Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when = 50 years and symptomatic for <= 7days were included. The intervention consisted of 200-300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311); OR for hospitalization or death was 0.919 (CI 0.592-1.416). CP effect on hospital admission or death was largest in patients with <= 5 days of symptoms (OR 0.658, 95%CI 0.394-1.085). CP did not decrease the time to full symptom resolution

Late Cretaceous UHP metamorphism recorded in kyanite-garnet schists from the Central Rhodope Mountains, Bulgaria.

In this study, we report the first discovery of microdiamond inclusions in kyanite–garnet schists from the Central Rhodope Mountains in Bulgaria. These inclusions occur in garnets from metapelites that are part of a meta-igneous and meta-sedimentary mélange hosted by Variscan (Hercynian) orthogneiss. Ultra-high-pressure (UHP) conditions are further supported by the presence of exsolved needles of quartz and rutile in the garnet and by geothermobarometry estimates that suggest peak metamorphic temperatures of 750–800 °C and pressures in excess of 4 GPa. The discovery of UHP conditions in the Central Rhodopes of Bulgaria compliments the well-documented evidence for such conditions in the southernmost (Greek) part of the Rhodope Massif. Dating of garnets from these UHP metapelites (Chepelare Shear Zone) using Sm–Nd geochronology indicates a Late Cretaceous age (70.5–92.7 Ma) for the UHP metamorphic event. This is significantly younger than previously reported ages and suggests that the UHP conditions are associated with the Late Mesozoic subduction of the Vardar Ocean northward beneath the Moesian platform (Europe). The present-day structure of the RM is the result of a series of subduction–exhumation events that span the Cenozoic, alongside subsequent post-orogenic extension and metamorphic core complex formation

Un quadrivio: pensiero, societ\ue0, arti e lettere, natura

Recensione al volume Pippo Ciorra, Jean-Louis Cohen (a cura di), Gli architetti di Zevi. Storia e controstoria dell\u2019architettura italiana 1944-2000, Quodlibet, Macerata, 2018

Un quadrivio: pensiero, societ\ue0, arti e lettere, natura

Recensione al volume: ETTORE SOTTSASS, Molto difficile da dire, a cura di Matteo Codignola, Adelphi, Milano, 2019