Development of a method of oriented immobilization of lipases on a solid carrier

The methods of oriented immobilization of lipases on a solid carrier - Silochrome C-80 have been developed. The resulting sorbents were tested in the process of obtaining biodiesel from cotton oil. It was shown that immobilized lipase on Silochrome C-80 with NH2 group has the highest transetrification ability and stability, while in sorbents with the enzyme immobilized with -COOH and -SH groups this value was 87 and 53%, respectively. Biocatalysis using an affinity sorbent of immobilized lipase with the –NH2 group has a high operational stability, which, after 240 hours of operation, retains more than 50%, and after 480 hours, 17% retains its initial activity

Investigation of the Effect of Surface Roughness on Cyclic Durability

The article considers the effect of surface roughness on cyclic durability. The effect of electrolytic polishing on the cyclic durability of metal materials has been studied. Some parameters of surface roughness after electrolytic polishing and untreated surface are determined. Tests for cyclic durability of samples with surface treatment by electrolytic polishing and samples without surface treatment were carried out.В статье рассмотрено влияние шероховатости поверхности на циклическую долговечность. Исследовано, как влияет электролитическое полирование на циклическую долговечность металлических материалов. Определены некоторые параметры шероховатости поверхности после электролитического полирования и необработанной поверхности. Проведены испытания на циклическую долговечность образцов с поверхностной обработкой электролитическим полированием и образцов без поверхностной обработки

Исследование фармакокинетики противотуберкулезного препарата Биомайрин

Resume. The results of a studying the pharmacokinetics of the anti-tuberculosis drug Biomayrin in experimental animals (rats) after oral administration were presented. A comparative analysis of the pharmacokinetic parameters of Biomayrin with a comparing drug (a mixture of rifampicin, ethambutol and isoniazid) showed that the bioavailability of isoniazid increased four times as a part of Biomayrin, the ethambutol and rifampicin three times compared to the comparing drug, thereby showing a prolonged effect. It should also be noted that the introduction of isoniazid into the polysaccharide matrix retards its metabolism to the therapeutically inactive acetylisoniazid.Представлены результаты изучения фармакокинетики противотуберкулезного препарата Биомайрин у экспериментальных животных (крысы) после перорального введения. Сравнительный анализ фармакокинетических параметров Биомайрина с препаратом сравнения (смесь рифампицина, этамбутола и изониазида) показал, что в составе Биомайрина период полувыведения изониазида больше в четыре раза, этамбутола и рифампицина - в три раза, чем у препарата сравнения, тем самым проявляется пролонгированный эффект. Следует также отметить, что введение изониазида в полисахаридную матрицу замедляет его метаболизм в терапевтически неактивный ацетилизониазид

Tudying antisclerosis action of amaranth oil isolated from seeds of helios variety on hyperlipidemia twin mode

The work is devoted to study of lipids of amaranth seeds of the Gelios variety, acclimatized in Uzbeki-stan conditions, grown in 2015. Seed oil contents were established within 7.68% of the initial mass. The quantity of squalene in seeds was 0.44%. Amaranth oil contained rather large quantity of unsaturated fat-ty acids - 73.28-72.72%, including up to 1.17% of omega-3 - alpha-linolenic acid. The content of squalene in oils was 5.53-6.25%. No significant differences were found between triacylglyceride composition of the investigated cold-pressed and extracted oils. Besides toxicological properties, hypolipidemic and antioxi-dant activities of amaranth oil of Helios variety in comparison with amaranth oil Vitego were studie

Development of strength training of swimmers by the Breaststroke method

Aim: to determine the design and effectiveness of a complex of exercises aimed at improving the strength training of 15-16-year-olds engaged in swimming training. Methods: 1. Theoretical generalization and analysis of data of scientific and methodological literature; 2. Pedagogical testing; 3. Pedagogical experience; 4. Mathematical statistics style. Results: as a result of the study, an increase in strength training of young swimmers was achieved. Conclusion: the effectiveness of the methods developed for the development of strength training is confirmed by the growth temps of the indicators that characterize the strength of the swimmers

Impact of Irrigation Regime and Fertilization on Economic Efficiency in the Cultivation of Early Potatoes

The article presents the results of the cost-effectiveness of the combined application of fertilizer standards in different irrigation methods of sabella and selbano medium-ripe varieties of potatoe

EFFECTS OF CAPSAICINOIDS IN DIFFERENT CONCENTRATIONS ON RAT LIVER MITOCHONDRIAL SWELLING

Studying mitochondria and investigating in molecular levels are very significant for the estimation of medicinal properties of plants. Because mitochondria and MPTP are considered as specific “targets” not only for pathogens but also for pharmacological agents (Szewczyk et al., 2002). In folk medicine plants of Capsicum annuum L family are well-known with their medicinal properties since ancient times. These plants are commonly named as leguminous red peppers.Capsaicinoids are the main compounds giving bitter taste to pepper fruits. Yet 20 different capsaicinoids have been identified (Legin, 1996). Capsaicine and its analogs efficiently treat bronchial asthma, enuresis, inflammations of intestines, and different chronic deceases such as rheumatoid arthritis, osteoarthritis, neuralgia, and diabetic neuropathy (Kenji et al., 2010). However, the effects of capsaicinoids and proteins from red pepper Capsicum annuum L. on membranes, mitochondria and in molecular levels have not been studied.The aim of the work was to investigate the effects of capsaicinoids in different concentrations on rat liver mitochondrial swelling

Chemical composition and biological activity of seed oil of amaranth varieties

The work is devoted to study of seed oil composition of amaranth varieties: Kharkov, Lera, Andijan and Helios, acclimatized in Uzbekistan. We demonstrated the possibility of using reversed-phase HPLC using a refractometric detector, which allows simultaneous determination of squalene and triacylglycerides in plant seeds and determining the authenticity of amaranth oils. Established seed oiliness ranged from 6.39 to 7.81 % of the initial mass. Amaranth oil samples contained quite large amount of unsaturated fatty acids 72.72 – 73.28 %, 1.17 % of which is omega-3-alpha-linolenic acid. The squalene content in the seeds ranged from 0.35 % to 0.55 %. It was established that the squalene content in oils obtained by extraction is greater than the one obtained by cold pressing. In the triacylglyceride composition of the investigated cold-pressed and extracted oils, no significant differences were found

Chitosan Hydrogel Improves Bioavailability of Megosin

The aim of this study was to obtain chitosan hydrogels containing megosin, an antiviral medicinal substance, to prolong its bioavailability. Megosin as an immunomodulating agent possesses at least twice higher virostatic and virucidal activities than gossypol, the megosin precursor, and other imine derivatives of gossypol