Kidney surveillance in the spotlight: contrast-induced acute kidney injury illuminated

Acute kidney injury comprises a heterogeneous group of conditions characterized by a sudden decrease in renal function over hours to days. Contrast-induced acute kidney injury (CI-AKI) is caused by radiographic contrast agents used in diagnostic imaging. In the current issue of the JCI, Lau et al. use a mouse model of CI-AKI to study the role of resident and infiltrating phagocytes, recruited leukocytes, and tubular cells in the immune surveillance response to contrast agents. This study has the potential to provide innovative therapies for human CI-AKI

Telerobot task planning and reasoning: Introduction to JPL artificial intelligence research

A view of the capabilities and areas of artificial intelligence research which are required for autonomous space telerobotics extending through the year 2000 is given. In the coming years, JPL will be conducting directed research to achieve these capabilities, as well as drawing heavily on collaborative efforts conducted with other research laboratories

A personal networking solution

This paper presents an overview of research being conducted on Personal Networking Solutions within the Mobile VCE Personal Distributed Environment Work Area. In particular it attempts to highlight areas of commonality with the MAGNET initiative. These areas include trust of foreign devices and service providers, dynamic real-time service negotiation to permit context-aware service delivery, an automated controller algorithm for wireless ad hoc networks, and routing protocols for ad hoc networking environments. Where possible references are provided to Mobile VCE publications to enable further reading

The use of function points to find cost analogies

Finding effective techniques for the early estimation of project effort remains an important — and frustratingly elusive — research objective for the software development community. We have conducted an empirical study of 21 real time projects for a major software developer. The study collected a range of counts and measures derived from specification documents, including a derivative of Function Points intended for highly constrained systems. Notwithstanding the fact that the projects were drawn from a comparatively stable environment, traditional approaches for building prediction systems, (for example, regression analysis) failed to yield a useful predictive model. By contrast, estimation based upon the automated search for analogous projects produced more accurate estimates. How much this is a characteristic of this particular dataset and how much these findings might be more generally replicated is uncertain. Nevertheless, these results should act as encouragement for follow up research on a much under utilised estimation technique

Interband effects in the c-axis optical conductivity in YBaCuO

The normal state optical conductivity is calculated for a layered metal with two layers per unit cell coupled through a transverse hopping matrix element $t_\perp$. The optical response involves an interband term in addition to the more familiar intraband term which leads to the usual Drude form. The interband term is only weakly temperature dependent, even for an inelastic scattering rate which is linear in T. It gives a $c$-axis response which extends in frequency over the entire band width although there can be structure on this energy scale which reflects details of the electronic structure. In particular, at low energy, the $c$-axis response can develop a gap or pseudogap as the temperature is lowered. At high temperature, a Drude response will be seen only if the intraband transitions, which are of order $t_\perp^4$, become important compared with the interband transitions which are of order $t_\perp^2$.Comment: 12 Pages, 9 postscript figures, submitted to Phys. Rev.

Role of CuO chains in vortex core structure in YBa2Cu3O{7-delta}

The Bogoliubov-deGennes equations are solved for a proximity model for YBa_2Cu_3O_{7-\delta} in a magnetic field. The model explicitly includes the effects of the one-dimensional CuO chains, whose influence on the vortex core structure is studied. The rapid vortex core contraction as a function of field which is seen experimentally at low magnetic fields is naturally explained by the presence of the chains.Comment: 9 pages, 5 figure

Securing personal distributed environments

The Personal Distributed Environment (PDE) is a new concept being developed by Mobile VCE allowing future mobile users flexible access to their information and services. Unlike traditional mobile communications, the PDE user no longer needs to establish his or her personal communication link solely through one subscribing network but rather a diversity of disparate devices and access technologies whenever and wherever he or she requires. Depending on the services’ availability and coverage in the location, the PDE communication configuration could be, for instance, via a mobile radio system and a wireless ad hoc network or a digital broadcast system and a fixed telephone network. This new form of communication configuration inherently imposes newer and higher security challenges relating to identity and authorising issues especially when the number of involved entities, accessible network nodes and service providers, builds up. These also include the issue of how the subscribed service and the user’s personal information can be securely and seamlessly handed over via multiple networks, all of which can be changing dynamically. Without such security, users and operators will not be prepared to trust their information to other networks

Theoretical Studies of Several Small-Ring Precursors to (+)-JQ1

We present the results of DFT(B3LYP) calculations on several precursors to (+)-JQ1 using an accurate basis set, including a report of conformational analysis, thermochemistry, optimized geometries and electrostatic potentials, and calculated IR and Raman spectra. Species include (I)1H-1,4-diazepin-2(3H)-imine, (II) 9H-[1,2,4]triazolo[4,3-a][1,4]diazepine, (III) 6H-thieno[3,2-f][1,2,4]triazolo[4,3a][1,4]diazepine, and (IV) 4-(4-chlorophenyl)-6H-thieno[3,2f][1,2,4]triazolo[4,3-a][1,4]diazepine. Studies are also reported on monobrominated (II)-(IV) substituted at the chiral center of the seven member ring, including a comparison of the energetics of equatorial versus axial bromination of the parent precursor. Implications with regard to the larger structure of (+)-JQ1 are discussed

Calibration, navigation, and registration of MAMS data for FIFE

The International Satellite Land Surface Climatology Project (ISLSCP) was conducted to study the interaction of the atmosphere with the land surface and the research problems associated with the interpretation of satellite data over the Earth's land surface. The experimental objectives of the First ISLSCP Field Experiment (FIFE) were the simultaneous acquisition of satellite, atmospheric, and surface data and to use these data to understand the processes controlling energy/mass exchange at the surface. The experiment site is a 15 x 15 km area southeast of Manhattan, Kansas, intersected by Interstate 70 and Kansas highway 177. The Konza Prairie portion is 5 x 5 km and is a controlled experiment site consisting primarily of native tall grass prairie vegetation. The remainder of the site is grazing and farm land with trees along creek beds that are scattered over the area. Airborne multispectral imagery from the Multispectral Atmospheric Mapping Sensor (MAMS) was collected over this region on two days during Intensive Field Campaign-1 (1FC-1) to study the time and space variability of remotely-sensed geophysical parameters. These datasets consist of multiple overflights covering about a 60-min period during late morning on June 4, 1987 and shortly after dark on the following day. Image data from each overpass were calibrated and Earth located with respect to each other using aircraft inertial navigation system parameters and ground control points. These were the first MAMS flights made with 10-bit thermal data

Weighing Aims in Doxastic Deliberation

In this paper, I defend teleological theories of belief against the exclusivity objection. I argue that despite the exclusive influence of truth in doxastic deliberation, multiple epistemic aims interact when we consider what to believe. This is apparent when we focus on the processes involved in specific instances (or concrete cases) of doxastic deliberation, such that the propositions under consideration are specified. First, I out- line a general schema for weighing aims. Second, I discuss recent attempts to defend the teleological position in relation to this schema. And third, I develop and defend my proposal that multiple epistemic aims interact in doxastic deliberation—a possibility which, as of yet, has received no serious attention in the literature