49 research outputs found
Scale-invariance of galaxy clustering
Some years ago we proposed a new approach to the analysis of galaxy and
cluster correlations based on the concepts and methods of modern statistical
Physics. This led to the surprising result that galaxy correlations are fractal
and not homogeneous up to the limits of the available catalogs. The usual
statistical methods, which are based on the assumption of homogeneity, are
therefore inconsistent for all the length scales probed so far, and a new, more
general, conceptual framework is necessary to identifythe real physical
properties of these structures. In the last few years the 3-d catalogs have
been significatively improved and we have extended our methods to the analysis
of number counts and angular catalogs. This has led to a complete analysis of
all the available data that we present in this review. The result is that
galaxy structures are highly irregular and self-similar: all the available data
are consistent with each other and show fractal correlations (with dimension ) up to the deepest scales probed so far (1000 \hmp) and even more
as indicated from the new interpretation of the number counts. The evidence for
scale-invariance of galaxy clustering is very strong up to 150 \hmp due to
the statistical robustness of the data but becomes progressively weaker
(statistically) at larger distances due to the limited data. In These facts
lead to fascinating conceptual implications about our knowledge of the universe
and to a new scenario for the theoretical challenge in this field.Comment: Latex file 165 pages, 106 postscript figures. This paper is also
available at http://www.phys.uniroma1.it/DOCS/PIL/pil.html To appear in
Physics Report (Dec. 1997
Faced with inequality: chicken do not have a general dosage compensation of sex-linked genes
<p>Abstract</p> <p>Background</p> <p>The contrasting dose of sex chromosomes in males and females potentially introduces a large-scale imbalance in levels of gene expression between sexes, and between sex chromosomes and autosomes. In many organisms, dosage compensation has thus evolved to equalize sex-linked gene expression in males and females. In mammals this is achieved by X chromosome inactivation and in flies and worms by up- or down-regulation of X-linked expression, respectively. While otherwise widespread in systems with heteromorphic sex chromosomes, the case of dosage compensation in birds (males ZZ, females ZW) remains an unsolved enigma.</p> <p>Results</p> <p>Here, we use a microarray approach to show that male chicken embryos generally express higher levels of Z-linked genes than female birds, both in soma and in gonads. The distribution of male-to-female fold-change values for Z chromosome genes is wide and has a mean of 1.4â1.6, which is consistent with absence of dosage compensation and sex-specific feedback regulation of gene expression at individual loci. Intriguingly, without global dosage compensation, the female chicken has significantly lower expression levels of Z-linked compared to autosomal genes, which is not the case in male birds.</p> <p>Conclusion</p> <p>The pronounced sex difference in gene expression is likely to contribute to sexual dimorphism among birds, and potentially has implication to avian sex determination. Importantly, this report, together with a recent study of sex-biased expression in somatic tissue of chicken, demonstrates the first example of an organism with a lack of global dosage compensation, providing an unexpected case of a viable system with large-scale imbalance in gene expression between sexes.</p
Development of nested PCR based on the ViaB sequence to detect Salmonella typhi.
For a rapid diagnosis of typhoid fever, we developed a nested PCR based on the nucleotide sequence encoding the Vi antigen. All Salmonella typhi strains along with a Salmonella paratyphi C strain were PCR positive. This assay was able to detect S. typhi at the single-cell level