21 research outputs found
Response of Saos-2 osteoblast-like cells to kilohertz-resonance excitation in porous metallic scaffolds
Post-operative therapy for joint replacement is often performed to optimize bone volume and bone-implant contact. Methods, such as pulsed therapeutic ultrasound, have been shown to be a valuable addition to regular physiotherapy to increase bone regeneration. To evaluate the efficacy of kilohertz-frequency (kHz) resonant stimuli to additively manufactured implant analogues, Saos-2 cells were seeded onto porous stainless steel scaffolds and flat substrates. Resonant frequency modes were mapped in the low kHz range, and cells were subjected to daily stimulus for 10 min at a frequency of 1.278 kHz. kHz-frequency excitation was found to increase normalized alkaline phosphatase production by almost twofold on metallic substrates relative to non-vibrated control scaffolds, while peak velocity influenced alkaline phosphatase production on porous scaffolds but not flat substrates. Total cell proliferation was downregulated by excitation, and all excited samples displayed larger variability. This work indicates that vibration within the range of 0.16–0.48 mm/s may reduce cell proliferation, but favour osteogenic gene expression. This study highlights the potential of using kHz-resonance therapy to mitigate early-onset pore occlusion to achieve uniform osseointegration through porous metallic scaffolds.Postprint (author's final draft
Estudio de la aptitud de diferentes variedades de cerezas para su transformación industria
Preprin
The Historical Seismology at the Geophysical Institute of the University of Coimbra
Comunicação apresentada ao VIII Congresso Nacional de Geologia, em Braga (9-16 de Julho 2010)O Instituto Geofísico da Universidade de Coimbra (IGUC) foi fundado em 1864 como
observatório meteorológico. As observações sísmicas só terão sido iniciadas de forma regular 43 anos
mais tarde, em 1907. Os registos sísmicos que o IGUC possui actualmente representam uma das maiores
e melhor conservadas séries de registos sísmicos a nível mundial. Neste trabalho apresentaremos os
registos e os instrumentos utilizados no estudo da sismologia no IGUC, bem como o seu actual estado de
preservação, e a importância dos antigos registos sísmicos nos estudos científicos modernos.The Geophysical Institute of the University of Coimbra (IGUC) was founded in 1864 as the
meteorological observatory. The seismic observations only started regularly 43 years later, in 1907. The
seismic records that the IGUC have currently represent one of the largest and best preserved series of
seismic record worldwide. Ins this work we present the records and the instruments used in the study of
the seismology in the IGUC, as well as your current state of preservation, and the importance of the old
seismic records in the modern scientific studies
Estudio de la aptitud de diferentes variedades de cerezas para su transformación industria
Estudio de la aptitud de diferentes variedades de cerezas para su transformación industria
Sapientia, 1988, Vol. XLIII, nº 170 (número completo)
Contenido: La realidad del concepto de la trascendentalidad y pridcamentalidad (Cont.) / Octavio Nicolás Derisi – El entender como posesión : la función gnoseológica del verbo mental (Cont.) / J. L. González Alió -- ¿El alma humana “entre intelectual en potencia”, según Tomás de Aquino? / Ricardo Marimón Batlló – Notas y comentarios -- Bibliografí