the brain. For a given modularity threshold, networks derived from the MD group showed similar number of modules compared to their corresponding random networks, while networks derived from the LD group had more modules compared to their corresponding random networks. The MD group also had fewer grey nodes – a measure of overlapping modular structure. These results suggest that apparent structural difference in brain networks may be driven by differences in cortical thicknesses between groups. This demonstrates a structural organization that is consistent with a system that is less robust and less efficient in information processing. These findings provide some evidence of the relationship between socioeconomic deprivation and brain network topology

Library abstraction for C/C++ concurrency

When constructing complex concurrent systems, abstraction is vital: programmers should be able to reason about concurrent libraries in terms of abstract specifications that hide the implementation details. Relaxed memory models present substantial challenges in this respect, as libraries need not provide sequentially consistent abstractions: to avoid unnecessary synchronisation, they may allow clients to observe relaxed memory effects, and library specifications must capture these. In this paper, we propose a criterion for sound library abstraction in the new C11 and C++11 concurrency model, generalising the standard sequentially consistent notion of linearizability. We prove that our criterion soundly captures all client-library interactions, both through call and return values, and through the subtle synchronisation effects arising from the memory model. To illustrate our approach, we verify implementations against specifications for the lock-free Treiber stack and a producer-consumer queue. Ours is the first approach to compositional reasoning for concurrent C11/C++11 programs. 1