Trends in Competition and Profitability in the Banking Industry: A Basic Framework

This paper brings to the forefront the assumptions that we make when focusing on a particular type of explanation for bank profitability. We evaluate a broad field of research by introducing a general framework for a profit maximizing bank and demonstrate how different types of models can be fitted into this framework. Next, we present an overview of the current major trends in European banking and relate them to each model’s assumptions, thereby shedding light on the relevance, timeliness and shelf life of the different models. This way, we arrive at a set of recommendations for a future research agenda. We advocate a more prominent role for output prices, and suggest a modification of the intermediation approach. We also suggest ways to more clearly distinguish between market power and efficiency, and explain why we need time-dependent models. Finally, we propose the application of existing models to different size classes and sub-markets. Throughout we emphasize the benefits from applying several, complementary models to overcome the identification problems that we observe in individual models.

Designing a web-based learning support system for flow-chart proving in school geometry

This is the final version of the article. Available from the publisher via the DOI in this record.As international research confirms, many secondary school students can find it difficult to construct mathematical proofs. In this article, we explain the pedagogical and technological underpinnings of a web-based learning support system for students who are just starting to tackle deductive proving in geometry. We show how the system was designed to enable students to access the study of proofs in geometry by tackling proof problems where they can ‘drag’ sides, angles and triangles from the figural diagram of the problem to on-screen cells within a flow-chart proof format. When doing so, the system automatically converts the figural elements to their symbolic form and identifies any of four kinds of errors in the learners’ proof attempts, providing relevant feedback on-screen. We use empirical examples from our pilot studies to illustrate how this combination of technological features and systematic feedback can support student understanding of the structure of proof and how to plan one. Finally, we point out some limitations to mathematical expression and the usage of the flow-chart format, and indicate the prospect of minimizing such limitations by adopting a learning progression for the introductory lessons concerning deductive proofs.This research is supported by the Daiwa Anglo-Japanese Foundation (No. 7599/8141) and the Grant-in-Aid for Scientific Research (No. 26590230, 15 K12375, 16H02068, 16H03057), Ministry of Education, Culture, Sports, Science, and Technology, Japan. Special thanks to Yoichi Murakami who programmed this web-based system

Designing a web-based learning support system for flow-chart proving in school geometry

This is the final version of the article. Available from the publisher via the DOI in this record.As international research confirms, many secondary school students can find it difficult to construct mathematical proofs. In this article, we explain the pedagogical and technological underpinnings of a web-based learning support system for students who are just starting to tackle deductive proving in geometry. We show how the system was designed to enable students to access the study of proofs in geometry by tackling proof problems where they can ‘drag’ sides, angles and triangles from the figural diagram of the problem to on-screen cells within a flow-chart proof format. When doing so, the system automatically converts the figural elements to their symbolic form and identifies any of four kinds of errors in the learners’ proof attempts, providing relevant feedback on-screen. We use empirical examples from our pilot studies to illustrate how this combination of technological features and systematic feedback can support student understanding of the structure of proof and how to plan one. Finally, we point out some limitations to mathematical expression and the usage of the flow-chart format, and indicate the prospect of minimizing such limitations by adopting a learning progression for the introductory lessons concerning deductive proofs.This research is supported by the Daiwa Anglo-Japanese Foundation (No. 7599/8141) and the Grant-in-Aid for Scientific Research (No. 26590230, 15 K12375, 16H02068, 16H03057), Ministry of Education, Culture, Sports, Science, and Technology, Japan. Special thanks to Yoichi Murakami who programmed this web-based system

Beta-glucan reflects liver injury after preservation and transplantation in dogs.

Graft failure and extrahepatic organ complications, which frequently develop after transplantation, may be related to inflammatory mediators stimulated by endotoxin (ET). The role of endotoxemia after liver transplantation is controversial and may depend upon differences in the ET assay method used in the various contradicting studies. While the standard Limulus amebocyte lysate (LAL) is reactive for ET and beta-glucan, a novel turbidimetric assay method enables separate determinations of ET and beta-glucan. Beagle dogs undergoing orthotopic liver transplantation were divided into two groups. In Group I (n = 6) the grafts were transplanted immediately and in Group II (n = 6) grafts were preserved for 48 h in University of Wisconsin (UW) solution. Animals received cyclosporine immunosuppression and were followed for 14 days. Daily measurements of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were performed. Samples for ET and beta-glucan measurement were collected serially and processed using the turbidimetric assay method. While no graft failure was seen in Group I, three of six Group II animals died from graft failure within 1 day after transplantation. Preservation and reperfusion injury was much more severe in the Group II grafts than in Group I grafts. While endotoxemia could not be detected, postoperative beta-glucan levels (undetectable pretransplant) were seen in both groups. Beta-glucan levels were much higher in Group II grafts than in Group I grafts, and correlated with the severity of liver damage. In conclusion, this study shows that beta-glucan, instead of ET, appears during the early posttransplant period. We believe that posttransplant elevation of beta-glucan is related to liver damage, especially endothelial damage by preservation and reperfusion

Gorenstein homological algebra and universal coefficient theorems

We study criteria for a ring—or more generally, for a small category—to be Gorenstein and for a module over it to be of finite projective dimension. The goal is to unify the universal coefficient theorems found in the literature and to develop machinery for proving new ones. Among the universal coefficient theorems covered by our methods we find, besides all the classic examples, several exotic examples arising from the KK-theory of C*-algebras and also Neeman’s Brown–Adams representability theorem for compactly generated categories

Centromere Plasmid: A New Genetic Tool for the Study of Plasmodium falciparum

The introduction of transgenes into Plasmodium falciparum, a highly virulent human malaria parasite, has been conducted either by single crossover recombination or by using episomal plasmids. However, these techniques remain insufficient because of the low transfection efficiency and the low frequency of recombination. To improve the genetic manipulation of P. falciparum, we developed the centromere plasmid as a new genetic tool. First, we attempted to clone all of the predicted centromeres from P. falciparum into E. coli cells but failed because of the high A/T contents of these sequences. To overcome this difficulty, we identified the common sequence features of the centromere of Plasmodium spp. and designed a small centromere that retained those features. The centromere plasmid constructed with the small centromere sequence, pFCEN, segregated into daughter parasites with approximately 99% efficiency, resulting in the stable maintenance of this plasmid in P. falciparum even in the absence of drug selection. This result demonstrated that the small centromere sequence harboured in pFCEN could function as an actual centromere in P. falciparum. In addition, transgenic parasites were more rapidly generated when using pFCEN than when using the control plasmid, which did not contain the centromere sequence. Furthermore, in contrast to the control plasmid, pFCEN did not form concatemers and, thus, was maintained as a single copy over multiple cell divisions. These unique properties of the pFCEN plasmid will solve the current technical limitations of the genetic manipulation of P. falciparum, and thus, this plasmid will become a standard genetic tool for the study of this parasite