Fuzzy reasoning in K-means classification method

4 pages, no figures.-- Contributed to: 1999 EUSFLAT-ESTYLF Joint Conference (Palma de Mallorca, Spain, Sep 22-25, 1999).Domain analysis tries to reuse software in an effective way. New methodologies are starting to be able to automate the process, in different degrees, with the construction of a domain model for each problem. The general process is divided into several phases. One of the most diffcult tasks is the generation of the relationships which have to be defined between the components in the domain. In this paper the use of fuzzy logic and a statistical classification method in order to get the semantic relationships for each pair of components is presented.Publicad

Perception of innovation in Spain

Purpose: The purpose of this paper is to evaluate the innovation perception, in its different aspects, of the Spanish people. To this end, several ordered logit models have been developed to determine the extent to which socio-demographic characteristics and other aspects of innovation affect the perception of innovation. Design/methodology/approach: This paper analyses the perception of individuals about innovation in Spain and the related factors. It uses 2015 and 2018 data on individuals from Spanish surveys. The data include various measures of innovation perception, age, gender, educational level and other socio-economic variables. Findings: The results indicate that people have a better perception of innovation if they are being trained in innovation or have good information and communication technologies skills. Among the main results, there is a gender gap in the perception of innovation, as well as differences in terms of digital skills. Originality/value: To the best of the authors" knowledge, it is the first time of this kind of analysis in this country. The results are linked to the literature, but should nevertheless be taken into account, which is why some policy recommendations are presented below.This work was supported by the private research project of Company MasMovil and the public research projects of the Spanish Ministry of Economy, Universidad Carlos III de Madrid, and Competitiveness (MINECO), references TEC2017-88048-C2-2-R, RTC-2016-5595-2, RTC-2016-5191-8 and RTC-2016-5059-

Peer rejection and theory of mind. Longitudinal study of three children with autism spectrum disorder

El presente trabajo describe una investigación longitudinal con el objetivo principal de analizar en profundidad la situación de tres alumnos con autismo en un aula ordinaria, así como comprobar si existe relación entre teoría de la mente y su estatus sociométrico dentro del aula. Se analiza la opinión de los profesionales implicados en su educación y el estrés provocado a las familias. Los resultados indican que los niños que han mejorado en teoría de la mente, también han aumentado su estatus sociométrico, y a la inversa. Los resultados escuela-familia-niño se analizan en la discusión más detalladamente.The present study presents a longitudinal study based on the situation of three students with autism included in an ordinary classroom. The main objective is to know whether a relationship between theory of mind and its reputation state exists. In addition, professionals’ opinions caregivers’ stress are analysed. The results showed that children who had improvements in theory of mind, had also increased their sociometric status. In the same way, who had worsened in theory of mind had also decreased their sociometric status within the classroom. The results school-family-child are analysed in the discussion in more detail

El análisis de la cohesión, vinculación e integración sociales en las encuestas EgoNet

Background of INCASI Project H2020-MSCA-RISE-2015 GA 691004. WP1: CompilationEl objetivo de este artículo consiste en mostrar algunas de las posibilidades de análisis que ofrecen las redes Ego-centradas en lo que se refiere a la Cohesión, Vinculación e Integración social. El artículo indaga en ellas haciendo una propuesta de operativización de dichos conceptos y de análisis a partir de un caso de aplicación. Los datos empleados en los ejemplos ilustrativos de los conceptos provienen de una encuesta de redes Ego-centradas realizada en Catalunya.The objective of these papers consists to showing some possibilities of analysis Ego-net about social Cohesion, Linking and Integration. A proposal is done in order to analyze these concepts. The data used in the illustrative examples of the concepts come from a survey of Ego-centered networks in Catalonia

Geographic context configuration in fusion algorithms for maritime surveillance

Proceedings of: 17th International Conference on Information Fusion (FUSION 2014): Salamanca, Spain 7-10 July 2014.Real fusion system applications can be required to operate on wide areas for long periods of time. Adaptation is a basic capability under these circumstances. This paper presents a maritime surveillance platform designed to be flexible and robust. It features online configuration capabilities allowing to: (a) change the applied algorithms, (b) modify the operating parameters of the running algorithms, (c) tune the characterization of the available sensors. These configurations can be applied to limited spatial regions and time spans. This allows to use powerful or more specific configurations for localized scenarios (risks, clutter, alarms), or account for exceptional situations that can affect sensors, such as weather anomalies.This work was funded by contract between DEIMOS SPACE, S.L.U. and Universidad Carlos III, by Spanish Ministry of Economy and Competitiveness under grants TEC2012- 37832-C02-01, TEC2011-28626-C02-02, and by Madrid Region Gov., grant CAM CONTEXTS (S2009/TIC-1485).Publicad

Naturally occurring and engineered alphaviruses sensitive to double-stranded-RNA-activated protein kinase show restricted translation in mammalian cells, increased sensitivity to interferon, and marked oncotropism

Alphaviruses are insect-borne viruses that alternate between replication in mosquitoes and vertebrate species. Adaptation of some alphaviruses to vertebrate hosts has involved the acquisition of an RNA structure (downstream loop [DLP]) in viral subgenomic mRNAs that confers translational resistance to protein kinase (PKR)- mediated eIF2α phosphorylation. Here, we found that, in addition to promoting eIF2-independent translation of viral subgenomic mRNAs, presence of the DLP structure also increased the resistance of alphavirus to type I interferon (IFN). Aura virus (AURAV), an ecologically isolated relative of Sindbis virus (SV) that is poorly adapted to replication in vertebrate cells, displayed a nonfunctional DLP structure and dramatic sensitivity to type I IFN. Our data suggest that an increased resistance to IFN emerged during translational adaptation of alphavirus mRNA to vertebrate hosts, reinforcing the role that double-stranded RNA (dsRNA)-activated protein kinase (PKR) plays as both a constitutive and IFN-induced antiviral effector. Interestingly, a mutant SV lacking the DLP structure (SV-ΔDLP) and AURAV both showed a marked oncotropism for certain tumor cell lines that have defects in PKR expression and/or activation. AURAV selectively replicated in and killed some cell lines derived from human hepatocarcinoma (HCC) that lacked PKR response to infection or poly(I·C) transfection. The oncolytic activities of SV-ΔDLP and AURAV were also confirmed using tumor xenografts in mice, showing tumor regression activities comparable to wild-type SV. Our data show that translation of alphavirus subgenomic mRNAs plays a central role in IFN susceptibility and cell tropism, suggesting an unanticipated oncolytic potential that some naive arboviruses may have in virotherapy. IMPORTANCE Interferons (IFNs) induce the expression of a number of antiviral genes that protect the cells of vertebrates against viruses and other microbes. The susceptibility of cells to viruses greatly depends on the level and activity of these antiviral effectors but also on the ability of viruses to counteract this antiviral response. Here, we found that the level of one of the main IFN effectors in the cell, the dsRNAactivated protein kinase (PKR), greatly determines the permissiveness of cells to alphaviruses that lack mechanisms to counteract its activation. These naive viruses also showed a hypersensitivity to IFN, suggesting that acquisition of IFN resistance (even partial) has probably been involved in expanding the host range of alphaviruses in the past. Interestingly, some of these naive viruses showed a marked oncotropism for some tumor cell lines derived from human hepatocarcinoma (HCC), opening the possibility of their use in oncolytic therapy to treat human tumor

Chronic functional adaptations induced by the application of transcranial direct current stimulation combined with exercise programs: A systematic review of randomized controlled trials

This work was supported by the Spanish Ministry of Science, Innovation, and Universities under Grant (PID2021-128204OA-I00-AEI/FEDER, UE)[Abstract]: The present systematic review aimed to determine the chronic effects of the combination of transcranial direct current stimulation (tDCS) and exercise on motor function and performance outcomes. We performed a systematic literature review in the databases MEDLINE and Web of Science. Only randomized control trials that measured the chronic effect of combining exercise (comprising gross motor tasks) with tDCS during at least five sessions and measured any type of motor function or performance outcome were included. A total of 22 interventions met the inclusion criteria. Only outcomes related to motor function or performance were collected. Studies were divided into three groups: (a) healthy population (n = 4), (b) neurological disorder population (n = 14), and (c) musculoskeletal disorder population (n = 4). The studies exhibited considerable variability in terms of tDCS protocols, exercise programs, and outcome measures. Chronic use of tDCS in combination with strength training does not enhance motor function in healthy adults. In neurological disorders, the results suggest no additive effect if the exercise program includes the movements pretending to be improved (i.e., tested). However, although evidence is scarce, tDCS may enhance exercise-induced adaptations in musculoskeletal conditions characterized by pain as a limiting factor of motor function.Xunta de Galicia, Universidade da Coruna/CISUG ; (ED431B 2021/28

Compositional Evolution of the Variscan Intra-Orogenic Extensional Magmatism in the Valencia del Ventoso Plutonic Complex, Ossa-Morena Zone (SW Iberia): A View from Amphibole Compositional Relationships

The Ossa-Morena Zone (OMZ), SW Iberia, has numerous Lower Carboniferous compositionally zoned plutons that formed in a Variscan intra-orogenic extensional setting. This magmatism shows a wide compositional variation comprising alkaline, transitional, and calc-alkaline suites. The calc-alkaline suite was produced by hybridization of alkaline magmas with felsic melts generated by crustal anatexis related to the intrusion of mafic magmas in the middle crust. In this work, we present a textural and mineralogical study of the Variscan Valencia del Ventoso main pluton from the OMZ to track the compositional evolution of magmas during hybridization using constraints from amphibole compositions and to determine the P-T conditions of emplacement using amphibolebased thermobarometry. This pluton exhibits reverse zoning with an inner facies containing alkaline dolerites, gabbros, and quartz diorites, an intermediate facies with transitional diorites, and an outer facies with calc-alkaline quartz diorites to monzogranites. Magmas from the intermediate and border facies crystallized under oxidizing conditions at relatively low temperatures (range: 640–760 ◦C) and ca. 280–300 MPa, implying near H2O-saturated conditions. These rock facies show mineralogical evidence of hybridization between alkaline to mildly alkalic and calc-alkaline magmas. The former is inferred from the occurrence of antecrysts of labradorite-andesine, high-Ti pargasite-hastingsite, and biotite with deficiency in tetrahedral-site occupancy, a distinctive feature of biotite from the inner facies alkaline dolerites. This contrasts with later crystallization from the calc-alkaline magma of andesine-oligoclase, low-Ti magnesiohornblende-edenite, and biotite with full tetrahedral-site occupancy. Constraints from amphibole-melt compositional relationships in antecrystic high-Ti amphibole suggest that the alkaline magmatic component could have a high- to ultra-K affinity.Ministerio de Economía y Competitividad (Gobierno de España), CGL2017-84469-