322 research outputs found
Randomized and non-randomized designs for causal inference with longitudinal data in rare disorders.
In the United States, approximately 7000 rare diseases affect 30 million patients, and only 10% of these diseases have existing therapies. Sound study design and causal inference methods are essential to demonstrate the therapeutic efficacy, safety, and effectiveness of new therapies. In the rare diseases setting, several factors challenge the use of typical parallel control designs: the small patient population size, genotypic and phenotypic diversity, and the complexity and incomplete understanding of the disorder\u27s progression. Repeated measures, when spaced appropriately relative to disease progression and exploited in design and analysis, can increase study power and reduce variability in treatment effect estimation. This paper reviews these longitudinal designs and draws the parallel between some new and existing randomized studies in rare diseases and their less well-known controlled observational study designs. We show that self-controlled randomized crossover and N-of-1 designs have similar considerations as the observational case series and case-crossover designs. Also, randomized sequential designs have similar considerations to longitudinal cohort studies using sequential matching or weighting to control confounding. We discuss design and analysis considerations for valid causal inference and illustrate them with examples of analyses in multiple rare disorders, including urea cycle disorder and cystic fibrosis
Analysis of nonlinear modes of variation for functional data
A set of curves or images of similar shape is an increasingly common
functional data set collected in the sciences. Principal Component Analysis
(PCA) is the most widely used technique to decompose variation in functional
data. However, the linear modes of variation found by PCA are not always
interpretable by the experimenters. In addition, the modes of variation of
interest to the experimenter are not always linear. We present in this paper a
new analysis of variance for Functional Data. Our method was motivated by
decomposing the variation in the data into predetermined and interpretable
directions (i.e. modes) of interest. Since some of these modes could be
nonlinear, we develop a new defined ratio of sums of squares which takes into
account the curvature of the space of variation. We discuss, in the general
case, consistency of our estimates of variation, using mathematical tools from
differential geometry and shape statistics. We successfully applied our method
to a motivating example of biological data. This decomposition allows
biologists to compare the prevalence of different genetic tradeoffs in a
population and to quantify the effect of selection on evolution.Comment: Published in at http://dx.doi.org/10.1214/07-EJS080 the Electronic
Journal of Statistics (http://www.i-journals.org/ejs/) by the Institute of
Mathematical Statistics (http://www.imstat.org
Directional enrichment functions for finite element solutions of transient anisotropic diffusion
The present study proposes a novel approach for efficiently solving an anisotropic transient diffusion problem using an enriched finite element method. We develop directional enrichment for the finite elements in the spatial discretization and a fully implicit scheme for the temporal discretization of the governing equations. Within this comprehensive framework, the proposed class of exponential functions as enrichment enhance the approximation of the finite element method by capturing the directional based behaviour of the solution. The incorporation of these enrichment functions leverages a priori knowledge about the anisotropic problem using the partition of unity technique, resulting in significantly improved approximation efficiency while retaining all the advantages of the standard finite element method. Consequently, the proposed approach yields accurate numerical solutions even on coarse meshes and with significantly fewer degrees of freedom compared to the standard finite element methods. Moreover, the choice of mesh coarseness remains independent of the anisotropy in the problem, enabling the use of the same mesh regardless of changes in the anisotropy. Using extensive numerical experiments, we consistently demonstrate the efficiency of the proposed method in attaining the desired levels of accuracy. Our approach not only provides reliable and precise solutions but also extends the capabilities of the finite element method to effectively address aspects of the heterogeneous anisotropic transient diffusion problems that were previously considered ineffective when using this method
Concurrent abdominal body contouring and hernia repair is a safe choice: An analysis of the 2015-2020 ACS-NSQIP database
Variation in Continuous Reaction Norms: Quantifying Directions of Biological Interest
Abstract: Thermal performance curves are an example of continuous reaction norm curves of common shape. Three modes of variation in these curvesvertical shift, horizontal shift, and generalistspecialist tradeoffsare of special interest to evolutionary biologists. Since two of these modes are nonlinear, traditional methods such as principal components analysis fail to decompose the variation into biological modes and to quantify the variation associated with each mode. Here we present the results of a new method, template mode of variation (TMV), that decomposes the variation into predetermined modes of variation for a particular set of thermal performance curves. We illustrate the method using data on thermal sensitivity of growth rate in Pieris rapae caterpillars. The TMV model explains 67% of the variation in thermal performance curves among families; generalistspecialist tradeoffs account for 38% of the total betweenfamily variation. The TMV method implemented here is applicable to both differences in mean and patterns of variation, and it can be used with either phenotypic or quantitative genetic data for thermal performance curves or other continuous reaction norms that have a template shape with a single maximum. The TMV approach may also apply to growth trajectories, agespecific lifehistory traits, and other functionvalued traits
The Genetic Basis of Thermal Reaction Norm Evolution in Lab and Natural Phage Populations
Two major goals of laboratory evolution experiments are to integrate from genotype to phenotype to fitness, and to understand the genetic basis of adaptation in natural populations. Here we demonstrate that both goals are possible by re-examining the outcome of a previous laboratory evolution experiment in which the bacteriophage G4 was adapted to high temperatures. We quantified the evolutionary changes in the thermal reaction norms—the curves that describe the effect of temperature on the growth rate of the phages—and decomposed the changes into modes of biological interest. Our analysis indicated that changes in optimal temperature accounted for almost half of the evolutionary changes in thermal reaction norm shape, and made the largest contribution toward adaptation at high temperatures. Genome sequencing allowed us to associate reaction norm shape changes with particular nucleotide mutations, and several of the identified mutations were found to be polymorphic in natural populations. Growth rate measures of natural phage that differed at a site that contributed substantially to adaptation in the lab indicated that this mutation also underlies thermal reaction norm shape variation in nature. In combination, our results suggest that laboratory evolution experiments may successfully predict the genetic bases of evolutionary responses to temperature in nature. The implications of this work for viral evolution arise from the fact that shifts in the thermal optimum are characterized by tradeoffs in performance between high and low temperatures. Optimum shifts, if characteristic of viral adaptation to novel temperatures, would ensure the success of vaccine development strategies that adapt viruses to low temperatures in an attempt to reduce virulence at higher (body) temperatures
Accounting for Calibration Uncertainties in X-ray Analysis: Effective Areas in Spectral Fitting
While considerable advance has been made to account for statistical
uncertainties in astronomical analyses, systematic instrumental uncertainties
have been generally ignored. This can be crucial to a proper interpretation of
analysis results because instrumental calibration uncertainty is a form of
systematic uncertainty. Ignoring it can underestimate error bars and introduce
bias into the fitted values of model parameters. Accounting for such
uncertainties currently requires extensive case-specific simulations if using
existing analysis packages. Here we present general statistical methods that
incorporate calibration uncertainties into spectral analysis of high-energy
data. We first present a method based on multiple imputation that can be
applied with any fitting method, but is necessarily approximate. We then
describe a more exact Bayesian approach that works in conjunction with a Markov
chain Monte Carlo based fitting. We explore methods for improving computational
efficiency, and in particular detail a method of summarizing calibration
uncertainties with a principal component analysis of samples of plausible
calibration files. This method is implemented using recently codified Chandra
effective area uncertainties for low-resolution spectral analysis and is
verified using both simulated and actual Chandra data. Our procedure for
incorporating effective area uncertainty is easily generalized to other types
of calibration uncertainties.Comment: 61 pages double spaced, 8 figures, accepted for publication in Ap
A Searching and Automatic Video Tagging Tool for Events of Interest during Volleyball Training Sessions
Date of Conference: 14-18 October 2019Conference Name: 21st ACM International Conference on Multimodal Interaction, ICMI 2019Quick and easy access to performance data during matches and training sessions is important for both players and coaches. While there are many video tagging systems available, these systems require manual effort. This paper proposes a system architecture that automatically supplements video recording by detecting events of interests in volleyball matches and training sessions to provide tailored and interactive multi-modal feedback.ACM SIGCHIAISpeechBaiduMicrosoftOpenstreamSenseTim
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