Photon Entanglement Through Brain Tissue.

Photon entanglement, the cornerstone of quantum correlations, provides a level of coherence that is not present in classical correlations. Harnessing it by study of its passage through organic matter may offer new possibilities for medical diagnosis technique. In this work, we study the preservation of photon entanglement in polarization, created by spontaneous parametric down-conversion, after one entangled photon propagates through multiphoton-scattering brain tissue slices with different thickness. The Tangle-Entropy (TS) plots show the strong preservation of entanglement of photons propagating in brain tissue. By spatially filtering the ballistic scattering of an entangled photon, we find that its polarization entanglement is preserved and non-locally correlated with its twin in the TS plots. The degree of entanglement correlates better with structure and water content than with sample thickness

Analysis of performance characteristics in ground effect of a large scale V/STOL multi-fan-in-wing transport model

Performance characteristics from static tests in ground effect of V/STOL transport mode

An Intelligent Empowering Agent (IEA) to Provide Easily Understood and Trusted Health Information Appropriate to the User Needs

Most members of the public, including patients, usually obtain health information from Web searches using generic search engines, which is often overwhelming, too generic, and of poor quality. Although patients may be better informed, they are often none the wiser and not empowered to communicate with medical professionals so that their care is compatible with their needs, values, and best interests. Intelligent Empowering Agents (IEA) use AI to filter medical information and assist the user in the understanding of health information about specific complaints or health in general. We have designed and developed a prototype of an IEA that dialogues with the user in simple language, collects health information from the Web, and provides tailored, easily understood, and trusted information. It empowers users to create their own comprehensive and objective opinion on health matters that concern them. This paper describes the IEA main characteristics and presents the results of subjective and objective tests carried out to assess the effectiveness of the IEA

Adaptation of the Conditioned Assessment of Speech Production in Spanish

Purpose: The purpose of this article is to describe the adaptation of the Spanish adaptation of the CASP. Method: The authors adapted each segment into Spanish, then had 41 participants complete a survey to determine if each adapted segment was representative of the Spanish phonologic system. Thirty-six children (half with typical hearing, half with hearing loss) completed the CASP in English and Spanish. Paired samples t-tests were run to compare English and Spanish CASP scores between children with hearing loss and those with typical hearing. Results: All segments were adapted as needed into Spanish. There was no statistical difference between the English CASP scores (18.61 ± 2.03) and Spanish CASP scores (18.78 ± 1.99) for the children with typical hearing. Similarly, there was no statistical difference between the English CASP scores (16.78 ± 3.44) and Spanish CASP scores (16.67 ± 3.41) for the children with hearing loss. Children with typical hearing scored statistically significantly higher on the English and Spanish CASP than children with hearing loss. Discussion: The CASP-S is an appropriate Spanish adaptation of the CASP, which has been field-tested for use with young Spanish-speaking children with hearing loss

Endothelial ADAM10 utilization defines a molecular pathway of vascular injury in mice with bacterial sepsis

The endothelium plays a critical role in the host response to infection and has been a focus of investigation in sepsis. While it is appreciated that intravascular thrombus formation, severe inflammation, and loss of endothelial integrity impair tissue oxygenation during sepsis, the precise molecular mechanisms that lead to endothelial injury remain poorly understood. We demonstrate here that endothelial ADAM10 was essential for the pathogenesis of Staphylococcus aureus sepsis, contributing to α-toxin-mediated (Hla-mediated) microvascular thrombus formation and lethality. As ADAM10 is essential for endothelial development and homeostasis, we examined whether other major human sepsis pathogens also rely on ADAM10-dependent pathways in pathogenesis. Mice harboring an endothelium-specific knockout of ADAM10 were protected against lethal Pseudomonas aeruginosa and Streptococcus pneumoniae sepsis, yet remained fully susceptible to group B streptococci and Candida albicans sepsis. These studies illustrate a previously unknown role for ADAM10 in sepsis-associated endothelial injury and suggest that understanding pathogen-specific divergent host pathways in sepsis may enable more precise targeting of disease

Action Boundary Proximity Effects on Perceptual-Motor Judgments

INTRODUCTION: Designed as a more ecological measure of reaction times, the Perception-Action Coupling Task (PACT) has shown good reliability and within-subject stability. However, a lengthy testing period was required. Perceptual-motor judgments are known to be affected by proximity of the stimulus to the action boundary. The current study sought to determine the effects of action boundary proximity on PACT performance, and whether redundant levels of stimuli, eliciting similar responses, can be eliminated to shorten the PACT.METHODS: There were 9 men and 7 women who completed 4 testing sessions, consisting of 3 familiarization cycles and 6 testing cycles of the PACT. For the PACT, subjects made judgments on whether a series of balls presented on a tablet afford "posting" (can fit) through a series of apertures. There were 8 ratios of ball to aperture size (B-AR) presented, ranging from 0.2 to 1.8, with each ratio appearing 12 times (12 trials) per cycle. Reaction times and judgment accuracy were calculated, and averaged across all B-ARs. Ratios and individual trials within each B-AR were systematically eliminated. Variables were re-averaged, and intraclass correlation coefficients (ICC) and coefficients of variation (CVTE) were calculated in an iterative manner.RESULTS: With elimination of the 0.2 and 1.8 B-ARs, the PACT showed good reliability (ICC = 0.81-0.99) and consistent within-subject stability (CVTE = 2.2-14.7%). Reliability (ICC = 0.81-0.97) and stability (CVTE = 2.6-15.6%) were unaffected with elimination of up to 8 trials from each B-AR.DISCUSSION: The shortened PACT resulted in an almost 50% reduction in total familiarization/testing time required, significantly increasing usability.Johnson CD, LaGoy AD, Pepping G-J, Eagle SR, Beethe AZ, Bower JL, Alfano CA, Simpson RJ, Connaboy C. Action boundary proximity effects on perceptual-motor judgments. Aerosp Med Hum Perform. 2019; 90(12):1000-1008

Long-Duration Space Exploration and Emotional Health: Recommendations for Conceptualizing and Evaluating Risk.

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Spaceflight to Mars will by far exceed the duration of any previous mission. Although behavioral health risks are routinely highlighted among the most serious threats to crew safety, understanding of specific emotional responses most likely to occur and interfere with mission success has lagged in comparison to other risk domains. Even within the domain of behavioral health, emotional constructs remain to be ‘unpacked’ to the same extent as other factors such as attention and fatigue. The current paper provides a review of previous studies that have examined emotional responses in isolated, confined, extreme environments (ICE) toward informing a needed research agenda. We include research conducted during space flight, long-duration space simulation analogs, and polar environments and utilize a widely-accepted and studied model of emotion and emotion regulation by Gross [6] to conceptualize specific findings. Lastly, we propose four specific directions for future research: (1) use of a guiding theoretical framework for evaluating emotion responses in ICE environments; (2) leveraging multi-method approaches to improve the reliability of subjective reports of emotional health; (3) a priori selection of precise emotional constructs to guide measure selection; and (4) focusing on positive in addition to negative emotion in order to provide a more complete understanding of individual risk and resilience

PSEUDOMONAS AVR AND HOP PROTEINS, THEIR ENCODING NUCLEIC ACIDS, AND USE THEREOF

One aspect of the present invention relates to isolated nucleic acid molecules encoding avirulence proteins or polypeptides of Pseudomonas syringae pv. syringae DC 3000, or nucleic acid moleculues which are complementary thereto. Expression vectors, host cells, and transgenic plants which include the DNA molecules of the present invention are also disclosed. Another aspect relates to the isolated proteins or polypeptides and compositions containing the same. The various nucleic acid molecules and proteins of the present invention can be used to impart disease resistance to a plant, make a plant hypersusceptible to colonization by nonpathogenic bacteria, modify a metabolic pathway in a cell, cause eukaryotic cell death and treat a cancerous condition, as well as inhibit programmed cell death