Major Adverse Cardiovascular Events in Coronary Type 2 Diabetic Patients: Identification of Associated Factors Using Electronic Health Records and Natural Language Processing

Diabetes mellitus; Natural language processing; Risk factorsDiabetis mellitus; Processament del llenguatge natural; Factors de riscDiabetes mellitus; Procesamiento del lenguaje natural; Factores de riesgoPatients with Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are at high risk of developing major adverse cardiovascular events (MACE). This is a multicenter, retrospective, and observational study performed in Spain aimed to characterize these patients in a real-world setting. Unstructured data from the Electronic Health Records were extracted by EHRead®, a technology based on Natural Language Processing and machine learning. The association between new MACE and the variables of interest were investigated by univariable and multivariable analyses. From a source population of 2,184,662 patients, we identified 4072 adults diagnosed with T2DM and CAD (62.2% male, mean age 70 ± 11). The main comorbidities observed included arterial hypertension, hyperlipidemia, and obesity, with metformin and statins being the treatments most frequently prescribed. MACE development was associated with multivessel (Hazard Ratio (HR) = 2.49) and single coronary vessel disease (HR = 1.71), transient ischemic attack (HR = 2.01), heart failure (HR = 1.32), insulin treatment (HR = 1.40), and percutaneous coronary intervention (PCI) (HR = 2.27), whilst statins (HR = 0.73) were associated with a lower risk of MACE occurrence. In conclusion, we found six risk factors associated with the development of MACE which were related with cardiovascular diseases and T2DM severity, and treatment with statins was identified as a protective factor for new MACE in this study.This study was funded by AstraZeneca Spain (Externally Sponsored Scientific Research, ESR-18-13815) and sponsored by the Spanish Society of Cardiology

Thermodynamic stability of heterodimetallic [LnLn] complexes: synthesis and DFT studies

The solid-state and solution configurations of the heterodimetallic complexes (Hpy)[LaEr(HL)(3)(NO3)(py)(H2O)] (1), (Hpy)[CeEr(HL)(3)(NO3)(py)(H2O)] (2), (Hpy)[CeGd(HL)(3)(NO3)(py)(H2O)] (3), (Hpy)[PrSm(HL)(3)(NO3)(py)(H2O)] (4), and (Hpy)(2)[LaYb(HL)(3)(NO3)(H2O)](NO3) (5), in which H3L is 6-(3-oxo-3-(2-hydroxyphenyl)propionyl)pyridine-2-carboxylic acid and py is pyridine, were analyzed experimentally and by using DFT calculations. Complexes 3, 4, and 5 are described here for the first time, and were analyzed by using single-crystal X-ray diffraction and mass spectrometry. The theoretical study was also extended to the [LaCe] and [LaLu] analogues. The results are consistent with a remarkable selectivity of the metal distribution within the molecule in the solid state, enhanced by the size difference between the different ions. This selectivity was reduced in solution, particularly for ions with the most similar radii. This unique entry into 4f-4f heterometallic chemistry establishes for the first time the difference between the selectivity in solution and that in the solid state, as a result of changes to the coordination that follow the dissociation of terminal ligands upon dissolution of the complexes

A Performance Analysis Framework for WiFi/WiMAX Heterogeneous Metropolitan Networks Based on Cross-Layer Design

The communication between network nodes within different protocol domains is often regarded simply as a black box with unknown configuration conditions in the path. We address network heterogeneity using a white box approach and focus on its interconnection processes. To achieve this purpose, a Performance Analysis Framework (PAF) is proposed which is composed of the formalization of the latter using process algebra (PA) and the corresponding teletraffic performance models. In this contribution, we target the IEEE 802.16 and IEEE 802.11 protocols. For the teletraffic models, we extend previous models for such scenario with the inclusion of the following protocol operational parameters (metrics): bit error rate (BER), packet error ratio (PER), and packet length (pl). From the framework teletraffic models, the optimal packet length (OPL), end to end throughput, delay, and packet loss are obtained. The PAF outperforms previous modeling solutions in terms of delay and throughput relative to NS3 simulation results. </jats:p

Functionality and Quality of Life with Parkinson’s Disease after Use of a Dynamic Upper Limb Orthosis: A Pilot Study

Parkinson’s disease (PD) is a chronic, neurodegenerative movement disorder, whose symptoms have a negative impact on quality of life and functionality. Although its main treatment is pharmacological, non-pharmacological aids such as the dynamic elastomeric fabric orthosis (DEFO) merit an evaluation. Our objective is to assess the DEFO in upper limb (UL) functional mobility and in the quality of life of PD patients. A total of 40 patients with PD participated in a randomized controlled crossover study, and were assigned to a control group (CG) and to an experimental group (EG). Both groups used the DEFO for two months, the experimental group the first two months of the study and the control group the last two. Motor variables were measured in the ON and OFF states at the baseline assessment and at two months. Differences from the baseline assessment were observed in some motor items of the Kinesia assessment, such as rest tremor, amplitude, rhythm or alternating movements in the ON and OFF states with and without orthosis. No differences were found in the unified Parkinson’s disease rating scale (UPDRS) or the PD quality-of-life questionnaire. The DEFO improves some motor aspects of the UL in PD patients but this does not translate to the amelioration of the standard of functional and quality-of-life scales

EL RIEGO DE PRECISIÓN EN EL CULTIVO DE FRESA EN LA PROVINCIA DE HUELVA

[ES] El cultivo de fresa es el cultivo con mayor repercusión económica y social de la provincia de Huelva, ya que España es el principal productor de fresa fresca de Europa y el segundo del mundo, situándose el 95% de esa producción en la provincia de Huelva. Sin embargo, la zona donde se desarrolla el cultivo, el entorno del Parque Nacional de Doñana, es una de las zonas de mayor sensibilidad ambiental de Europa y cualquier actividad que se desarrolle debe evitar impactos negativos en el mismo. De lo anterior se deduce la necesidad de buscar un equilibrio para que agricultura y medio ambiente puedan convivir en el entorno de Doñana. Este trabajo se centra precisamente en eso, en optimizar el uso del agua en la zona mediante la implantación del riego de precisión en el cultivo de fresa, que consiste en dar a la planta el agua que necesita en el momento adecuado. La implantación de un sistema de riego de precisión se ha llevado a cabo en la campaña 2013/2014 en una finca comercial de la zona Almonte-El Rocío, provincia de Huelva. Para ello se ha implantado un ensayo en 5 sectores distintos, cada uno con un tipo de emisor diferente, en el que se realizó una programación óptima del riego basada en el cálculo de las necesidades teóricas del cultivo, el análisis hidráulico del sector y el movimiento del agua en el suelo, y cuyo comportamiento se comparó con un sector testigo manejado por el agricultor. Estas técnicas permitieron ahorrar un 43% de agua, en las condiciones particulares de suelo, variedad y configuración de la red riego de la finca de ensayo, obteniéndose un ligero aumento de producción respecto al manejo tradicional del agricultor, lo que se tradujo en un incremento de la rentabilidad del cultivo y de una mejora de la sostenibilidad en la producción intensiva de fresas.Martín Arroyo, M.; Fernandez García, I.; Gonzalez Perea, R.; García Morillo, J.; Rodríguez Díaz, J.; Camacho Poyato, E.; Montesinos Barrios, P. (2015). EL RIEGO DE PRECISIÓN EN EL CULTIVO DE FRESA EN LA PROVINCIA DE HUELVA. En XXXIII CONGRESO NACIONAL DE RIEGOS. Valencia 16-18 junio de 2015. Editorial Universitat Politècnica de València. https://doi.org/10.4995/CNRiegos.2015.1462OC