Spectra and Diagnostics for the Direct Detection of Wide-Separation Extrasolar Giant Planets

We calculate as a function of orbital distance, mass, and age the theoretical spectra and orbit-averaged planet/star flux ratios for representative wide-separation extrasolar giant planets (EGPs) in the optical, near-infrared, and mid-infrared. Stellar irradiation of the planet's atmosphere and the effects of water and ammonia clouds are incorporated and handled in a consistent fashion. We include predictions for 12 specific known EGPs. In the process, we derive physical diagnostics that can inform the direct EGP detection and remote sensing programs now being planned or proposed. Furthermore, we calculate the effects of irradiation on the spectra of a representative companion brown dwarf as a function of orbital distance.Comment: submitted to the Astrophysical Journal, 19 pages, 11 color figure

Propagation of spatially entangled qudits through free space

We show the propagation of entangled states of high-dimensional quantum systems. The qudits states were generated using the transverse correlation of the twin photons produced by spontaneous parametric down-conversion. Their free-space distribution was performed at the laboratory scale and the propagated states maintained a high-fidelity with their original form. The use of entangled qudits allow an increase in the quantity of information that can be transmitted and may also guarantee more privacy for communicating parties. Therefore, studies about propagating entangled states of qudits are important for the effort of building quantum communication networks.Comment: 5 Pages, 4 Figures, REVTeX

CARACTERÍSTICAS E MEDIDAS ULTRASSONOGRÁFICAS DO BAÇO DE CÃES E GATOS FILHOTES HÍGIDOS

O objetivo do estudo foi analisar e comparar as características e as mensurações ultrassonográficas do baço entre cães e gatos filhotes hígidos, estabelecendo padrões de normalidade e valores de referência. Foram utilizados 15 cães e 15 gatos machos hígidos, raça mista e idade média de seis meses. Os mesmos foram divididos em dois grupos, sendo grupo G1 com 15 cães filhotes com  peso médio de 3 kg e grupo G2 com 15 gatos filhotes com peso médio de 2 kg. Os animais foram submetidos ao exame ultrassonográfico do baço para visibilização das características internas e mensuração do órgão. As características estruturais ultrassonográficas do baço foram analisadas e comparadas entre as duas espécies de forma descritiva por meio de imagens obtidas no exame. As mensurações foram comparadas estatisticamente usando-se o programa SPSS®, com análise de variância (ANOVA), seguido do Teste de Tukey (P ? 0,05). Em ambos os grupos, foi observado  que as artérias esplênicas apresentaram menor diâmetro luminar em relação às veias esplênicas.   Nos cães e gatos filhotes, a ecotextura foi visibilizada homogênea e finamente granular. O baço dos cães filhotes tende a ser maior em comprimento (6,87 ± 0,03 cm) e largura (5,95 ± 0,07 cm) em relação ao comprimento (4,53 ± 0,02 cm) e largura (4,55 ± 0,04) nos gatos filhotes. Concluiu-se   que não existe diferença de ecotextura e ecogenicidade esplênica entre o cão filhote e gato filhote    e o baço dos cães filhotes apresentrou dimensões maiores, em comprimento e largura, em relação aos gatos filhotes. Palavras-chaves: baço; ecogenecidade; mensuração pequenos animais;   ultrassom

Enhanced glucose-induced intracellular signaling promotes insulin hypersecretion: Pancreatic beta-cell functional adaptations in a model of genetic obesity and prediabetes

Obesity is associated with insulin resistance and is known to be a risk factor for type-2 diabetes. In obese individuals, pancreatic beta-cells try to compensate for the increased insulin demand in order to maintain euglycemia. Most studies have reported that this adaptation is due to morphological changes. However, the involvement of beta-cell functional adaptations in this process needs to be clarified. For this purpose, we evaluated different key steps in the glucose-stimulated insulin secretion (GSIS) in intact islets from female ob/ob obese mice and lean controls. Obese mice showed increased body weight, insulin resistance, hyperinsulinemia, glucose intolerance and fed hyperglycemia. Islets from ob/ob mice exhibited increased glucose-induced mitochondrial activity, reflected by enhanced NAD(P)H production and mitochondrial membrane potential hyperpolarization. Perforated patch-clamp examination of beta-cells within intact islets revealed several alterations in the electrical activity such as increased firing frequency and higher sensitivity to low glucose concentrations. A higher intracellular Ca2+ mobilization in response to glucose was also found in ob/ob islets. Additionally, they displayed a change in the oscillatory pattern and Ca2+ signals at low glucose levels. Capacitance experiments in intact islets revealed increased exocytosis in individual ob/ob beta-cells. All these up-regulated processes led to increased GSIS. In contrast, we found a lack of beta-cell Ca2+ signal coupling, which could be a manifestation of early defects that lead to beta-cell malfunction in the progression to diabetes. These findings indicate that beta-cell functional adaptations are an important process in the compensatory response to obesity.This work was supported by grants from the Spanish Ministerio de Ciencia e Innovación (BFU2013-42789-P; BFU2011-28358)This work was supported by grants from the Generalitat Valenciana (PROMETEO/2011/080)This work was supported by grants from the European Foundation for the Study Diabetes (EFSD/BI Basic Programme

Management Effect on Rainfall Use Efficiency and Growth Rate of Spineless Cactus \u3cem\u3ecv.\u3c/em\u3e Miúda in Northeast Brazil

Spineless cactus has a high rainfall use efficiency. Under water deficit, they open their stomata during the night to capture atmospheric carbon dioxide when the air temperature is lower and relative humidity higher (Taiz and Zeiger, 2009), losing less water to the atmosphere. The rainfall use efficiency (RUE) can be expressed as the amount of water used by the crop to produce dry matter (Han and Felker, 1997). The RUE showed by spineless cactus, a CAM plant, is three to five times greater than the one observed in C3 and C4 plants (Felker and Russel, 1988; Nobel, 1991). Therefore, spineless cacti (Nopaleae opuntia) are important forage resource in northeast Brazil. Management practices, however, can affect the RUE and growth of spineless cactus, especially organic and mineral fertilization. Thus, the objective of this research was to evaluate the effect of organic and nitrogen fertilization and harvest frequency on rainfall use efficiency and growth rate of spineless cactus cv. Miúda (Nopalea cochenillifera Salm Dyck)

An analytical study of iboga alkaloids contained in Tabernanthe iboga-derived products offered by ibogaine treatment providers

Therapeutic properties of ibogaine in the treatment of addiction are attracting both clinicians and patients to its use. Since ibogaine is not an authorized medicine, the quality of these products is not always known, increasing the probability of adverse reactions. Objective: This study collects different types of iboga-derived samples from treatment providers, vendors and online buyers to analyse their content. Methods: Analysis of iboga products (n = 16) was performed using gas chromatography and mass spectrometry methods (GC/MS). Products included Iboga root bark, Total Alkaloids (TA), Purified Total Alkaloids (PTA HCl), ibogaine hydrochloride (ibogaine HCl) and one Voacanga africana root bark. Results: The content of ibogaine was highly variable, ranging from 0.6% to 11.2% for products sold as iboga root bark, from 8.2% to 32.9% for products sold as TA, 73.7% for one sample sold as PTA and from 61.5% to 73.4% for products sold as ibogaine HCl. One sample did not show any iboga alkaloids. Other alkaloids and unknown substances were found in almost all samples. Discussion: The purity of iboga products is highly variable. These results should be taken into consideration by suppliers and users, especially regarding correct dosing to avoid overdose, as well as potential interactions with other substances

Effects of a multidisciplinar cognitive rehabilitation program for patients with mild Alzheimer's disease

OBJECTIVE: To evaluate the effects of a multidisciplinary rehabilitation program on cognition, quality of life, and neuropsychiatry symptoms in patients with mild Alzheimer's disease. METHOD: The present study was a single-blind, controlled study that was conducted at a university-based day-hospital memory facility. The study included 25 Alzheimer's patients and their caregivers and involved a 12-week stimulation and psychoeducational program. The comparison group consisted of 16 Alzheimer's patients in waiting lists for future intervention. INTERVENTION: Group sessions were provided by a multiprofessional team and included memory training, computer-assisted cognitive stimulation, expressive activities (painting, verbal expression, writing), physiotherapy, and physical training. Treatment was administered twice a week during 6.5-h gatherings. MEASUREMENTS: The assessment battery comprised the following tests: Mini-Mental State Examination, Short Cognitive Test, Quality of Life in Alzheimer's disease, Neuropsychiatric Inventory, and Geriatric Depression Scale. Test scores were evaluated at baseline and the end of the study by raters who were blinded to the group assignments. RESULTS: Measurements of global cognitive function and performance on attention tasks indicated that patients in the experimental group remained stable, whereas controls displayed mild but significant worsening. The intervention was associated with reduced depression symptoms for patients and caregivers and decreased neuropsychiatric symptoms in Alzheimer's subjects. The treatment was also beneficial for the patients' quality of life. CONCLUSION: This multimodal rehabilitation program was associated with cognitive stability and significant improvements in the quality of life for Alzheimer's patients. We also observed a significant decrease in depressive symptoms and caregiver burden. These results support the notion that structured nonpharmacological interventions can yield adjunct and clinically relevant benefits in dementia treatment

Effects of Tectonics and Large Scale Climatic Changes On the Evolutionary History of \u3ci\u3eHyalomma\u3c/i\u3e ticks

Hyalomma Koch, 1844 are ixodid ticks that infest mammals, birds and reptiles, to which 27 recognized species occur across the Afrotropical, Palearctic and Oriental regions. Despite their medical and veterinary importance, the evolutionary history of the group is enigmatic. To investigate various taxonomic hypotheses based on morphology, and also some of the mechanisms involved in the diversification of the genus, we sequenced and analysed data derived from two mtDNA fragments, three nuclear DNA genes and 47 morphological characters. Bayesian and Parsimony analyses based on the combined data (2242 characters for 84 taxa) provided maximum resolution and strongly supported the monophyly of Hyalomma and the subgenus Euhyalomma Filippova, 1984 (including H. punt Hoogstraal, Kaiser and Pedersen, 1969). A predicted close evolutionary association was found between morphologically similar H. dromedarii Koch, 1844, H. somalicum Tonelli Rondelli, 1935, H. impeltatum Schulze and Schlottke, 1929 and H. punt, and together they form a sister lineage to H. asiaticum Schulze and Schlottke, 1929, H. schulzei Olenev, 1931 and H. scupense Schulze, 1919. Congruent with morphological suggestions, H. anatolicum Koch, 1844, H. excavatum Koch, 1844 and H. lusitanicum Koch, 1844 form a clade and so also H. glabrum Delpy, 1949, H. marginatum Koch, 1844, H. turanicum Pomerantzev, 1946 and H. rufipes Koch, 1844. Wide scale continental sampling revealed cryptic divergences within African H. truncatum Koch, 1844 and H. rufipes and suggested that the taxonomy of these lineages is in need of a revision. The most basal lineages in Hyalomma represent taxa currently confined to Eurasia and molecular clock estimates suggest that members of the genus started to diverge approximately 36.25 million years ago (Mya). The early diversification event coincides well with the collision of the Indian and Eurasian Plates, an event that was also characterized by large scale faunal turnover in the region. Using S-Diva, we also propose that the closure of the Tethyan seaway allowed for the genus to first enter Africa approximately 17.73 Mya. In concert, our data supports the notion that tectonic events and large scale global changes in the environment contributed significantly to produce the rich species diversity currently found in the genus Hyalomma