A new approach for simulating the paleo-evolution of the Northern Hemisphere ice sheets

Offline forcing methods for ice-sheet models often make use of an index approach in which temperature anomalies relative to the present are calculated by combining a simulated glacial–interglacial climatic anomaly field, interpolated through an index derived from the Greenland ice-core temperature reconstruction, with present-day climatologies. An important drawback of this approach is that it clearly misrepresents climate variability at millennial timescales. The reason for this is that the spatial glacial–interglacial anomaly field used is associated with orbital climatic variations, while it is scaled following the characteristic time evolution of the index, which includes orbital and millennial-scale climate variability. The spatial patterns of orbital and millennial variability are clearly not the same, as indicated by a wealth of models and data. As a result, this method can be expected to lead to a misrepresentation of climate variability and thus of the past evolution of Northern Hemisphere (NH) ice sheets. Here we illustrate the problems derived from this approach and propose a new offline climate forcing method that attempts to better represent the characteristic pattern of millennial-scale climate variability by including an additional spatial anomaly field associated with this timescale. To this end, three different synthetic transient forcing climatologies are developed for the past 120 kyr following a perturbative approach and are applied to an ice-sheet model. The impact of the climatologies on the paleo-evolution of the NH ice sheets is evaluated. The first method follows the usual index approach in which temperature anomalies relative to the present are calculated by combining a simulated glacial–interglacial climatic anomaly field, interpolated through an index derived from ice-core data, with present-day climatologies. In the second approach the representation of millennial-scale climate variability is improved by incorporating a simulated stadial–interstadial anomaly field. The third is a refinement of the second one in which the amplitudes of both orbital and millennial-scale variations are tuned to provide perfect agreement with a recently published absolute temperature reconstruction over Greenland. The comparison of the three climate forcing methods highlights the tendency of the usual index approach to overestimate the temperature variability over North America and Eurasia at millennial timescales. This leads to a relatively high NH ice-volume variability on these timescales. Through enhanced ablation, this results in too low an ice volume throughout the last glacial period (LGP), below or at the lower end of the uncertainty range of estimations. Improving the representation of millennial-scale variability alone yields an important increase in ice volume in all NH ice sheets but especially in the Fennoscandian Ice Sheet (FIS). Optimizing the amplitude of the temperature anomalies to match the Greenland reconstruction results in a further increase in the simulated ice-sheet volume throughout the LGP. Our new method provides a more realistic representation of orbital and millennial-scale climate variability and improves the transient forcing of ice sheets during the LGP. Interestingly, our new approach underestimates ice-volume variations on millennial timescales as indicated by sea-level records. This suggests that either the origin of the latter is not the NH or that processes not represented in our study, notably variations in oceanic conditions, need to be invoked to explain millennial-scale ice-volume fluctuations. We finally provide here both our derived climate evolution of the LGP using the three methods as well as the resulting ice-sheet configurations. These could be of interest for future studies dealing with the atmospheric or/and oceanic consequences of transient ice-sheet evolution throughout the LGP and as a source of climate input to other ice-sheet models

The Antarctic Ice Sheet response to glacial millennial-scale variability

The Antarctic Ice Sheet (AIS) is the largest ice sheet on Earth and hence a major potential contributor to future global sea-level rise. A wealth of studies suggest that increasing oceanic temperatures could cause a collapse of its marine-based western sector, the West Antarctic Ice Sheet, through the mechanism of marine ice-sheet instability, leading to a sea-level increase of 3–5&thinsp;m. Thus, it is crucial to constrain the sensitivity of the AIS to rapid climate changes. The last glacial period is an ideal benchmark period for this purpose as it was punctuated by abrupt Dansgaard–Oeschger events at millennial timescales. Because their center of action was in the North Atlantic, where their climate impacts were largest, modeling studies have mainly focused on the millennial-scale evolution of Northern Hemisphere (NH) paleo ice sheets. Sea-level reconstructions attribute the origin of millennial-scale sea-level variations mainly to NH paleo ice sheets, with a minor but not negligible role of the AIS. Here we investigate the AIS response to millennial-scale climate variability for the first time. To this end we use a three-dimensional, thermomechanical hybrid, ice sheet–shelf model. Different oceanic sensitivities are tested and the sea-level equivalent (SLE) contributions computed. We find that whereas atmospheric variability has no appreciable effect on the AIS, changes in submarine melting rates can have a strong impact on it. We show that in contrast to the widespread assumption that the AIS is a slow reactive and static ice sheet that responds at orbital timescales only, it can lead to ice discharges of around 6&thinsp;m SLE, involving substantial grounding line migrations at millennial timescales.</p

Impact of millennial-scale oceanic variability on the Greenland ice-sheet evolution throughout the last glacial period

Temperature reconstructions from Greenland ice-sheet (GrIS) ice cores indicate the occurrence of more than 20 abrupt warmings during the last glacial period (LGP) known as Dansgaard-Oeschger (D-O) events. Although their ultimate cause is still debated, evidence from both proxy data and modelling studies robustly links these to reorganisations of the Atlantic Meridional Overturning Circulation (AMOC). During the LGP, the GrIS expanded as far as the continental shelf break and was thus more directly exposed to oceanic changes than in the present. Therefore oceanic temperature fluctuations on millennial timescales could have had a non-negligible impact on the GrIS. Here we assess the effect of millennial-scale oceanic variability on the GrIS evolution from the last interglacial to the present day. To do so, we use a three-dimensional hybrid ice-sheet–shelf model forced by subsurface oceanic temperature fluctuations, assumed to increase during D-O stadials and decrease during D-O interstadials. Since in our model the atmospheric forcing follows orbital variations only, the increase in total melting at millennial timescales is a direct result of an increase in basal melting. We show that the GrIS evolution during the LGP could have been strongly influenced by oceanic changes on millennial timescales, leading to oceanically induced ice-volume contributions above 1&thinsp;m sea level equivalent (SLE). Also, our results suggest that the increased flux of GrIS icebergs as inferred from North Atlantic proxy records could have been triggered, or intensified, by peaks in melting at the base of the ice shelves resulting from increasing subsurface oceanic temperatures during D-O stadials. Several regions across the GrIS could thus have been responsible for ice mass discharge during D-O events, opening the possibility of a non-negligible role of the GrIS in oceanic reorganisations throughout the LGP.</p

Simulating the Laurentide Ice Sheet of the Last Glacial Maximum

In the last decades, great effort has been made to reconstruct the Laurentide Ice Sheet (LIS) during the Last Glacial Maximum (LGM; ca. 21 000 years before present, 21 kyr ago). Uncertainties underlying its modelling have led to notable differences in fundamental features such as its maximum elevation, extent and total volume. As a result, the uncertainty in ice dynamics and thus in ice extent, volume and ice stream stability remains large. We herein use a higher-order three-dimensional ice sheet model to simulate the LIS under LGM boundary conditions for a number of basal friction formulations of varying complexity. Their consequences for the Laurentide ice streams, configuration, extent and volume are explicitly quantified. Total volume and ice extent generally reach a constant equilibrium value that falls close to prior LIS reconstructions. Simulations exhibit high sensitivity to the dependency of the basal shear stress on the sliding velocity. In particular, a regularised Coulomb friction formulation appears to be the best choice in terms of ice volume and ice stream realism. Pronounced differences are found when the basal friction stress is thermomechanically coupled: the base remains colder, and the LIS volume is lower than in the purely mechanical friction scenario counterpart. Thermomechanical coupling is fundamental for producing rapid ice streaming, yet it leads to a similar ice distribution overall.</p

Failure of Supervised Chloroquine and Primaquine Regimen for the Treatment of Plasmodium vivax in the Peruvian Amazon

The widespread use of primaquine (PQ) and chloroquine (CQ), together, may be responsible for the relatively few, isolated cases of chloroquine-resistant P. vivax (CQRPV) that have been reported from South America. We report here a case of P. vivax from the Amazon Basin of Peru that recurred against normally therapeutic blood levels of CQ. Four out of 540 patients treated with combination CQ and PQ had a symptomatic recurrence of P. vivax parasitemia within 35 days of treatment initiation, possibly indicating CQ failure. Whole blood total CQ level for one of these four subjects was 95 ng/ml on the day of recurrence. Based on published criteria that delineate CQRPV as a P. vivax parasitemia, either recrudescence or relapse, that appears against CQ blood levels >100 ng/mL, we document the occurrence of a P. vivax strain in Peru that had unusually high tolerance to the synergistic combination therapy of CQ + PQ that normally works quite well

Epidemiología de las enfermedades reumáticas en México. Un estudio de 5 regiones basado en la metodología COPCORD

To estimate the prevalence of musculoskeletal (MSK) disorders and to describe predicting variables associated with rheumatic diseases in 5 regions of México

Diferencias en paisajes sonoros de sistemas silvopastoriles y potreros tradicionales del piedemonte llanero, Meta, Colombia

We recorded the soundscape at four cattle ranches at the foothills of the Meta department, Colombia. We used eight acoustic recorders, four in silvopastoral systems and four in traditional cattle systems. Each recorder operated for 1 minute every 10 minutes, for an average of 4 days, in November 2019. We obtained 4743 one-minute recordings, 57.3% for traditional cattle systems and 42.7% for silvopastoral systems. Differences were found in the acoustic activity and use of the acoustic space, which are related to the distance to the streams. The variables distance to roads and streams explain the variation in richness of bird and anuran, which was lower in silvopastoral systems than traditional cattle systems. This may be related to the design of the silvopatoral system (Mimosa trianae monoculture). Future silvopastoral initiatives should include more diverse designs in order to contrast the type of metrics evaluated in this study.Registramos el paisaje sonoro en cuatro fincas ganaderas en el piedemonte llanero del departamento del Meta, Colombia. Se utilizaron ocho grabadoras acústicas, cuatro en  silvopastoriles de potreros arbolados y cuatro en sistemas de ganadería tradicional. Cada grabadora estuvo grabando 1 minuto cada 10 minutos, durante un promedio de 4 días, en noviembre de 2019. Se obtuvieron 4743 grabaciones de un minuto, 57.3% para sistemas de potreros tradicionales y 42.7% para potreros arbolados. Se encontraron diferencias en la actividad acústica y el uso del espacio acústico, el cual está relacionado a la distancia a las quebradas. Las variables distancia a vías y a quebradas explicaron la variación de riqueza de aves y anuros, la cual fue menor para potreros arbolados en relación a los potreros tradicionales, lo que puede estar relacionado con el diseño del sistema silvopatoril (monocultivo de falso yopo, Mimosa trianae). Futuras iniciativas silvopastoriles deberían incluir diseños más diversos para poder contrastar el tipo de métricas evaluadas en este estudio

Exploiting endocytosis for transfection of mRNA for cytoplasmatic delivery using cationic gold nanoparticles

Gene therapy holds promise to cure various diseases at the fundamental level. For that, efficient carriers are needed for successful gene delivery. Synthetic 'non-viral' vectors, as cationic polymers, are quickly gaining popularity as efficient vectors for transmitting genes. However, they suffer from high toxicity associated with the permeation and poration of the cell membrane. This toxic aspect can be eliminated by nanoconjugation. Still, results suggest that optimising the oligonucleotide complexation, ultimately determined by the size and charge of the nanovector, is not the only barrier to efficient gene delivery. We herein develop a comprehensive nanovector catalogue comprising different sizes of Au NPs functionalized with two different cationic molecules and further loaded with mRNA for its delivery inside the cell. Tested nanovectors showed safe and sustained transfection efficiencies over 7 days, where 50 nm Au NPs displayed the highest transfection rates. Remarkably, protein expression was increased when nanovector transfection was performed combined with chloroquine. Cytotoxicity and risk assessment demonstrated that nanovectors are safe, ascribed to lesser cellular damage due to their internalization and delivery via endocytosis. Obtained results may pave the way to design advanced and efficient gene therapies for safely transferring oligonucleotides

Poor sleep quality decreases concurrent training benefits in markers of metabolic syndrome and quality of life of morbidly obese patients

Indexación: Scopus.Background: Sleep quality (SQ) plays a role in multiple activities of daily living, but little is known about its role in concurrent training [CT, high-intensity interval (HIIT) plus resistance training (RT)] adaptations for metabolic syndrome (MetS) and health-related quality of life (HRQoL) markers. The aim of the present study was to determine the effects of a 20-week CT programme on MetS and HRQoL markers according to the SQ of morbidly obese patients. Methods: Twenty-nine morbidly obese patients were allocated to one of two groups: good sleep quality (GSQ, n = 15, 38.07 ± 12.26 years) and poor sleep quality (PSQ, n = 14, 40.79 ± 11.62 years). HRQoL, body mass index, waist circumference (WC), systolic and diastolic blood pressure (SBP and DBP, respectively), and plasma outcomes were measured. Results: The GSQ group reported significant changes (pre-vs. post-intervention) in WC (114.0 ± 3.1 vs. 110.4 ± 3.4 cm, p = 0.012), SBP (137.0 ± 4.3 vs. 125.6 ± 1.8 mmHg, p = 0.006), and HRQoL general health (51.33 ± 21.08 vs. 64.33 ± 16.24, p = 0.020). By contrast, the PSQ group showed significant changes only in SQ (9.00 ± 2.42 vs. 5.36 ± 2.84, p = 0.004). Conclusions: Morbidly obese PSQ patients showed a lower response for improving MetS and HRQoL markers after a 20-week CT programme than GSQ peers. However, there was a greater effect size for decreasing WC and SBP in favour of the GSQ compared with the PSQ group, suggesting that there are limitations to CT benefits on these outcomes in the PSQ group. These results call for more complex future studies. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.https://www.mdpi.com/1660-4601/17/18/680