Spleenic lymphoma villous lymphocytes: Case report and literature review

ABSTRACT BACKGROUND: Splenic lymphoma with villous lymphocytes (SLVL) is a rare but recognized distinct disease entity among chronic B lymphoproliferative disorders. It is frequently misdiagnosed as chronic lymphocytic leukaemia, (CLL) Prolymphocytic leukaemia or Hairy Cell leukaemia. Few cases have been reported worldwide. METHOD: The case records of a sixty year old Nigerian male with a splenic lymphoma and a review of the literature on the subject using MEDLINE, other internet sources and manual library search was utilized. RESULT: A sixty-year-old male with splenic lymphoma with villous lymphocytes, seen at the Ahmadu Bello University Teaching Hospital Zaria is presented. However review of the blood film, bone marrow and Splenic aspirates showed absolute lymphocytosis, consisting of “villous” lymphocytes. He was commenced on an alkylating agent and a glucocorticoid, with partial remission in the first three months but was lost to follow up.CONCLUSION: Adequate morphologic evaluation is advocated particularly in the resource limited settings were Cytogenetics, immunohistochemistry and immunophenotyping are not available. Nigerian Journal of Medicine Vol. 16 (1) 2007: pp. 71-7

Phytochemical, nutritional and antimicrobial properties of the leaves of Nigerian Ziziphus Spina – Christi (l.) Willd

Z. spina found in the tropical regions of the world is a small tree capable of resisting heat and drought. Traditionally, the leaves of the plant are preserved as feed for animals during intense drought as well as used to treat external wounds, swellings, diarrhea, and intestinal spasm among others. Phytochemical screening was performed using standard procedures, while the nutritional and antibacterial studies were conducted using the Association of Analytical Chemist (AOAC) and agar well diffusion methods respectively. The result of the phytochemical screening confirmed the presence of flavonoids, tannins, saponins, reducing sugars, among others. Moisture content (27.24 ± 1.19 %), total ash (29.11 ± 0.66 %), acid insoluble ash (1.43 ± 0.06 %), alcohol-soluble extractive (0.26 ± 0.14 %) and water-soluble extractive (0.72 ± 0.12 %) values were obtained from the quantitative proximate analysis. The mineral analysis revealed 14 ± 0.09, 135 ± 1.29 and 1.05 ± 0.19 mg/100 g dry weight as the sodium, potassium and phosphorus compositions respectively. Escherichia coli was found to be the most susceptible bacteria to the extract with an MIC value of 0.25 mg/ml while Staphylococcus aureus was the most resistant strain with an MIC value of 1.00 mg/ml. Conclusively, the leaves of the plant may find use in food formulation operations as well as explored further for the treatment of microbial infections. Keyword: Antimicrobial, Extract, MIC, Nutritional, Ziziphus spin