Studies on the hyperplasia ('regeneration') of the rat liver following partial hepatectomy. Changes in lipid peroxidation and general biochemical aspects

Using the experimental model of partial hepatectomy in the rat, we have examined the relationship between cell division and lipid peroxidation activity. In rats entrained to a regime of 12 h light/12 h dark and with a fixed 8 h feeding period in the dark phase, partial hepatectomy is followed by a rapid regeneration of liver mass with cycles of synchronized cell division at 24 h intervals. The latter phenomenon is indicated in this study by pulses of thymidine kinase activity having maxima at 24 h, 48 h and 72 h after partial hepatectomy. Microsomes prepared from regenerating livers show changes in lipid peroxidation activity (induced by NADPH/ADP/iron or by ascorbate/iron), which is significantly decreased relative to that in microsomes from sham-operated controls, again at 24 h, 48 h and 72 h after the operation. This phenomenon has been investigated with regard to possible underlying changes in the content of microsomal fatty acids, the microsomal enzymes NADPH:cytochrome c reductase and cytochrome P-450, and the physiological microsomal antioxidant alpha-tocopherol. The cycles of decreased lipid peroxidation activity are apparently due, at least in part, to changes in microsomal alpha-tocopherol content that are closely associated in time with thymidine kinase activity

Transport of flexible chiral objects in a uniform shear flow

The transport of slightly deformable chiral objects in a uniform shear flow is investigated. Depending on the equilibrium configuration one finds up to four different asymptotic states that can be distinguished by a lateral drift velocity of their center of mass, a rotational motion about the center of mass and deformations of the object. These deformations influence the magnitudes of the principal axes of the second moment tensor of the considered object and also modify a scalar index characterizing its chirality. Moreover, the deformations induced by the shear flow are essential for the phenomenon of dynamical symmetry breaking: Objects that are achiral under equilibrium conditions may dynamically acquire chirality and consequently experience a drift in the lateral direction.Comment: 25 pages, 16 figure

T-Bar clasp-retained removable partial denture as an alternative to implant-based prosthetic treatment

This article reports the case of a 55-year-old female patient who presented with unsatisfactory temporary crowns in the right mandibular premolars and molars, and a premolar-to-molar fixed partial denture in the left side. The clinical and radiographic examinations revealed a fracture of the left first premolar that was a retainer of the fixed partial denture and required extraction. Initially, the acrylic resin crowns were replaced by new ones, and a provisional RPD was made using acrylic resin and orthodontic wire clasps to resolve the problem arising from the loss of the fixed partial denture. Considering the patient's high esthetic demands, the treatment options for the definitive prosthetic treatment were discussed with her and rehabilitation with implant-supported dentures was proposed because the clinical conditions of the residual alveolar ridge were suitable for implant installation, and the patient's general health was excellent. However, the patient did not agree because she knew of a failed case of implant-retained denture in a diabetic individual and was concerned. The patient was fully informed that implant installation was the best indication for her case, but the arguments were not sufficient to change her decision. The treatment possibilities were presented and the patient opted for a clasp-retained removable partial denture (RPD) associated with the placement of crowns in the pillar teeth. The temporary RPD was replaced by the definitive RPD constructed subsequently. Although RPD was not the first choice, satisfactory esthetic and functional outcomes were achieved, overcaming the patient's expectations. This case report illustrates that the dentist must be prepared to deal with situations where, for reasons that cannot be managed, the patient does not accept the treatment considered as the most indicated for his/her case. Alternatives must be proposed and the functional and esthetic requirements must be fulfilled in the best possible manner.Este artigo relata o caso de uma paciente de 55 anos que apresentava no arco mandibular coroas provisórias insatisfatórias nos pré-molares do lado direito e uma prótese parcial fixa de molar a pré-molar no lado esquerdo. Os exames clínico e radiográfico revelaram uma fratura do primeiro pré-molar esquerdo que era um retentor da prótese parcial fixa e teve a extração indicada. Inicialmente, as coroas provisórias foram substituídas por novas e uma prótese parcial removível provisória foi confeccionada com resina acrílica e grampos de fio ortodôntico a fim resolver os problemas relacionados à perda da prótese parcial fixa. Considerando a forte demanda estética da paciente, foram discutidas as opções de tratamento protético definitivo. Foi proposta a reabilitação com prótese implanto-suportada uma vez que as condições clínicas do rebordo alveolar se apresentavam adequadas para instalação de implantes e a saúde geral da paciente era excelente. Entretanto, a paciente não concordou com o tratamento proposto, alegando saber de um caso clínico em que houve insucesso na reabilitação por prótese implanto-suportada em um paciente diabético. Ela foi inteiramente informada de que a colocação de implantes era a melhor indicação para seu caso, mas os argumentos não foram suficientes para mudar sua decisão. As possibilidades de tratamento foram apresentadas e a paciente optou por uma prótese parcial removível (PPR) retida a grampos associada com coroas nos dentes pilares. Na seqüência, a PPR provisória foi substituída por uma PPR definitiva. Embora a PPR não tivesse sido a primeira escolha, foram obtidos resultados estéticos e funcionais satisfatórios, superando as expectativas da paciente. Este relato de caso ilustra que o dentista deve estar preparado para enfrentar situações em que, por razões que não possam ser administradas, o paciente não aceite o tratamento considerado mais indicado para seu caso. Alternativas devem ser propostas e as exigências estéticas e funcionais devem ser contempladas da melhor maneira possível

Quantum nondemolition-like, fast measurement scheme for a superconducting qubit

We present a measurement protocol for a flux qubit coupled to a dc-Superconducting QUantum Interference Device (SQUID), representative of any two-state system with a controllable coupling to an harmonic oscillator quadrature, which consists of two steps. First, the qubit state is imprinted onto the SQUID via a very short and strong interaction. We show that at the end of this step the qubit dephases completely, although the perturbation of the measured qubit observable during this step is weak. In the second step, information about the qubit is extracted by measuring the SQUID. This step can have arbitrarily long duration, since it no longer induces qubit errors.Comment: published version, minor correction

Geometrically Induced Multiple Coulomb Blockade Gaps

We have theoretically investigated the transport properties of a ring-shaped array of small tunnel junctions, which is weakly coupled to the drain electrode. We have found that the long range interaction together with the semi-isolation of the array bring about the formation of stable standing configurations of electrons. The stable configurations break up during each transition from odd to even number of trapped electrons, leading to multiple Coulomb blockade gaps in the the $I-V$ characteristics of the system.Comment: 4 Pages (two-columns), 4 Figures, to be published in Physical Review Letter

Coherent oscillations in a Cooper-pair box

This paper is devoted to an analysis of the experiment by Nakamura {\it et al.} (Nature {\bf 398}, 786 (1999)) on the quantum state control in Josephson junctions devices. By considering the relevant processes involved in the detection of the charge state of the box and a realistic description of the gate pulse we are able to analyze some aspects of the experiment (like the amplitude of the measurement current) in a quantitative way

Crossover from weak to strong coupling regime in dispersive circuit QED

We study the decoherence of a superconducting qubit due to the dispersive coupling to a damped harmonic oscillator. We go beyond the weak qubit-oscillator coupling, which we associate with a phase Purcell effect, and enter into a strong coupling regime, with qualitatively different behavior of the dephasing rate. We identify and give a physicaly intuitive discussion of both decoherence mechanisms. Our results can be applied, with small adaptations, to a large variety of other physical systems, e. g. trapped ions and cavity QED, boosting theoretical and experimental decoherence studies.Comment: Published versio

Decoherence by electromagnetic fluctuations in double-quantum-dot charge qubits

We discuss decoherence due to electromagnetic fluctuations in charge qubits formed by two lateral quantum dots. We use an effective circuit model to evaluate correlations of voltage fluctuations in the qubit setup. These correlations allows us to estimate energy (T1) and phase (T2) relaxation times of the the qubit system. Our theoretical estimate of the quality factor due to dephasing by electromagnetic fluctuations yields values much higher than those found in recent experiments, indicating that other sources of decoherence play a dominant role.Comment: 12 pages, 5 figure

Single-electron transistor effect in a two-terminal structure

A peculiarity of the single-electron transistor effect makes it possible to observe this effect even in structures lacking a gate electrode altogether. The proposed method can be useful for experimental study of charging effects in structures with an extremely small central island confined between tunnel barriers like a nanometer-sized quantum dot or a macromolecule probed with a tunneling microscope), where it is impossible to provide a gate electrode for control of the tunnel current.Comment: 5 pages, 2 figure