Female terminalia of lower Brachycera - I (Diptera).

Die weiblichen Terminalien von 33 Arten aus 27 Gattungen folgender Familien werden als Beitrag zur Klassifizierung der niederen Brachyceren beschrieben: Solvidae (= Xylomyidae), Xylophagidae s. lat. (Rachiceridae, Xylophagidae, Coenomyiidae und Exeretoneuridae s. lat. (Pelecorhynchidae und Rhagionidae), Athericidae und Vermileonidae.Die weiblichen Terminalien von 33 Arten aus 27 Gattungen folgender Familien werden als Beitrag zur Klassifizierung der niederen Brachyceren beschrieben: Solvidae (= Xylomyidae), Xylophagidae s. lat. (Rachiceridae, Xylophagidae, Coenomyiidae und Exeretoneuridae s. lat. (Pelecorhynchidae und Rhagionidae), Athericidae und Vermileonidae

Wearable biomedical monitoring system using TextileNet

金沢大学理工研究域電子情報学系We developed and tested a biomedical monitoring system using TextileNet, a flexible conductive garment for wearable computing. TextileNet detects biological signals while simplifying communication and power supply wiring. TextileNet also acts as an electromagnetic interference (EMI) shield, which makes it possible to use simpler amplifiers in the system. Using TextileNet, a huge amount of biological information can be processed simultaneously. © 2006 IEEE

Wearable electromyography measurement system using cable-free network system on conductive fabric

金沢大学大学院自然科学研究科情報システムObjective: To solve the complicated wires and battery maintenance problems in the application of wearable computing for biomedical monitoring, the electromyography (EMG) measurement system using conductive fabric for power supply and electric shield for noise reduction is proposed. Material and methods: The basic cable-free network system using conductive fabric, named as "TextileNet" is developed. The conductive fabric has the function of electric shield for noise reduction in EMG measurement, and it enables the precise EMG measurement with wearable system. Results: The specifications of the developed prototype TextileNet system using wear with conductive fabric were communication speed of 9600 bit/s and power supply of 3 W for each device. The electric shield effect was evaluated for precise EMG measurement, and the shield efficacy of conductive fabric was estimated as high as that of shield room. Conclusions: TextileNet system solves both the problems of complicated wires and battery maintenance in wearable computing systems. Conductive fabric used in TextileNet system is also effective for precise EMG measurement as electric shield. The combination of TextileNet system and EMG measurement device will implement the cable-free, battery-free wearable EMG measurement system. © 2007 Elsevier B.V. All rights reserved

Endogenous agonist–bound S1PR3 structure reveals determinants of G protein–subtype bias

脂質受容体の新たな活性化機構を解明 --脂質がまっすぐ伸びて活性化--. 京都大学プレスリリース. 2021-06-10.Sphingosine-1-phosphate (S1P) regulates numerous important physiological functions, including immune response and vascular integrity, via its cognate receptors (S1PR1 to S1PR5); however, it remains unclear how S1P activates S1PRs upon binding. Here, we determined the crystal structure of the active human S1PR3 in complex with its natural agonist S1P at 3.2-Å resolution. S1P exhibits an unbent conformation in the long tunnel, which penetrates through the receptor obliquely. Compared with the inactive S1PR1 structure, four residues surrounding the alkyl tail of S1P (the “quartet core”) exhibit orchestrating rotamer changes that accommodate the moiety, thereby inducing an active conformation. In addition, we reveal that the quartet core determines G protein selectivity of S1PR3. These results offer insight into the structural basis of activation and biased signaling in G protein–coupled receptors and will help the design of biased ligands for optimized therapeutics

Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin

X線自由電子レーザーを用いて、光照射によるチャネルロドプシンの構造変化の過程を捉えることに成功. 京都大学プレスリリース. 2021-03-26.Channelrhodopsins (ChRs) are microbial light-gated ion channels utilized in optogenetics to control neural activity with light . Light absorption causes retinal chromophore isomerization and subsequent protein conformational changes visualized as optically distinguished intermediates, coupled with channel opening and closing. However, the detailed molecular events underlying channel gating remain unknown. We performed time-resolved serial femtosecond crystallographic analyses of ChR by using an X-ray free electron laser, which revealed conformational changes following photoactivation. The isomerized retinal adopts a twisted conformation and shifts toward the putative internal proton donor residues, consequently inducing an outward shift of TM3, as well as a local deformation in TM7. These early conformational changes in the pore-forming helices should be the triggers that lead to opening of the ion conducting pore

Vampires in the village Žrnovo on the island of Korčula: following an archival document from the 18th century

Središnja tema rada usmjerena je na raščlambu spisa pohranjenog u Državnom arhivu u Mlecima (fond: Capi del Consiglio de’ Dieci: Lettere di Rettori e di altre cariche) koji se odnosi na događaj iz 1748. godine u korčulanskom selu Žrnovo, kada su mještani – vjerujući da su se pojavili vampiri – oskvrnuli nekoliko mjesnih grobova. U radu se podrobno iznose osnovni podaci iz spisa te rečeni događaj analizira u širem društvenom kontekstu i prate se lokalna vjerovanja.The main interest of this essay is the analysis of the document from the State Archive in Venice (file: Capi del Consiglio de’ Dieci: Lettere di Rettori e di altre cariche) which is connected with the episode from 1748 when the inhabitants of the village Žrnove on the island of Korčula in Croatia opened tombs on the local cemetery in the fear of the vampires treating. This essay try to show some social circumstances connected with this event as well as a local vernacular tradition concerning superstitions