Mutual prodrug of cephazolin and benzydamin: 3-[(1-benzyl-1H-indazol-3-yl)­oxy]-N,N-dimethyl­propan-1-aminium 3-{[(5-methyl-1,3,4-thia­diazol-2-yl)sulfan­yl]meth­yl}-8-oxo-7-[(1H-tetra­zol-1-yl)acetamido]-5-thia-1-aza­bicyclo­[4.2.0]octane-2-carboxyl­ate (benzydaminium cephazolinate)

In the crystal of the title mol­ecular salt, C19H24N3O+·C14H13N8O4S3 −, the cations and anions are linked by N—H⋯O hydrogen bonds. Short intra­molecular C—H⋯O contacts occur within the anion and inter­molecular C—H⋯O and C—H⋯π bonds help to establish the packing

Transition metal acetylsalicylates and their anti-inflammatory activity.

Mononuclear and binuclear transition metal [Co(II), Cu(II), Ni(II) and Zn(II)] acetylsalicylates of the type [M(L)2], [M(L)2Cl2] and [(M)2(L)4] have been prepared and characterized on the basis of their physical, spectral and analytical data. The complexes have been investigated in an in vivo animal model for anti-inflammatory activity and show a better effect and a more potent action than acetylsalicylic acid

Intraocular Metastasis as the Presenting Symptom of NSCLC and the Role of Bevacizumab: A Case Report

Introduction: Metastasis to the eye is a rare clinical entity accounting for about 2-9% ocular malignancies. Clinical awareness can lead to prompt diagnosis and appropriate management.Case presentation: We here present a case of a 60-year-old patient who visited to several ophthalmologists with the complaint of blurry vision in his left eye. He was diagnosed with anterior uveitis and elevated intraocular pressure. A masquerade syndrome was suspected, and anterior chamber paracentesis was performed, which revealed metastatic non-small cell lung cancer (NSCLC). CT chest revealed a left lung mass with right paratracheal lymphadenopathy. No other evidence of metastatic disease was found on PET/CT scan and MRI of the brain. He received treatment for stage IV lung cancer with carboplatin, paclitaxel, and bevacizumab. The intraocular tumor cell infiltration was treated with intravitreal bevacizumab that resulted in subjective and objective improvement.Conclusion: Metastasis to the eye may present in a masquerade-like fashion as intraocular inflammation. Tumor specific therapy directed locally within the eye may be a component of an overall treatment plan.

2-[6-Thioxo-5-(2,4,6-trimethyl­phen­yl)-1,3,5-thia­diazinan-3-yl]acetic acid

In the mol­ecule of the title compound, C14H18N2O2S2, the 1,3,5-thia­diazinane-2-thione ring adopts an envelope conformation with one of the N atoms at the flap position. The plane throught the five co-planar atoms of the heterocycle is oriented at a dihedral angle of 80.59 (8)° with respect to the aromatic ring. In the crystal structure, weak inter­molecular O—H⋯S inter­actions link the mol­ecules into chains along the b axis

OPTIMIZATION OF PARAMETERS OF COTTON FABRIC WHITENESS

In this project work, the performance of peroxide bleaching commercial bluing agent, and different fluorescent brightening on the degree of whiteness of cotton fabric was investigated and compared. Here all the experiments were done on cotton fabric; both for woven knit structures in exhausted method. Maximum whiteness is found by applying optical brightening agent of Synowhite 4KB brand of 1.2% on the weight of materials at 80oC for 40 minutes treatment of cotton fabric along with salt of 5gm/L after bleaching. Furthermore, the influence of surface characteristics of the substrate on whiteness index was observed. CIE whiteness Index was measured by spectrophotometer at the standard illuminant D65

OPTIMIZATION OF PARAMETERS OF COTTON FABRIC WHITENESS

In this project work, the performance of peroxide bleaching commercial bluing agent, and different fluorescent brightening on the degree of whiteness of cotton fabric was investigated and compared. Here all the experiments were done on cotton fabric; both for woven knit structures in exhausted method. Maximum whiteness is found by applying optical brightening agent of Synowhite 4KB brand of 1.2% on the weight of materials at 80oC for 40 minutes treatment of cotton fabric along with salt of 5gm/L after bleaching. Furthermore, the influence of surface characteristics of the substrate on whiteness index was observed. CIE whiteness Index was measured by spectrophotometer at the standard illuminant D65