Exploratory Talks as a Tool for Co-Diagnosis: Comparative Analysis of Residential Neighbourhoods in New Belgrade & Almere Haven

[Intro] The paper introduces a participatory tool for assessment of the Middle-Class Mass Housing (MCMH) in Europe that was simultaneously applied in two studies, on the two cases New Belgrade (Serbia) and Almere Haven (The Netherlands). The studies were exploring the values, problems and opportunities of these residential neighbourhoods through the eyes of their residents. [Method] A comparative analysis reveals contrasting and complementary aspects of the two cases. Exploratory interviews and surveys were used to collect testimonies of residents, informing the method of assessment (co-diagnosis) in residential neighbourhoods. By applying the same tool and comparing results, the paper contributes to a validation of this method for research on MCMH neighbourhoods in different regions and for different MCMH typologies and scales. [Result] The paper highlights some main themes of residents’ analysis of their neighbourhood’s strengths and weaknesses. Aspects discussed are, among others, deterioration (technical, functional, social), sense of community, place attachment, maintenance and taking care, ownership and appropriation, quality of public spaces and green areas, satisfaction and comfort. Both researches are still in development, but some preliminary conclusions can be sketched. Although both cases were built in the same decades (1970s-80s), they seem to hold opposite architectural and urban characteristics. New Belgrade is composed of modernist blocks with mass housing types in a high-rise urban pattern with mainly collective green spaces. Almere Haven is a suburban low-rise pattern and consists of a wide variety of typologies, materials and a range of private, collective and public green spaces. However, the residents’ opinions and assessments show many similarities, regarding the themes they address and the values and problems they identify. [Value for MCMH] The paper illustrates the diversity of MCMH in two different European regions and projects, identifying the broad scope that is needed to assess MCMH. Moreover, the method of exploratory talks with residents is identified as an important participatory tool within the broader analytical framework for MCMH neighbourhoods

The Anterior Cingulate Cortex Predicts Future States to Mediate Model-Based Action Selection

Behavioral control is not unitary. It comprises parallel systems, model based and model free, that respectively generate flexible and habitual behaviors. Model-based decisions use predictions of the specific consequences of actions, but how these are implemented in the brain is poorly understood. We used calcium imaging and optogenetics in a sequential decision task for mice to show that the anterior cingulate cortex (ACC) predicts the state that actions will lead to, not simply whether they are good or bad, and monitors whether outcomes match these predictions. ACC represents the complete state space of the task, with reward signals that depend strongly on the state where reward is obtained but minimally on the preceding choice. Accordingly, ACC is necessary only for updating model-based strategies, not for basic reward-driven action reinforcement. These results reveal that ACC is a critical node in model-based control, with a specific role in predicting future states given chosen actions.Akam et al. investigate mouse anterior cingulate cortex (ACC) in a sequential decision-making task, finding that ACC predicts future states given chosen actions and indicates when these predictions are violated. Transiently inhibiting ACC prevents mice from using observed state transitions to guide subsequent choices, impairing model-based reinforcement learning

Chronic arthritis leads to disturbances in the bone collagen network

Peer reviewe

Impact of COVID-19 Pandemic on TAVR Activity: A Worldwide Registry

Background: The COVID-19 pandemic had a considerable impact on the provision of structural heart intervention worldwide. Our objectives were: 1) to assess the impact of the COVID-19 pandemic on transcatheter aortic valve replacement (TAVR) activity globally; and 2) to determine the differences in the impact according to geographic region and the demographic, development, and economic status of diverse international health care systems. Methods: We developed a multinational registry of global TAVR activity and invited individual TAVR sites to submit TAVR implant data before and during the COVID-19 pandemic. Specifically, the number of TAVR procedures performed monthly from January 2019 to December 2021 was collected. The adaptive measures to maintain TAVR activity by each site were recorded, as was a variety of indices relating to type of health care system and national economic indices. The primary subject of interest was the impact on TAVR activity during each of the pandemic waves (2020 and 2021) compared with the same period pre–COVID-19 (2019). Results: Data were received from 130 centers from 61 countries, with 14 subcontinents and 5 continents participating in the study. Overall, TAVR activity increased by 16.7% (2,337 procedures) between 2018 and 2019 (ie, before the pandemic), but between 2019 and 2020 (ie, first year of the pandemic), there was no significant growth (–0.1%; –10 procedures). In contrast, activity again increased by 18.9% (3,085 procedures) between 2020 and 2021 (ie, second year of the pandemic). During the first pandemic wave, there was a reduction of 18.9% (945 procedures) in TAVR activity among participating sites, while during the second and third waves, there was an increase of 6.7% (489 procedures) and 15.9% (1,042 procedures), respectively. Further analysis and results of this study are ongoing and will be available at the time of the congress. Conclusion: The COVID-19 pandemic initially led to a reduction in the number of patients undergoing TAVR worldwide, although health care systems subsequently adapted, and the number of TAVR recipients continued to grow in subsequent COVID-19 pandemic waves. Categories: STRUCTURAL: Valvular Disease: Aorti

The striatum encodes action-specific forces of the forelimb.

In order to survive, animals must execute appropriate actions from their diverse repertoire to achieve specific goals. While past work has identified that the basal ganglia, and specifically the striatum, are critical for learning which action is appropriate based on reinforcement, the role that striatum plays in actually generating the appropriate action has been less studied. Our lab and others have shown that the concomitant activation of two subpopulations in the striatum (D1 receptor-expressing (D1R) striatonigral neurons and D2 receptor-expressing (D2R) striatopallidal neurons) encodes full-body movements, such as rearing, turning, and lever pressing. One possibility is that the striatum encodes full body movements as a consequence of its somatotopy, as recent work has elucidated a detailed mapping of the body in striatum, with different subregions of the striatum encoding the hind limb, forelimb, mouth, and others. Another possibility is that the relationship between striatum and action has finer granularity, and the striatum actually encodes specific actions and specific forces of the same body part. We asked whether ensembles of D1R and D2R SPNS within a single somatotopic region of striatum encode and actually modulate specific actions executed with a single effector – the forelimb. In addition, we asked how reinforcement and plasticity at glutamatergic synapses to SPNs modifies striatum’s encoding of fine action

Exploratory Talks as a Tool for Co-Diagnosis: Comparative Analysis of Residential Neighbourhoods in New Belgrade & Almere Haven

[Intro] The paper introduces a participatory tool for assessment of the Middle-Class Mass Housing (MCMH) in Europe that was simultaneously applied in two studies, on the two cases New Belgrade (Serbia) and Almere Haven (The Netherlands). The studies were exploring the values, problems and opportunities of these residential neighbourhoods through the eyes of their residents. [Method] A comparative analysis reveals contrasting and complementary aspects of the two cases. Exploratory interviews and surveys were used to collect testimonies of residents, informing the method of assessment (co-diagnosis) in residential neighbourhoods. By applying the same tool and comparing results, the paper contributes to a validation of this method for research on MCMH neighbourhoods in different regions and for different MCMH typologies and scales. [Result] The paper highlights some main themes of residents’ analysis of their neighbourhood’s strengths and weaknesses. Aspects discussed are, among others, deterioration (technical, functional, social), sense of community, place attachment, maintenance and taking care, ownership and appropriation, quality of public spaces and green areas, satisfaction and comfort. Both researches are still in development, but some preliminary conclusions can be sketched. Although both cases were built in the same decades (1970s-80s), they seem to hold opposite architectural and urban characteristics. New Belgrade is composed of modernist blocks with mass housing types in a high-rise urban pattern with mainly collective green spaces. Almere Haven is a suburban low-rise pattern and consists of a wide variety of typologies, materials and a range of private, collective and public green spaces. However, the residents’ opinions and assessments show many similarities, regarding the themes they address and the values and problems they identify. [Value for MCMH] The paper illustrates the diversity of MCMH in two different European regions and projects, identifying the broad scope that is needed to assess MCMH. Moreover, the method of exploratory talks with residents is identified as an important participatory tool within the broader analytical framework for MCMH neighbourhoods

WHotLAMP: A simple, inexpensive, and sensitive molecular test for the detection of SARS-CoV-2 in saliva.

Despite the development of effective vaccines against SARS-CoV-2, epidemiological control of the virus is still challenging due to slow vaccine rollouts, incomplete vaccine protection to current and emerging variants, and unwillingness to get vaccinated. Therefore, frequent testing of individuals to identify early SARS-CoV-2 infections, contact-tracing and isolation strategies remain crucial to mitigate viral spread. Here, we describe WHotLAMP, a rapid molecular test to detect SARS-CoV-2 in saliva. WHotLAMP is simple to use, highly sensitive (~4 viral particles per microliter of saliva) and specific, as well as inexpensive, making it ideal for frequent screening. Moreover, WHotLAMP does not require toxic chemicals or specialized equipment and thus can be performed in point-of-care settings, and may also be adapted for resource-limited environments or home use. While applied here to SARS-CoV-2, WHotLAMP can be modified to detect other pathogens, making it adaptable for other diagnostic assays, including for use in future outbreaks

Portuguese recommendations for pain management by pharmocotherapy in inflammatory arthritis

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