Nitric oxide mediates interleukin-1 induced inhibition of glycosaminoglycan synthesis in rat articular cartilage

Interleek-1β (IL-1) is a key mediator of cartilage matrix degradation in osteoarthritis and rheumatoid arthritis. It was found that the IL-1-induced suppression of glycosaminoglycan (GAG) synthesis in rat articular cartilage occurred simultaneously with the accumulation of nitrite (a metabolite of nitric oxide (NO) in aqueous milieu) in the culture medium. NO-synthase inhibitors, L-NMMA and L-NIO, inhibited both these IL-1 effects. Dexamethasone suppressed GAG synthesis additively to IL-1, but did not alter nitrite accumulation. Three NO-donors (GEA 3175, SNAP and SIN-1) also had an inhibitory effect on cartilage GAG synthesis. Therefore, it is concluded that IL-1 induced suppression of GAG synthesis in rat articular cartilage is mediated by the production of NO

A combined HST and XMM-Newton campaign for the magnetic O9.7 V star HD 54879: towards constraining the weak-wind problem of massive stars

Context: HD 54879 (O9.7 V) is one of a dozen O-stars for which an organized atmospheric magnetic field has been detected. To gain insights into the interplay between atmospheres, winds, and magnetic fields of massive stars, we acquired UV and X-ray data of HD 54879 using the Hubble Space Telescope and the XMM-Newton satellite. In addition, 35 optical amateur spectra were secured to study the variability of HD 54879. A multiwavelength (X-ray to optical) spectral analysis is performed using the Potsdam Wolf-Rayet (PoWR) model atmosphere code and the xspec software. Results: The photospheric parameters are typical for an O9.7 V star. The microturbulent, macroturbulent, and projected rotational velocities are lower than previously suggested (<4 km/s). An initial mass of 16$\,M_\odot$ and an age of 5 Myr are inferred from evolutionary tracks. We derive a mean X-ray emitting temperature of $\log T_{\rm X} = 6.7\,$[K] and an X-ray luminosity of $\log L_\text{X} = 32\,$[erg/s]. Short- and long-scale variability is seen in the H-alpha line, but only a very long period of $P \approx 5\,$yr could be estimated. Assessing the circumstellar density of HD 54879 using UV spectra, we can roughly estimate the mass-loss rate HD 54879 would have in the absence of a magnetic field as $\log \dot{M}_{B=0}\approx -9.0\,[{M_\odot}/{\rm yr}]$. The magnetic field traps the stellar wind up to the Alfv\'en radius > $12\,R_\odot$, implying that its true mass-loss rate is $\log \dot{M}< -10.2\,[{M_\odot}/{\rm yr}]$. Hence, density enhancements around magnetic stars can be exploited to estimate mass-loss rates of non-magnetic stars of similar spectral types, essential for resolving the weak wind problem. Conclusions: Our study confirms that strongly magnetized stars lose little or no mass, and supplies important constraints on the weak-wind problem of massive main sequence stars.Comment: Accepted for publication in A&A on Aug. 9, 2017, 12 + 1 pages, 15 figures. Paper replaced due to typos and missing acknowledgment

SALSA - a sectional aerosol module for large scale applications

"The sectional aerosol module SALSA is introduced. The model has been designed to be implemented in large scale climate models, which require both accuracy and computational efficiency. We have used multiple methods to reduce the computational burden of different aerosol processes to optimize the model performance without losing physical features relevant to problematics of climate importance. The optimizations include limiting the chemical compounds and physical processes available in different size sections of aerosol particles; division of the size distribution into size sections using size sections of variable width depending on the sensitivity of microphysical processing to the particles sizes; the total amount of size sections to describe the size distribution is kept to the minimum; furthermore, only the relevant microphysical processes affecting each size section are calculated. The ability of the module to describe different microphysical processes was evaluated against explicit microphysical models and several microphysical models used in air quality models. The results from the current module show good consistency when compared to more explicit models. Also, the module was used to simulate a new particle formation event typical in highly polluted conditions with comparable results to more explicit model setup.""The sectional aerosol module SALSA is introduced. The model has been designed to be implemented in large scale climate models, which require both accuracy and computational efficiency. We have used multiple methods to reduce the computational burden of different aerosol processes to optimize the model performance without losing physical features relevant to problematics of climate importance. The optimizations include limiting the chemical compounds and physical processes available in different size sections of aerosol particles; division of the size distribution into size sections using size sections of variable width depending on the sensitivity of microphysical processing to the particles sizes; the total amount of size sections to describe the size distribution is kept to the minimum; furthermore, only the relevant microphysical processes affecting each size section are calculated. The ability of the module to describe different microphysical processes was evaluated against explicit microphysical models and several microphysical models used in air quality models. The results from the current module show good consistency when compared to more explicit models. Also, the module was used to simulate a new particle formation event typical in highly polluted conditions with comparable results to more explicit model setup.""The sectional aerosol module SALSA is introduced. The model has been designed to be implemented in large scale climate models, which require both accuracy and computational efficiency. We have used multiple methods to reduce the computational burden of different aerosol processes to optimize the model performance without losing physical features relevant to problematics of climate importance. The optimizations include limiting the chemical compounds and physical processes available in different size sections of aerosol particles; division of the size distribution into size sections using size sections of variable width depending on the sensitivity of microphysical processing to the particles sizes; the total amount of size sections to describe the size distribution is kept to the minimum; furthermore, only the relevant microphysical processes affecting each size section are calculated. The ability of the module to describe different microphysical processes was evaluated against explicit microphysical models and several microphysical models used in air quality models. The results from the current module show good consistency when compared to more explicit models. Also, the module was used to simulate a new particle formation event typical in highly polluted conditions with comparable results to more explicit model setup."Peer reviewe

Winding effects on brane/anti-brane pairs

We study a brane/anti-brane configuration which is separated along a compact direction by constructing a tachyon effective action which takes into account transverse scalars. Such an action is relevant in the study of HQCD model of Sakai and Sugimoto of chiral symmetry breaking, where the size of the compact circle sets the confinement scale. Our approach is motivated by string theory orbifold constructions and gives a route to model inhomogeneous tachyon decay. We illustrate the techniques involved with a relatively simple example of a harmonic oscillator on a circle. We will then repeat the analysis for the Sakai-Sugimoto model and show that by integrating out the winding modes will provide us with a renormalized action with a lower energy than that of truncating to zero winding sector.Comment: 21 pages, 3 figures. v3: discussion and references added, published versio

Weak Magnetic Fields in Two Herbig Ae Systems: The SB2 AK Sco and the Presumed Binary HD 95881

We report the detection of weak mean longitudinal magnetic fields in the Herbig Ae double-lined spectroscopic binary AK Sco and in the presumed spectroscopic Herbig Ae binary HD95881 using observations with the High Accuracy Radial velocity Planet Searcher polarimeter (HARPSpol) attached to the European Southern Observatory's (ESO's) 3.6m telescope. Employing a multi-line singular value decomposition (SVD) method, we detect a mean longitudinal magnetic field =-83+-31G in the secondary component of AK Sco on one occasion. For HD95881, we measure =-93+-25G and =105+-29G at two different observing epochs. For all the detections the false alarm probability is smaller than 10^-5. For AK Sco system, we discover that accretion diagnostic Na I doublet lines and photospheric lines show intensity variations over the observing nights. The double-lined spectral appearance of HD95881 is presented here for the first time

Measurement of the differential Drell-Yan cross section in proton-proton collisions at s√= 13 TeV

Measurements of the differential cross section for the Drell-Yan process, based on proton-proton collision data at a centre-of-mass energy of 13 TeV, collected by the CMS experiment, are presented. The data correspond to an integrated luminosity of 2.8 (2.3) fb−1 in the dimuon (dielectron) channel. The total and fiducial cross section measurements are presented as a function of dilepton invariant mass in the range 15 to 3000 GeV, and compared with the perturbative predictions of the standard model. The measured differential cross sections are in good agreement with the theoretical calculations.Peer reviewe

High concentrations of sub-3nm clusters and frequent new particle formation observed in the Po Valley, Italy, during the PEGASOS 2012 campaign

The concentrations of neutral and charged sub3nm clusters and their connection to new particle formation (NPF) were investigated during the PEGASOS campaign (7 June-9 July 2012) at the San Pietro Capofiume measurement station in the Po Valley, Italy. Continuous high concentrations of sub-3nm clusters were detected during the measurement period, although the condensation sink was relatively high (median value 1.1 x 10(-2) s(-1)). The median cluster concentrations were 2140 and 7980 cm 3 in the size bins of 1.5-1.8 and 1.8-3 nm, and the majority of them were electrically neutral. NPF events were observed during the measurement period frequently, on 86% of the days. The median growth rates of clusters during the events were 4.3, 6.0 and 7.2 nm h(-1) in the size ranges of 1.5-3, 3-7 and 720 nm. The median formation rate of 1.6 nm clusters was high, 45 cm 3 s(-1), and it exceeded the median formation rate of 2 nm clusters by 1 order of magnitude. The ion-induced nucleation fraction was low; the median values were 0.7% at 1.6 nm and 3.0% at 2 nm. On NPF event days the neutral cluster concentration had a maximum around 09: 00 (local winter time), which was absent on a non-event day. The increase in the cluster concentrations in the morning coincided with the increase in the boundary layer height. At the same time radiation, temperature and SO2 concentration increased, and RH and condensation sink decreased. The concentrations of neutral and charged clusters were observed to have a positive correlation with sulfuric acid proxy, indicating the significance of sulfuric acid for the cluster formation in San Pietro Capofiume. The condensation sink had a negative correlation with the concentration of charged clusters but no clear relation to the neutral cluster concentration. This finding, together with back-trajectory analysis, suggests that the precursor vapors of the clusters and background aerosol particles, acting as their sink, have possibly originated from the same sources, including e.g., power plants and industrial areas in the Po Valley.Peer reviewe

Measurement of electroweak WZ boson production and search for new physics in WZ plus two jets events in pp collisions at root s=13 TeV

A measurement of WZ electroweak (EW) vector boson scattering is presented. The measurement is performed in the leptonic decay modes WZ -> l nu l'l', where l, l' = e, mu. The analysis is based on a data sample of proton-proton collisions at root s = 13 TeV at the LHC collected with the CMS detector and corresponding to an integrated luminosity of 35.9 fb(-1) . The WZ plus two jet production cross section is measured in fiducial regions with enhanced contributions from EW production and found to be consistent with standard model predictions. The EW WZ production in association with two jets is measured with an observed (expected) significance of 2.2 (2.5) standard deviations. Constraints on charged Higgs boson production and on anomalous quartic gauge couplings in terms of dimension-eight effective field theory operators are also presented. (C) 2019 The Author(s). Published by Elsevier B.V.Peer reviewe

Charged-particle nuclear modification factors in XeXe collisions at root S-NN=5.44 TeV

A search has been performed for heavy resonances decaying to ZZ or ZW in 2l2q final states, with two charged leptons (l = e, mu) produced by the decay of a Z boson, and two quarks produced by the decay of a W or Z boson. The analysis is sensitive to resonances with masses in the range from 400 to 4500 GeV. Two categories are defined based on the merged or resolved reconstruction of the hadronically decaying vector boson, optimized for high- and low-mass resonances, respectively. The search is based on data collected during 2016 by the CMS experiment at the LHC in proton-proton collisions with a center-of-mass energy of root s = 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1). No excess is observed in the data above the standard model background expectation. Upper limits on the production cross section of heavy, narrow spin-1 and spin-2 resonances are derived as a function of the resonance mass, and exclusion limits on the production of W' bosons and bulk graviton particles are calculated in the framework of the heavy vector triplet model and warped extra dimensions, respectively.A search has been performed for heavy resonances decaying to ZZ or ZW in 2l2q final states, with two charged leptons (l = e, mu) produced by the decay of a Z boson, and two quarks produced by the decay of a W or Z boson. The analysis is sensitive to resonances with masses in the range from 400 to 4500 GeV. Two categories are defined based on the merged or resolved reconstruction of the hadronically decaying vector boson, optimized for high- and low-mass resonances, respectively. The search is based on data collected during 2016 by the CMS experiment at the LHC in proton-proton collisions with a center-of-mass energy of root s = 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1). No excess is observed in the data above the standard model background expectation. Upper limits on the production cross section of heavy, narrow spin-1 and spin-2 resonances are derived as a function of the resonance mass, and exclusion limits on the production of W' bosons and bulk graviton particles are calculated in the framework of the heavy vector triplet model and warped extra dimensions, respectively.The differential yields of charged particles having pseudorapidity within vertical bar eta vertical bar < 1 are measured using xenon-xenon (XeXe) collisions at root S-NN = 5.44 TeV. The data, corresponding to an integrated luminosity of 3.42 mu b(-1), were collected in 2017 by the CMS experiment at the LHC. The yields are reported as functions of collision centrality and transverse momentum, pT, from 0.5 to 100 GeV. A previously reported pT spectrum from proton-proton collisions at root S = 5.02 TeV is used for comparison after correcting for the difference in center-of-mass energy. The nuclear modification factors using this reference, R-AA*, are constructed and compared to previous measurements and theoretical predictions. In head-on collisions, the R-AA* has a value of 0.17 in the pT range of 6-8 GeV, but increases to approximately 0.7 at 100 GeV. Above approximate to 6 GeV, the XeXe data show a notably smaller suppression than previous results for lead-lead (PbPb) collisions at root S-NN = 5.02 TeV when compared at the same centrality (i.e., the same fraction of total cross section). However, the XeXe suppression is slightly greater than that for PbPb in events having a similar number of participating nucleons.Peer reviewe

Search for a W ' boson decaying to a tau lepton and a neutrino in proton-proton collisions at root s=13 TeV

A search for a new high-mass resonance decaying to a tau lepton and a neutrino is reported. The analysis uses proton-proton collision data collected by the CMS experiment at the LHC at root s= 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1). The search utilizes hadronically decaying tau leptons. No excess in the event yield is observed at high transverse masses of the tau and missing transverse momentum. An interpretation of results within the sequential standard model excludes W' boson masses below 4.0 TeV at 95% confidence level. Existing limits are also improved on models in which the W' boson decays preferentially to fermions of the third generation. Heavy W' bosons with masses less than 1.7-3.9 TeV, depending on the coupling in the non-universal G(221) model, are excluded at 95% confidence level. These are the most stringent limits on this model to date. (C) 2019 The Author(s). Published by Elsevier B.V.Peer reviewe