Relationship between MPV and paraoxonase-1 activity, brachial artery diameter and IMT in patients with diabetes mellitus

Aims: Higher mean platelet volume (MPV) in diabetic patients has been considered as an emerging risk factor for diabetes related micro- and macrovascular complications. Human paraoxonase 1/arylesterase (PON1), which has antioxidant and antiatherogenic properties, is documented in high oxidative stress conditions like uncontrolled diabetes. The present study aimed to evaluate the relationship between mean platelet volume (MPV) and paraoxonase-1 (PON-1) activity, brachial artery diameter (BAd) and intima media thickness (BA-IMT), in diabetic patients with regard to obesity and diabetic complications.Methods: Two-hundred and one diabetic patients (mean age: 52.4 ± 13.4 years, 73.6% females) were grouped according to obesity and diabetic complications (microvascular and macrovascular). Data on demographics, anthropometrics, diabetic complications, MPV levels, BAd and BA-IMT, and serum paraoxonase and arylesterase activities were recorded. The correlation of MPV values to paraoxonase and arylesterase activities, BAd and BA-IMT was evaluated.Results: Paraoxonase and arylesterase values were 119.8 ± 37.5 U/L and 149.0 ± 39.9 U/L, respectively, with no significant difference in respect of obesity and macrovascular complications. Significantly lower values for paraoxonase (107.5 ± 30.7 vs. 123.9 ± 38.8 U/L, p = 0.007) and arylesterase (132.1 ± 30.2 vs. 154.7 ± 41.2, U/L, p = 0.001) were noted in patients with microvascular complications. MPV values were 9.10 ± 0.87 fL, with no significant difference across the groups and no significant correlation with other parameters.Conclusion: In conclusion, PON-1 activity is more significantly decreased in diabetic patients with microvascular than macrovascular complications with no effects on MPV values. On the other hand, no relationship was found between thrombogenic activity and PON-1 activity, BAd and BA-IMT regardless of obesity and diabetic complications.Keywords: cardiovascular, diabetes, insulin resistance, obesity, vasculatur

Endovascular Treatment Of Peripheral And Visceral Arterial Injuries In Patients With Acute Trauma

BACKGROUND: The present study is an evaluation of the efficacy of endovascular treatment in emergency setting for patients with acute peripheral and visceral arterial injury secondary to penetrating or blunt trauma. METHODS: Twelve patients (11 men) aged 35.8 +/- 11.3 years (range: 18-56 years) with penetrating or blunt trauma who underwent endovascular treatment in our department between March 2010 and June 2014 for peripheral and visceral arterial injury were retrospectively reviewed. Selective coil embolization was performed on 11 patients and particle embolization of the injured vessel was performed on 1 patient. Criteria for endovascular treatment included active extravasation or pseudoaneurysm on contrast-enhanced computed tomography and decrease in hemoglobin level or temporary hemodynamic instability. RESULTS: Arterial injuries were secondary to penetrating injury due to gunshot wound in 4 patients and stab wound in 5, and blunt abdominal injury as result of traffic accident in 3 patients. Traumatic lesions were in the right hepatic artery (n=3), left hepatic (n=2), right hepatic and right renal (n=1), left inferior epigastric (n=2), left facial (n=1), anterior tibial (n=1), and deep femoral (n=1) arteries. Technical success with no procedural complications was seen in all cases. Two patients died due to coexisting injuries on 29th and 43rd days of hospitalization. Median hospitalization period was 6.0 days (range: 1-43 days) and mean intensive care unit hospitalization was 7.7 days (range: 0-43 days). CONCLUSION: In our experience, endovascular treatment was a safe and effective option for acute traumatic peripheral and visceral arterial lesions.WoSScopu

Concomitant Transarterial and Transvenous Embolization of a Pelvic Arteriovenous Malformation Using a New Liquid Embolic Agent, Squid-12 and Detachable Coils

We describe a complex congenital pelvic AVM with multiple feeding arteries arising from the side branches of the right internal iliac artery and a single draining vein in a male patient. Concomitant transarterial and transvenous embolization with a new liquid embolic agent Squid-12 and metallic coils enabled a complete embolization at a single session. Squid-12 is composed of ethylene vinyl alcohol copolymers and its lower viscosity makes it a promising agent for the treatment of AVMs. The patient showed prompt resolution of the symptoms and complete devascularization of the AVM lesion was persisted on the 1-month control angiography. The patient was asymptomatic on the 6th month follow-up

Evaluation of a mobile phone based student immediate feedback system

The purpose of this study is to explore a cell-phone Short Message Service (SMS) - based immediate feedback system and to reveal opinions of instructors. This study is designed as a qualitative one and data were collected via semi-structured interviews with 4 instructors who used the system in their classrooms. The significance of this study is to help to remove obstacles about the design of such cell-phone based immediate feedback systems and exploring pedagogical guidelines/principles

Endovascular repair of thoracic and abdominal aortic ruptures: a single-center experience

PURPOSE: We aimed to present our preliminary single-center experience of the endovascular management of thoracic and abdominal aortic ruptures. MATERIALS AND METHODS: Between September 2010 and May 2012, 11 consecutive patients (nine males, two females; age range, 26–80 years) with thoracic and abdominal aortic ruptures underwent endovascular repair in our unit. Thoracoabdominal computed tomography (CT) angiography was performed for diagnosis and follow-up. Patients were selected for endovascular repair by a cardiovascular surgeon, anesthesiologist, and interventional radiologist. All repairs were performed using commercially available stent-grafts. The patients were followed up with CT angiography before discharge, at six months, and yearly thereafter. RESULTS: Three patients died by day 30. One patient died due to an unsuccessful procedure and hemodynamic instability; two patients died because of comorbidities. The other eight patients were followed for six to 24 months after the procedure. No endoleaks or late ruptures were observed during the follow-up period. The patient with iatrogenic thoracic aortic rupture developed paraplegia after the procedure. CONCLUSION: Reduced mortality due to aortic rupture has been reported with the expanding use of endovascular repair. Reports of small centers are important because of the rarity of these pathologies, and because transferring patients with aortic rupture to a referral center is not usually possible

Endovascular repair of thoracic and abdominal aortic ruptures: a single-center experience

PURPOSE We aimed to present our preliminary single-center experience of the endovascular management of thoracic and abdominal aortic ruptures

INTERVENTIONAL RADIOLOGY ORIGINAL ARTICLE

We aimed to present our preliminary single-center experience of the endovascular management of thoracic and abdominal aortic ruptures. MATERIALS AND METHOD

Percutaneous management of bile leaks after laparoscopic cholecystectomy

Amaç: Laparaskopik kolesistektomi sonrası gelişen safra kaçaklarının yönetiminde minimal invaziv girişimlerin yerini vurgulamayı ve bu hastaların yönetiminde uyguladığımız tedavi yaklaşımımızı tartışmayı amaçladık. Gereç ve Yöntem: Laparoskopik kolesistektomi sonrası semptomatik safra kaçağı olan 25 hasta retrospektif olarak değerlendirildi. Tedavi yönetiminde hastaların geliş semptomlarına göre perkütan koleksiyon drenajı, endoskopik retrograd kolanjiyopankreatografi (ERCP), perkütan transhepatik kolanjiyografi (PTK) ve perkütan biliyer drenaj (PBD) uygulandı. Bulgular: Hastaların ortalama yaşı 55 olup (31-84), 15’i kadın, 10’u erkekti. Hastaların 13’üne ultrasonografi (US) veya bilgisayarlı tomografi (BT) eşliğinde perkütan koleksiyon drenajı uygulandı. Bu hastaların 9’unda başka tedaviye gerek kalmadan tam iyileşme sağlandı. Diğer dört hastaya yüksek hacimli safra drenajı nedeniyle ERCP uygulandı. Sarılık ve yüksek bilirubin düzeyleri olan 9 hastada ilk tedavi seçeneği olarak ERCP uygulandı. Üç hasta ise akut batın semptomları nedeniyle tekrar opere edildi. ERCP, manyetik rezonans kolanjiyopankreatografi ve PTK uygulanan hastalarda safra yolu yaralanmaları Strasberg sınıflamasına göre sınıflandırıldı. Bunlardan 7 hastada tip A, üç hastada tip E2, üç hastada tip E3 ve bir hastada tip E4 yaralanma tespit edildi. Sonuç: Laparoskopik kolesistektomi sonrası semptomatik safra kaçağı olan hastalarda geliş semptomları izlenecek tedavi prosedürünün belirlenmesinde yardımcı olmaktadır.Objective: To discuss the importance of minimally invasive treatment options in the management of bile leaks after laparoscopic cholecystectomy and to present our approach in the management. Materials and Methods: Management of 25 patients with symptomatic bile leak after laparoscopic cholecystectomy was retrospectively evaluated. Percutaneous collection drainage, endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic cholangiography (PTC) and percutaneous biliary drainage were performed regarding the presenting symptoms of the patients for the management. Results: Mean age of the patients (15 women, 10 men) was 55. Either ultrasonography or computed tomography guided percutaneous drainage was performed in 13 patients. By only percutaneous drainage 9 of the patients were completely recovered. In 4 of them ERCP was performed because of high drainage volume. In 9 of the patients with jaundice and high bilirubin levels ERCP was performed as the first option. And 3 patients were reoperated because of acute abdomen signs. ERCP, MRCP and PTC revealed type A in 7, type E2 in three, type E3 in three and type E4 in one of the patients according to Strasberg classification. Conclusion: Presenting symptoms of the patients with symptomatic bile leaks are helpful in the determination of the treatment option