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Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- Baršić Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
- Bean Sarah
- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
- Berry Lindsay
- Berry Lindsay
- Berry Scott
- Berry Scott
- Bhimani Zahra
- Bhimani Zahra
- Bihari Shailesh
- Bihari Shilesh
- Binnie Alexandra
- Bion Julian
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Katie
- Birkinshaw Isobel
- Black Ethel
- Bloos Frank
- Board Jasmin
- Bone Allsion
- Bonner Stephen
- Bonten Marc
- Bonten Marc
- Borgatta Barbara
- Borrill Zoe
- Bosch Ziekenhuis Jeroen
- Boschert Catherine
- Bossard Isabelle
- Boumahni Dounia
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouwman Wietske
- Bowler Helen
- Boyd Craig
- Bracke Stephanie
- Bradbury Charlotte
- Bradbury Charlotte
- Bradley-Potts Joanne
- Brailsford Jane
- Brain Matthew
- Brant Emily
- Breen Patrick
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Browne Troy
- Brunkhorst Frank
- Brunkhorst Frank
- Budd Joanna
- Buehner Ulrike
- Buhr Heidi
- Bullman Laetitia
- Burns Karen
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- Bélteczki János
- Cabreros Leilani
- Calfee Carolyn
- Callender Owen
- Campbell Andy
- Campbell Hilary
- Campbell Lewis
- Camsooksai Julie
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- Carrier Marc
- Cartner Brittney
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- Casey Siobhan
- Castro Ferreira Ricardo Manuel
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- Cathcart Susanne
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Centofanti John
- Chablani Manish
- Chamara Warnapura Loku
- Chan Carmen
- Chan Charles
- Chan Peter
- Charlewood Richard
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chudeau Nicolas
- Cirstea Emanuel
- Clarey Emma
- Claridge Helen
- Clark Michele
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- Claxton Andrew
- Clermont Giles
- Cloutier Ève
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- Codreanu Daniel
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- Collier Dawn
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- Collins Joanne
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- Cooper Melanie
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- Cowton Amanda
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- Crisp Nikki
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- Cutler Sean
- Cviljevic Sabina
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- Davies Michelle
- Dawda Ashlish
- Day Christopher
- De Beaux Fiona
- De Bus Liesbet
- de Courcy-Golder Kim
- de Jager P
- de Jong Menno
- De Jong Menno
- de Jonge E
- de la Fuente Martos Carmen
- de Lima Pereira Tiago Nuno Alfaro
- de Man Angelique
- De Waele Jan
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- Derde Lennie
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- Elsefi Tarek
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- Everitt Robert
- Evers Mirjam
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- Ferguson Niall
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- Fitzgerald Mark
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- Friedrich Hinrichs Carl
- Frohlich Stephen
- Fysh Ed
- Gallagher Linda Jude
- Ganguly Saibal
- Ganpat Radhika
- Garcia Rebecca
- Gardiner-Hill Caroline
- Garrard Hywel
- Garrard William
- Gates Simon
- Gattas David
- Gellamucho Minerva
- Gendall Emma
- Genetu Roman Mary
- Geng Wenli
- Geri Guillaume
- Ghamraoui Ali
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- Gibson Charly
- Girard Timothy
- Girijadevi Dinu
- Gledhill Lisa
- Godement Mathieu
- Golden David
- Goligher Ewan
- Gomm Linda
- Goodson Jennifer
- Goodwin Jayne
- Goossens Herman
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Gordon Anthony
- Gordon Anthony C
- Gordon Elizabeth
- Gosbell Iain
- Gould Richard
- Grecu Irina
- Green Cameron
- Green Cameron
- Gregory Jane
- Gresha Rebecca
- Grimmer Lisa
- Grimwade Kate
- Guilder E
- Guitton Christophe
- Hacking Danielle
- Hadebe Bernard
- Hagel Stefan
- Haidar Ghady
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- Hall Kathryn
- Hamilton David Oliver
- Hamilton-Davies Colin
- Hamlyn Vincent
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- Haniffa Rashan
- Haniffa Rashan
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- Health Monash
- Heinonen Jonna
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- Henderson Steven
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- Hickey Naomi
- Higgins Alisa M
- Higgins Lisa
- Hill Helen
- Hills Thomas
- Hills Tom
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- Hoff Uwe
- Hoiting Oscar
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- Horton Sarah
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- Horvat Christopher
- Howcroft Clare
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- Hullegie Sebastiaan J
- Hulley Amanda
- Hulme Jonathan
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- Johnston Paul
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- Kruger Peter
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- Labbe Vincent
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- Lawler Patrick R
- Lawless Patrick
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- Linstrum Kelsey
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- Seymour Christopher
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- Thomson Nicola
- Thrush Jessica
- Tilney Emma
- Tinmouth Alan
- Tong Steve
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- Triulzi Darrell
- Trodd Dawn
- Tsang Jennifer
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- Turgeon Alexis
- Turki Salah
- Turner Anne
- Turner Anne
- Turner-Bone Ian
- Turns Margaret
- Uddin Ruzena
- Udy Andrew
- Uyeki Tim
- Vaara Suvi
- Vahtera Annukka
- Vamplew Luke
- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van de Veerdonk Frank
- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- van’t Hoff Willian
- Vates Jennifer
- Vautier Sarah
- Vazquez-Grande Gloria
- Venkatesh Bala
- Venkatesh Balasubramanian
- Venz Ellen
- Verlander Mark
- Verrier Nathalie
- Victor Saji
- Vieillard-Baron Antoine
- Voicu Sebastian
- Vowell Emma
- Vujaklija Brajković Ana
- Vuylsteke Alain
- Wagh Atul
- Walden Andrew
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Ward Kathryn
- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
- Wiseman Sophie
- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
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- Albatni Safa Sasi
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- Alboon Mosab
- Alboridy Muneera
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- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
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- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
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- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
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- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
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- Alqaarh Aya
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- Alrifae Ghaliya Mohamed H
- Alrosan Risan
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- Alsaid Hamza
- Alsaify Esmat
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- Alshawadfy Abdelrhman
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- Alsheik Ahmad
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- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
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- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
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- Atadag Yildiz Buyukdereli
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- Yildirim Yasemin
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- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
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- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
The Twice Borne Fiction: French Translations of Indian English Literature
- Author
- Desai Kiran
- Desai Kiran
- Dingwaney Anuradha
- Huggan Graham
- Innes Catherine Lynette
- Kamala N.
- Krishnaswamy N.
- Lahiri Jhumpa
- Lahiri Jhumpa
- Masani Zareer
- Mehrez Samia
- Mukherjee Meenakshi
- Municipal Library of Paris
- Ranasinha Ruvani
- Rollason Christopher
- Rushdie Salman
- Sengupta Mahasweta
- Spivak Gayatri Chakravorty
- Tejpal Tarun J.
- Tejpal Tarun J.
- Tymoczko Maria
- Venuti Lawrence
- Wilsmore S. J.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Sea passages: cultural flows in Caribbean poetry
- Author
- Bettinger Elfi
- Bhabha Homi K.
- Birgit Neumann
- Boyce Davies Carole
- Braidotti Rosi
- Brathwaite Edward K
- Brathwaite Edward K
- Bucknor Michael
- Cassirer Ernst
- Chakrabarty Dipesh
- Clifford James
- Collier Gordon
- Dabydeen David
- DeCaires Narain Denise
- DeLoughrey Elizabeth
- DeLoughrey Elizabeth M
- Donnell Alison
- Eckstein Lars
- Ellis Keith
- Forbes Curdella
- Fulford Sarah
- Gill Jo
- Gilroy Paul
- Glissant Édouard
- Griffin David Ray
- Gumbrecht Hans Ulrich
- Hoving Isabel
- Innes Catherine Lynette
- Jan Rupp
- Leer Martin
- Moise Myriam
- Müller Gesine
- Nichols Grace
- Pennycook Alastair
- Philip M. NourbeSe
- Phillips Caryl
- Pratt Mary Louise
- Rigby Kate
- Rostek Joanna
- Rotella Guy
- Sellin E
- Soja Edward W.
- Stein Mark
- Thieme John
- Tiffin Helen
- Walcott Derek
- Walcott Derek
- Walcott Derek
- Wilton Andrew
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Alternative genomic diagnoses for individuals with a clinical diagnosis of Dubowitz syndrome.
- Author
- Agrawal Pankaj B.
- Akdemir Zeynep Coban
- Al Sharhan Hind
- Aleck Kyrieckos A.
- Antaki Danny
- Au Ping-Yee B
- Aydin Hatip
- Bamshad Michael J.
- Beggs Alan H.
- Bilguvar Kaya
- Blue Elizabeth E.
- Boerwinkle Eric
- Boycott Kym M.
- Brand Harrison
- Brownstein Catherine A.
- Buyske Steve
- Chodirker Bernard N.
- Choi Jungmin
- Chudley Albert E.
- Clericuzio Carol L.
- Cox Gerald F.
- Curry Cynthia J.
- de Boer Elke
- de Vries Bert B.A.
- Doriqui Maria Juliana Rodovalho
- Dunn Kathryn
- Dutmer Cullen M.
- Dyment David A.
- England Eleina M.
- Fahrner Jill A.
- Genetti Casie A.
- Genomics Centers for Mendelian
- Gezdirici Alper
- Geçkinli Bilgen Bilge
- Gibson William T.
- Gleeson Joseph G.
- Greenberg Cheryl R.
- Hall April
- Hamosh Ada
- Hartley Taila
- Innes A. Micheil
- Jhangiani Shalini N.
- Karaca Ender
- Kernohan Kristin D.
- Lauzon Julie
- Lewis M. E. Suzanne
- Lowry R. Brian
- López-Giráldez Francesc
- Matise Tara C.
- McEvoy-Venneri Jennifer
- McInnes Brenda
- Mhanni Aziz
- Minaur Sixto Garcia
- Moilanen Jukka S.
- Nguyen An
- Nickerson Deborah A.
- Nowaczyk Małgorzata J.M.
- O’Donnell-Luria Anne H.
- Pajusalu Sander
- Pehlivan Davut
- Penney Lynette S.
- Posey Jennifer E.
- Poterba Timothy
- Prontera Paolo
- Sawyer Sarah L.
- Sobreira Nara
- Stanley Valentina
- Torun Deniz
- Wargowski David S.
- Witmer P. Dane
- Wong Isaac
- Xing Jinchuan
- Zaki Maha S.
- Zhang Yeting
- Õunap Katrin
- Publication venue
- United States
- Publication date
- 01/01/2020
- Field of study
Dubowitz syndrome (DubS) is considered a recognizable syndrome characterized by a distinctive facial appearance and deficits in growth and development. There have been over 200 individuals reported with Dubowitz or a "Dubowitz-like" condition, although no single gene has been implicated as responsible for its cause. We have performed exome (ES) or genome sequencing (GS) for 31 individuals clinically diagnosed with DubS. After genome-wide sequencing, rare variant filtering and computational and Mendelian genomic analyses, a presumptive molecular diagnosis was made in 13/27 (48%) families. The molecular diagnoses included biallelic variants in SKIV2L, SLC35C1, BRCA1, NSUN2; de novo variants in ARID1B, ARID1A, CREBBP, POGZ, TAF1, HDAC8, and copy-number variation at1p36.11(ARID1A), 8q22.2(VPS13B), Xp22, and Xq13(HDAC8). Variants of unknown significance in known disease genes, and also in genes of uncertain significance, were observed in 7/27 (26%) additional families. Only one gene, HDAC8, could explain the phenotype in more than one family (N = 2). All but two of the genomic diagnoses were for genes discovered, or for conditions recognized, since the introduction of next-generation sequencing. Overall, the DubS-like clinical phenotype is associated with extensive locus heterogeneity and the molecular diagnoses made are for emerging clinical conditions sharing characteristic features that overlap the DubS phenotype
Alternative genomic diagnoses for individuals with a clinical diagnosis of Dubowitz syndrome
- Author
- C. C. (Care4Rare Consortium)
- C. F. (Centers For Mendelian Genomics)
- Agrawal P. B. (Pankaj B.)
- Al Sharhan H. (Hind)
- Aleck K. A. (Kyrieckos A.)
- Antaki D. (Danny)
- Au P. B. (Ping-Yee B.)
- Aydin H. (Hatip)
- Bamshad M. J. (Michael J.)
- Beggs A. H. (Alan H.)
- Bilguvar K. (Kaya)
- Blue E. E. (Elizabeth E.)
- Boerwinkle E. (Eric)
- Boycott K. M. (Kym M.)
- Brand H. (Harrison)
- Brownstein C. A. (Catherine A.)
- Buyske S. (Steve)
- Chodirker B. (Bernard)
- Choi J. (Jungmin)
- Chudley A. E. (Albert E.)
- Clericuzio C. L. (Carol L.)
- Coban Akdemir Z. (Zeynep)
- Cox G. F. (Gerald F.)
- Curry C. (Cynthia)
- De Boer E. (Elke)
- De Vries B. B. (Bert B. A.)
- Dunn K. (Kathryn)
- Dutmer C. M. (Cullen M.)
- Dyment D. A. (David A.)
- England E. M. (Eleina M.)
- Fahrner J. A. (Jill A.)
- Garcia Minaur S. (Sixto)
- Geckinli B. B. (Bilgen B.)
- Genetti C. A. (Casie A.)
- Gezdirici A. (Alper)
- Gibson W. T. (William T.)
- Gleeson J. G. (Joseph G.)
- Greenberg C. R. (Cheryl R.)
- Hall A. (April)
- Hamosh A. (Ada)
- Hartley T. (Taila)
- Innes A. M. (A. Micheil)
- Jhangiani S. N. (Shalini N.)
- Karaca E. (Ender)
- Kernohan K. (Kristin)
- Lauzon J. L. (Julie L.)
- Lewis M. E. (M. E. Suzanne)
- Lowry R. B. (R. Brian)
- López-Giráldez F. (Francesc)
- Matise T. C. (Tara C.)
- McEvoy-Venneri J. (Jennifer)
- McInnes B. (Brenda)
- Mhanni A. (Aziz)
- Moilanen J. (Jukka)
- Nguyen A. (An)
- Nickerson D. A. (Deborah A.)
- Nowaczyk M. J. (Malgorzata J. M.)
- O'Donnell-Luria A. (Anne)
- Pajusalu S. (Sander)
- Pehlivan D. (Davut)
- Penney L. S. (Lynette S.)
- Posey J. E. (Jennifer E.)
- Poterba T. (Timothy)
- Prontera P. (Paolo)
- Rodovalho Doriqui M. J. (Maria Juliana)
- Sawyer S. L. (Sarah L.)
- Sobreira N. (Nara)
- Stanley V. (Valentina)
- Torun D. (Deniz)
- Wargowski D. (David)
- Witmer P. D. (P. Dane)
- Wong I. (Isaac)
- Xing J. (Jinchuan)
- Zaki M. S. (Maha S.)
- Zhang Y. (Yeting)
- Õunap K. (Katrin)
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Abstract
Dubowitz syndrome (DubS) is considered a recognizable syndrome characterized by a distinctive facial appearance and deficits in growth and development. There have been over 200 individuals reported with Dubowitz or a “Dubowitz-like” condition, although no single gene has been implicated as responsible for its cause. We have performed exome (ES) or genome sequencing (GS) for 31 individuals clinically diagnosed with DubS. After genome-wide sequencing, rare variant filtering and computational and Mendelian genomic analyses, a presumptive molecular diagnosis was made in 13/27 (48%) families. The molecular diagnoses included biallelic variants in SKIV2L, SLC35C1, BRCA1, NSUN2; de novo variants in ARID1B, ARID1A, CREBBP, POGZ, TAF1, HDAC8, and copy-number variation at1p36.11(ARID1A), 8q22.2(VPS13B), Xp22, and Xq13(HDAC8). Variants of unknown significance in known disease genes, and also in genes of uncertain significance, were observed in 7/27 (26%) additional families. Only one gene, HDAC8, could explain the phenotype in more than one family (N = 2). All but two of the genomic diagnoses were for genes discovered, or for conditions recognized, since the introduction of next-generation sequencing. Overall, the DubS-like clinical phenotype is associated with extensive locus heterogeneity and the molecular diagnoses made are for emerging clinical conditions sharing characteristic features that overlap the DubS phenotype
Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial.
- Author
- Adam Fiona
- Adamali Huzaifa
- Adams Nick
- Ahmed Mohammed
- Alderman Joseph
- Alfridi Afaq
- Ali Liaquat
- Alloway Karen
- Antoine-Pitterson Pearlene
- Anumakonda Vikram
- Arndtz Sophie
- Attwood Ben
- Atwal Inderjit
- Babores Marta
- Baillie J. Kenneth
- Bainbridge Pamela
- Baker Laurence
- Bakerly Nawar
- Bamford Amy
- Bancroft Hollie
- Bangash Mansoor
- Barns Debi
- Baryschpolec Sonia
- Bates Michelle
- Beeby Deborah
- Begum Safia
- Bell Stephanie
- Bellamy Mary
- Bentley Andrew
- Bergin Colin
- Bhandal Khushpreet
- Bhatnagar Rahul
- Bibby Anna
- Bigg Julie
- Birkhamshaw Ed
- Black Ethel
- Black Karen
- Blackledge Bethan
- Bloch Susannah
- Board Perry
- Boschi Samuele
- Boyle Rosalind
- Bozic Will
- Bradburn Kirstie
- Bradley Judy M.
- Brindle Kayleigh
- Brown Jaclyn
- Brown Michael
- Buckman Carol
- Burhan Hassan
- Burrows Kate
- Burton Ben
- Burton Matthew
- Buttle Tom
- Carey John
- Carlin Chris
- Carnahan Mandy
- Carpenter Mark
- Catlow Laura
- Chabo Cathleen
- Charles Bethan
- Chauhan Varun
- Chotalia Minesh
- Chue Amy
- Clarke Sam
- Clarke Sarah
- Clarke Sheron
- Clements Suzanne
- Clive Amelia
- Coates Jim
- Cochrane Patricia
- Collins Ben
- Concannon Donal
- Connolly Bronwen A.
- Cooper Brendan
- Cooper Lauren
- Cooper Simon
- Couper Keith
- Cowan Elena
- Crawshaw Anjali
- Crooks Michael
- Crowley Louise
- Daffern Claire
- Dalemo Keji
- Darbyshire Alex
- Dark Paul
- Dark Paul
- Dave Chirag
- Davey Fleur
- David Mini
- De Soyza Anthony
- De Wong Huan
- De-Soyza Anthony
- Dennis Anna V.
- Devrell Anne
- Dhani Sundip
- Dhasmana Devesh
- Dight Emily
- Diver Sarah
- Dodd James
- Doidge James
- Donaldson Denise
- Doonan Reece
- Dosanjh Davinder
- Douse Jonathon
- Duffy Nick
- Duncan Tracy
- Edwards Helena
- Edwards Julia
- Edwards Sarah
- El Khaleq Yazeed Abed
- Elneima Omer
- Fairbairn Sara
- Fairbairn Sara
- Faruqi Shoaib
- Felongco Mae
- Ferguson Kathryn
- Fletcher Simon
- Flockton Rachel
- Forster Elliott
- Fox Lauren
- Francis Rebecca
- Fuller Liz
- Fullerton Duncan
- Gabriel Claire
- Gallagher Emma
- Gane Matthew
- Garner Zoe
- Gautam Manish
- Gendall Emma
- Ghani Hakim
- Ghattas Sandy
- Ghuman Belinder
- Giles Ben
- Glass Lynn
- Glynn Patricia
- Goff Elizabeth
- Gogokhia Atena
- Gompertz Simon
- Gorman Ellen A.
- Gosling Sally
- Gray Alasdair
- Gray Georgina
- Green Alastair
- Green Chris
- Green Christopher A.
- Green William
- Griffiths Nicola
- Grummett Jo
- Guck Johnny
- H-Davies Yasmin
- Hacon Christian
- Hamill Raymond
- Hamilton David O.
- Hamilton Leigh
- Hamilton Louisa
- Hardy Emma
- Hart Nicholas
- Harvey Alice
- Harvey Dan
- Harvey Matt
- HASH(0x55aa099b6600)
- Hawes Liz
- Hawkins Peter
- Hayton Emma
- Hee Siew Wan
- Hersey Peter
- Hicks Alexander
- Higbee Daniel
- Hill Cat
- Hill Maddy
- Holland Maureen
- Hopkins Bridget
- Horner Dan
- Hossain Ejaz
- Houghton Catherine
- Houston Tom
- Hughes Paul R.
- Hunter Karl
- Huq Syed S.
- Hutchinson Dorothy
- Ibrahim Wadah
- Innes Nicholas
- Innes Richard
- Irving Ben
- Jennings Louise
- Jha Rajeev
- Jhanji Shaman
- Ji Chen
- Johnston Brian
- Jones Beth
- Joseph Rosane
- Kelly Lisa
- Kelly Martin
- Kimbley Zoe
- Knowles Karen
- Konda Shruthi
- Krishnamurthy Vinodh
- Lall Ranjit
- Lameirinhas Claudia
- Land David
- Lane Steph
- Lankester Liana
- Le Breuilly Martin
- Lear Gary
- Lee Hannah
- Lee Kai
- Lee Stephanie
- Lee Xiang
- Leech Claire
- Lees Diana
- Lentaigne Julian
- Lenton Daniel
- Linhartova Lucie
- Linkson Lynette
- Lopez Maria
- Lowe Catherine
- Lowsby Richard
- Lugg Sebastian
- Lui Patrick
- Lynch Daniella
- MacDonald Chloe
- MacDonald Sonia
- Mackenzie Joe
- Madathil Shyam
- Madathil Shyam
- Mahadevan Venkat
- Mahadevan Venkateswaran
- Majeed Nasir
- Mamman Madhu
- Manan Sana
- Marsden Tracy
- McAlinden Paul
- McAndrew Paul
- McAuley Daniel F.
- McAuley Hamish J. C.
- McClintock Declan
- McGarry Erin
- McGhee Christopher
- McGowan Nicola
- McGregor Amanda
- McKemey Emily
- McMillan Alison
- McMorrow Liam
- Mehta Meera
- Messer Ben
- Messer Benjamin
- Milne Alice
- Miodragovic Serge
- Moon Maria
- Moreland Gayle
- Morley Anna
- Morrison Andrew
- Moudgil Harmesh
- Muhammad Ambreen
- Mulla Suleman
- Mundin Rachel
- Murray Lisa
- Murray Sarah
- Mussawar Gulfam
- Muthiah Chockalingam
- Myint Yadee M. M.
- Naftel Jen
- Nagarajan Thapas
- Naisbitt Jay
- Navarro Alessio
- Naylor Jon
- Nesbitt Jay
- Neville Daniel
- Ng Man Kwong Georges
- Norman Chloe
- Normanton Robert
- O'Connor Laura
- O'Riordan Devaki
- Oelofse Tessa
- O’Farrell Stephen
- O’Kane Cecilia
- Packer Gregory
- Padfield Emma
- Page Matt
- Pagett Katherine
- Parekh Dhruv
- Parekh Dhruv
- Parkin Emma M.
- Parsons Penny
- Patel Jaimin
- Patel Jaimin
- Patel Mamta
- Patel Manish
- Pearson Claire (Rebecca)
- Pendlebury Jessica
- Penman Julie
- Pennington Christopher
- Perez Jane
- Perkins Gavin D.
- Perry Emily
- Pinder Emma
- Pooley Justine
- Proudfoot Nicola
- Purewal Bally
- Rabbani Rana
- Rai Jeskaran
- Rao Deepak
- Rauf Farrukh
- Raynes Kerry
- Reddy Harsha
- Regan Scott
- Richardson Maxwell
- Rippon Naomi
- Rivers Vanessa
- Roberts Claire
- Rochester Adam
- Rodgers Elaine
- Roman Jaime F.
- Ross Clare
- Ross Clare
- Rossall Clare
- Rostron Anthony
- Rostron Anthony J.
- Rowley Megan
- Roy Alistair
- Rupani Hitasha
- Russell Richard J.
- Saim Mohammad
- Saim Mohammad
- Salmon Natasha
- Sanctuary Thomas
- Sandrey Victoria
- Scott Greg
- Sehgal Nita
- Senior Kay F.
- Shackleford Helen
- Shah Peer A.
- Shalan Korah
- Shaw David
- Shepherd Kate
- Simonds Anita K.
- Simonds Anita K.
- Skilton Emma
- Slaughter Melanie
- Smith Andrew
- Smith David
- Smith Kerry
- Smuts Sara
- Snelson Catherine
- Solomon Louise
- Staddon Louise
- Stallard Nigel
- Steiner Michael
- Steiner Michael
- Stewart Colin
- Stimpson Emily
- Strickland Natalie
- Sundayi Saul
- Sutton Benjamin
- Szarazova Nina
- Talbot Nicholas
- Tate Matthew
- Tatham Kate C.
- Taylor Melanie
- Tengende Joyce
- Tey Chia L.
- Thackray-Nocera Susannah
- Thomas Victoria
- Thompson Fiona
- Thompson Richard
- Thompson Rob
- Thornley Sarah
- Thrasyvoulou Laura
- Tsakiridou Kyriaki
- Turner Richard D.
- Turnpenny Beth
- Vancheeswaran Rama
- Vancheeswaran Rama
- Veenith Tonny
- Vidler Jennifer
- Vythilingam Siyamini
- Waddy Samuel D.
- Waite Alicia
- Wakinshaw Fiona
- Walsh Berni
- Watkins Emma
- Watson Mark
- Waugh Victoria
- Welbourne Jessie
- Welch Hugh
- Wells Colin
- Welters Ingeborg
- West Sophie D.
- Wheeler Helen
- White Marie
- Whitehouse Tony
- Wiffen Laura
- Wilhelmsen Elva
- Williams Karen
- Williams Rachel
- Willis Adrian
- Willis Heather
- Wilson Jeremy
- Winter Jonathan
- Wood Jill
- Woods Lindsey
- Woolhouse Ian
- Wright Harriet
- Yang Yingjja
- Yeung Joyce
- Yousuf Ahmed
- Zaki Ahmed
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 24/01/2022
- Field of study
Importance
Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) have been recommended for acute hypoxemic respiratory failure in patients with COVID-19. Uncertainty exists regarding the effectiveness and safety of these noninvasive respiratory strategies.
Objective
To determine whether either CPAP or HFNO, compared with conventional oxygen therapy, improves clinical outcomes in hospitalized patients with COVID-19-related acute hypoxemic respiratory failure.
Design, Setting, and Participants
A parallel group, adaptive, randomized clinical trial of 1273 hospitalized adults with COVID-19-related acute hypoxemic respiratory failure. The trial was conducted between April 6, 2020, and May 3, 2021, across 48 acute care hospitals in the UK and Jersey. Final follow-up occurred on June 20, 2021.
Interventions
Adult patients were randomized to receive CPAP (n = 380), HFNO (n = 418), or conventional oxygen therapy (n = 475).
Main Outcomes and Measures
The primary outcome was a composite of tracheal intubation or mortality within 30 days.
Results
The trial was stopped prematurely due to declining COVID-19 case numbers in the UK and the end of the funded recruitment period. Of the 1273 randomized patients (mean age, 57.4 [95% CI, 56.7 to 58.1] years; 66% male; 65% White race), primary outcome data were available for 1260. Crossover between interventions occurred in 17.1% of participants (15.3% in the CPAP group, 11.5% in the HFNO group, and 23.6% in the conventional oxygen therapy group). The requirement for tracheal intubation or mortality within 30 days was significantly lower with CPAP (36.3%; 137 of 377 participants) vs conventional oxygen therapy (44.4%; 158 of 356 participants) (absolute difference, -8% [95% CI, -15% to -1%], P = .03), but was not significantly different with HFNO (44.3%; 184 of 415 participants) vs conventional oxygen therapy (45.1%; 166 of 368 participants) (absolute difference, -1% [95% CI, -8% to 6%], P = .83). Adverse events occurred in 34.2% (130/380) of participants in the CPAP group, 20.6% (86/418) in the HFNO group, and 13.9% (66/475) in the conventional oxygen therapy group.
Conclusions and Relevance
Among patients with acute hypoxemic respiratory failure due to COVID-19, an initial strategy of CPAP significantly reduced the risk of tracheal intubation or mortality compared with conventional oxygen therapy, but there was no significant difference between an initial strategy of HFNO compared with conventional oxygen therapy. The study may have been underpowered for the comparison of HFNO vs conventional oxygen therapy, and early study termination and crossover among the groups should be considered when interpreting the findings.
Trial Registration
isrctn.org Identifier: ISRCTN16912075
Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19
- Author
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Aguilar-Dano April
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Amri Ali
- Al Enezi Farhan
- Al Qasim Eman
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderink Bashar
- Alderman Meera
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Farisha
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Alqahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Amatya Sameena
- Ambrosino Richard
- Anders Jeanette
- Anderson Thomas
- Andreae Mark
- Andric Zdravko
- Angus Derek
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Apte Yogesh
- Arabi Yaseen
- Arachchige Malka
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Aryal Diptesh
- Asif Namra
- Aspinwall Angelique
- Attanayaka Udara
- Attokaran Antony
- Attwood Ben
- Au Carly
- Austin Karen
- Austin Pauline
- Avard Bronwyn
- Awan Sidra
- Azaiz Amine
- Azergui Nora
- Azzaui Harun
- Babel Jakša
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Baillie Kenneth
- Bain William
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barbazza Leanne
- Barber Russell
- Barbier François
- Barge Deborah
- Bari Sara
- Bariola Ryan
- Barker Gareth
- Barnes Nicky
- Baron Rebecca
- Barreau Amelie
- Bart Robert
- Bartholdy Roland
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastola Sirjana
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bean Sarah
- Beane Abi
- Beard Gregory
- Beasley Richard
- Beavis Sarah
- Bedford Caroline
- Beer Deborah
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Beltran Mercedes
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Benyon Sarah
- Benzekri Dalila
- Berdaguer Fernando
- Bergin Colin
- Berry Lindsay
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bhattarai Binita
- Bhimani Zahra
- Bhonagiri Deepak
- Biddie Simon
- Bihari Shailesh
- Binnie Alexandra
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Bland Yvonne
- Blank Elisabeth
- Bloos Frank
- Board Jasmin
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Hélène
- Bojunga Jörg
- Bone Allison
- Bonner Stephen
- Bonten Marc
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brajković Ana
- Brakké Karen
- Brant Emily
- Breen Patrick
- Bremmer Pamela
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brieger Klaus-Gerd
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Louise
- Browne Troy
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank
- Brunskill Nigel
- Bryan-Morris Kayla
- Buchanan Philip
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Bélteczki János
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callender Owen
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Lewis
- Campbell Ryan
- Campisi Josie
- Campos Sara
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Frédérick
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Brittney
- Carter David
- Carter Jay
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- Raithatha Ajay
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- Ramakrishnan N
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- Schueler Robert
- Schuster-Bruce Martin
- Schutgens Roger
- Schweikert Sacha
- Schütze Bianka
- Scott Kathryn
- Scott Paula
- Scott Zoe
- Scully Michael
- Seaman Rebecca
- Seidu Fatima
- Sekiwala Rose
- Sellers Katharine
- Selmi Carlo
- Sement Arnaud
- Senya Ho
- Seppelt Ian
- Serpa-Neto Ary
- Serri Karim
- Sever Helena
- Sevilla Chanthou
- Seymour Christopher
- Shah Asim
- Shah Faraaz
- Shahid Tasnin
- Shaikh Mohiuddin
- Shankar-Hari Manu
- Shaw David
- Shaw Deborah
- Shaw Joanne
- Shearer Audrey
- Sheath Ben
- Shehabi Yahya
- Shekar Kiran
- Shelton Sarah
- Shetty Varun
- Shimabukuro-Vornhagen Alexander
- Shovelton Charmaine
- Shree Madhu
- Shrestha Tapaswi
- Shuker Karen
- Shyamsundar Murali
- Siami Shidasp
- Sibin Sindhu
- Sicat Christine
- Siddiqui Atif
- Siddiqui Ayesha
- Sidéris Georgios
- Sikondari Nyma
- Silversides Jon
- Sim Malcolm
- Simmonds Catherine
- Simons Koen
- Simpson Benjamin
- Simpson Joanna
- Simpson Scott
- Simpson Tom
- Sinclair Julie-Ann
- Singh Jayaprakash
- Singh Rajeev
- Singh Vanessa
- Singleton Jo
- Sinha Pratik
- Skinner Denise
- Skorko Agnieszka
- Skrtich Aimee
- Slaughter Melanie
- Slieker Kitty
- Sligl Wendy
- Sloots-Cuppen Sonja
- Small Charlotte
- Smallwood Andrew
- Smee Joanna
- Smit Albertine
- Smith Alex
- Smith Catherine
- Smith Emma
- Smith John
- Smith Judith
- Smith Julie
- Smith Lucie
- Smith Matthew
- Smith Paul
- Smith Roger
- Smith Simon
- Smith Tim
- Smuts Sara
- Smyth Kirsty
- Smyth Michelle
- Smyth Naoise
- Soar Natalie
- Solesbury Amanda
- Somerville Alastair
- Song Rima
- Soukup Jens
- Southern David
- Southin Sara
- Spain Sandra
- Spencer Stephen
- Spencer Thomas
- Speyer Rebecca
- Spittle Nick
- Spivey Michael
- Spong Adam
- Sprinckmoller Stefan
- Squires Rebecca
- Stambaugh Martha
- Stammers Katie
- Stanciu Delia
- Stanworth Simon
- Starke Lisa
- Stavor Dara
- Stedman Roger
- Steffen Melanie
- Stephanie Gelinotte
- Sterba Martin
- Stevenson Lesley
- Stewart Richard
- Stone Sarah
- Stratton Emma
- Stronach Lucy
- Subbanna Umesh
- Suber Tomeka
- Sukuraman Anila
- Summerfield Anna
- Summers Charlotte
- Sundaram Radha
- Sundaran Dhinesh
- Surti Zuhra
- Sutherland Helen
- Sutherland Sara-Beth
- Sutterlin Laetitia
- Sutton Joanne
- Svitškar Nikolai
- Swabe Jacqueline
- Sweet Katie
- Sy Eric
- Szakmany Tamas
- Szigligeti Gábor
- Szőke Viktória
- Tai Charlotte
- Talia Nadine
- Tallott Mandy
- Tamme Kadri
- Taqdees Huda
- Tarr Esther
- Tate Margaret
- Tatham Kate
- Taylor Holly
- Taylor Melanie
- Templeton Maie
- Thomas Amy
- Thomas Emma
- Thomas Helen
- Thomas Matt
- Thomas Vicky
- Thompson Patricia
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Thurairatnam Saranya
- Tierney Carey
- Tinmouth Alan
- Tlayjeh Haytham
- Toffalo Sue
- Tolppa Timo
- Tomlinson Helen
- Tong Steve
- Tong Steven
- Tony Kiran
- Totzke Juliane
- Touma Omar
- Towns Miriam
- Trapani Tony
- Trask Kara
- Traverse Eleanor
- Tridente Ascanio
- Trim Fiona
- Trimmer Ken
- Triulzi Darrell
- Troeman Darren
- Trues Estefania
- Truman Nicholas
- Tsakiridou Kyriaki
- Tsang Jennifer
- Tsinaslanidis Georgios
- Tuckwell Caroline
- Tully Redmond
- Tully Riona
- Tung Raymond
- Turgeon Alexis
- Turki Salah
- Turner Anne
- Turner Keri
- Turner-Bone Ian
- Turns Margaret
- Tv Bharath
- Udayanga Ishara
- Uddin Ruzena
- Udy Andrew
- Umrani Zulfiqar
- Uriel Alison
- Ustianowski Andrew
- Uyeki Tim
- Vaara Suvi
- Vaduganathan Muthiah
- Vahtera Annukka
- Vale Cassandra
- Valentine Eliza
- Vamplew Luke
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van Bree Sjoerd
- van de Veerdonk Frank
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
- van der Heyden Kymbalee
- van der Kraan-Donker Annemarie
- van Gulik Laura
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Oosten Nienke
- van Opdorp Marjolein
- van Vonderen Marit
- van Zanten Arthur
- van Zuylen Tamara
- Vanjak Christian
- Vanmali Piyush
- Vargas Jr. Jesus
- Varghese Siby
- Vautier Sarah
- Vazquez-Grande Gloria
- Veenith Tonny
- Venkatesh Bala
- Venz Ellen
- Verlander Mark
- Vermassen Joris
- Vermeiren Daisy
- Verrier Nathalie
- Vertue Mark
- Verula Jerik
- Victor Saji
- Viehman Alex
- Vieillard-Baron Antoine
- Vignesh C
- Vincent Rachel
- Virdee Satwinder
- Visser Yorik
- Vita Tina
- Vodovar Dominique
- Voicu Sebastian
- Voigt Ingo
- Voiriot Guillaume
- Voza Antonio
- Vrolijk Loes
- Vuylsteke Alain
- Wagh Atul
- Wahl Nadine
- Waite Alicia
- Walden Andrew
- Walker Gena
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Wang Shu
- Ward Geraldine
- Ward Kathryn
- Ward Luke
- Warnapura Loku
- Warnock Majella
- Watchorn Olivia
- Waters Abby
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watts Angela
- Waugh Victoria
- Webb Steve
- Weber Lisa
- Weerasinghe Thanuja
- Weismann Dirk
- Weiss Daniel
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Whitehouse Tony
- Wibrow Bradley
- Wigbers Jeanette
- Wilby Elizabeth
- Wilcox Elizabeth
- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Karen
- Williams Patricia
- Williams Tony
- Williams Virginie
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wiseman Sophie
- Wisniewski Mary
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Helen
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yang Yang
- Yarad Elizabeth
- Yates David
- Yealy Donald
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Đimoti Renata
- Publication venue
- American Medical Association
- Publication date
- 05/04/2022
- Field of study
International audienc