A surface electrode point Paul trap

We present a model as well as experimental results for a surface electrode radio-frequency Paul trap that has a circular electrode geometry well-suited for trapping of single ions and two-dimensional planar ion crystals. The trap design is compatible with microfabrication and offers a simple method by which the height of the trapped ions above the surface may be changed \emph{in situ}. We demonstrate trapping of single and few Sr+ ions over an ion height range of 200-1000 microns for several hours under Doppler laser cooling, and use these to characterize the trap, finding good agreement with our model.Comment: 10 pages, 11 figures, 1 tabl

Battle of the sexes over paternity

Reproductive behaviors have evolved through severe inter-sexual competition. We have recently described a behavior in post-mated female Drosophila melanogaster that controls ejaculate retention and sperm storage, and is a possible mechanism by which females who have mated with several partners can choose which sperm that is stored and used for fertilization. This behavior can also regulate exposure of the female to harmful effects of male SFP that are present in the ejaculate. Our study identified the neural pathway functioning in the female brain that regulates this behavior

Suppression of Heating Rates in Cryogenic Surface-Electrode Ion Traps

Dense arrays of trapped ions provide one way of scaling up ion trap quantum information processing. However, miniaturization of ion traps is currently limited by sharply increasing motional state decoherence at sub-100 um ion-electrode distances. We characterize heating rates in cryogenically cooled surface-electrode traps, with characteristic sizes in 75 um to 150 um range. Upon cooling to 6 K, the measured rates are suppressed by 7 orders of magnitude, two orders of magnitude below previously published data of similarly sized traps operated at room temperature. The observed noise depends strongly on fabrication process, which suggests further improvements are possible.Comment: 4 pages, 4 figure

New parameterization of air-sea exchange coefficients and its impact on intensity prediction under major tropical cyclones

Understanding and quantifying air-sea exchanges of enthalpy and momentum fluxes are crucial for the advanced prediction of tropical cyclone (TC) intensity. Here, we present a new parameterization of air-sea fluxes at extreme wind speeds from 40 m s−1 to 75 m s−1, which covers the range of major TCs. Our approach assumes that the TC can reach its maximum potential intensity (MPI) if there are no influences of external forces such as vertical wind shear or other environmental constraints.This method can estimate the ratio of the enthalpy and momentum exchange coefficient (Ck/Cd) under the most intense TCs without direct flux measurements. The estimation showed that Ck/Cd increases with wind speed at extreme winds above 40 m s−1. Two types of surface layer schemes of the Hurricane Weather and Research Forecast (HWRF) were designed based on the wind speed dependency of the Ck/Cd found at high winds: (i) an increase of Ck/Cd based on decreasing Cd (Cd_DC) and (ii) an increase of Ck/Cd based on increasing Ck (Ck_IC). The modified surface layer schemes were compared to the original HWRF scheme (using nearly fixed Cd and Ck at extreme winds; CTRL) through idealized experiments and real-case predictions. The idealized experiments showed that Cd_DC reduced frictional dissipation in the air-sea interface as well as significantly reduced sea surface cooling, making the TC stronger than other schemes. As a result, Cd_DC reduced the mean absolute error and negative bias by 15.0% (21.0%) and 19.1% (32.0%), respectively, for all lead times of Hurricane Irma in 2017 (Typhoon Mangkhut in 2018) compared to CTRL. This result suggests that new parameterization of Ck/Cd with decreasing Cd at high winds can help improve TC intensity prediction, which currently suffers from underestimating the intensity of the strongest TCs

Effect of oxygen plasma etching on graphene studied with Raman spectroscopy and electronic transport

We report a study of graphene and graphene field effect devices after exposure to a series of short pulses of oxygen plasma. We present data from Raman spectroscopy, back-gated field-effect and magneto-transport measurements. The intensity ratio between Raman "D" and "G" peaks, I(D)/I(G) (commonly used to characterize disorder in graphene) is observed to increase approximately linearly with the number (N(e)) of plasma etching pulses initially, but then decreases at higher Ne. We also discuss implications of our data for extracting graphene crystalline domain sizes from I(D)/I(G). At the highest Ne measured, the "2D" peak is found to be nearly suppressed while the "D" peak is still prominent. Electronic transport measurements in plasma-etched graphene show an up-shifting of the Dirac point, indicating hole doping. We also characterize mobility, quantum Hall states, weak localization and various scattering lengths in a moderately etched sample. Our findings are valuable for understanding the effects of plasma etching on graphene and the physics of disordered graphene through artificially generated defects.Comment: 10 pages, 5 figure

Autophagy in Adipocyte Browning: Emerging Drug Target for Intervention in Obesity

Autophagy, lipophagy, and mitophagy are considered to be the major recycling processes for protein aggregates, excess fat, and damaged mitochondria in adipose tissues in response to nutrient status-associated stress, oxidative stress, and genotoxic stress in the human body. Obesity with increased body weight is often associated with white adipose tissue (WAT) hypertrophy and hyperplasia and/or beige/brown adipose tissue atrophy and aplasia, which significantly contribute to the imbalance in lipid metabolism, adipocytokine secretion, free fatty acid release, and mitochondria function. In recent studies, hyperactive autophagy in WAT was observed in obese and diabetic patients, and inhibition of adipose autophagy through targeted deletion of autophagy genes in mice improved anti-obesity phenotypes. In addition, active mitochondria clearance through activation of autophagy was required for beige/brown fat whitening – that is, conversion to white fat. However, inhibition of autophagy seemed detrimental in hypermetabolic conditions such as hepatic steatosis, atherosclerosis, thermal injury, sepsis, and cachexia through an increase in free fatty acid and glycerol release from WAT. The emerging concept of white fat browning–conversion to beige/brown fat– has been controversial in its anti-obesity effect through facilitation of weight loss and improving metabolic health. Thus, proper regulation of autophagy activity fit to an individual metabolic profile is necessary to ensure balance in adipose tissue metabolism and function, and to further prevent metabolic disorders such as obesity and diabetes. In this review, we summarize the effect of autophagy in adipose tissue browning in the context of obesity prevention and its potential as a promising target for the development of anti-obesity drugs

Laser ablation loading of a surface-electrode ion trap

We demonstrate loading by laser ablation of $^{88}$Sr$^+$ ions into a mm-scale surface-electrode ion trap. The laser used for ablation is a pulsed, frequency-tripled Nd:YAG with pulse energies of 1-10 mJ and durations of 3-5 ns. An additional laser is not required to photoionize the ablated material. The efficiency and lifetime of several candidate materials for the laser ablation target are characterized by measuring the trapped ion fluorescence signal for a number of consecutive loads. Additionally, laser ablation is used to load traps with a trap depth (40 meV) below where electron impact ionization loading is typically successful ($\gtrsim$ 500 meV).Comment: 4 pages, 4 figure

Submarine groundwater discharge: updates on its measurement techniques, geophysical drivers, magnitudes, and effects

The number of studies concerning Submarine Groundwater Discharge (SGD) grew quickly as we entered the twenty-first century. Many hydrological and oceanographic processes that drive and influence SGD were identified and characterized during this period. These processes included tidal effects on SGD, water and solute fluxes, biogeochemical transformations through the subterranean estuary, and material transport via SGD from land to sea. Here we compile and summarize the significant progress in SGD assessment methodologies, considering both the terrestrial and marine driving forces, and local as well as global evaluations of groundwater discharge with an emphasis on investigations published over the past decade. Our treatment presents the state-of-the-art progress of SGD studies from geophysical, geochemical, bio-ecological, economic, and cultural perspectives. We identify and summarize remaining research questions, make recommendations for future research directions, and discuss potential future challenges, including impacts of climate change on SGD and improved estimates of the global magnitude of SGD