Towards Quantum Superpositions of a Mirror: an Exact Open Systems Analysis - Calculational Details

We give details of calculations analyzing the proposed mirror superposition experiment of Marshall, Simon, Penrose, and Bouwmeester within different stochastic models for state vector collapse. We give two methods for exactly calculating the fringe visibility in these models, one proceeding directly from the equation of motion for the expectation of the density matrix, and the other proceeding from solving a linear stochastic unravelling of this equation. We also give details of the calculation that identifies the stochasticity parameter implied by the small displacement Taylor expansion of the CSL model density matrix equation. The implications of the two results are briefly discussed. Two pedagogical appendices review mathematical apparatus needed for the calculations.Comment: 9 pages, LaTeX. Minor changes mad

Responsive Urban Models by Processing Sets of Heterogeneous Data

This paper presents some steps in experimentation aimed at describing urban spaces made following the series of earthquakes that affected a vast area of central Italy starting on 24 August 2016. More specifically, these spaces pertain to historical centres of limited size and case studies that can be called "problematic" (due to complex morphological and settlement conditions, because they are difficult to access, or because they have been affected by calamitous events, etc.). The main objectives were to verify the use of sets of heterogeneous data that are already largely available to define a workflow and develop procedures that would allow some of the steps to be automated as much as possible. The most general goal was to use the experimentation to define a methodology to approach the problem aimed at developing descriptive responsive models of the urban space, that is, morphological and computer-based models capable of being modified in relation to the constantly updated flow of input data

Towards Quantum Superpositions of a Mirror: an Exact Open Systems Analysis

We analyze the recently proposed mirror superposition experiment of Marshall, Simon, Penrose, and Bouwmeester, assuming that the mirror's dynamics contains a non-unitary term of the Lindblad type proportional to -[q,[q,\rho]], with q the position operator for the center of mass of the mirror, and \rho the statistical operator. We derive an exact formula for the fringe visibility for this system. We discuss the consequences of our result for tests of environmental decoherence and of collapse models. In particular, we find that with the conventional parameters for the CSL model of state vector collapse, maintenance of coherence is expected to within an accuracy of at least 1 part in 10^{8}. Increasing the apparatus coupling to environmental decoherence may lead to observable modifications of the fringe visibility, with time dependence given by our exact result.Comment: 4 pages, RevTeX. Substantial changes mad

Creating a campus-wide research data services committee: The good, The bad, and The…... Part 2: Launching your collaboration

A panel of presenters in this two-part webinar series shared their experiences about how academic libraries are taking the lead in developing cross-campus collaborations in establishing research data committees to spearhead institutional efforts related to data stewardship and digital projects. This interactive session lead participants through the various steps needed in order to initiate a similar effort within their institutional context. Part 2: Launching your collaboration Learning Objectives: Identify best practices and lessons learned for working with established committees who are working on broad-scale projects and programs Evaluate different institutional models to compare and customize for different academic environments Analyze best practices strategies for successful project management, collaboration, and program development for established committee

Creating a campus-wide research data services committee: The good, The bad, and The...... Part 1: Building bridges and planting seeds

A panel of presenters in this two-part webinar series shared their experiences about how academic libraries are taking the lead in developing cross-campus collaborations in establishing research data committees to spearhead institutional efforts related to data stewardship and digital projects. This interactive session lead participants through the various steps needed in order to initiate a similar effort within their institutional context. Part 1: Building bridges and planting seeds Learning Objectives: Focus on early-stage efforts to build partnerships and bring key stakeholders to the table Acquire practical tips for addressing the institutional challenges involved in developing a campus-wide data committee Identify key individuals who could be instrumental in establishing a campus-wide data committe

Physical Chemistry of Chloroquine Permeation through the Cell Membrane with Atomistic Detail

We provide a molecular-level description of the thermodynamics and mechanistic aspects of drug permeation through the cell membrane. As a case study, we considered the antimalaria FDA approved drug chloroquine. Molecular dynamics simulations of the molecule (in its neutral and protonated form) were performed in the presence of different lipid bilayers, with the aim of uncovering key aspects of the permeation process, a fundamental step for the drug’s action. Free energy values obtained by well-tempered metadynamics simulations suggest that the neutral form is the only permeating protomer, consistent with experimental data. H-bond interactions of the drug with water molecules and membrane headgroups play a crucial role for permeation. The presence of the transmembrane potential, investigated here for the first time in a drug permeation study, does not qualitatively affect these conclusions

Total orthotopic small bowel transplantation in swine under FK 506

Previous experimental studies in rodents and in dogs have established the efficacy of FK 506 in controlling the immunologic events following small bowel or multivisceral transplantation.1–5 To complete the assessment of FK 506 in experimental small bowel transplantation, we present here our experience with the frequently used swine model

PPARγ and cognitive performance

Recent findings have led to the discovery of many signaling pathways that link nuclear receptors with human conditions, including mental decline and neurodegenerative diseases. PPARγ agonists have been indicated as neuroprotective agents, supporting synaptic plasticity and neurite outgrowth. For these reasons, many PPARγ ligands have been proposed for the improvement of cognitive performance in different pathological conditions. In this review, the research on this issue is extensively discussed

Fragment-based discovery of a regulatory site in thioredoxin glutathione reductase acting as "doorstop" for NADPH entry

Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases. However, individual FAD/NAD reductases are difficult to inhibit in a selective manner with off target inhibition reducing usefulness of identified compounds. Thioredoxin glutathione reductase (TGR), a high molecular weight thioredoxin reductase-like enzyme, has emerged as a promising drug target for the treatment of schistosomiasis, a parasitosis afflicting more than 200 million people. Taking advantage of small molecules selected from a high-throughput screen and using X-ray crystallography, functional assays, and docking studies, we identify a critical secondary site of the enzyme. Compounds binding at this site interfere with well-known and conserved conformational changes associated with NADPH reduction, acting as a doorstop for cofactor entry. They selectivity inhibit TGR from Schistosoma mansoni and are active against parasites in culture. Since many members of the FAD/NAD-linked reductase family have similar catalytic mechanisms the unique mechanism of inhibition identified in this study for TGR broadly opens new routes to selectively inhibit homologous enzymes of central importance in numerous diseases