Reflection on the reflective ethics of charity

This article is a reflection on the NSU Winter Symposium of March 2020, entitled ‘Feminism and Hospitality: Religious and Critical Perspectives in dialogue with a Secular Age’. It contends with moral judgments which regard charity as an act of alienation from the other and as a reiteration of hierarchies of power. Instead of this conceptualisation, I propose an ethics of charity in terms of an ethics of the reflective agency of otherness. This ethics of charity entails acts of aid for an other which stem from the recognition of the agency pertaining to both parties. It will be shown how this recognition of agency, and the reciprocity it entails, is critical for the success of the charitable endeavour in two ways: first, for the manifestation of the act itself of aiding and providing for another; second, for the assertion of the other’s own agency through the reciprocal act of charity

U.S. State Government Economic and Social Performance: Unified vs. Divided and Democrat vs. Republican Controlled State Governments

This paper is looking for an empirical answer to the questions: Is a unified government’s performance superior to a divided government’s performance and is the performance of a unified government controlled by the Democratic Party superior to or inferior to the performance of a unified government under the control of the Republican Party? The evaluation of the performance of the government was done using two groups of variables, three economic variables, and three social variables. The empirical analyses of data from the contiguous U.S. states (1990-2014) suggest that the economic performance of states with a unified government is inferior to the performance of states with a divided government. On the other hand, unified governments perform better in the social area as compared to divided governments. There are important differences in performance between the Democratic and Republican Parties. Unified governments under the Democratic Party are more successful in lowering unemployment rate and increasing the number of jobs compared to Republican Party unified government. Unified governments controlled by the Democratic Party lower the poverty rate and the crime rate and have no effect on the GINI coefficient while Republican Party unified governments increase the GINI coefficient

GATA1 (GATA binding protein 1 (globin transcription factor1))

Review on GATA1 (GATA binding protein 1 (globin transcription factor1)), with data on DNA, on the protein encoded, and where the gene is implicated

Paradox of Stubbornness: The Epistemology of Stereotypes Regarding Women

The discrepancy between individual women and the stereotypes attributed to the group as a ‎whole has become progressively greater and more explicit over the course of history. The stereotypes remain the same age-old ‎allegations whilst the ‎developments in the occupations of women and the traits they have opportunity to express have increased the distance between women and those ascribed traits. Stereotypes’ abstention from revision in light of contrary evidence constitutes an epistemic paradox for it entails conflict between the stereotypical knowledge and empirical evidence, as well as between the stereotypical knowledge and other empirical knowledges. This paradox of stubbornness also raises the question as to the epistemic source of stereotypes. For, people at young ages encounter evidence which should have formed a more complex knowledge regarding women rather than the pervasive stereotypical knowledge. It is this extremity of absurdness of stereotypes regarding women that is utile to understanding stereotypes as a whole. The epistemic paradox that is engrained in all stereotypes is exposed uncompromisingly by this group. The paradox cannot be dismissed with excuses of having a small basis of evidence, such as may be said regarding other social groups with which one may have had minimal or no contact. Thus, stereotypes of women provide a limit case to understanding the epistemology of this paradoxical form of knowledge. The traits and epistemic phenomena which render stereotypes epistemically puzzling and intriguing is the relationship between knowledges. Stereotypical knowledge regarding women as a group conflict with one’s experience-founded knowledges of particular women, deeming the corporate body of knowledge incoherent. Quine’s theory of knowledge, with its holistic empirical approach endorsing conceptual schemes, provides fertile ground for this analysis. The novelty in his account is his establishment of the criteria of coherency, which shifts the focal point of epistemic inquiry away from the adequacy of individual knowledges with empirical evidence to the intra-knowledge relationships themselves. In his empiricism, Quine rather examines the interactions between knowledges and the overarching coherence of the body of knowledge as a holistic unit. Quine creates place in his account for mechanism which provide for the epistemic incongruences of stubbornness and conflict found between stereotypical knowledges and empirical evidence. These very mechanisms are what this paper requests to examine. Quine, ultimately, formulates knowledge as a collectively held fabric consisting of relations and of posits – socially constructed mechanisms which are empirically-irreducible and implemented pragmatically for the organisation of empirical evidence. According to Quine, the fabric formation is a conceptual scheme sourced in social heritage. People are bestowed with an eclectic framework of ‎knowledge to pragmatically merge between an inherited, collective conceptual scheme and the personally experienced empirical evidence. This paper will delve into Quine’s fabric of knowledge, its relations, and inner-mechanisms. The finding of stereotypes to be an age-old posit entrenched pragmatically – thus stubbornly – in the collective conceptual scheme, will explain the epistemic paradoxes they entail and offer insight to their revision in light of empiric reality and its women

SIL (SCL/TAL1 interrupting locus)

Review on SIL (SCL/TAL1 interrupting locus), with data on DNA, on the protein encoded, and where the gene is implicated

Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene

Background: Gene duplication and exonization of intronic transposed elements are two mechanisms that enhance genomic diversity. We examined whether there is less selection against exonization of transposed elements in duplicated genes than in single-copy genes. Results: Genome-wide analysis of exonization of transposed elements revealed a higher rate of exonization within duplicated genes relative to single-copy genes. The gene for TIF-IA, an RNA polymerase I transcription initiation factor, underwent a humanoid-specific triplication, all three copies of the gene are active transcriptionally, although only one copy retains the ability to generate the TIF-IA protein. Prior to TIF-IA triplication, an Alu element was inserted into the first intron. In one of the non-protein coding copies, this Alu is exonized. We identified a single point mutation leading to exonization in one of the gene duplicates. When this mutation was introduced into the TIF-IA coding copy, exonization was activated and the level of the protein-coding mRNA was reduced substantially. A very low level of exonization was detected in normal human cells. However, this exonization was abundant in most leukemia cell lines evaluated, although the genomic sequence is unchanged in these cancerous cells compared to normal cells. Conclusion: The definition of the Alu element within the TIF-IA gene as an exon is restricted to certain types of cancers; the element is not exonized in normal human cells. These results further our understanding of the delicate interplay between gene duplication and alternative splicing and of the molecular evolutionary mechanisms leading to genetic innovations. This implies the existence of purifying selection against exonization in single copy genes, with duplicate genes free from such constrains

How large are departures from lithostatic pressure? Constraints from host-inclusion elasticity

Minerals trapped as inclusions within other host minerals will develop non-lithostatic pressures during both prograde and retrograde metamorphism because of the differences between the thermo-elastic properties of the host and inclusion phases. There is only a single possible path in P-T space, the entrapment isomeke, along which no residual pressure would be developed in a host/inclusion system; non-lithostatic pressures are developed in inclusions as a result of the external pressure and temperature deviating from the isomeke that passes through the entrapment conditions. With modern equation of state and elasticity data for minerals now available it is possible to perform precise calculations of the isomekes for mineral pairs. These show that isomeke lines are not straight lines in P-T space at metamorphic conditions. We show that silicate inclusions in silicate hosts tend to have flat isomekes, with small values of dP/dT(isomeke), because of the small range of thermal expansion coefficients of silicate minerals. As a consequence, the general behaviour under decompression is for soft silicate inclusions in stiffer hosts to develop excess pressures, whereas a stiff silicate inclusion in a softer matrix will experience lower pressures than lithostatic pressure. The opposite effects occur for compression after entrapment on the prograde path. The excess pressures in inclusions, including allowance for mutual elastic relaxation of the host and inclusion, are most easily calculated by using the isomeke as a basis. Analysis of the simplest possible model of a host-inclusion system indicates that deviations from lithostatic pressure in excess of 1 GPa can be readily produced in quartz inclusions within garnets in metamorphic rocks. For softer host minerals such as feldspars the pressure deviations are smaller, because of greater elastic relaxation of the host. The maximum pressure deviation from lithostatic pressure in the host phase around the inclusion is one-third of the pressure deviation in the inclusion. Routines for performing these calculations have been added to the EosFit7c software package

CXCR4 mediates leukemic cell migration and survival in the testicular microenvironment

The testis is the second most frequent extramedullary site of relapse in pediatric acute lymphoblastic leukemia (ALL). The mechanism for B-cell (B) ALL cell migration towards and survival within the testis remains elusive. Here, we identified CXCL12-CXCR4 as the leading signaling axis for B-ALL cell migration and survival in the testicular leukemic niche. We combined analysis of primary human ALL with a novel patient-derived xenograft (PDX)-ALL mouse model with testicular involvement. Prerequisites for leukemic cell infiltration in the testis were prepubertal age of the recipient mice, high surface expression of CXCR4 on PDX-ALL cells, and CXCL12 secretion from the testicular stroma. Analysis of primary pediatric patient samples revealed that CXCR4 was the only chemokine receptor being robustly expressed on B-ALL cells both at the time of diagnosis and relapse. In affected patient testes, leukemic cells localized within the interstitial space in close proximity to testicular macrophages. Mouse macrophages isolated from affected testes, in the PDX model, revealed a macrophage polarization towards a M2-like phenotype in the presence of ALL cells. Therapeutically, blockade of CXCR4-mediated functions using an anti-CXCR4 antibody treatment completely abolished testicular infiltration of PDX-ALL cells and strongly impaired the overall development of leukemia. Collectively, we identified a prepubertal condition together with high CXCR4 expression as factors affecting the leukemia permissive testicular microenvironment. We propose CXCR4 as a promising target for therapeutic prevention of testicular relapses in childhood B-ALL. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland