222 research outputs found
Introduction to the special section for the 2005 West Off Fukuoka Prefecture Earthquake
The discovery of Hepatocyte Growth Factor (HGF) and its significance for cell biology, life sciences and clinical medicine
It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor, c-Met. In fetal stages, HGF-neutralization, or c-Met gene destruction, leads to hypoplasia of many organs, indicating that HGF signals are essential for organ development. Endogenous HGF is required for self-repair of injured livers, kidneys, lungs and so on. In addition, HGF exerts protective effects on epithelial and non-epithelial organs (including the heart and brain) via anti-apoptotic and anti-inflammatory signals. During organ diseases, plasma HGF levels significantly increased, while anti-HGF antibody infusion accelerated tissue destruction in rodents. Thus, endogenous HGF is required for minimization of diseases, while insufficient production of HGF leads to organ failure. This is the reason why HGF supplementation produces therapeutic outcomes under pathological conditions. Moreover, emerging studies delineated key roles of HGF during tumor metastasis, while HGF-antagonism leads to anti-tumor outcomes. Taken together, HGF-based molecules, including HGF-variants, HGF-fragments and c-Met-binders are available as regenerative or anti-tumor drugs. Molecular analysis of the HGF-c-Met system could provide bridges between basic biology and clinical medicine
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Remarkable progress in the physical parameters of net-current free plasmas has been made in the Large Helical Device (LHD) since the last Fusion Energy Conference in Chengdu, 2006 (O.Motojima et al., Nucl. Fusion 47 (2007) S668). The beta value reached 5 % and a high beta state beyond 4.5% from the diamagnetic measurement has been maintained for longer than 100 times the energy confinement time. The density and temperature regimes also have been extended. The central density has exceeded 1.0 x 10^21 m^-3 due to the formation of an Internal Diffusion Barrier (IDB). The ion temperature has reached 6.8 keV at the density of 2 x 10^19m^-3, which is associated with the suppression of ion heat conduction loss. Although these parameters have been obtained in separated discharges, each fusion-reactor relevant parameter has elucidated the potential of net-current free heliotron plasmas. Diversified studies in recent LHD experiments are reviewed in this paper
A convergent hierarchy of semidefinite programs characterizing the set of quantum correlations
We are interested in the problem of characterizing the correlations that
arise when performing local measurements on separate quantum systems. In a
previous work [Phys. Rev. Lett. 98, 010401 (2007)], we introduced an infinite
hierarchy of conditions necessarily satisfied by any set of quantum
correlations. Each of these conditions could be tested using semidefinite
programming. We present here new results concerning this hierarchy. We prove in
particular that it is complete, in the sense that any set of correlations
satisfying every condition in the hierarchy has a quantum representation in
terms of commuting measurements. Although our tests are conceived to rule out
non-quantum correlations, and can in principle certify that a set of
correlations is quantum only in the asymptotic limit where all tests are
satisfied, we show that in some cases it is possible to conclude that a given
set of correlations is quantum after performing only a finite number of tests.
We provide a criterion to detect when such a situation arises, and we explain
how to reconstruct the quantum states and measurement operators reproducing the
given correlations. Finally, we present several applications of our approach.
We use it in particular to bound the quantum violation of various Bell
inequalities.Comment: 33 pages, 2 figure
Search for astronomical neutrinos from blazar TXS 0506+056 in super-kamiokande
We report a search for astronomical neutrinos in the energy region from several GeV to TeV in the direction of the blazar TXS 0506+056 using the Super-Kamiokande detector following the detection of a 100 TeV neutrinos from the same location by the IceCube collaboration. Using Super-Kamiokande neutrino data across several data samples observed from 1996 April to 2018 February we have searched for both a total excess above known backgrounds across the entire period as well as localized excesses on smaller timescales in that interval. No significant excess nor significant variation in the observed event rate are found in the blazar direction. Upper limits are placed on the electron- and muon-neutrino fluxes at the 90% confidence level as 6.0 Ă 10â7 and 4.5 Ă 10â7â9.3 Ă 10â10 [erg cmâ2 sâ1], respectively
The statistical neuroanatomy of frontal networks in the macaque
We were interested in gaining insight into the functional properties of frontal networks based upon their anatomical inputs. We took a neuroinformatics approach, carrying out maximum likelihood hierarchical cluster analysis on 25 frontal cortical areas based upon their anatomical connections, with 68 input areas representing exterosensory, chemosensory, motor, limbic, and other frontal inputs. The analysis revealed a set of statistically robust clusters. We used these clusters to divide the frontal areas into 5 groups, including ventral-lateral, ventral-medial, dorsal-medial, dorsal-lateral, and caudal-orbital groups. Each of these groups was defined by a unique set of inputs. This organization provides insight into the differential roles of each group of areas and suggests a gradient by which orbital and ventral-medial areas may be responsible for decision-making processes based on emotion and primary reinforcers, and lateral frontal areas are more involved in integrating affective and rational information into a common framework
Granulocyte colony-stimulating factor-producing squamous cell carcinoma of the lower gingiva: a case report
Search for astronomical neutrinos from blazar TXS 0506+056 in Super-Kamiokande
We report a search for astronomical neutrinos in the energy region from several GeV to TeV in the direction of the blazar TXS 0506+056 using the Super-Kamiokande detector following the detection of a 100 TeV neutrinos from the same location by the IceCube collaboration. Using Super-Kamiokande neutrino data across several data samples observed from 1996 April to 2018 February we have searched for both a total excess above known backgrounds across the entire period as well as localized excesses on smaller timescales in that interval. No significant excess nor significant variation in the observed event rate are found in the blazar direction. Upper limits are placed on the electron- and muon-neutrino fluxes at the 90% confidence level as 6.0 Ă 10â7 and 4.5 Ă 10â7â9.3 Ă 10â10 [erg cmâ2 sâ1], respectively
Search for proton decay into three charged leptons in 0.37 megaton-years exposure of the Super-Kamiokande
A search for proton decay into three charged leptons has been performed by using 0.37 Mtonâ
years of data collected in Super-Kamiokande. All possible combinations of electrons, muons, and their antiparticles consistent with charge conservation were considered as decay modes. No significant excess of events has been found over the background, and lower limits on the proton lifetime divided by the branching ratio have been obtained. The limits range between 9.2Ă10^33 and 3.4Ă10^34 years at 90% confidence level, improving by more than an order of magnitude upon limits from previous experiments. A first limit has been set for the pâÎŒ^âe^+e^+ mode
Search for Cosmic-ray Boosted Sub-GeV Dark Matter using Recoil Protons at Super-Kamiokande
We report a search for cosmic-ray boosted dark matter with protons using the
0.37 megatonyears data collected at Super-Kamiokande experiment during
the 1996-2018 period (SKI-IV phase). We searched for an excess of proton
recoils above the atmospheric neutrino background from the vicinity of the
Galactic Center. No such excess is observed, and limits are calculated for two
reference models of dark matter with either a constant interaction
cross-section or through a scalar mediator. This is the first experimental
search for boosted dark matter with hadrons using directional information. The
results present the most stringent limits on cosmic-ray boosted dark matter and
exclude the dark matter-nucleon elastic scattering cross-section between
and for dark matter mass
from 10 MeV/ to 1 GeV/.Comment: With 1-page appendi
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