Propuesta de rediseño de distribución de planta y proceso de Picking en el Banco de alimentos de Bogotá

El presente documento incluye el análisis de las problemáticas encontradas en el Banco de Alimentos de Bogotá, la creación de las propuestas para mejorar la operación de la bodega 5 de dicha Fundación, el análisis de los resultados obtenidos y la medición del impacto generado. El Banco de Alimentos de Bogotá cuenta con una bodega encargada de todos los procesos logisticos de los productos no alimenticios (Bodega 5). Con objetivo de mejorar su operación, se realizó un estudio de oportunidades el cual derivó en varias propuestas de mejora. Estas propuestas se basan principalmente en la implementación del sistema de codificación UNSPSC, la utilización de un sistema de información para el correcto control y futuro desarrollo de indicadores de gestión, un nuevo diseño de layout de la bodega basado en la categorización ABC de los productos y otras políticas, y un modelo matemático que reduce la distancia necesaria para completar una orden de pedido de 15 elementos.This document includes the analysis of problems found at the “Banco de .Alimentos de Bogota" food bank, the proposals to improve the operation of the non- alimentary warehouse (Warehouse 5), the analysis of the obtained results after performing the proposals and the measurement of it’s impact. The “Banco de Alimentos de Bogota” food bank has a warehouse ( Warehouse 5) dedicated to non - alimentary products and their logistics processes. In order to improve its operation, a study of opportunities was carried out, which led to several improvement proposals. These proposals are mainly based on the implementation of the UNSPSC coding system, the use of an information system to improve the inventory control and future development of performance indicators, a new layout design of the warehouse based on the ABC categorization of the products and other policies, and a mathematical model that reduces the distance needed to complete a 15-item order.Ingeniero (a) IndustrialPregrad

VECTOS: An Integrated System for Monitoring Risk Factors Associated With Urban Arbovirus Transmission.

In Colombia, as in many Latin American countries, decision making and development of effective strategies for vector control of urban diseases such as dengue, Zika, and chikungunya is challenging for local health authorities. The heterogeneity of transmission in urban areas requires an efficient risk-based allocation of resources to control measures. With the objective of strengthening the capacity of local surveillance systems to identify variables that favor urban arboviral transmission, a multidisciplinary research team collaborated with the local Secretary of Health officials of 3 municipalities in Colombia (Giron, Yopal, and Buga), in the design of an integrated information system called VECTOS from 2015 to 2018. Information and communication technologies were used to develop 2 mobile applications to capture entomological and social information, as well as a web-based system for the collection, geo-referencing, and integrated information analysis using free geospatial software. This system facilitates the capture and analysis of epidemiological information from the Colombian national surveillance system (SIVIGILA), periodic entomological surveys-mosquito larvae and pupae in premises and peridomestic breeding sites-and surveys of knowledge, attitudes, and practices (KAP) in a spatial and temporal context at the neighborhood level. The data collected in VECTOS are mapped and visualized in graphical reports. The system enables real-time monitoring of weekly epidemiological indicators, entomological indices, and social surveys. Additionally, the system enables risk stratification of neighborhoods, using selected epidemiological, entomological, demographic, and environmental variables. This article describes the VECTOS system and the lessons learned during its development and use. The joint analysis of epidemiological and entomological data within a geographic information system in VECTOS gives better insight to the routinely collected data and identifies the heterogeneity of risk factors between neighborhoods. We expect the system to continue to strengthen vector control programs in evidence-based decision making and in the design and enhanced follow-up of vector control strategies

Conocimientos, actitudes y prácticas sobre dengue, tras aplicación de estrategias de movilización social. Yopal-Casanare, Colombia, 2012

Introduction: in Colombia, Casanare is one of the departments with the greatest dengue transmission. Its main city, Yopal, implemented as of 2008 strategies of social mobilization (COMBI) to control the disease. The study objective was to identify knowledge, attitudes and practices (KAP) about dengue to strengthen actions on information, education, communication and control/prevention.Materials and methods: cross-sectional descriptive study; KAP-survey application at urban zone; analysis of data/variables with Epi-Info 3.5.1® with descriptive statistics.Results: 120 subjects surveyed; women 73,3%; median age 36-yr (range 12-82); dominant age-group was 14-44 (63,3%); average time of residence 17-yr (1-34); 97,5% knew about dengue; 64,5% knew about Aedes aegypti vector transmission. On control measures, 91,7% were informed about recipients' destruction; 89,8% about habitats' elimination; 67,5% answered everyone is responsible of control measures.Conclusions: awareness on dengue as disease by identifying both vector and control mechanisms; people considered everyone's participation and responsibility for dengue control. To continue and promote communitary participation, to make articulated, continued activities to strengthen habits and to invite children to replicate these practices.Introducción: en Colombia, entre los departamentos de mayor transmisión del dengue está Casanare. Yopal, su capital desde 2008 ha implementado estrategias de movilización social (COMBI) para controlarlo.Objetivo: identificar conocimientos-actitudes-prácticas (CAP) sobre dengue, para fortalecer acciones de información, educación, comunicación de control/ prevención.Materiales y métodos: estudio descriptivo transversal, aplicación en zona urbana de encuesta-CAP, análisis de variables con Epi-Info 3.5.1® mediante estadística descriptiva.Resultados: 120 encuestados, mujeres 73,3%, mediana de edad 36 (rango 12-82) años; grupo etario predominante 14-44 (63,3%); promedio residencia 17(±1-34) años; conocían el dengue 97,5%, vector transmisor Aedes aegypti64,2%. Medidas de control: destrucción de recipientes 91,7%, eliminación de criaderos 89,8%; responsables del control: todos 67,5%.Conclusiones: reconocimiento del dengue como enfermedad, identificando vector y mecanismos de control; consideraron la participación de todos como responsables de su control. Continuar/promover la participación comunitaria, realizar actividades articuladas/continuas para reforzar hábitos e invitar a la población infantil a replicar su práctica

Presentación de paciente con ofidotoxicosis severa

El ofidismo en el mundo es un problema sanitario al que debe prestársele especial atención por causa de las características clínicas y las situaciones epidemiológicas en que se presentan las mordeduras de serpientes venenosas. Este problema posee el agravante adicional de que, generalmente, es sufrido por individuos de escasos recursos económicos y de poblaciones marginales.  Se realizó una revisión bibliografía relacionada con la temática. Presentación de un caso. The ophidism in the world is a health problem that must be given special attention because of the clinical characteristics and epidemiological situations in which poisonous snake bites occur. This problem has the additional aggravation that, generally, it is suffered by individuals of limited economic resources and marginal populations. A literature review related to the subject was carried out. Presentation of a cas.O ofidismo no mundo é um problema de saúde que merece atenção especial devido às características clínicas e situações epidemiológicas em que ocorrem as picadas de cobras venenosas. Este problema tem o agravamento adicional que, geralmente, é sofrido por indivíduos de recursos econômicos limitados e populações marginais. Uma revisão de literatura relacionada ao assunto foi realizada. Apresentação de um cas

Potential Involvement of Oxidative Stress, Apoptosis and Proinflammation in Ipconazole-Induced Cytotoxicity in Human Endothelial-like Cells

2022 Descuento MDPITriazole fungicides are widely used in the world, mainly in agriculture, but their abuse and possible toxic effects are being reported in some in vivo and in vitro studies that have demonstrated their danger to human health. This in vitro study evaluated the cytotoxicity, oxidative stress and proinflammation of EA.hy926 endothelial cells in response to ipconazole exposure. Using the MTT assay, ipconazole was found to produce a dose-dependent reduction (*** p < 0.001; concentrations of 20, 50 and 100 µM) of cell viability in EA.hy926 with an IC50 of 29 µM. Also, ipconazole induced a significant increase in ROS generation (** p < 0.01), caspase 3/7 (** p < 0.01), cell death (BAX, APAF1, BNIP3, CASP3 and AKT1) and proinflammatory (NLRP3, CASP1, IL1β, NFκB, IL6 and TNFα) biomarkers, as well as a reduction in antioxidant (NRF2 and GPx) biomarkers. These results demonstrated that oxidative stress, proinflammatory activity and cell death could be responsible for the cytotoxic effect produced by the fungicide ipconazole, such that this triazole compound should be considered as a possible risk factor in the development of alterations in cellular homeostasis.Universidad Intercultural de la Amazonia VPIDepto. de Farmacología y ToxicologíaFac. de FarmaciaTRUEpubDescuento UC

Primer consenso colombiano sobre Chagas congénito y orientación clínica a mujeres en edad fértil con diagnóstico de Chagas

ResumenLa transmisión congénita de la enfermedad de Chagas ha sido poco estudiada en Colombia y existen pocos procedimientos rutinarios en el sistema de salud para el manejo de esta enfermedad. Por ello se desarrolló un consenso de expertos dirigido a generar recomendaciones de diagnóstico y tratamiento de Chagas congénito y orientación a mujeres en edad fértil. Con ese propósito se realizó una búsqueda extensiva de la literatura, empleando una combinación de términos MeSH (Chagas, Chagas congénito, prevención, control, diagnóstico, tratamiento y embarazo) para reflejar el estado del arte en cada tema de interés. Después de ello, se leyeron los resúmenes y aquellos seleccionados para análisis del texto completo. La literatura relevante se sintetizó, clasificó y organizó en tablas y se presentó al panel de expertos, el cual estaba constituido por 30 profesionales en diferentes áreas. Mediante la metodología Delphi se realizaron 2 rondas de cuestionarios virtuales y una reunión presencial en los cuales se evaluaron los niveles de acuerdo entre los participantes. Los puntos con falta de consenso durante las 2 rondas virtuales se expusieron durante las mesas de discusión en la ronda presencial. La evidencia utilizada se adaptó a las particularidades nacionales según el caso y se aprobó el contenido del documento final. Se propone que estas recomendaciones sean usadas por profesionales de la salud en Colombia.AbstractCongenital transmission of Chagas disease has not been extensively studied in Colombia, and there are no standardized processes in the health system regarding the specific diagnosis, treatment and follow-up of this disease. In order to generate recommendations on congenital Chagas disease and Chagas in women of childbearing age in Colombia, a consensus of experts was developed. An extensive literature search through the Medline database was carried out using the MeSH terms: «Chagas disease/congenital», «prevention and control», «diagnosis», «therapeutics» and «pregnancy». Appropriate abstracts were selected and the full texts were analyzed. The relevant information was synthesized, classified, and organized into tables and figures and was presented to a panel of experts, which was composed of 30 professionals from various fields. Based on the Delphi methodology, three rounds of consultation were conducted. The first and second rounds were based on electronic questionnaires that measured the level of consensus of each question among the participants. The third round was based on a face-to-face discussion focusing on those questions without consensus in the previous consultations. The evidence was adapted to national circumstances on a case-by-case basis, and the content the final document was approved. These recommendations are proposed for use in routine medical practice by health professionals in Colombia

Primer consenso colombiano sobre Chagas congénito y orientación clínica a mujeres en edad fértil con diagnóstico de Chagas

La transmisión congénita de la enfermedad de Chagas ha sido poco estudiada en Colombia y existen pocos procedimientos rutinarios en el sistema de salud para el manejo de esta enfermedad. Por ello se desarrolló un consenso de expertos dirigido a generar recomendaciones de diagnóstico y tratamiento de Chagas congénito y orientación a mujeres en edad fértil. Con ese propósito se realizó una búsqueda extensiva de la literatura, empleando una combinación de términos MeSH (Chagas, Chagas congénito, prevención, control, diagnóstico, tratamiento y embarazo) para reflejar el estado del arte en cada tema de interés. Después de ello, se leyeron los resúmenes y aquellos seleccionados para análisis del texto completo. La literatura relevante se sintetizó, clasificó y organizó en tablas y se presentó al panel de expertos, el cual estaba constituido por 30 profesionales en diferentes áreas. Mediante la metodología Delphi se realizaron 2 rondas de cuestionarios virtuales y una reunión presencial en los cuales se evaluaron los niveles de acuerdo entre los participantes. Los puntos con falta de consenso durante las 2 rondas virtuales se expusieron durante las mesas de discusión en la ronda presencial. La evidencia utilizada se adaptó a las particularidades nacionales según el caso y se aprobó el contenido del documento final. Se propone que estas recomendaciones sean usadas por profesionales de la salud en Colombia

First Colombian consensus on congenital Chagas and clinical approach for women of child-bearing age diagnosed with Chagas

Abstract Congenital transmission of Chagas disease has not been extensively studied in Colombia, and there are no standardized processes in the health system regarding the specific diagnosis, treatment and follow-up of this disease. To generate recommendations on congenital Chagas disease and Chagas in women of childbearing age in Colombia, a consensus of experts was developed. An extensive literature search through the Medline database was carried out using the MeSH terms: «Chagas disease/congenital», «prevention and control», «diagnosis», «therapeutics» and «pregnancy». Appropriate abstracts were selected and the full texts were analyzed. The relevant information was synthesized, classified, and organized into tables and figures and was presented to a panel of experts, which was composed of 30 professionals from various fields. Based on the Delphi methodology, three rounds of consultation were conducted. The first and second rounds were based on electronic questionnaires that measured the level of consensus of each question among the participants. The third round was based on a face-to-face discussion focusing on those questions without consensus in the previous consultations. The evidence was adapted to national circumstances on a case-by-case basis, and the content the final document was approved. These recommendations are proposed for use in routine medical practice by health professionals in Colombia

Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 M^PRO

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.SARS-CoV-2 main protease is a common target for inhibition assays due to its high conservation among coronaviruses. Since flavonoids show antiviral activity, several in silico works have proposed them as potential SARS-CoV-2 main protease inhibitors. Nonetheless, there is reason to doubt certain results given the lack of consideration for flavonoid promiscuity or main protease plasticity, usage of short library sizes, absence of control molecules and/or the limitation of the methodology to a single target site. Here, we report a virtual screening study where dorsilurin E, euchrenone a11, sanggenol O and CHEMBL2171598 are proposed to inhibit main protease through different pathways. Remarkably, novel structural mechanisms were observed after sanggenol O and CHEMBL2171598 bound to experimentally proven allosteric sites. The former drastically affected the active site, while the latter triggered a hinge movement which has been previously reported for an inactive SARS-CoV main protease mutant. The use of a curated database of 4.8 k flavonoids, combining two well-known docking software (AutoDock Vina and AutoDock4.2), molecular dynamics and MMPBSA, guaranteed an adequate analysis and robust interpretation. These criteria can be considered for future screening campaigns against SARS-CoV-2 main protease.Consejo Nacional de Ciencia, Tecnología e Innovación TecnológicaRevisión por pare