4,003 research outputs found
Biochemical analysis of human Dna2
Yeast Dna2 helicase/nuclease is essential for DNA replication and assists FEN1 nuclease in processing a subset of Okazaki fragments that have long single-stranded 5' flaps. It is also involved in the maintenance of telomeres. DNA2 is a gene conserved in eukaryotes, and a putative human ortholog of yeast DNA2 (ScDNA2) has been identified. Little is known about the role of human DNA2 (hDNA2), although complementation experiments have shown that it can function in yeast to replace ScDNA2. We have now characterized the biochemical properties of hDna2. Recombinant hDna2 has single-stranded DNA-dependent ATPase and DNA helicase activity. It also has 5'–3' nuclease activity with preference for single-stranded 5' flaps adjacent to a duplex DNA region. The nuclease activity is stimulated by RPA and suppressed by steric hindrance at the 5' end. Moreover, hDna2 shows strong 3'–5' nuclease activity. This activity cleaves single-stranded DNA in a fork structure and, like the 5'–3' activity, is suppressed by steric hindrance at the 3'-end, suggesting that the 3'–5' nuclease requires a 3' single-stranded end for activation. These biochemical specificities are very similar to those of the ScDna2 protein, but suggest that the 3'–5' nuclease activity may be more important than previously thought
Development of single-cell protectors for sealed silver-zinc cells
Three design approaches to cell-level protection were developed, fabricated, and tested. These systems are referred to as the single-cell protector (SCP), multiplexed-cell protector(MCP). To evaluate the systems 18-cell battery packs without cell level control were subjected to cycle life test. A total of five batteries were subjected to simulate synchronous orbit cycling at 40% depth of discharge at 22C. Batteries without cell-level protection failed between 345 and 255 cycles. Cell failure in the cell level protected batteries occurred between 412 and 540. It was determined that the cell-level monitoring and protection is necessary to attain the long cycle life of a AgZn battery. The best method of providing control and protection of the AgZn cells depends on the specific application and capability of the user
Development of single cell protectors for sealed silver-zinc cells, phase 1
A single cell protector (SCP) assembly capable of protecting a single silver-zinc (Ag Zn) battery cell was designed, fabricated, and tested. The SCP provides cell-level protection against overcharge and overdischarge by a bypass circuit. The bypass circuit consists of a magnetic-latching relay that is controlled by the high and low-voltage limit comparators. Although designed specifically for secondary Ag-Zn cells, the SCP is flexible enough to be adapted to other rechargeable cells. Eighteen SCPs were used in life testing of an 18-cell battery. The cells were sealed Ag-Zn system with inorganic separators. For comparison, another 18-cell battery was subjected to identical life test conditions, but with battery-level protection rather than cell-level. An alternative approach to the SCP design in the form of a microprocessor-based system was conceptually designed. The comparison of SCP and microprocessor approaches is also presented and a preferred approach for Ag-Zn battery protection is discussed
Exact solution for the stationary Kardar-Parisi-Zhang equation
We obtain the first exact solution for the stationary one-dimensional
Kardar-Parisi-Zhang equation. A formula for the distribution of the height is
given in terms of a Fredholm determinant, which is valid for any finite time
. The expression is explicit and compact enough so that it can be evaluated
numerically. Furthermore, by extending the same scheme, we find an exact
formula for the stationary two-point correlation function.Comment: 9 pages, 3 figure
Polynuclear growth model, GOE and random matrix with deterministic source
We present a random matrix interpretation of the distribution functions which
have appeared in the study of the one-dimensional polynuclear growth (PNG)
model with external sources. It is shown that the distribution, GOE, which
is defined as the square of the GOE Tracy-Widom distribution, can be obtained
as the scaled largest eigenvalue distribution of a special case of a random
matrix model with a deterministic source, which have been studied in a
different context previously. Compared to the original interpretation of the
GOE as ``the square of GOE'', ours has an advantage that it can also
describe the transition from the GUE Tracy-Widom distribution to the GOE.
We further demonstrate that our random matrix interpretation can be obtained
naturally by noting the similarity of the topology between a certain
non-colliding Brownian motion model and the multi-layer PNG model with an
external source. This provides us with a multi-matrix model interpretation of
the multi-point height distributions of the PNG model with an external source.Comment: 27pages, 4 figure
Supergiant Barocaloric Effects in Acetoxy Silicone Rubber over a Wide Temperature Range: Great Potential for Solid-state Cooling
Solid-state cooling based on caloric effects is considered a viable
alternative to replace the conventional vapor-compression refrigeration
systems. Regarding barocaloric materials, recent results show that elastomers
are promising candidates for cooling applications around room-temperature. In
the present paper, we report supergiant barocaloric effects observed in acetoxy
silicone rubber - a very popular, low-cost and environmentally friendly
elastomer. Huge values of adiabatic temperature change and reversible
isothermal entropy change were obtained upon moderate applied pressures and
relatively low strains. These huge barocaloric changes are associated both to
the polymer chains rearrangements induced by confined compression and to the
first-order structural transition. The results are comparable to the best
barocaloric materials reported so far, opening encouraging prospects for the
application of elastomers in near future solid-state cooling devices.Comment: 19 pages, 7 figures, 2 table
Asymmetric I-V characteristics and magnetoresistance in magnetic point contacts
We present a theoretical study of the transport properties of magnetic point
contacts under bias. Our calculations are based on the Keldish's
non-equilibrium Green's function formalism combined with a self-consistent
empirical tight-binding Hamiltonian, which describes both strong ferromagnetism
and charging effects. We demonstrate that large magnetoresistance solely due to
electronic effects can be found when a sharp domain wall forms inside a
magnetic atomic-scale point contact. Moreover we show that the symmetry of the
- characteristic depends on the position of the domain wall in the
constriction. In particular diode-like curves can arise when the domain wall is
placed off-center within the point contact, although the whole structure does
not present any structural asymmetry.Comment: 7 figures, submitted to PR
Effect of exchange interaction on fidelity of quantum state transfer from a photon qubit to an electron-spin qubit
We analyzed the fidelity of the quantum state transfer (QST) from a
photon-polarization qubit to an electron-spin-polarization qubit in a
semiconductor quantum dot, with special attention to the exchange interaction
between the electron and the simultaneously created hole. In order to realize a
high-fidelity QST we had to separate the electron and hole as soon as possible,
since the electron-hole exchange interaction modifies the orientation of the
electron spin. Thus, we propose a double-dot structure to separate the electron
and hole quickly, and show that the fidelity of the QST can reach as high as
0.996 if the resonant tunneling condition is satisfied.Comment: 5 pages, 4 figures, to be published in Phys. Rev. B Rapid
Communication
Gauge Structure of Vacuum String Field Theory
We study the gauge structure of vacuum string field theory expanded around
the D-brane solution, namely, the gauge transformation and the transversality
condition of the massless vector fluctuation mode. We find that the gauge
transformation on massless vector field is induced as an anomaly; an infinity
multiplied by an infinitesimal factor. The infinity comes from the singularity
at the edge of the eigenvalue distribution of the Neumann matrix, while the
infinitesimal factor from the violation of the equation of motion of the
fluctuation modes due to the regularization for the infinity. However, the
transversality condition cannot be obtained even if we take into account the
anomaly contribution.Comment: 19 pages, LaTeX2
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