Postpartal recurrent non-ST elevation myocardial infarction in essential thrombocythaemia: case report and review of the literature

Normal pregnancy corresponds to a procoagulant state. Acute myocardial infarction during pregnancy is rare, yet considering the low non-pregnant risk score of childbearing women it is still surprisingly frequent. We report a case of postpartum recurrent non-ST elevation myocardial infarction in a 40-year-old caucasian woman with essential thrombocythaemia in the presence of a positive JAK-2 mutation and an elevated anti-cardiolipin IgM antibody titer. In the majority of cases of myocardial infarction in pregnancy or in the peripartal period, atherosclerosis, a thrombus or coronary artery dissection is observed. The combination of essential thrombocythaemia and elevated anti-cardiolipin IgM antibody titer in the presence of several cardiovascular risk factors seems to be causative in our case. In conclusion, with the continuing trend of childbearing at older ages, rare or unlikely conditions leading to severe events such as myocardial infarction must be considered in pregnant women

A Practical Method for Mapping of Pesticide Loss Risk in Cultivated Soils of Greece

In an attempt to map the soil factors controlling pesticide losses, surface soil samples were collected from 196 sites in the cultivated area of Trifyllia, SW Peloponnese, Greece. Up to now, the pesticide losses risk in the studied area is unknown. For this aim, the following key characteristics that affect movement or binding have been taken into consideration: soil texture, slope and soil organic matter content. A GIS map was compiled from discrete soil variables that affect pesticide losses (leaching and/or runoff). According to soil texture, 3 moderate leaching risk classes, 2 high and 1 low were defined, and the respective classes based on Soil Organic Matter (SOM) content were 3 low risk classes, 2 moderate and 1 class of high risk. The study area consists of two soil slope classes 0-2% and 2-6% which were used to calculate the leaching potential of pesticides. The compiled maps can be used by local authorities in order to minimize the potential negative environmental impacts of pesticide usage at farm level, and to suggest various mitigation strategies. Appropriate farming practices must be applied to decrease leaching or losses by runoff in order to mitigate the pollution of shallow aquifers and surface waters in SW Peloponnese. Rational irrigation management is of high importance as it increases the pesticide effectiveness and reduces off site movement. Moreover, runoff of pesticides can be reduced by using minimum tillage techniques to mitigate soil erosion. Finally, farming systems and practices that increase soil organic matter content (e.g. no tillage) can reduce substantially the risk of water pollution by pesticides

Simultaneous clinical resolution of focal segmental glomerulosclerosis associated with chronic lymphocytic leukaemia treated with fludarabine, cyclophosphamide and rituximab

<p>Abstract</p> <p>Background</p> <p>Although renal involvement in advanced haematological malignancies is common, glomerulonephritis associated with lymphoproliferative disorders is rare, and the related pathogenetic mechanisms are still poorly understood. We present a rare case of chronic lymphocytic leukaemia(CLL)-associated focal segmental glomerulosclerosis with nephrotic-range proteinuria.</p> <p>Case presentation</p> <p>A 53-year-old Caucasian man, previously healthy, with no history of hypertension, alcohol use or smoking presented with rapid weight gain, massive peripheral oedema, and hypertension. Laboratory findings included a white blood cell count of 49,800 cells/mm³with an absolute lymphocyte count of 47,000 cells/mm³, serum albumin of 2.3 g/dL, urea 65 mg/dL, and creatinine 1.5 mg/dL. A 24-hour urine collection contained 7.1 g protein and significant haematuria. A peripheral blood smear showed mature lymphocytosis and smudge cells. Diagnostic imaging showed mild paraaortic lymphadenopathy with no renal abnormalities. Bone marrow aspiration and trephine biopsy showed diffuse and focal infiltration with B-CLL lymphocytes. Percutaneous renal biopsy revealed total sclerosis in 3/21(14%) of the glomeruli and focal and segmental solidification and sclerosis in 4/21 (19%) glomeruli. A regimen of fludarabine, cyclophosphamide and rituximab was successful in inducing remission of the CLL and clinical resolution of the nephritic-range proteinuria.</p> <p>Conclusions</p> <p>A multidisciplinary approach to monitor both the malignancy and the glomerular lesions is crucial for the optimal management of paraneoplastic glomerulonephritis. Although chemotherapy with fludarabine, cyclophosphamide and rituximab successfully treated CLL-associated nephrotic syndrome in our patient, further studies are required to confirm efficacy in this setting.</p

Pseudomamma of the inguinal region in a female patient: A case report

Introduction: Supernumerary breasts are relative common benign congenital anomalies. General population occurrence rates vary up to 6% according to ethnicity and gender. Higher incidence is recorded in Asian individuals, especially Japanese. Embryonic breast development of the mammary ridge (milk line) is explained and supernumerary breast tissue resulting from involution failure of any portion of the embryonic mammary folds is described. Presentation of case: We report a case of supernumerary breast (pseudomamma) in a female occupying her right inguinal region that was treated in the breast unit of our hospital. Differential diagnosis, imaging methods, operative approach, surgical treatment and histological verification are specified. Discussion: Classification system for supernumerary breast tissue is presented, high risk population is identified and congenital malformations linked to it are outlined. Evaluation of diagnostic workup and limitations are stated. Cancerous degeneration and justification for surgical removal of the accessory gland is discussed. Conclusion: Differential diagnosis of lesions along the milk line should always be inclusive of developmental abnormalities such as any type of supernumerary breast, often overlooked due to small size, although carrying a malignant potential equal to normally positioned breasts. Surgical correction is a sensible approach, often encouraged by the patients. Additional evaluation is recommended due to the frequent accompanying urinary tract and cardiac anomalies

A Privacy-by-Design Contextual Suggestion System for Tourism

We focus on personal data generated by the sensors and through the everyday usage of smart devices and take advantage of these data to build a non-invasive contextual suggestion system for tourism. The system, which we call Pythia, exploits the computational capabilities of modern smart devices to offer high quality personalized POI (point of interest) recommendations. To protect user privacy, we apply a privacy by design approach within all of the steps of creating Pythia. The outcome is a system that comprises important architectural and operational innovations. The system is designed to process sensitive personal data, such as location traces, browsing history and web searches (query logs), to automatically infer user preferences and build corresponding POI-based user profiles. These profiles are then used by a contextual suggestion engine to anticipate user choices and make POI recommendations for tourists. Privacy leaks are minimized by implementing an important part of the system functionality at the user side, either as a mobile app or as a client-side web application, and by taking additional precautions, like data generalization, wherever necessary. As a proof of concept, we present a prototype that implements the aforementioned mechanisms on the Android platform accompanied with certain web applications. Even though the current prototype focuses only on location data, the results from the evaluation of the contextual suggestion algorithms and the user experience feedback from volunteers who used the prototype are very positive

Waste Management and the Circular Economy in Cyprus—The Case of the SWAN Project

The increase in waste volume and greenhouse gas emissions and decrease in raw-material reserves are some of the serious problems that our planet is facing. The measures needed to address these issues cannot be implemented under the prevailing linear economy model; hence, the circular economy model has been introduced. The successful implementation of circularity, whose basic principles include waste reduction, reuse, and recycling, requires a change in the behaviour of all the parties involved and is expected to lead to industrial–urban symbiosis schemes. The present paper looks at the current state and future prospects of the circular economy in Cyprus, based on the evidence drawn from an EU-funded project entitled “a digital Solid Waste reuse plAtform for BalkaN” (Project Acronym: SWAN). The project’s main objective was the design and development of a digital solid waste reuse platform involving four countries: Greece, Albania, Bulgaria, and Cyprus. Using the data collected, in the context of this project, from a sample of Cypriot industries, we looked into the familiarisation of the respondents with the basic concepts of circularity and their willingness to participate in symbiotic value chains. Moreover, we examined the composition of the waste streams produced by those industries and proposed potential waste reuse business models and subsequent symbiotic clusters