Isolamento de Salmonella spp. em pombos (Columba livia) no Distrito Federal : aspecto de relevância ao sistema de vigilância em saúde

Dissertação (mestrado)—Universidade de Brasília, Faculdade de Agronomia e Medicina Veterinária, Programa de Pós-Graduação em Saúde Animal, 2014.A domesticação de pombos da espécie Columba livia, no Brasil, é citada em relatos históricos do século XVI, quando estes além de fonte de alimentação eram também utilizados para transporte de mensagens. Por soltura e fácil adaptação às condições ambientais, estes animais se multiplicaram e, nas áreas urbanas, são atualmente considerados pragas. Esta coabitação de humanos e pombos levanta hipóteses e confirmações de agravos e zoonoses. A salmonelose é uma das doenças passíveis de transmissão para humanos. Apesar de, no Brasil, ocorrer subnotificação e pouco acompanhamento dos casos de diarreias agudas, reconhecem-se os gastos e impactos que este agravo representa para a assistência básica em saúde. A presença de pombos, principalmente nas áreas com exposição de alimentos, hospitais e escolas, representa um risco à saúde coletiva. De uma amostragem de 100 aves, onde foram coletadas fezes, pelo método de raspagem de mucosa intestinal, 2 amostras apresentaram positividade para isolamento de Salmonella spp. Tipificadas pelo Centro de Referência Nacional de Enteroinfecções Bacterianas, Laboratório de Enterobactérias, da Fundação Oswaldo Cruz – FIOCRUZ, Rio de Janeiro, identificaram-se como Salmonella Typhimurium e Salmonella Saintpaul, ambas com impacto na saúde humana. A partir destes dados, as medidas atualmente adotadas pelo Órgão de Vigilância Ambiental em Saúde do Distrito Federal necessitam de redirecionamento e suporte de Órgãos e Instituições Governamentais, uma vez que o Distrito Federal é uma das Unidades Federativas do Brasil com nítidos problemas em relação aos pombos em área urbana, seja pela arquitetura ou cultura da população. _______________________________________________________________________________________ ABSTRACTThe domestication of pigeons (Columba livia), in Brazil, has historical accounts of the sixteenth century, when they were power supply and used for message transport. For loosening and easy adaptation to environmental conditions, these animals have multiplied and, in urban areas, are considered pests. This cohabitation of humans and pigeons raised hypotheses and confirmations of diseases and zoonosis. Salmonellosis is one of the likely disease transmission to humans. In Brazil, there are little follow underreporting of cases of acute diarrhea occur, but are recognized as expenses and the impact that this grievance is to basic health care. The presence of pigeons, especially in areas exposed to food, hospitals and schools, represents a risk to public health. From a sample of 100 pigeons, which faeces were collected by the method of scraping the intestinal mucosa, 2 samples were positive for Salmonella spp. Typified by National Reference Center for Bacterial intestinal infections, Enterobacteria Laboratory of the Oswaldo Cruz Foundation - FIOCRUZ, Rio de Janeiro, resulted in Salmonella Typhimurium and Salmonella Saintpaul, both with impact on human health. From these data, the measures currently adopted by the board of Environmental Health Survey of Distrito Federal, Brazil, require targeting, since the local is one of the Federative Units of Brazil with clear problems regarding pigeons in urban areas, caused by the architecture or the culture or the population

Socio-epidemiological characterization of human leptospirosis in the Federal District, Brazil, 2011-2015

INTRODUCTION: Human leptospirosis (HL) in the Federal District (DF), Brazil, is endemic and requires studies to characterize the socio-epidemiological profile of the vulnerable population. METHODS: Seventy-nine autochthonous cases of HL between 2011-2015 were analyzed based on the databases of the Epidemiological and Environmental Health Surveillance Department, DF. RESULTS: The male population aged 31-45 years represented 86% of the leptospirosis cases; most belonged to the social classes D and E. CONCLUSIONS: In the DF, preventive measures should be concentrated on economically active male adults of social classes C, D, and E with the aim of promoting health

High anti-SARS-CoV-2 antibody seroconversion rates before the second wave in Manaus, Brazil, and the protective effect of social behaviour measures: results from the prospective DETECTCoV-19 cohort

Background: The city of Manaus, Brazil, has seen two collapses of the health system due to the COVID-19 pandemic. We report anti-SARS-CoV-2 nucleocapsid IgG antibody seroconversion rates and associated risk factors in Manaus residents before the second wave of the epidemic in Brazil. Methods: A convenience sample of adult (aged ≥18 years) residents of Manaus was recruited through online and university website advertising into the DETECTCoV-19 study cohort. The current analysis of seroconversion included a subgroup of DETECTCoV-19 participants who had at least two serum sample collections separated by at least 4 weeks between Aug 19 and Oct 2, 2020 (visit 1), and Oct 19 and Nov 27, 2020 (visit 2). Those who reported (or had no data on) having a COVID-19 diagnosis before visit 1, and who were positive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at visit 1 were excluded. Using an in-house ELISA, the reactivity index (RI; calculated as the optical density ratio of the sample to the negative control) for serum anti-SARS-CoV-2 nucleocapsid IgG antibodies was measured at both visits. We calculated the incidence of seroconversion (defined as RI values ≤1·5 at visit 1 and ≥1·5 at visit 2, and a ratio >2 between the visit 2 and visit 1 RI values) during the study period, as well as incidence rate ratios (IRRs) through cluster-corrected and adjusted Poisson regression models to analyse associations between seroconversion and variables related to sociodemographic characteristics, health access, comorbidities, COVID-19 exposure, protective behaviours, and symptoms. Findings: 2496 DETECTCoV-19 cohort participants returned for a follow-up visit between Oct 19 and Nov 27, 2020, of whom 204 reported having COVID-19 before the first visit and 24 had no data regarding previous disease status. 559 participants were seropositive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at baseline. Of the remaining 1709 participants who were seronegative at baseline, 71 did not meet the criteria for seroconversion and were excluded from the analyses. Among the remaining 1638 participants who were seronegative at baseline, 214 showed seroconversion at visit 2. The seroconversion incidence was 13·06% (95% CI 11·52–14·79) overall and 6·78% (5·61–8·10) for symptomatic seroconversion, over a median follow-up period of 57 days (IQR 54–61). 48·1% of seroconversion events were estimated to be asymptomatic. The sample had higher proportions of affluent and higher-educated people than those reported for the Manaus city population. In the fully adjusted and corrected model, risk factors for seroconversion before visit 2 were having a COVID-19 case in the household (IRR 1·49 [95% CI 1·21–1·83]), not wearing a mask during contact with a person with COVID-19 (1·25 [1·09–1·45]), relaxation of physical distancing (1·31 [1·05–1·64]), and having flu-like symptoms (1·79 [1·23–2·59]) or a COVID-19 diagnosis (3·57 [2·27–5·63]) between the first and second visits, whereas working remotely was associated with lower incidence (0·74 [0·56–0·97]). Interpretation: An intense infection transmission period preceded the second wave of COVID-19 in Manaus. Several modifiable behaviours increased the risk of seroconversion, including non-compliance with non-pharmaceutical interventions measures such as not wearing a mask during contact, relaxation of protective measures, and non-remote working. Increased testing in high-transmission areas is needed to provide timely information about ongoing transmission and aid appropriate implementation of transmission mitigation measures. Funding: Ministry of Education, Brazil; Fundação de Amparo à Pesquisa do Estado do Amazonas; Pan American Health Organization (PAHO)/WHO.World Health OrganizationRevisión por pare

Human leptospirosis in the Federal District, Brazil, 2011-2015: eco-epidemiological characterization

Abstract INTRODUCTION: Leptospirosis is an infectious disease that affects more than 5,000 people per year in Brazil. The Federal District (FD) lacks epidemiological studies of human leptospirosis and presents concerning rates of this disease, especially considering its lethality. METHODS: Seventy-nine autochthonous human cases of leptospirosis between 2011 and 2015 were analyzed, with the probable infection location serving as a basis for the collection and analysis of the environmental and epidemiological variables. RESULTS: The incidence of the disease ranged from 0.68-13.39 per 100,000 inhabitants in 21 of the 31 administrative regions that compose the FD. The local profile of human leptospirosis was predominantly associated with urban areas during the rainy season, population access to the sewage network, the treated water network, and the public garbage collection service. The vast majority of cases had a strong association with synanthropic rodents at the infection sites. CONCLUSIONS: In order to prevent and control potentially lethal human leptospirosis infection, the eco-epidemiological characterization of this disease is a valuable tool for public policies of prevention, control, and surveillance. In addition to population awareness, the systematized control of synanthropic rodents could be the main health action to reduce the incidence of this disease in the FD

Socio-epidemiological characterization of human leptospirosis in the Federal District, Brazil, 2011-2015

Abstract INTRODUCTION: Human leptospirosis (HL) in the Federal District (DF), Brazil, is endemic and requires studies to characterize the socio-epidemiological profile of the vulnerable population. METHODS: Seventy-nine autochthonous cases of HL between 2011-2015 were analyzed based on the databases of the Epidemiological and Environmental Health Surveillance Department, DF. RESULTS: The male population aged 31-45 years represented 86% of the leptospirosis cases; most belonged to the social classes D and E. CONCLUSIONS: In the DF, preventive measures should be concentrated on economically active male adults of social classes C, D, and E with the aim of promoting health

Human leptospirosis in the Federal District, Brazil, 2011-2015: eco-epidemiological characterization

<div><p>Abstract INTRODUCTION: Leptospirosis is an infectious disease that affects more than 5,000 people per year in Brazil. The Federal District (FD) lacks epidemiological studies of human leptospirosis and presents concerning rates of this disease, especially considering its lethality. METHODS: Seventy-nine autochthonous human cases of leptospirosis between 2011 and 2015 were analyzed, with the probable infection location serving as a basis for the collection and analysis of the environmental and epidemiological variables. RESULTS: The incidence of the disease ranged from 0.68-13.39 per 100,000 inhabitants in 21 of the 31 administrative regions that compose the FD. The local profile of human leptospirosis was predominantly associated with urban areas during the rainy season, population access to the sewage network, the treated water network, and the public garbage collection service. The vast majority of cases had a strong association with synanthropic rodents at the infection sites. CONCLUSIONS: In order to prevent and control potentially lethal human leptospirosis infection, the eco-epidemiological characterization of this disease is a valuable tool for public policies of prevention, control, and surveillance. In addition to population awareness, the systematized control of synanthropic rodents could be the main health action to reduce the incidence of this disease in the FD.</p></div

Human leptospirosis in the Federal District, Brazil, 2011-2015: eco-epidemiological characterization

<div><p>Abstract INTRODUCTION: Leptospirosis is an infectious disease that affects more than 5,000 people per year in Brazil. The Federal District (FD) lacks epidemiological studies of human leptospirosis and presents concerning rates of this disease, especially considering its lethality. METHODS: Seventy-nine autochthonous human cases of leptospirosis between 2011 and 2015 were analyzed, with the probable infection location serving as a basis for the collection and analysis of the environmental and epidemiological variables. RESULTS: The incidence of the disease ranged from 0.68-13.39 per 100,000 inhabitants in 21 of the 31 administrative regions that compose the FD. The local profile of human leptospirosis was predominantly associated with urban areas during the rainy season, population access to the sewage network, the treated water network, and the public garbage collection service. The vast majority of cases had a strong association with synanthropic rodents at the infection sites. CONCLUSIONS: In order to prevent and control potentially lethal human leptospirosis infection, the eco-epidemiological characterization of this disease is a valuable tool for public policies of prevention, control, and surveillance. In addition to population awareness, the systematized control of synanthropic rodents could be the main health action to reduce the incidence of this disease in the FD.</p></div