Participation in International Telecommunication Projects for Intercultural Communication and Creating an English Authentic Environment Development

[EN] This article describes the experience of participation in one international telecommunication project My City and Me, conducted by the U.S. International Education and Resource Network (iEARN) that united 26,000 teachers, around 2,000,000 students from 140 countries for working on 3,000 projects in 30 different languages. The Project resulted in fostering ESL learner’ awareness of intercultural communication. Moreover, the Project participants learned how to choose the right technologies and software and create an authentic English environment.http://ocs.editorial.upv.es/index.php/HEAD/HEAD18Kalizhanova, A.; Ibrayeva, B.; Ishmuratova, M. (2018). Participation in International Telecommunication Projects for Intercultural Communication and Creating an English Authentic Environment Development. Editorial Universitat Politècnica de València. 99-105. https://doi.org/10.4995/HEAD18.2018.7902OCS9910

Autonomous Learners’ Metacognitive Awareness Development with the Help of Trello Board

[EN] This article focuses on the necessity and inevitability of organization of ESL students’ self-work with the help of free online platform Trello Board. The authors point out that the use of such information and communication technology as Trello Board increases learners’ metacognitive awareness of self-regulation and self-assessment in ESL. The authors also indicate the facilitation of active feedback between ESL learners and their instructor as well as peer-review. The authors share their experience of the use of Trello Board in the educational ecosystem of Bolashak Academy in Kazakhstan. According to the authors, Trello Board provides a broad range of features to control students, maintain their level of motivation, and develop their collaboration in various project works or academic writing tasks.  http://ocs.editorial.upv.es/index.php/HEAD/HEAD18Kalizhanova, A.; Ibrayeva, B.; Ishmuratova, M. (2018). Autonomous Learners’ Metacognitive Awareness Development with the Help of Trello Board. Editorial Universitat Politècnica de València. 55-62. https://doi.org/10.4995/HEAD18.2018.7633OCS556

Isolation and In Silico Anti-SARS-CoV-2 Papain-Like Protease Potentialities of Two Rare 2-Phenoxychromone Derivatives from Artemisia spp.

Two rare 2-phenoxychromone derivatives, 6-demethoxy-4`-O-capillarsine (1) and tenuflorin C (2), were isolated from the areal parts of Artemisia commutata and A. glauca, respectively, for the first time. Being rare in nature, the inhibition potentialities of 1 and 2 against SARS-CoV-2 was investigated using multistage in silico techniques. At first, molecular similarity and fingerprint studies were conducted for 1 and 2 against co-crystallized ligands of eight different COVID-19 enzymes. The carried-out studies indicated the similarity of 1 and 2 with TTT, the co-crystallized ligand of COVID-19 Papain-Like Protease (PLP), (PDB ID: 3E9S). Therefore, molecular docking studies of 1 and 2 against the PLP were carried out and revealed correct binding inside the active site exhibiting binding energies of −18.86 and −18.37 Kcal/mol, respectively. Further, in silico ADMET in addition to toxicity evaluation of 1 and 2 against seven models indicated the general safety and the likeness of 1 and 2 to be drugs. Lastly, to authenticate the binding and to investigate the thermodynamic characters, molecular dynamics (MD) simulation studies were conducted on 1 and PLP.Peer Reviewe

Jusanin, a New Flavonoid from Artemisia commutata with an In Silico Inhibitory Potential against the SARS-CoV-2 Main Protease

A new flavonoid, Jusanin, (1) has been isolated from the aerial parts of Artemisia commutata. The chemical structure of Jusanin has been elucidated using 1D, 2D NMR, and HR-Ms spectroscopic methods to be 5,2′,4′-trihydroxy-6,7,5′-trimethoxyflavone. Being new in nature, the inhibition potential of 1 has been estimated against SARS-CoV-2 using different in silico techniques. Firstly, molecular similarity and fingerprint studies have been conducted for Jusanin against co-crystallized ligands of eight different SARS-CoV-2 essential proteins. The studies indicated the similarity between 1 and X77, the co-crystallized ligand SARS-CoV-2 main protease (PDB ID: 6W63). To confirm the obtained results, a DFT study was carried out and indicated the similarity of (total energy, HOMO, LUMO, gap energy, and dipole moment) between 1 and X77. Accordingly, molecular docking studies of 1 against the target enzyme have been achieved and showed that 1 bonded correctly in the protein’s active site with a binding energy of −19.54 Kcal/mol. Additionally, in silico ADMET in addition to the toxicity evaluation of Jusanin against seven models have been preceded and indicated the general safety and the likeness of Jusanin to be a drug. Finally, molecular dynamics simulation studies were applied to investigate the dynamic behavior of the Mpro-Jusanin complex and confirmed the correct binding at 100 ns. In addition to 1, three other metabolites have been isolated and identified to be сapillartemisin A (2), methyl-3-[S-hydroxyprenyl]-cumarate (3), and β-sitosterol (4).Peer Reviewe

Dynamics of the Accumulation of Essential Oils in the Roots of

For the first time, the dynamics of the accumulation of essential oil in the underground organs of Ferula foetida grown on the territory of the Mangistau region (the Western Kazakhstan), depending on the age of the plant and the place of growth, are investigated. The maximum accumulation of essential oil is noted for the 4th year of vegetation (0.98%), the minimum – for the annual plants (0.14%). The largest quantitative composition of essential oil is noted in the sands of Tuyesu and on the elevation of Tynymbay Shoky, the minimum – in the vicinity of the Karkol wintering. As the results of the study the optimal places of raw materials harvesting and collection dates are determined

Geographical innovations in the flora of the Mangystau region

This article gives the new 7 species to the flora of vascular plants of Mangystau region (Artemisia sieversiana Willd., Ribes aureum Pursh, Tulipa gerneriana L. (T. schrenkii Regn. M. Roem., Tulipa patens Agardh ex Schult. & Schult.fil, Malus siversii (Ledeb.) M. Roem., Urtica dioica L. and Lonicera tatarica L.). The plants are discovered during expeditionary research 2013-2018 on the territory of the Western Karatau Range, the South Aktau Range, the North Ustyurt Plateau and the Tyubka-ragan Peninsula. The short information on floristic innovations is given. The updated composition of the flora of vascular plants of the Mangystau region was 684 species

Creation of an electronic trilingual dictionary of biological terms with linguoculturological components

Digitization of educational system of the Republic of Kazakhstan, coupled with the Trilingualism program, has revealed the problem of the lack of trilingual training and resource books and, as a result, their mass creation in electronic form. This article deals with the experience of creating a disk version of an electronic trilingual dictionary of biological terms with a linguoculturological component using the Adobe Dreamweaver program. The experience of application and use based on a survey of teachers suggests that Adobe Dreamweaver is ideal for visualizing the linguoculturological component of the term in order to effectively memorize the latter.La digitalización del sistema educativo de la República de Kazajstán, junto con el programa de trilingüismo, ha revelado el problema de la falta de capacitación trilingüe y libros de recursos y, como resultado, su creación masiva en forma electrónica. Este artículo trata sobre la experiencia de crear una versión en disco de un diccionario electrónico trilingüe de términos biológicos con un componente linguoculturológico utilizando el programa Adobe Dreamweaver. La experiencia de aplicación y uso basada en una encuesta de docentes sugiere que Adobe Dreamweaver es ideal para visualizar el componente linguoculturológico del término con el fin de memorizar efectivamente este último

Advantages of using paleontological components in extracurricular activities in the english language for middle-school students

The article explores the use of the elements of paleontology in extracurricular activities in the English language, since the materials enriched with the linguocultural and historical components contribute to the introduction of students to the linguistic cultures of other ethnic groups within a single state and increase the motivation for learning languages. The correct use of such materials in the project activities of schoolchildren provides opportunities for developing social activism and improving cross-cultural and linguistic competencies. The elements of paleontology in extracurricular activities in the English language could also contribute positively to the expansion of knowledge base in such school subjects as English and Biology and could potentially provide a deeper immersion in the culture and history of their country and their small homeland.O artigo examina o uso dos elementos de paleontologia em atividades extracurriculares em inglês, visto que os materiais, ricos em componentes linguísticas-culturológicas e históricas, contribuem para o envolvimento de um indivíduo em culturas linguísticas de outros grupos étnicos no interior de um mesmo país, e incrementam a motivação para aprender línguas. A aplicação correta de tais materiais nas atividades de projeto das crianças escolares potencialmente desenvolve uma posição cívica ativa, assim como as competências interculturais e linguísticas. Elementos de paleontologia em atividades extracurriculares em inglês também poderiam influenciar positivamente a ampliação de conhecimentos nas disciplinas, tais como Inglês e o curso escolar de Biologia, e potencialmente poderia proporcionar a imersão mais profunda em cultura e história do seu país, e da sua pequena terra natal.Aquí se discute el uso de elemento de paleontología en activididades extraescolares dirigidas en el idioma inglés porque los materiales ricos en aspectos culturológicos lingüísticos e históricos facilitan el conocimiento de indivíduos con culturas lingüísticas de otras grupas étnicas en el marco de un estado común así como producen una motivación alta para aprender idiomas extranjeros. La aplicación correcta de esos materiales en los proyectos desarrollados por los alumnos puede desarrollar su posición civil activa así como sus competencias lingüísticas e interculturales. Los elementos de paleontología en las actividades extraescolares en el idioma inglés también pueden tener un efecto positivo en el aumento del volumen de conocimientos en tales asignaturas como el idioma inglés y la biología y asegurar una inmersión más profunda en la cultura e historia del país nativos así como de la patria chica