The quality of education of teachers-engineers in the republic of belarus

The system of quality management of education of teachers-engineers on the basis of the environmental approach is consideredРассматривается система управления качеством образования педагогов-инженеров на основе средового подход

ORGANIZATION OF EDUCATIONAL PROCESS BASED ON ADAPTIVE MANAGEMENT

Рассматривается организация образовательного процесса в техническом университете с опорой на адаптивное управлениеWe consider the organization of the educational process a technical university with the support of adaptive managemen

ВЛИЯНИЕ ТЕХНОЛОГИИ ПОДГОТОВКИ ПОВЕРХНОСТИ ОСНОВЫ НА ФИЗИКО-МЕХАНИЧЕСКИЕ И ЭКСПЛУАТАЦИОННЫЕ СВОЙСТВА ЭЛЕКТРОДУГОВЫХ ПОКРЫТИЙ

The paper investigates dependence of qualitative and operational coating properties on technological parameters pertaining to surface preparation of glass products and coating application.Проведено исследование зависимости качественных и эксплуатационных характеристик покрытий от технологических параметров процесса подготовки поверхности изделий из стекла и нанесения покрытий

STRUCTURE AND CONTENT ENGINEERING AND PEDAGOGICAL PERSONNEL TRAINING IN THE REPUBLIC OF BELARUS

Рассматривается двухступенчатая система подготовки инженерно-педагогических для учреждений профессионально-технического и среднего специального образования в Республике БеларусьWe consider a two-stage system of engineering and pedagogical training for institutions of vocational and secondary special education in the Republic of Belaru

Возможности и перспективы использования СВЧ-радиометрии в медицине и научных исследованиях

Розглянуті можливості та перспективи використання НВЧ-радіометрії для реєстрації і вимірювання електромагнітних полів і випромінювань біооб’єктів та людини. Проаналізовані основні принципи побудови радіометричних систем дециметрового діапазону, а також напрямки біомедичного використання НВЧ-радіометрів.The possibilities and perspectives were discussed of using EHF-radiometry for registration and measurement pf electromagnetic fields as well as bioobject’s and human radiation. The basic principles of construction of dm-range radiometric system were analyzed as well as the trends of biomedical utilization of EHF-radiometers.Рассмотрены возможности и перспективы использования СВЧ-радиометрии для регистрации и измерения электромагнитных полей и излучений биообъектов и человека. Проанализированы основные принципы построения радиометрических систем дециметрового диапазона, а также направления биомедицинского использования СВЧ-радиометров

Автоматизированный измеритель коэффициента отражения в полосе поглощения

В статті розглянутий спосіб та пристрій для вимірювання коефіцієнта відбиття, що забезпечують підвищення точності в широкій смузі частот НВЧ-діапазону.The method and device for measurement of reflection coefficient ensuring the accuracy improvement within wide band of UHF-frequency range are considered in the paper.В статье рассмотрен способ и устройство для измерения коэффициента отражения, обеспечивающих повышение точности в широкой полосе частот СВЧ-диапазона

Socio-Cultural Factor in the Training of a Teacher-Engineer

Рассматриваются аспекты социокультурной сферы в образовательном процессе подготовки педагога-инженера; обобщаются пути социокультурного развития будущего специалиста.The aspects of the socio-cultural sphere in the educational process of teacher-engineer training are considered; the ways of socio-cultural development of the future specialist are summarized

Education of Modern Specialist as a Pedagogical Category

В статье рассматриваются составляющие понятия «образованность» в отношении современного специалиста; анализируются социальные характеристики и возможности образовательной практики.The article discusses the components of the concept of «education» in relation to a modern specialist; social characteristics and possibilities of educational practice are analyzed

Associations of CYP2D6, ABCB1 2677G>T/A and 3435C>T with effectiveness and safety of pharmacotherapy for acute psychotic episodes in adolescents over 28 days

Introduction. Pharmacokinetic genetic factors are prognostically relevant when prescribing antipsychotics to adult patients. Currently, there is a dearth of research on adolescents with an acute psychotic episode. Aim. To identify possible associations of CYP2D6, CYP3A4/5 and ABCB1 gene polymorphic variants with the efficacy and safety of pharmacotherapy in adolescents with an acute psychotic episode within 28 days. Materials and methods. The study included 68 adolescents with an established diagnosis of acute polymorphic psychotic disorder at the time of admission (F23.0-9 according to ICD- 10). All patients received an antipsychotic as their main therapy. Patients were monitored for 28 days. The effectiveness of antipsychotics was assessed using the Children’s Global Assessment Scale (CGAS), Positive and Negative Symptoms Scale (PANSS), Clinical Global Impression Severity (CGI-S) and Improvement (CGI-I). The safety of pharmacotherapy was assessed using the UKU Side Effects Rating Scale (UKU SERS), Sympson-Angus Scale (SAS), Barnes Akathisia rating scale (BARS). From each patient we obtained a buccal scraped epithelium, extracted DNA from it by sorbent method and detected carriage of genetic polymorphisms CYP3A4*22 (rs2740574), CYP3A5*3 (6986A>G, rs776746), CYP2D6*4, *9, *10 (rs3892097, rs4986774, rs1065852), ABCB1 1236C>T (rs1128503), 2677G>T/A (rs2032582), 3435C>T (rs1045642) by real-time PCR. Results. Carriers of ABCB1 2677G>T/A significantly less frequently demonstrated response to pharmacotherapy according to PANSS scale on day 14 compared to GG homozygotes (64.6 % vs. 94.7 %; p=0.014). Carriers of the ABCB1 3435C>T differed by a higher total UKU SERS score on day 14 compared to CC genotype carriers (9.21±5.95 vs. 5.1±4.48; p=0.037). Patients with «intermediate» CYP2D6 metabolism were more likely to have reduced sleep duration (13.6 % vs. 0 %; p=0.031). ABCB1 2677G>T/A (51 % vs. 15.8 %; p=0.012) and 3435C>T (46.6 % vs. 10 %; p=0.039) were more frequently associated with dry mouth. ABCB1 3435C>T carriers were also more likely to have orthostatic vertigo (34.5 % vs. 0 %; p=0.028). Conclusion. Carriage of the ABCB1 3435C>T was associated with greater efficacy of pharmacotherapy for acute psychotic episode in adolescents after 28 days, but also increases the risk of adverse reactions in the first 2 weeks of treatment. The ABCB1 2677G>T/A was associated with an increased risk of adverse reactions as well as less reduction of psychotic symptoms on day 14 of pharmacotherapy

Analysis of associations between pharmacodynamic genetic factors and antipsychotics’ effectiveness and safety in adolescents with acute psychotic episodes taking antipsychotics during a 28-day follow-up

Introduction. Antipsychotics are the main drugs for treatment of schizophrenia spectrum disorders. Pharmacodynamic genetic factors are being actively studied to improve the accuracy of antipsychotic selection based on pharmacogenetic testing. Purpose of this study: to establish associations of genetic polymorphisms of the DRD2, DRD3, DRD4, HTR2A, COMT, ZNF804A, and ANKS1B genes with the efficacy and safety of antipsychotics in adolescents with an acute psychotic episode during a 28-day follow-up. Materials and methods. The study included 68 adolescents with an established diagnosis of acute polymorphic psychotic disorder at the time of admission (F23.0-9 according to ICD-10). All patients received an antipsychotic as their main therapy. Patients were monitored for 28 days. The effectiveness of antipsychotics was assessed using the Children’s Global Assessment Scale (CGAS), Positive and Negative Symptoms Scale (PANSS), Clinical Global Impression Severity (CGI-S) and Improvement (CGI-I). The safety of pharmacotherapy was assessed using the UKU Side Effects Rating Scale (UKU SERS), Sympson-Angus Scale (SAS), Barnes Akathisia rating scale (BARS). From each patient we obtained a buccal scraped epithelium, extracted DNA from it by sorbent method and detected carriage of genetic polymorphisms DRD2 rs1800497 (C>T), DRD3 rs6280 (C>T), DRD3 rs324026 (C>T), DRD4 rs1800955 (C>T), HTR2A rs6313 (T>C), COMT rs4680 (Val158Met, G>A), ZNF804A rs1344706 (A>C), ANKS1B rs7968606 (C>T) by real-time PCR. Results. DRD2 rs1800497 T allele carriers had a stronger reduction in the PANSS subscore «Productive Symptomatics» on day 14 (Me=-7.0 [-9.0;-5.0] vs Me=-7.0 [-8.0;-2.0]; p=0.018) and day 28 of follow-up (Me=-11.0 [-9.0;-5.5] vs Me=-8.0 [-8.0;-2.0]; p=0.019). Also, greater improvement on the CGAS scale on day 14 of follow-up was seen in TC+CC HTR2A rs6313 carriers (Me=2.0 [1.0;3.0] vs. Me=2.0 [1.0;2.0]; p=0.029). DRD3 rs324026 homozygous carriers (TT) had a significantly lower SAS score (Me=0.5 [0.0; 1.0] vs. Me=1.0 [0.0; 5.0]; p=0.016) and UKU subscore «Neurological Disorders» on 28 days of antipsychotic therapy (Me=0.0 [0.0; 0.0] vs. Me=1.0 [0.0; 3.8]; p=0.005). DRD3 rs324026 TT carriers also had lower severity of akathisia according to the BARS scale. Carriers of the T DRD4 rs1800955 allele had a higher SAS scale score on day 28 of therapy compared with CC homozygotes (Me=1.0 [0.0;4.0] vs Me=0.0 [0.0;1.0]; p=0.036). Conclusion. The DRD2 rs1800497 was a predictor of better reduction of productive symptoms; HTR2A rs6313 demonstrated a similar association. The DRD2 rs1800497 polymorphic variant was a predictor of better reduction of productive symptomatology; HTR2A rs6313 demonstrated a similar association. DRD3 rs324026 and HTR2A rs6313 were associated with a lower frequency of neurological adverse reactions and akathisia. In contrast, carriers of the DRD4 rs1800955 were more prone to adverse reactions on pharmacotherapy