406 research outputs found
A prediabéteszhez társult hypertonia kezelése
Condition prior to diabetes is designated as prediabetes. The use of this term is recommended if fasting plasma glucose exceeds normal level but does not reach the characteristic result of real diabetes. Prediabetes is often characterized by combination of visceral obesity, glucose and lipid metabolism disorders and changes in blood pressure. Change of life style is more important in the treatment of prediabetes associated hypertension than in other hypertensive diseases. In this case, metabolically neutral antihypertensive medication is the treatment of choice. The growing obesity epidemic underlines the significance of prediabetes associated hypertension in public health. While 25% of the adult population suffering from this kind of hypertensive disease, the optimal solution has to be found together with patients, physicians and the money lenders of the social security system
75 – 15. Egy rendhagyĂł Ă©vfordulĂłs párbeszĂ©d : Egy racionálisan hĂvĹ‘ ateista Ă©s egy teolĂłgus doktorjelölt kĂ©pzeletbeli eszmecserĂ©je = 75 – 15. An unusual anniversary dialogue : An imaginary exchange between a rational atheist and a doctoral candidate in theology
A termĂ©szeti Ă©s civilizáciĂł katasztrĂłfák paradigmatikus elmĂ©lete cĂmű dolgozat, amelyen vezĂ©relvkĂ©nt a kockázati rendszerek kölcsönhatása vonul vĂ©gig, három kutatási problĂ©makörre terjed ki. Egyedi, izolált esemĂ©nyek logikai (nemvalĂłszĂnűsĂ©gi) kockázatelmĂ©lete azokkal a kockázati rendszerekkel foglalkozik, amelyek a környezetĂĽkkel valĂł kölcsönhatásuk során megĹ‘rzik önazonosságukat, azaz állapotuk fĂĽggetlen változĂłkĂ©nt kezelhetĹ‘, az állapotváltozásukat meghatározĂł szabályok – más szĂłval a rendszerek logikai struktĂşrája – változatlan. | The thesis entitled” The Paradigmatic Theory of Natural and Civilization Catastrophes”,
whose guiding principle is the interaction of risk systems, covers three research problem areas. The
logical (nonprobabilistic) risk theory of unique, isolated events deals with those risk systems that
preserve their identity during their interaction with their environment, i.e. their state can be treated as
an independent variable, the rules determining their state change - in other words, the logical structure
of the systems - remain unchanged.
A cellular automaton model of self-identical tessellation security risk systems deals with weakly
interacting risk systems. These are characterized by the fact that the states of the risk systems depend
on each other's states according to specific rules, but they preserve their identity, the rules determining
their change of state are unchanged.
Logical conflict theory forms the study of risk systems in strong interaction – in conflict. These are
the risk systems that may lose their identity during their interaction, become other systems, and in
general, their state change and behavior can be derived from the logical structure of the conflict
situations that are tolerated to some extent in a specific technical sense of the word
Reanalysis of genotype distributions published in Neurology between 1999 and 2002
The authors tested 123 genotypes described in 54 papers published in the journal Neurology between 1999 and 2002 to ascertain whether these genotype distributions deviated from Hardy - Weinberg equilibrium (HWE). Unreported deviations from HWE in 19 genotype distributions described in 11 of the papers were discovered. The authors also report additional information that could have been extracted after calculating HWE and conclude that HWE values should be mandatory in population genetic studies published in Neurology
A hipofizis-mellékvesekéreg rendszer agyi szabályozása krónikus stresszt okozó betegségmodellekben = Regulation of the pituitary-adrenocortical system in chronic stress disease models
Vizsgálataink során igazoltuk, hogy a krĂłnikus hipotalamo-hipofĂzis-mellĂ©kvese tengely aktiváciĂłhoz szĂĽksĂ©ges a nucleus paraventricularis hypothalami jelenlĂ©te, bár más agyterĂĽletekre is szĂĽksĂ©g van. Az általános vĂ©lekedĂ©ssel ellentĂ©tben a vazopresszin szabályozĂł szerepe nem kerĂĽl elĹ‘tĂ©rbe krĂłnikus stressz során, illetve igazán hosszĂş stimulusok alkalmazása szĂĽksĂ©ges kis hatás megjelenĂ©sĂ©hez. Akut stressz esetĂ©n a stressz fajtájátĂłl fĂĽggĹ‘en tölt be a vazopresszin járulĂ©kos szabályozĂł szerepet. Ugyanakkor a vazopresszin ACTH-elválasztást szabályozĂł szerepe nagyon fontos perinatálisan, ekkor azonban a kortikoszteron szekrĂ©ciĂł ACTH-tĂłl fĂĽggetlenĂĽl szabályozĂłdik, mely jelensĂ©g további vizsgálatokat igĂ©nyel. A kannabinoidok szerepĂ©t a CB1 receptor knockout egĂ©r törzsön vizsgálva sem az akut, sem a krĂłnikus stressz-reaktivitás befolyásolásában nem találtuk fontosnak ezt a receptorfĂ©lesĂ©get, ellenben az alap hormon-szintek tĂłnusos gátlásában lehet szerepe. | We confirmed that during chronic stress the role of nucleus paraventricularis hypothalami in hypothalamo-pituitary-adrenal axis regulation is important however not exclusive. The regulatory role of vasopressin does not come into front during prolonged stimuli or quite long procedure is needed. The role of vasopressin during acute regulation is stress-dependent and permissive. On the other hand during perinatal period the absence of vasopressin completely abolishes the stress-induced ACTH secretion while the corticosterone elevations seem to be reserved. This discrepancy needs further evaluation. We could not find a role of cannabinoids during acute and chronic stressful stimuli. However, in the absence of CB1 receptors the corticosterone resting levels were elevated in mice suggesting a constant inhibitory tone
Parental Burnout in Hungary : Development and Psychometric Evaluation of the Hungarian Parental Burnout Assessment (PBA-HUN)
Introduction: Parental burnout might take place when excessive demands overwhelm the parents' resources.Aims: To develop and validate the Hungarian version of the Parental Burnout Assessment (PBA-HUN), an instrument designed to measure parental burnout; and to determine the prevalence of parental burnout in Hungary.Methods: Data were collected via an online survey from parents with at least one child living in the household (N = 1215; 82.6% mothers; M-age = 38.68 years; SDage = 6.27 years). Confirmatory factor analysis was used to investigate the factor structure of the PBA-HUN.Results: The four-factor structure of the original PBA was replicated, confirming the following factors: exhaustion in one's parental role, contrast with one's parental role, feelings of being fed up, and emotional distancing from one's children. A second-order model with a higher-order factor representing overall parental burnout also fit the data well. The internal consistency of both the subscale and total scores was excellent (alpha >= 0.84). Parental burnout had a moderately strong negative correlation with life satisfaction, and weak or moderate positive correlations with perceived stress, depression, vital exhaustion, and COVID-specific perceived stress supporting the construct validity of the PBA-HUN. The prevalence of parental burnout stood at 5.8% in this sample. The weak relationship between PBA-HUN scores and sociodemographic factors was also similar to those found in prior studies. Parental burnout correlated negatively with the number of hours spent sleeping and engaging in spare time activity, respectively.Conclusions: The PBA-HUN is a reliable and valid tool to assess parental burnout in Hungary
A stressz-függő viselkedés (szorongás) vazopresszinerg és oxytocinerg kontrollja: vizsgálatok Brattleboro patkányok felhasználásával = Neuropeptidergic control of stress-related behavior including anxiety-related behavior by arginine vasopressin and oxytocin: studies employing the model organism Brattleboro rat
A modern társadalmakat gazdaságilag leginkább sĂşjtĂł betegsĂ©gek közĂĽl a stresszel kapcsolatba hozhatĂł szorongás Ă©s a depressziĂł elĹ‘fordulása kiemelkedĹ‘. A stressz-tengely szabályozásában betöltött fontos szerepĂ©bĹ‘l kiindulva a vazopresszin (AVP) fontos az Ă©rzelmi zavarok kialakulásában is. KĂsĂ©rleteiben a nucleus paraventricularis hypothalami (PVN) sejtjeibĹ‘l ĂĽrĂĽlĹ‘ AVP neuromodulátor szerepĂ©t vizsgáltuk stresszben Ă©s ezzel kapcsolatos Ă©rzelmi zavarokban. ModellállatkĂ©nt termĂ©szetes mutáciĂłval AVP hiányossá vált Brattleboro patkányokat használtunk. A kutatásainkat az alapkĂ©rdĂ©st befolyásolĂł egyĂ©b tĂ©nyezĹ‘k vizsgálatára is kiterjesztettĂĽk. Kimutattuk, hogy az AVP felnĹ‘tt állatban stressz-fĂĽggĹ‘ mĂłdon járul hozzá a adrenokortikotropin (hipofĂzeális stressz-komponens) elválasztáshoz, mĂg a perinatális korban szabályozĂł szerepe elsĹ‘dleges. Ugyanakkor, a stressz-tengely hipofĂzeális Ă©s mellĂ©kvese komponenseinek szintje disszociál, azaz a glukokortikoid elválasztást ismeretlen faktorok is szabályozzák. A stressz-során a PVN-ben parakrin mĂłdon ĂĽrĂĽlĹ‘ AVP elĹ‘segĂti a stressz-tengely kiindulási állapotba valĂł visszatĂ©rĂ©sĂ©t. A Brattleboro patkányok csökkent stressz-reaktivitásukkal összhangban kevĂ©sbĂ© depressziĂłs fenotĂpust mutatnak centrális támadásponttal. Vizsgálataink a szervezetben zajlĂł stressz-folyamatok szabályozásának jobb megĂ©rtĂ©sĂ©hez vittek közelebb. EredmĂ©nyeinket számos nemzetközi konferencián, 20 nemzetközi folyĂłirat cikkben Ă©s 4 könyvfejezetben ismertettĂĽk. | In modern societies the prevalence of stress-induced anxiety and depression is increasing. Based upon the important regulatory role of vasopressin (AVP) in stress-axis, its prominent role in the development of emotional disorders could be also supposed. Our goal was to examine the neuromodulatory role of AVP, released from the paraventricular nucleus of the hypothalamus (PVN), in stress and related psychopathologies. As a model animal we used naturally AVP mutant Brattleboro rats. The research was extended to the examination of other related processes. We showed that in adult animals AVP had stress-dependent contribution to the adrenocorticotropin (hypophyseal stress component) release, while it was the primary regulator during the perinatal period. However, the hypophyseal and adrenal level of the stress-axis were dissociated, thus glucocorticoid secretion could be regulated by unknown factors as well. The AVP, released in a paracrine manner from the PVN, promoted the return of the stress hormone levels to the initial state. In accordance with reduced stress reactivity Brattleboro rats showed less depressive-like phenotype based on a central effect. Our studies added details to the regulation of stress processes and related psychopathologies. We presented the results on many international conferences, in 20 peer-reviewed international journals and 4 book-chapters
Glukokortikoidok és magatartási rendellenességek: agresszió, szorongás, és depresszió integrált vizsgálata = Glucocorticoids and behavioural disorders: a study integrating effects on aggression, anxiety and depression
Ă–sszehasonlĂtĂł mĂłdon leĂrtuk az abnormális Ă©s normális agresszivitás idegrendszeri hátterĂ©t. Kidolgoztuk a stressz által indukált szorongásnak egy Ăşj modelljĂ©t, Ă©s leĂrtuk ennek idegrendszeri hátterĂ©t. Vizsgáltuk a depressziĂł stresszfĂĽggĂ©sĂ©t, Ă©s ennek idegrendszeri hátterĂ©t. Mindhárom viselkedĂ©si modell esetĂ©ben (glukokotikoid-fĂĽggĹ‘ abnormális agressziĂł modell, stressz által kiváltott szociális elkerĂĽlĂ©s modell, szociális alárendeltsĂ©g által kiváltott depressziĂł modell) tisztáztuk a glukokortikoidok szerepĂ©t. FarmakolĂłgiai kĂsĂ©rleteinkben Ăşj, potenciális gyĂłgyszercĂ©lpontokat azonosĂtottunk (az NK1 receptort az abnoprmális agressziĂł esetĂ©ben, illetve a CB1 receptort a stressz által kiváltott szorongás esetĂ©ben). MegfigyelĂ©seket tettĂĽnk a három magatartási zavar integrált szabályozására vonatkozĂłlag. A projekt keretĂ©ben vĂ©gzett vizsgálatokbĂłl eddig 22 publikáciĂł szĂĽletett, amelyek összesĂtett impakt faktora megközelĂti a 80-at. Az eredmĂ©nyekbĹ‘l mĂ©g további 4-5 publikáciĂł Ărását tervezzĂĽk. Az eltelt rövid idĹ‘ alatt (a publikáciĂłk jelentĹ‘s rĂ©sze 2007-ben illetve 2008-ban szĂĽletett) a projekt keretĂ©ben Ărt publikáciĂłkra több mint 100-szor hivatkoztak. | We compared the neural background of normal and abnormal aggression in a model recently developed by us. We developed a new model of stress-induced anxiety, and characterized its neural background. The stress- dependence of depression symptoms was studied in a model involving chronic social submission. The role of glucocorticoids was clarified in all three models (i.e. the glucocorticoid-dependent abnormal aggression model, the stress-induced social avoidance model, and the submission-induced depression model). New pharmacological targets were identified for abnormal aggression and stress-induced anxiety (the NK1 receptor and the cannabinoid CB1 receptor, respectively). We also studied the integrated control of aggression, anxiety and depression. The project lead to 22 publications so far, the cumulative impact factor of which is close to 80. We plan to write 4-5 publications in addition. In the short time elapsed, the above mentioned 22 publications were cited more than 100 times. We mention that many of the publications were written in 2007 and 2008
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